Targeting Homeostatic Synaptic Plasticity for Treatment of Mood Disorders
Open accessAbstract
Ketamine exerts rapid antidepressant action in depressed and treatment-resistant depressed patients within hours. At the same time, ketamine elicits a unique form of functional synaptic plasticity that shares several attributes and molecular mechanisms with well-characterized forms of homeostatic synaptic scaling. Lithium is a widely used mood stabilizer also proposed to act via synaptic scaling for its antimanic effects. Several studies to date have identified specific forms of homeostatic synaptic plasticity that are elicited by these drugs used to treat neuropsychiatric disorders. In the last two decades, extensive work on homeostatic synaptic plasticity mechanisms have shown that they diverge from classical synaptic plasticity mechanisms that process and store information and thus present a novel avenue for synaptic regulation with limited direct interference with cognitive processes. In this review, we discuss the intersection of the findings from neuropsychiatric treatments and homeostatic plasticity studies to highlight a potentially wider paradigm for treatment advance.
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The synaptic scaling hypothesis proposes that ketamine restores stress-impaired excitatory synapses by blocking spontaneously activated NMDARs, reducing Ca2+ influx and CaMK/eEF2K activity, de-suppressing eEF2 translation, increasing GluA1 and BDNF, and raising synaptic AMPAR expression.
“This hypothesis posits that ketamine restores stress-impaired excitatory synapses by blocking a subset of NMDARs that are preferentially activated by spontaneous glutamate release.”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [154]
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Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
Self-citationBienenstock, E., Cooper, L., & Munro, P. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-01-00032.1982 · Cited by 2,896 · see citing works
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485 · see citing works
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226 · see citing works
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works
Self-citationNeuroligins and neurexins link synaptic function to cognitive disease
Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849 · cited 1× · see citing works
“Mutations in a number of synaptic proteins linked to autism have shown particular proteins play critical roles in distinct forms of homeostatic plasticity (Zoghbi, 2003; Südhof, 2008).”
BackgroundSynaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715 · see citing works
Tsodyks, M. V., & Markram, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.719 · Cited by 1,607 · see citing works
LITHIUM SALTS IN THE TREATMENT OF PSYCHOTIC EXCITEMENT
Cade, J. F. (1949) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1949.tb36912.x · Cited by 1,456 · see citing works
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349 · see citing works
The Story of Rett Syndrome: From Clinic to Neurobiology
Chahrour, M., & Zoghbi, H. Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.001 · Cited by 1,265 · see citing works
Lithium salts in the treatment of psychotic excitement
Cade, J. F. (1999) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.1999.06241.x · Cited by 1,146 · see citing works
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
Bassell, G. J., & Warren, S. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.004 · Cited by 1,051 · see citing works
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046 · see citing works
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
Conrad, K. L., Tseng, K. Y., Uejima, J. L., Reimers, J. M., Heng, L.-J., Shaham, Y., Marinelli, M., & Wolf, M. E. (2008) · Nature · doi:10.1038/nature06995 · Cited by 790 · see citing works
Huettner, J. E., & Bean, B. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.4.1307 · Cited by 751 · see citing works
A study of supersensitivity in denervated mammalian skeletal muscle
Axelsson, J., & Thesleff, S. (1959) · The Journal of Physiology · doi:10.1113/jphysiol.1959.sp006233 · Cited by 740 · see citing works
Daly, E. J., Singh, J. B., Fedgchin, M., Cooper, K., Lim, P., Shelton, R. C., Thase, M. E., Winokur, A., Van Nueten, L., Manji, H., et al. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.3739 · Cited by 718 · see citing works
Postnatal neurodevelopmental disorders: meeting at the synapse?
