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Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies
Silva, M. C., & Haggarty, S. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238948 · Cited by 89
Elucidating the composition and conservation of the autophagy pathway in photosynthetic eukaryotes
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“In addition, autophagy is an effective defense mechanism against pathogens and recycling machinery for macromolecules that helps the cell to cope with nutrient scarcity.(20-22) Along with its survival role, autophagy can lead to programmed cell death upon severe stress, in a process accompanied by autophagosomes.”
BackgroundCementsome, a new interpretation of the membrane-coating granule
Hashimoto, K. (1971) · Archives of Dermatological Research · doi:10.1007/bf00584589 · Cited by 84
“Acid phosphatase is certainly a marker of lysosomes and, if present within a granule delimited with a trilaminar membrane, such as the cementsome, places it in a class of lysosome [4, 30].”
BackgroundWu, L., Wang, Y., James, T. D., Jia, N., & Huang, C. (2018) · Chemical Communications · doi:10.1039/c8cc02330a · Cited by 80
Lysosomal microautophagy: an emerging dimension in mammalian autophagy
Kuchitsu, Y., & Taguchi, T. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.11.005 · Cited by 93
Group XV phospholipase A2, a lysosomal phospholipase A2
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“They are characterized by an acidic pH optimum and are critically important for the degradation of intracellular and extracellular macromolecules that are trafficked to the lysosome by endocytic, phagocytic, and autophagic pathways [1,2].”
BackgroundThe Lysosomal System in Neuronal Cell Death: A Reviewa
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The Structure and Development of the Vacuolar System in the Fat Body of Insects
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Stria Ultrastructure and Vessel Transport in Acoustic Trauma
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“tron microscopy (TEM) studies of germinating spores in 1969,(10) shortly after Christian de Duve coined the term autophagy.(11) We have come a long way from these initial mor-”
BackgroundIs autophagy associated with diabetes mellitus and its complications? A review
Bhattacharya, D., Mukhopadhyay, M., Bhattacharyya, M., & Karmakar, P. (2018) · EXCLI journal · doi:10.17179/excli2018-1353 · Cited by 82
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“…the initial breakdown of transported proteins (Kirschke and Barrett, 1985; Kominami et al., 1991; Bohley and Seglen, 1992), and its suppression would presumably lead to the accumulation of incompletely digested proteins and proteinaceous structures (for discussion, see de Duve and Wattiaux, 1966).”
BackgroundLysosomal enzyme activity in rats with adjuvant-induced arthritis.
Anderson, A. J. B. (1970) · Annals of the Rheumatic Diseases · doi:10.1136/ard.29.3.307 · Cited by 82
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Sialidase of Rat Liver and Kidney
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Renal tubular mechanisms of organic solute transport
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Adaptive Response, Evidence of Cross-Resistance and Its Potential Clinical Use
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“The term microautophagy was proposed in 1966 when it was suggested that tiny portions of cytoplasm could be sequestered and subsequently engulfed by lysosomes [60].”
BackgroundRole of Macrophage Lysosomal Enzymes in the Degradation of Nucleosomes of Apoptotic Cells
Odaka, C., & Mizuochi, T. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.10.5346 · Cited by 81
The Cytophysiology of Insect Blood
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Triglyceride breakdown in rat liver the demonstration of three different lipases
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Pathomechanisms in the neuronal ceroid lipofuscinoses
Nelvagal, H. R., Lange, J., Takahashi, K., Tarczyluk-Wells, M. A., & Cooper, J. D. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165570 · Cited by 80
Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking
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Role of Autophagy in Lung Inflammation
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“This process of cellular recycling and degradation was coined autophagy in 1963 (5, 6).”
BackgroundAutophagy, Redox Signaling, and Ventricular Remodeling
Gurusamy, N., & Das, D. K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2524 · Cited by 83
“Autophagy in cardiac myocytes was first reported by Sybers et al. in 1976 (130), approximately one decade after the initial description of autophagy in mammalian cells (18).”
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Multicompartment Artificial Organelles Conducting Enzymatic Cascade Reactions inside Cells
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Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins
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Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity
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“However, the initial enthusiasm about these single-membrane-bound digestive organelle”
BackgroundUltrastructural changes in the epithelium during fusion of the palatal processes in rats
Hayward, A. F. (1969) · Archives of Oral Biology · doi:10.1016/0003-9969(69)90188-5 · Cited by 79
Neuronal autophagy in experimental scrapie
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“The morphological manifestation of autophagic activity is the autophagic vacuole (AV) [6].”
LIPOFUSCIN (AGING) PIGMENT GRANULES OF THE NEWBORN HUMAN LIVER
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“The contents of the lipofuscin granules are believed to be mainly the undigested residue of lysosomal hydrolysis (for discussion, see de Duve and Wattiaux, 1966 ; Goldfischer et al., 1966 ; Frank and Christensen, 1968) .”
