Cited by 3,033Cellular transport and secretionAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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Functions of Lysosomes

de Duve, Christian, Wattiaux, Robert·1966·Annual Review of Physiology

DOI 10.1146/annurev.ph.28.030166.002251

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“Lysosomes were observed by de Duve and colleagues as acidic cytoplasmic organelles (de Duve and Wattiaux, 1966).”
Background
Chronic Solar Dermatosis: A Light and Electron Microscopic Study of the Dermis*
Mitchell, R. E. (1967) · Journal of Investigative Dermatology · doi:10.1038/jid.1967.33 · Cited by 176
Ca2+/H+ exchange in acidic vacuoles of Trypanosoma brucei
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Cell killing by lysosomotropic detergents.
Miller, D. K., Griffiths, E., Lenard, J., & Firestone, R. A. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.6.1841 · Cited by 174
“... the detergents ;(e)bothcellular uptakeandsensitivity todetergent aminesisafunctionofthedensityand/orgrowthstateofthe cells, withthemostrapidlygrowingcellsbeingmostsensitive . Whiletheprecisemechanism wherebylysosomotropic detergentskillcellsisnotyetknown, itishighlylikelyfrom the aboveobservations thatitistherelea…”
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Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker's yeast fuel advances in biomedical research
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Granulocytes and no-reflow phenomenon in irreversible hemorrhagic shock.
Barroso-Aranda, J., Schmid‐Schönbein, G. W., Zweifach, B. W., & Engler, R. L. (1988) · Circulation Research · doi:10.1161/01.res.63.2.437 · Cited by 173
Autophagy in the cardiovascular system
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“One of the ﬁ rst reports that described autophagy in the heart was published in the mid 1970s, one decade after the initial description of autophagy in mammalian cells [7].”
Background
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders
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Cell death and the disease process. The role of calcium
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Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.
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Authors: de Duve, C., & Wattiaux, R.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 1966-03
Volume: 28
Issue: 1
Pages: 435-492
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.ph.28.030166.002251
OpenAlex: W2138948114
Cited by: 3,033
References: 0
Citations by year: 2026: 25 · 2025: 56 · 2024: 58 · 2023: 50 · 2022: 47 · 2021: 75 · 2020: 68 · 2019: 54 · 2018: 79 · 2017: 65 · 2016: 70 · 2015: 63 · 2014: 64 · 2013: 64 · 2012: 51
FWCI: 111.33
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: lysosomes, lysosomal function, intracellular digestion, acid hydrolases, membrane trafficking, endocytosis, autophagy
MeSH terms: Animals, Lysosomes, In Vitro Techniques

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