Zoghbi, H. Y. (2003) · Science · doi:10.1126/science.1089071 · Cited by 691 · see citing works
Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
O’Brien, R. J., Kamboj, S., Ehlers, M. D., Rosen, K. R., Fischbach, G. D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80624-8 · Cited by 688 · see citing works
Zalfa, F., Giorgi, M., Primerano, B., Moro, A., Di Penta, A., Reis, S., Oostra, B., & Bagni, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00079-5 · Cited by 676 · see citing works
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
Moda-Sava, R. N., Murdock, M. H., Parekh, P. K., Fetcho, R. N., Huang, B. S., Huynh, T. N., Witztum, J., Shaver, D. C., Rosenthal, D. L., Alway, E. J., et al. (2019) · Science · doi:10.1126/science.aat8078 · Cited by 643 · see citing works
Sutton, M. A., Ito, H. T., Cressy, P., Kempf, C., Woo, J. C., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.040 · Cited by 633 · see citing works
Dendritic Spine Structural Anomalies in Fragile-X Mental Retardation Syndrome
Irwin, S. A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.1038 · Cited by 626 · see citing works
Inactivity produces increases in neurotransmitter release and synapse size
Murthy, V. N., Schikorski, T., Stevens, C. F., & Zhu, Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00500-1 · Cited by 612 · see citing works
Increased Levels of Glutamate in Brains from Patients with Mood Disorders
Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works
Price, R. B., Nock, M. K., Charney, D. S., & Mathew, S. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.029 · Cited by 600 · see citing works
Ultrastructural evidence for synaptic scaling across the wake/sleep cycle
de Vivo, L., Bellesi, M., Marshall, W., Bushong, E. A., Ellisman, M. H., Tononi, G., & Cirelli, C. (2017) · Science · doi:10.1126/science.aah5982 · Cited by 574 · see citing works
Evidence that fragile X mental retardation protein is a negative regulator of translation
Laggerbauer, B. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.4.329 · Cited by 571 · see citing works
Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
Study, T. P. O. B. D., Mertens, J., Wang, Q.-W., Kim, Y., Yu, D. X., Pham, S., Yang, B., Zheng, Y., Diffenderfer, K. E., Zhang, J., et al. (2015) · Nature · doi:10.1038/nature15526 · Cited by 562 · see citing works
Homer1a drives homeostatic scaling-down of excitatory synapses during sleep
Diering, G. H., Nirujogi, R. S., Roth, R. H., Worley, P. F., Pandey, A., & Huganir, R. L. (2017) · Science · doi:10.1126/science.aai8355 · Cited by 516 · see citing works
Burrone, J., O'Byrne, M., & Murthy, V. N. (2002) · Nature · doi:10.1038/nature01242 · Cited by 487 · see citing works
The mechanisms and functions of spontaneous neurotransmitter release
Kavalali, E. T. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3875 · Cited by 486 · see citing works
Self-citationAdaptation to Synaptic Inactivity in Hippocampal Neurons
Thiagarajan, T. C., Lindskog, M., & Tsien, R. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.037 · Cited by 482 · see citing works
The fragile X mental retardation protein inhibits translation via interacting with mRNA
Li, Z. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.11.2276 · Cited by 448 · see citing works
Rapid Synaptic Scaling Induced by Changes in Postsynaptic Firing
Ibata, K., Sun, Q., & Turrigiano, G. G. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.031 · Cited by 446 · see citing works
Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity
Aoto, J., Nam, C. I., Poon, M. M., Ting, P., & Chen, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.012 · Cited by 397 · see citing works
Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease
Styr, B., & Slutsky, I. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0080-x · Cited by 314 · see citing works
Maintaining the Stability of Neural Function: A Homeostatic Hypothesis
Davis, G. W., & Bezprozvanny, I. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.847 · Cited by 302 · see citing works
Neuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake
Hengen, K. B., Pacheco, A. T., McGregor, J. N., Hooser, S. D. V., & Turrigiano, G. G. (2016) · Cell · doi:10.1016/j.cell.2016.01.046 · Cited by 295 · see citing works
Regulation of Dendritic Protein Synthesis by Miniature Synaptic Events
Sutton, M. A., Wall, N. R., Aakalu, G., & Schuman, E. (2004) · Science · doi:10.1126/science.1096202 · Cited by 286 · see citing works
Acute suppression of spontaneous neurotransmission drives synaptic potentiation
Nosyreva, E., Szabla, K., Autry, A. E., Ryazanov, A. G., Monteggia, L. M., & Kavalali, E. T. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4998-12.2013 · Cited by 283 · cited 4× · see citing works
“Notably, application of TTX alone was not sufficient to trigger eEF2 dephosphorylation or the homeostatic plasticity (Nosyreva et al., 2013) demonstrating these events are activity independent.”