BackgroundLocke, M. (1969) · Tissue and Cell · doi:10.1016/s0040-8166(69)80021-2 · Cited by 80
Effects of calcitonin on osteoclasts in vivo
Lucht, U. (1973) · Cell and Tissue Research · doi:10.1007/bf00307190 · Cited by 77
The ultrastructure of rat lung changes induced by an anorectic drug (Chlorphentermine)
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Where do they come from? Insights into autophagosome formation
Hamasaki, M., & Yoshimori, T. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.061 · Cited by 79
“other small degradative products [9] thus maintaining a stable nutrient source for rapid adaptation to emergency situations.”
BackgroundSohal, R. S., Peters, P. D., & Hall, T. A. (1977) · Tissue and Cell · doi:10.1016/0040-8166(77)90051-9 · Cited by 77
PVC bacteria: variation of, but not exception to, the Gram-negative cell plan
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Simultaneous visualization of lipid droplets and lysosomes using a single fluorescent probe
Meng, F., Niu, J., Zhang, H., Yang, R., Lu, Q., Yu, Y. F., Liu, Z., Niu, G., & Yu, X. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.129148 · Cited by 72
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“Many display empty “pitted areas within their confines and now resemble terminal 290 MURRAY A. MATTHEWS AND LAWRENCE KRUGER lysosomes (Deduve and Wattiaux, ’66; Hruban and Rechcigl, ’69).”
BackgroundLysosomal phospholipases A1 and A2 of bovine adrenal medulla
Smith, A. D., & Winkler, H. J. S. (1968) · Biochemical Journal · doi:10.1042/bj1080867 · Cited by 77
Lysosomes and myocardial cellular injury
Ricciutti, M. A. (1972) · The American Journal of Cardiology · doi:10.1016/0002-9149(72)90040-9 · Cited by 77
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“[12] [13] [14] Multiple membrane sources (plasma membrane, ER/endoplasmic reticulum, mitochondria, endosomes, Golgi) and regulatory factors are involved in the process of autophagy to recognize various cargos and activate downstream components of various pathways (reviewed in ref.”
BackgroundThe Regulatory Properties of the Ccr4–Not Complex
Hagkarim, N. C., & Grand, R. J. A. (2020) · Cells · doi:10.3390/cells9112379 · Cited by 76
P-glycoprotein and resistance to anticancer drugs
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ROS, autophagy, mitochondria and cancer: Ras, the hidden master?
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Autophagy in the brain of neonates following hypoxia–ischemia shows sex- and region-specific effects
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Acid Hydrolase Activities and Lysosomal Integrity in Liver Biopsies from Patients with Iron Overload
Peters, T. J., & Seymour, C. A. (1976) · Clinical Science · doi:10.1042/cs0500075 · Cited by 76
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An electron microscope study of differentiation and growth in oocytes of Ophioderma panamensis
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Dual-Functional NIR AIEgens for High-Fidelity Imaging of Lysosomes in Cells and Photodynamic Therapy
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Autophagy and neurodegeneration
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“Although the basic mechanisms of autophagy and some of its physiologic functions have been known for more than 50 years [ 4 ,5], there is currently a renewed interest in this topic.”
BackgroundProtective effect of lupeol and lupeol linoleate in hypercholesterolemia associated renal damage
Varadarajan, S., Kumar, S. A., Varalakshmi, P., & Sujatha, V. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9786-5 · Cited by 75
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The ovary of the guppy Poecilia reticulata
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The lysosomal membrane complex. Focal point of primary steroid hormone action
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Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease
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“strained by containment within lysosomes (34).”
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Melanin and Cellular Reactions to Ultraviolet Radiation
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SELECTIVE RELEASE OF CONTENT FROM MICROSOMAL VESICLES WITHOUT MEMBRANE DISASSEMBLY
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“The intracellular autophagy program was initially recognized and described histologically approximately 50 years ago [2, 3].”
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“Soon after the initial discovery and characterization of lysosomes by DeDuve and his coworkers, these investigators proceeded to elucidate the role of lysosomes in the intracellular digestion of autologous and heterologous materials [ 1-3 ].”
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OBSERVATIONS ON THE FINE STRUCTURE OF THE CRYPTOPHYCEAE. I. THE GENUS CRYPTOMONAS1,2
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“actually not far off from original suggestions from the late 1960s [213] and 1970s [214], when early studies in mammalian cells proposed the ER as the source of the isolation membrane.”
BackgroundIntracellular symbiotes of the pea aphid, Acyrthosiphon pisum
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Endoplasmic reticulum and autophagy in rat hepatocytes.
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Metadata
- Authors
- de Duve, C., & Wattiaux, R.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1966-03
- Volume
- 28
- Issue
- 1
- Pages
- 435-492
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2138948114
- Cited by
- 3,033
- References
- 0
- Citations by year
- 2026: 25 · 2025: 56 · 2024: 58 · 2023: 50 · 2022: 47 · 2021: 75 · 2020: 68 · 2019: 54 · 2018: 79 · 2017: 65 · 2016: 70 · 2015: 63 · 2014: 64 · 2013: 64 · 2012: 51
- FWCI
- 111.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- lysosomes, lysosomal function, intracellular digestion, acid hydrolases, membrane trafficking, endocytosis, autophagy
- MeSH terms
- Animals, Lysosomes, In Vitro Techniques
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