Cited by 3,033Cellular transport and secretionAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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Functions of Lysosomes

de Duve, Christian, Wattiaux, Robert·1966·Annual Review of Physiology

DOI 10.1146/annurev.ph.28.030166.002251

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Background
Digestive Activity of Lysosomes
Fowler, S., & Duve, C. D. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94453-4 · Cited by 252
Self-citation
Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?
Higgins, G. C., & Coughlan, M. T. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12503 · Cited by 257
“…removal of mitochondria Classical autophagy, as it was first described by De Duve, is a non-selective process whereby cytosolic contents (long-lived proteins and organelles) are sequestered into autophagosomes for transport to lysosomes for bulk degradation (De Duve and Wattiaux, 1966).”
Background
Hsp70 – a master regulator in protein degradation
Fernández-Fernández, M. R., Gragera, M., Ochoa‐Ibarrola, L., Quintana‐Gallardo, L., & Valpuesta, J. (2017) · FEBS Letters · doi:10.1002/1873-3468.12751 · Cited by 260
Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries
Oku, M., & Sakai, Y. (2018) · BioEssays · doi:10.1002/bies.201800008 · Cited by 271
DIFFERENTIATION OF MONOCYTES
NICHOLS, B. A., Bainton, D. F., & Farquhar, M. G. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.50.2.498 · Cited by 250
The Role of Uric Acid as an Endogenous Danger Signal in Immunity and Inflammation
Oskouie, F. G., & Shi, Y. (2011) · Current Rheumatology Reports · doi:10.1007/s11926-011-0162-1 · Cited by 254
“It is important to recognize that such a scenario suggests the release of phagolysosomal content, which has long been considered a death signal to the cell [41].”
Background
Structure and function of blood and connective tissue cells of the fresh water pulmonate Lymnaea stagnalis studied by electron microscopy and enzyme histochemistry
Sminia, T. (1972) · Cell and Tissue Research · doi:10.1007/bf00307004 · Cited by 249
EVOLUTION OF THE PEROXISOME
Duve, C. D. (1969) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1969.tb43124.x · Cited by 249
Self-citation
Aging: Central role for autophagy and the lysosomal degradative system
Rajawat, Y. S., Hilioti, Z., & Bossis, I. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.001 · Cited by 254
Autophagy, lipophagy and lysosomal lipid storage disorders
Ward, C., Martínez-López, N., Otten, E. G., Carroll, B., Maetzel, D., Singh, R., Sarkar, S., & Korolchuk, V. I. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.01.006 · Cited by 254
“The term autophagywasfirst described in 1966 and is translated from Greek to mean “self-eating” [1].”
Background

Authors: de Duve, C., & Wattiaux, R.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 1966-03
Volume: 28
Issue: 1
Pages: 435-492
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.ph.28.030166.002251
OpenAlex: W2138948114
Cited by: 3,033
References: 0
Citations by year: 2026: 25 · 2025: 56 · 2024: 58 · 2023: 50 · 2022: 47 · 2021: 75 · 2020: 68 · 2019: 54 · 2018: 79 · 2017: 65 · 2016: 70 · 2015: 63 · 2014: 64 · 2013: 64 · 2012: 51
FWCI: 111.33
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: lysosomes, lysosomal function, intracellular digestion, acid hydrolases, membrane trafficking, endocytosis, autophagy
MeSH terms: Animals, Lysosomes, In Vitro Techniques

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