BackgroundInfluentialSelf-citationSutton, M. A., Taylor, A. M., Ito, H. T., Pham, A., & Schuman, E. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.030 · Cited by 274 · see citing works
Abnormal Glutamatergic Neurotransmission and Neuronal-Glial Interactions in Acute Mania
Öngür, D., Jensen, J. E., Prescot, A. P., Stork, C., Lundy, M. Y., Cohen, B. M., & Renshaw, P. F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.014 · Cited by 272 · see citing works
Li, J., Pelletier, M. R., Perez-Velazquez, J. L., & Carlen, P. L. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1085 · Cited by 268 · see citing works
Homeostatic Control of Presynaptic Neurotransmitter Release
Davis, G. W., & Müller, M. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071740 · Cited by 261 · see citing works
Synaptic Mechanisms Underlying Rapid Antidepressant Action of Ketamine
Kavalali, E. T., & Monteggia, L. M. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12040531 · Cited by 258 · see citing works
Self-citationHashimoto, R., Takei, N., Shimazu, K., Christ, L. A., Lu, B., & Chuang, D. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00217-4 · Cited by 257 · see citing works
Single-Cell Optogenetic Excitation Drives Homeostatic Synaptic Depression
Goold, C. P., & Nicoll, R. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.020 · Cited by 244 · see citing works
The dialectic of Hebb and homeostasis
Turrigiano, G. G. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0258 · Cited by 242 · see citing works
Corbin, F. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.9.1465 · Cited by 235 · see citing works
Gideons, E. S., Kavalali, E. T., & Monteggia, L. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323920111 · Cited by 232 · see citing works
Self-citationNitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial
Nagele, P., Duma, A., Kopec, M., Gebara, M. A., Parsoei, A., Walker, M., Janski, A., Panagopoulos, V. N., Cristancho, P., Miller, J. P., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.016 · Cited by 230 · see citing works
Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
Frère, S. G. A., & Slutsky, I. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.028 · Cited by 230 · see citing works
The Supersensitivity of Denervated Structures: A Law of Denervation
Cannon, W. B., & Rosenblueth, A. (2013) · Medical Entomology and Zoology · Cited by 220 · see citing works
MeCP2-Dependent Transcriptional Repression Regulates Excitatory Neurotransmission
Nelson, E. D., Kavalali, E. T., & Monteggia, L. M. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.062 · Cited by 218 · see citing works
Self-citationModeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys
Chen, Y., Yu, J., Niu, Y., Qin, D., Liu, H., Li, G., Hu, Y., Wang, J., Lu, Y., Kang, Y., et al. (2017) · Cell · doi:10.1016/j.cell.2017.04.035 · Cited by 204 · see citing works
BDNF at the synapse: why location matters
Song, M., Martinowich, K., & Lee, F. S. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.144 · Cited by 198 · see citing works
Effects of a ketamine metabolite on synaptic NMDAR function
Suzuki, K., Nosyreva, E., Hunt, K. W., Kavalali, E. T., & Monteggia, L. M. (2017) · Nature · doi:10.1038/nature22084 · Cited by 180 · see citing works
Self-citationLan, M. J., McLoughlin, G. A., Griffin, J. L., Tsang, T. M., Huang, J. T.-J., Yuan, P., Manji, H. K., Holmes, E. C., & Bahn, S. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002130 · Cited by 179 · see citing works
Soden, M. E., & Chen, L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3660-10.2010 · Cited by 175 · see citing works
Jakawich, S. K., Nasser, H. B., Strong, M. J., McCartney, A. J., Perez, A. S., Rakesh, N., Carruthers, C. J. L., & Sutton, M. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.034 · Cited by 171 · see citing works
NMDA receptors inhibit synapse unsilencing during brain development
Adesnik, H., Li, G., During, M. J., Pleasure, S. J., & Nicoll, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800946105 · Cited by 161 · see citing works
