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“In 1966, Christian de Duve and Robert Wattiaux first visualized mitophagy in mammalian cells [16].”
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“The phenomenon of autophagy first was described by the late Christian de Duve nearly half a century ago [6].”
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“Macroautophagy (De Duve and Wattiaux, 1966) can be induced by a number of signals (e.g., hypoxia, nutrient depletion, cellular damage, production of oxygen reactive species).”
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“deDuve and Wattiaux ( 10 ) refer to the Golgi apparatus and the lysosomes as the intracellular digestive apparatus.”
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“In the absence of any alternative, and with lysosomal degradation as the most logical explanation for targeting all known classes of proteins at the time, Christian de Duve summarized his view on the subject in a review article published in the mid-1960s, saying: ‘Just as extracellular digestion is successfully carrie…”
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“…however, it wasn’t until 50 years later that de Duve proposed this degradation might be caused by selective, mitochondrial specific autophagy (De Duve & Wattiaux, 1966) following the visualisation of mitochondria within autophagosomes/lysosomes (Ashford & Porter, 1962; Novikoff & Essner, 1962).”
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“In microautophagy, lysosomal compartments incorporate the cytoplasm and specific proteins (de Duve and Wattiaux 1966).”
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“Large arrowheads indicate P-element insertions tested during this work, which are the following: (1) EP648 (Szeged); (2) l(3)S005042 (Szeged); (3) l(3)S012719 (Szeged); (4) EP3015b (Szeged); (5) EP3310 (Szeged); (6) EP3332 (Szeged); (7) EP3176 (Szeged); (8) KG10152 (Bloomington); (9) EP772 (Szeged); (10) KG00325 (Bloo…”
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Metadata
- Authors
- de Duve, C., & Wattiaux, R.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1966-03
- Volume
- 28
- Issue
- 1
- Pages
- 435-492
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2138948114
- Cited by
- 3,033
- References
- 0
- Citations by year
- 2026: 25 · 2025: 56 · 2024: 58 · 2023: 50 · 2022: 47 · 2021: 75 · 2020: 68 · 2019: 54 · 2018: 79 · 2017: 65 · 2016: 70 · 2015: 63 · 2014: 64 · 2013: 64 · 2012: 51
- FWCI
- 111.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- lysosomes, lysosomal function, intracellular digestion, acid hydrolases, membrane trafficking, endocytosis, autophagy
- MeSH terms
- Animals, Lysosomes, In Vitro Techniques
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