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Hall, T., Sandefur, S. L., Frye, C. C., et al. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2016.02.022 · Cited by 172
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Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells
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“The self-eating/autophagy process was first described in neurons, viewed by electron microscopy, over four decades ago.(3,4) It has taken many years to recognize macroautophagy (autophagy hereafter) as a cellular process implicated in multiple physiological and pathological situations (for reviews, see refs.”
BackgroundAutophagy: molecular machinery, regulation, and implications for renal pathophysiology
Periyasamy‐Thandavan, S., Jiang, M., Schoenlein, P. V., & Dong, Z. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00033.2009 · Cited by 170
“However, in the late 1960s, autophagy was found to be enhanced in various organs including newborn kidney (29).”
BackgroundPalikaras, K., Daskalaki, I., Markaki, M., & Tavernarakis, N. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.04.005 · Cited by 181
“Mitochondrial selective autophagy was first monitored in hepatocytes upon glucagon stimulation and is associated with proper liver function and homeostasis (De Duve & Wattiaux, 1966).”
BackgroundEffect of insulin on protein turnover in heart muscle.
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THE UPTAKE AND DIGESTION OF IODINATED HUMAN SERUM ALBUMIN BY MACROPHAGES IN VITRO
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IN VITRO INDUCTION OF LYSOSOMAL ENZYMES BY PHAGOCYTOSIS
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“The additional possibilities that the foreign materials altered the pinocytic rates of parenchymal and/or phagocytic cells, that the nondigestible particles were complexed to digestible protein when ingested, and that the autophagy induced by foreign materials makes any explanation of whole animal results difficult (1…”
BackgroundCytochemical studies on GERL, provacuoles, and vacuoles in root meristematic cells of Euphorbia
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Vacuolation: Origin and development of the lysosomal apparatus in root-tip cells
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Cellular degeneration in the production of some mutant phenotypes in Drosophila melanogaster
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“De Duve and Wattiaux (1966) first reported that lethal cell injury occurs as a result of release of hydrolytic enzymes from damaged lysosomes.”
BackgroundSelective escape of proteins from the mitochondria during mitophagy
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Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death
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Variability in the Chemical Composition of Human Skin Surface Lipids*
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AUTOPHAGIC VACUOLES PRODUCED IN VITRO
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Autophagy in hepatic adaptation to stress
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“Shortly after the discovery of lysosomes (42) and the pro-”
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“De Duve and Wattiaux[3] suggested as long ago time, investigators were hampered by the inability to extract and purify sufficient quantities of enzyme toas 1966 the possibility of treatment of LSDs by treat even a single patient for more than a fewreplacement of the defective enzyme by infusion of months.normal enzyme.”
BackgroundInfluentialLysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel
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“An autogenous origin for the eukaryotic endomembrane system was suggested more than 40 years ago [34,35] and is supported by recent evidence [36,37].”
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“Since 1963, de Duve and Wattiaux [19] has defined the degradation process (delivering cytoplasmic matter to lysosomes) as “autophagy” by high-resolution transmission electron microscopy.”
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Background
Metadata
- Authors
- de Duve, C., & Wattiaux, R.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1966-03
- Volume
- 28
- Issue
- 1
- Pages
- 435-492
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2138948114
- Cited by
- 3,033
- References
- 0
- Citations by year
- 2026: 25 · 2025: 56 · 2024: 58 · 2023: 50 · 2022: 47 · 2021: 75 · 2020: 68 · 2019: 54 · 2018: 79 · 2017: 65 · 2016: 70 · 2015: 63 · 2014: 64 · 2013: 64 · 2012: 51
- FWCI
- 111.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- lysosomes, lysosomal function, intracellular digestion, acid hydrolases, membrane trafficking, endocytosis, autophagy
- MeSH terms
- Animals, Lysosomes, In Vitro Techniques
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