Evoked and Spontaneous Transmission Favored by Distinct Sets of Synapses
Peled, E. S., Newman, Z. L., & Isacoff, E. Y. (2014) · Current Biology · doi:10.1016/j.cub.2014.01.022 · Cited by 158 · see citing works
Antidepressant actions of ketamine: from molecular mechanisms to clinical practice
Monteggia, L. M., & Zarate, C. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.12.004 · Cited by 149 · see citing works
Self-citationLnenicka, G., Atwood, H., & Marin, L. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02252.1986 · Cited by 146 · see citing works
A Critical and Cell-Autonomous Role for MeCP2 in Synaptic Scaling Up
Blackman, M. P., Djukic, B., Nelson, S. B., & Turrigiano, G. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3077-12.2012 · Cited by 136 · see citing works
Larson, J., Jessen, R. E., Kim, D., Fine, A.-K. S., & du Hoffmann, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2638-05.2005 · Cited by 135 · see citing works
Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility
Styr, B., Gonen, N., Zarhin, D., Ruggiero, A., Atsmon, R., Gazit, N., Braun, G., Frère, S. G. A., Vertkin, I., Shapira, I., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.045 · Cited by 126 · see citing works
Eastwood, S. L., & Harrison, P. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.004 · Cited by 122 · see citing works
Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1
Tatavarty, V., Pacheco, A. T., Kuhnle, C. G., Lin, H. K., Koundinya, P., Miska, N. J., Hengen, K. B., Wagner, F. F., Hooser, S. D. V., & Turrigiano, G. G. (2020) · Neuron · doi:10.1016/j.neuron.2020.02.033 · Cited by 122 · see citing works
Recent insights into the mode of action of memantine and ketamine
Johnson, J. W., Glasgow, N. G., & Povysheva, N. V. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.11.006 · Cited by 117 · see citing works
Lin, P.-Y., Kavalali, E. T., & Monteggia, L. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.020 · Cited by 112 · see citing works
Self-citationZhang, Z., Marro, S. G., Zhang, Y., Arendt, K. L., Patzke, C., Zhou, B., Fair, T., Yang, N., Südhof, T. C., Wernig, M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aar4338 · Cited by 110 · see citing works
How does ketamine elicit a rapid antidepressant response?
Kavalali, E. T., & Monteggia, L. M. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.11.005 · Cited by 109 · see citing works
Self-citationThe Role of Hippocampal GluR1 and GluR2 Receptors in Manic-Like Behavior
Du, J., Creson, T. K., Wu, L., Ren, M., Gray, N. A., Falke, C., Wei, Y., Wang, Y., Blumenthal, R., Machado‐Vieira, R., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3080-07.2008 · Cited by 106 · see citing works
Upward synaptic scaling is dependent on neurotransmission rather than spiking
Fong, M., Newman, J. P., Potter, S. M., & Wenner, P. (2015) · Nature Communications · doi:10.1038/ncomms7339 · Cited by 101 · see citing works
Wang, H.-L., Zhang, Z., Hintze, M., & Chen, L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3964-11.2011 · Cited by 99 · see citing works
Pharmacological Management of Bipolar Depression: Acute Treatment, Maintenance, and Prophylaxis
Vieta, E., & Valentí, M. (2013) · CNS Drugs · doi:10.1007/s40263-013-0073-y · Cited by 95 · see citing works
Regulation of AMPA Receptor Trafficking and Function by Glycogen Synthase Kinase 3
Wei, J., Liu, W., & Yan, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.121376 · Cited by 93 · see citing works
Age-dependent long-term adaptation of crayfish phasic motor axon synapses to altered activity
Lnenicka, G. A., & Atwood, H. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-02-00459.1985 · Cited by 89 · see citing works
Retinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms
Arendt, K. L., Zhang, Y., Jurado, S., Malenka, R. C., Südhof, T. C., & Chen, L. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.009 · Cited by 87 · see citing works
Miniature end‐plate potentials in rat skeletal muscle poisoned with botulinum toxin.
