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Protein synthesis and turnover in normal and hypertrophied heart
Rabinowitz, M. (1973) · The American Journal of Cardiology · doi:10.1016/0002-9149(73)91033-3 · Cited by 72
Wollert, T. (2019) · Current Biology · doi:10.1016/j.cub.2019.06.014 · Cited by 72
Impact of context-dependent autophagy states on tumor progression
Assi, M., & Kimmelman, A. C. (2023) · Nature Cancer · doi:10.1038/s43018-023-00546-7 · Cited by 80
Assays to Monitor Autophagy in Saccharomyces cerevisiae
Torggler, R., Papinski, D., & Kraft, C. (2017) · Cells · doi:10.3390/cells6030023 · Cited by 78
“The term autophagy was coined already in the 1960s by Christian De Duve [7,8].”
BackgroundThe Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
Ke, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123940 · Cited by 78
Light and electron microscopic studies on cellular alterations in the normal bovine placentome
Björkman, N. H. (1969) · The Anatomical Record · doi:10.1002/ar.1091630103 · Cited by 71
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A light- and electron-microscopic study of bacterial invasion in Whipple's disease.
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The fine structure of the mouse odontoblast
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Lysosomal enzyme activity in the interstitial fluid of solid mouse tumour transplants
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Isolation of human PMN leukocytes and granules: observations on early blood diluion and on heparin.
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Autophagy and Its Implications Against Early Full Nutrition Support in Critical Illness
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Regulation of neuronal autophagy and the implications in neurodegenerative diseases
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“Autophagy (from the Greek words “auto”: self and “phago”: eating) was first described in 1963 by Nobel-prize laureate Christian de Duve (De Duve and Wattiaux, 1966), although dense intracellular bodies that may have been autophagosomes were observed a few years earlier (Ashford and Porter, 1962,…”
Alternative pathways for MHC class I presentation: a new function for autophagy
Chemali, M., Radtke, K., Desjardins, M., & English, L. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0660-3 · Cited by 73
“The term ‘‘autophagy’’ was coined almost 50 years ago by Christian de Duve to describe a mechanism leading to the sequestration of part of the cytoplasm and different organelles into double-membrane vacuoles that were observed by electron microscopy in mammalian tissues [ 13 ].”
BackgroundMechanisms of lysosomal enzyme release from leukocytes
Hoffstein, S. T., & Weissmann, G. (1975) · Arthritis & Rheumatism · doi:10.1002/art.1780180213 · Cited by 70
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Serum Enzyme Changes after Hepatic Dearterialization in Man
Almersjö, O., Bengmark, S., Engevik, L., et al. (1968) · Annals of Surgery · doi:10.1097/00000658-196801000-00002 · Cited by 70
Alterations in the fine structure of the rat epididymis after vasectomy
Flickinger, C. J. (1972) · The Anatomical Record · doi:10.1002/ar.1091730304 · Cited by 70
Dexamethasone and DMSO in experimental transorbital cerebral infarction.
de la Torre, J. C., & Surgeon, J. W. (1976) · Stroke · doi:10.1161/01.str.7.6.577 · Cited by 70
Thimann, K. V., Paleg, L. G., West, C. A., Skoog, F. K., & Schmitz, R. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-668646-3.50010-1 · Cited by 71
Electron Microscopic Study of Cadmium Nephrotoxicity in the Rat
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
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Crosstalk Between ROS and Autophagy in Tumorigenesis: Understanding the Multifaceted Paradox
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Lipid accumulation of hypoxic tissue culture cells.
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Indian childhood cirrhosis in an American child
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Fate of sperm tail components after incorporation into the hamster egg
Hiraoka, J.-I., & Hirao, Y.-H. (1988) · Gamete Research · doi:10.1002/mrd.1120190408 · Cited by 69
Wolff, K. S. (1970) · Archives of Dermatology · doi:10.1001/archderm.1970.04000030020004 · Cited by 69
Lysosomes in Tetrahymena pyriformis I. Some properties and lysosomal localization of acid hydrolases
Müller, M., Baudhuin, P., & Duve, C. D. (1966) · Journal of Cellular Physiology · doi:10.1002/jcp.1040680211 · Cited by 68
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“Consequently, we concluded that (1) the enzymeNOEV complex has lower free energy than the unbound enzyme, and (2) protonation of an active site residue causes free energy change consistent with the chemical chaperone hypothesis.”
BackgroundDiurnal variation of autophagy in rod visual cells in the rat
Rem�, C., & Sulser, M. (1977) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00409832 · Cited by 68
Kotoulas, O. B., Kalamidas, S. A., & Kondomerkos, D. J. (2004) · Microscopy Research and Technique · doi:10.1002/jemt.20046 · Cited by 70
“This process includes the sequestration of polysaccharide in the autophagosomes and its subsequent degradation in the autolysosomes (DeDuve and Wattiaux 1966; Hers, 1964; Rosenfeld, 1964; Smith et al., 1968).”
BackgroundToxoplasma gondii and ocular toxoplasmosis: pathogenesis.
