The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Type-2 pericytes participate in normal and tumoral angiogenesis
Open accessAbstract
Tissue growth and function depend on vascularization, and vascular insufficiency or excess exacerbates many human diseases. Identification of the biological processes involved in angiogenesis will dictate strategies to modulate reduced or excessive vessel formation. We examine the essential role of pericytes. Their heterogeneous morphology, distribution, origins, and physiology have been described. Using double-transgenic Nestin-GFP/NG2-DsRed mice, we identified two pericyte subsets. We found that Nestin-GFP−/NG2-DsRed+ (type-1) and Nestin-GFP+/NG2-DsRed+ (type-2) pericytes attach to the walls of small and large blood vessels in vivo; in vitro, type-2, but not type-1, pericytes spark endothelial cells to form new vessels. Matrigel assay showed that only type-2 pericytes participate in normal angiogenesis. Moreover, when cancer cells were transplanted into Nestin-GFP/NG2-DsRed mice, type-1 pericytes did not penetrate the tumor, while type-2 pericytes were recruited during its angiogenesis. As inhibition of angiogenesis is a promising strategy in cancer therapy, type-2 pericytes may provide a cellular target susceptible to signaling and pharmacological manipulation in treating malignancy. This work also reports the potential of type-2 pericytes to improve blood perfusion in ischemic hindlimbs, indicating their potential for treating ischemic illnesses.
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Cites
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“Some have proposed that MSCs are pericytes on the basis of shared markers in vivo and in vitro (22), and attention has turned to pericytes as stem cells with broad organ distribution (5, 28, 29, 52, 58, 70, 73).”
BackgroundAngiogenesis as a therapeutic target
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Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
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Microenvironmental regulation of tumour angiogenesis
De Palma, M., Biziato, D., & Petrova, T. V. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.51 · Cited by 1,847
Role of tumor microenvironment in tumorigenesis
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Stimuli‐responsive nanotherapeutics for precision drug delivery and cancer therapy
Qiao, Y., Wan, J., Zhou, L., Ma, W., Yang, Y., Luo, W., Yu, Z., & Wang, H. (2019) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1527 · Cited by 332
Green Chemistry Synthesis of Silver Nanoparticles and Their Potential Anticancer Effects
Ratan, Z. A., Haidere, M. F., Nurunnabi, M., Shahriar, S. M., Ahammad, A. J. S., Shim, Y. Y., Reaney, M. J. T., & Cho, J. Y. (2020) · Cancers · doi:10.3390/cancers12040855 · Cited by 328
Metadata
- Authors
- Birbrair, A., Zhang, T., Wang, Z.-M., Messi, M. L., Olson, J. D., Mintz, A., & Delbono, O.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2014-07-01
- Volume
- 307
- Issue
- 1
- Pages
- C25-C38
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2117923390
- Cited by
- 333
- References
- 14
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Birbrair, A., Zhang, T., Wang, Z.-M., Messi, M. L., Olson, J. D., Mintz, A., & Delbono, O. (2014). Type-2 pericytes participate in normal and tumoral angiogenesis. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00084.2014
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