Kim, Y. I., Lømo, T., Lupa, M. T., et al. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015484 · Cited by 84 · see citing works
Isoflurane produces antidepressant effects and induces TrkB signaling in rodents
Antila, H., Ryazantseva, M., Popova, D., Sipilä, P., Guirado, R., Kohtala, S., Yalcin, I., Lindholm, J., Vesa, L., Sato, V., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08166-9 · Cited by 84 · see citing works
Sara, Y., Bal, M., Adachi, M., Monteggia, L. M., & Kavalali, E. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5234-10.2011 · Cited by 82 · see citing works
Self-citationReese, A. L., & Kavalali, E. T. (2015) · eLife · doi:10.7554/elife.09262 · Cited by 78 · see citing works
Self-citationPresenilin 1 regulates homeostatic synaptic scaling through Akt signaling
Pratt, K. G., Zimmerman, E. C., Cook, D. G., & Sullivan, J. (2011) · Nature Neuroscience · doi:10.1038/nn.2893 · Cited by 77 · see citing works
Systematic overview of lithium treatment in acute mania
Poolsup, Po, A. L. W., & de Oliveira, R. B. (2000) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2000.00278.x · Cited by 76 · see citing works
MeCP2 Phosphorylation Is Required for Modulating Synaptic Scaling through mGluR5
Zhong, X., Li, H., & Chang, Q. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2784-12.2012 · Cited by 71 · see citing works
An Intrinsic Transcriptional Program Underlying Synaptic Scaling during Activity Suppression
Schaukowitch, K., Reese, A. L., Kim, S.-K., Kilaru, G., Joo, J., Kavalali, E. T., & Kim, T.-K. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.033 · Cited by 71 · see citing works
Self-citationA metaplasticity view of the interaction between homeostatic and Hebbian plasticity
Yee, A., Hsu, Y.-T., & Chen, L. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0155 · Cited by 70 · see citing works
Lindskog, M., Li, L., Groth, R. D., Poburko, D., Thiagarajan, T. C., Han, X., & Tsien, R. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016399107 · Cited by 70 · see citing works
Monteggia, L. M., Malenka, R. C., & Deisseroth, K. A. (2014) · Nature · doi:10.1038/515200a · Cited by 69 · see citing works
Self-citationReimers, J. M., Loweth, J. A., & Wolf, M. E. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12422 · Cited by 66 · see citing works
Metaplastic Effects of Subanesthetic Ketamine on CA1 Hippocampal Function
Izumi, Y., & Zorumski, C. F. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.08.002 · Cited by 63 · see citing works
Rapid and sustained homeostatic control of presynaptic exocytosis at a central synapse
Delvendahl, I., Kita, K., & Müller, M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909675116 · Cited by 61 · see citing works
Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling
Gideons, E. S., Lin, P.-Y., Mahgoub, M., Kavalali, E. T., & Monteggia, L. M. (2017) · eLife · doi:10.7554/elife.25480 · Cited by 57 · see citing works
Self-citationDu, J., GRAY, N. A., Falke, C., Yuan, P., Szabo, S. T., & Manji, H. K. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.031 · Cited by 56 · see citing works
Age dependence of the rapid antidepressant and synaptic effects of acute NMDA receptor blockade
Nosyreva, E., Autry, A. E., Kavalali, E. T., & Monteggia, L. M. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00094 · Cited by 51 · see citing works
Self-citationSelective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
Crawford, D. C., Ramirez, D. M. O., Trauterman, B., Monteggia, L. M., & Kavalali, E. T. (2017) · Nature Communications · doi:10.1038/ncomms14436 · Cited by 51 · see citing works
Self-citationPresynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca 2+ entry pathway
Piedras-Renterı́a, E. S., Pyle, J. L., Diehn, M., Glickfeld, L. L., Harata, N. C., Cao, Y. Q., Kavalali, E. T., Brown, P. O., & Tsien, R. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308188100 · Cited by 50 · see citing works
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Electroconvulsive seizure promotes spine maturation in newborn dentate granule cells in adult rat
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An Improved Test for Detecting Multiplicative Homeostatic Synaptic Scaling
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Lithium Pharmacogenetics: Where Do We Stand?