Pavesio, C. E., & Lightman, S. (1996) · British Journal of Ophthalmology · doi:10.1136/bjo.80.12.1099 · Cited by 68
The calyceal synapse of type I vestibular hair cells
Hamilton, D. W. (1968) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(68)80034-6 · Cited by 68
Conidiophore and Spore Development in Aspergillus nidulans
Oliver, P. T. P. (1972) · Journal of General Microbiology · doi:10.1099/00221287-73-1-45 · Cited by 68
“Vacuolation developed in the older regions of the stalk in association with bodies morphologically similar to autophagic vacuoles (De Duve & Wattiaux, 1966).”
BackgroundLysosomal Enzymes as Agents of Turnover of Soluble Cytoplasmic Proteins
Dean, R. T. (1975) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1975.tb02342.x · Cited by 68
Kaushik, S., & Cuervo, A. M. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.002 · Cited by 66
Insulin action on protein metabolism
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Some characteristics of the alanine aminotransferase- and arginase-inactivating system of lysosomes
Haider, M., & Segal, H. L. (1972) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(72)90136-1 · Cited by 67
Acid Phosphatase Activity in Melanosomes
Seiji, M., & Kikuchi, A. (1969) · Journal of Investigative Dermatology · doi:10.1038/jid.1969.33 · Cited by 67
Sunburn Effect on Keratinosomes
Wilgram, G. F. (1970) · Archives of Dermatology · doi:10.1001/archderm.1970.04000050009002 · Cited by 67
The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases
Chan, T., Wilkinson‐Berka, J. L., Deliyanti, D., Hunter, D., Fung, A. T.-C., Liew, G., & White, A. J. R. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108255 · Cited by 68
Autophagy Modulators in Cancer Therapy
Buzun, K., Gornowicz, A., Lesyk, R., Bielawski, K., & Bielawska, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115804 · Cited by 68
Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism
Wende, A. R., Young, M. E., Chatham, J. C., Zhang, J., Rajasekaran, N. S., & Darley-Usmar, V. M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.05.022 · Cited by 66
Hu, L., Wang, H., Huang, L., Zhao, Y. L., & Wang, J. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9460462 · Cited by 66
“Mitophagy is a cargo-specific autophagy that selectively removes damaged mitochondria [48].”
BackgroundNon-Apoptotic Cell Death Signaling Pathways in Melanoma
Hartman, M. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082980 · Cited by 66
Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles
Qiu, K., Du, Y., Liu, J., Guan, J., Chao, H., & Diao, J. (2020) · Theranostics · doi:10.7150/thno.42134 · Cited by 65
Use of monoclonal antibody against human neutrophil elastase in normal and leukaemic myeloid cells.
Pulford, K. A. F., Erber, W. N., Crick, J. A., et al. (1988) · Journal of Clinical Pathology · doi:10.1136/jcp.41.8.853 · Cited by 66
PATEL, H. P., Diaz, L. A., Anhalt, G. J., et al. (1984) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12273480 · Cited by 66
Sekhon, S. S., & Beams, H. W. (1969) · American Journal of Anatomy · doi:10.1002/aja.1001250307 · Cited by 66
Brooker, B. E. (1971) · Cell and Tissue Research · doi:10.1007/bf00335057 · Cited by 66
Lysosomes, membranes and aging
Hochschild, R. (1971) · Experimental Gerontology · doi:10.1016/s0531-5565(71)80014-1 · Cited by 66
Soluble synthetic polymers in biological systems
Drobnik, J., & Rypáček, F. (1984) · Advances in polymer science · doi:10.1007/3-540-12796-8_9 · Cited by 66
The neuromyopathy of vincristine in the guinea pig
Bradley, W. G. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90014-6 · Cited by 66
THE EFFECTS OF ENUCLEATION ON THE CYTOPLASMIC MEMBRANES OF AMOEBA PROTEUS
Flickinger, C. J. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.37.2.300 · Cited by 66
Regulation of Exercise-Induced Autophagy in Skeletal Muscle
Rocchi, A., & He, C. (2017) · Current Pathobiology Reports · doi:10.1007/s40139-017-0135-9 · Cited by 69
“The Vps34 kinase complex generates the lipid phosphatidylinositol 3-phospate (PI3P), which in turn recruits additional PI3P-binding autophagy proteins, including WIPI1 and DFCP1, and promotes autophagosome formation [21–23].”
InfluentialEmerging roles of autophagy in metabolism and metabolic disorders
Rocchi, A., & He, C. (2015) · Frontiers in Biology · doi:10.1007/s11515-015-1354-2 · Cited by 66
“Literally defined as cellular “self-eating,” autophagy is an evolutionarily conserved catabolic process that targets longlived cytoplasmic proteins or damaged organelles for lysosomal degradation (De Duve and Wattiaux, 1966).”