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Regulation of synaptic scaling by action potential–independent miniature neurotransmission
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Synaptic Vesicle Recycling Adapts to Chronic Changes in Activity
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Self-citationLoss of Doc2-Dependent Spontaneous Neurotransmission Augments Glutamatergic Synaptic Strength
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Self-citationSpontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
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Firing Rate Homeostasis Can Occur in the Absence of Neuronal Activity-Regulated Transcription
Tyssowski, K. M., Letai, K. C., Rendall, S., Tan, C., Nizhnik, A., Kaeser, P. S., & Gray, J. M. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1108-19.2019 · Cited by 18 · see citing works
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Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action
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Self-citationKetamine and rapid antidepressant action: New treatments and novel synaptic signaling mechanisms
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Synaptic Mechanisms Regulating Mood State Transitions in Depression
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A Synaptic Locus for TrkB Signaling Underlying Ketamine Rapid Antidepressant Action
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Self-citationHydroxynorketamines: Pharmacology and Potential Therapeutic Applications
Highland, J. N., Zanos, P., Riggs, L. M., Georgiou, P., Clark, S. M., Morris, P. J., Moaddel, R., Thomas, C. J., Zarate, C. A., Pereira, E. F. R., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000149 · Cited by 92 · see citing works
Ketamine and the Future of Rapid-Acting Antidepressants
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Chapman, C. A., Nuwer, J. L., & Jacob, T. C. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.911020 · Cited by 62 · see citing works
A thalamic-primary auditory cortex circuit mediates resilience to stress
Li, H.-Y., Zhu, M.-Z., Yuan, X.-R., Guo, Z.-X., Pan, Y.-D., Li, Y.-Q., & Zhu, X.-H. (2023) · Cell · doi:10.1016/j.cell.2023.02.036 · Cited by 64 · see citing works
Bridging Rapid and Sustained Antidepressant Effects of Ketamine
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Self-citationHyperexcitability and homeostasis in fragile X Syndrome.
Liu, X., Kumar, V., Tsai, N.-P., & Auerbach, B. D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.805929 · Cited by 53 · see citing works
Suzuki, K., Kim, J.-W., Nosyreva, E., Kavalali, E. T., & Monteggia, L. M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109918 · Cited by 49 · see citing works
Self-citationKetamine’s rapid antidepressant effects are mediated by Ca2+-permeable AMPA receptors
Zaytseva, A., Bouckova, E., Wiles, M. J., Wustrau, M. H., Schmidt, I. G., Mendez-Vazquez, H., Khatri, L., & Kim, S. (2023) · eLife · doi:10.7554/elife.86022 · Cited by 48 · see citing works
Plasticity of synapses and reward circuit function in the genesis and treatment of depression
Thompson, S. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01422-1 · Cited by 40 · see citing works
Höflich, A., Kraus, C., Pfeiffer, R. M., Seiger, R., Rujescu, D., Zarate, C. A., Kasper, S., Winkler, D., & Lanzenberger, R. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01318-6 · Cited by 34 · see citing works
Bowman, M. A., Vitela, M., Clarke, K. M., Koek, W., & Daws, L. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207581 · Cited by 33 · see citing works
Koesters, A. G., Rich, M. M., & Engisch, K. L. (2024) · The Neuroscientist · doi:10.1177/10738584221112336 · Cited by 17 · see citing works
- Authors
- Kavalali, E. T., & Monteggia, L. M.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Kavalali, Ege T.
- Monteggia, Lisa M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 106
- Issue
- 5
- Pages
- 715-726
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC7517590
- OpenAlex
- W3033976424
- Cited by
- 179
- References
- 114
- Citations by year
- 2026: 20 · 2025: 32 · 2024: 30 · 2023: 28 · 2022: 31 · 2021: 32 · 2020: 6
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- homeostatic plasticity, synaptic scaling, mood disorders, depression, ketamine, lithium, treatment-resistant depression, mania, synaptic regulation
- MeSH terms
- Animals, Bipolar Disorder, Depressive Disorder, Major, Major Depressive Disorder, Homeostasis, Humans, Ketamine, Neuronal Plasticity, Synapses, Lithium Compounds, Excitatory Amino Acid Antagonists, Antimanic Agents, Mood Disorders, Depressive Disorder, Treatment-Resistant
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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