Fine structure of the spermatheca of Apis mellifera
Dallai, R. (1975) · Journal of Insect Physiology · doi:10.1016/0022-1910(75)90072-4 · Cited by 65
Myoclonic Epilepsy With Lafora Bodies
Gambetti, P. L. (1971) · Archives of Neurology · doi:10.1001/archneur.1971.00490060017002 · Cited by 65
Development of the endometrium during the estrous cycle in the bitch
Barrau, M. D., Abel, J. H., Verhage, H. G., et al. (1975) · American Journal of Anatomy · doi:10.1002/aja.1001420105 · Cited by 65
Autophagy in aging and in neurodegenerative disorders
Rajawat, Y. S., & Bossis, I. (2008) · HORMONES · doi:10.14310/horm.2002.1111037 · Cited by 66
“The contents of the autophagosome are released into the lysosomal cavity, where degradation takes place by the action of hydrolytic enzymes, which is facilitated by the acidic lysosomal environment.(11)”
BackgroundEffect of anti-inflammatory drugs on lysosomes and lysosomal enzymes from rat liver
Smith, R. J., Sabin, C., Gilchrest, H., et al. (1976) · Biochemical Pharmacology · doi:10.1016/0006-2952(76)90129-5 · Cited by 65
A histochemical study of gut maturation.
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Morphology and cytochemistry of the Golgi apparatus of rat salivary gland acinar cells
Hand, A. R. (1971) · American Journal of Anatomy · doi:10.1002/aja.1001300203 · Cited by 65
Cavalier‐Smith, T. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016006 · Cited by 67
“De Duve and Wattiaux (1966) suggested that rough ER evolved by budding from the CM of a wall-less bacterium when evolving an ability to ingest other cells by a primitive version of phagocytosis, with subsequent differentiation of internalized vesicles producing the Golgi apparatus and lysosomes for…”
BackgroundYoon, M. C., Solania, A., Jiang, Z., Christy, M. P., Podvin, S., Mosier, C., Lietz, C. B., Ito, G., Gerwick, W. H., Wolan, D. W., et al. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00138 · Cited by 67
Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis
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Endosymbiosis before eukaryotes: mitochondrial establishment in protoeukaryotes
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Dopamine and noradrenaline transport into subcellular vesicles of the striatum
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Character and origin of vacuoles induced in mammalian cells by the cytotoxin of Helicobacter pylori
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Structure and function of the fresh water spongeEphydatia fluviatilis L. (Porifera)
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Role of Lysosomes in Carrageenan-Induced Cecal Ulceration
Abraham, R., Fabian, R. J., Golberg, L., & Coulston, F. (1974) · Gastroenterology · doi:10.1016/s0016-5085(19)32703-9 · Cited by 64
Multiple Forms of Cathepsin D from Bovine Uterus
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LYSOSOMAL CHANGES IN RAT HEPATIC PARENCHYMAL CELLS AFTER GLUCAGON ADMINISTRATIONI
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Studies on the structure-bound sedimentability of some rat liver lysosome hydrolases
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Concerning a possible mechanism for selective capture of cytoplasmic proteins by lysosomes
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Uriniferous Tubule: Structural and Functional Organization
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Biliary protein output by isolated perfused rat livers. Effects of bile salts
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Biosynthesis of an insulin precursor by islet tissue of cod (Gadus callarias)
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“In principle, microautophagy represents a collection of processes, best characterized in yeast, which involve direct internalization of cytoplasmic cargo into the lumen of lysosomes by invaginations of the delimiting single bilayer lysosomal membrane [83-86].”
BackgroundMolecular Mechanisms of Autophagy in Cancer Development, Progression, and Therapy
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BackgroundUnderlying Mechanism of Lysosomal Membrane Permeabilization in CNS Injury: A Literature Review
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“Lysosomes are organelles with single membranes that house a multitude of acidic hydrolases, and their primary cellular function is the degradation of exogenous or endogenous macromolecular material [15, 16].”
Approaches for Studying Autophagy in Caenorhabditis elegans
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“is a powerful approach for the identification of phagophores and autophagosomes that are sequestering fragmented mitochondria [87].”
BackgroundThe fluorescence toolbox for visualizing autophagy
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Ubiquitin and endocytic protein sorting
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Increased activity of lysosomal enzymes in human atherosclerotic aortas
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TSPO is a REDOX regulator of cell mitophagy
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Metadata
- Authors
- de Duve, C., & Wattiaux, R.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1966-03
- Volume
- 28
- Issue
- 1
- Pages
- 435-492
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2138948114
- Cited by
- 3,033
- References
- 0
- Citations by year
- 2026: 25 · 2025: 56 · 2024: 58 · 2023: 50 · 2022: 47 · 2021: 75 · 2020: 68 · 2019: 54 · 2018: 79 · 2017: 65 · 2016: 70 · 2015: 63 · 2014: 64 · 2013: 64 · 2012: 51
- FWCI
- 111.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- lysosomes, lysosomal function, intracellular digestion, acid hydrolases, membrane trafficking, endocytosis, autophagy
- MeSH terms
- Animals, Lysosomes, In Vitro Techniques
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