Cited by 305Endoplasmic Reticulum Stress and DiseaseTelomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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The unfolded protein response and cellular senescence. A Review in the Theme: Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease

Pluquet, Olivier, Pourtier, Albin, Abbadie, Corinne·2015·American Journal of Physiology-Cell Physiology

DOI 10.1152/ajpcell.00334.2014

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Abstract

The endoplasmic reticulum (ER) is a multifunctional organelle critical for the proper folding and assembly of secreted and transmembrane proteins. Perturbations of ER functions cause ER stress, which activates a coordinated system of transcriptional and translational controls called the unfolded protein response (UPR), to cope with accumulation of misfolded proteins and proteotoxicity. It results in ER homeostasis restoration or in cell death. Senescence is a complex cell phenotype induced by several stresses such as telomere attrition, DNA damage, oxidative stress, and activation of some oncogenes. It is mainly characterized by a cell enlargement, a permanent cell-cycle arrest, and the production of a secretome enriched in proinflammatory cytokines and components of the extracellular matrix. Senescent cells accumulate with age in tissues and are suspected to play a role in age-associated diseases. Since senescence is a stress response, the question arises of whether an ER stress could occur concomitantly with senescence and participate in the onset or maintenance of the senescent features. Here, we described the interconnections between the UPR signaling and the different aspects of the cellular senescence programs and discuss the implication of UPR modulations in this context.

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The Hallmarks of Aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Signal integration in the endoplasmic reticulum unfolded protein response
Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,431
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., & Mori, K. (2001) · Cell · doi:10.1016/s0092-8674(01)00611-0 · Cited by 4,054
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1×
“(3) demonstrated that this accumulation of senescent cells in tissues with aging is directly responsible for some age-related dysfunctions.”
Background
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M. A., Sadri, N., Yun, C., Popko, B., Paules, R. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,336
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
Schröder, M., & Kaufman, R. J. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074134 · Cited by 3,099

Flagged first, then by citations

Show all 143 references

Research works printed but not linked: 7

Campisi J, 2011, Semin Cancer Biol, 21, 354
Casoli T, 2013, Curr Pharm Des, 19, 1727
Chinta SJ, 2014, Exp Gerontol
Matos L, J Gerontol A Biol Sci Med Sci
Wang E, 1995, Cancer Res, 55, 2284
Wei S, 1999, Cancer Res, 59, 1539
10.1172/jci200521848 · DOI

Sorted by citations

Hallmarks of Cellular Senescence
Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605
Senescent cells: an emerging target for diseases of ageing
Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.116 · Cited by 1,284
Endoplasmic reticulum stress signalling-from basic mechanisms to clinical applications
Almanza, A., Carlesso, A., Chintha, C., Creedican, S., Doultsinos, D., Leuzzi, B., Luís, A., McCarthy, N., Montibeller, L., More, S., et al. (2019) · The FEBS Journal · doi:10.1111/febs.14608 · Cited by 1,034
Exploiting senescence for the treatment of cancer
Wang, L., Lankhorst, L., & Bernards, R. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-022-00450-9 · Cited by 867
Senescence and cancer — role and therapeutic opportunities
Schmitt, C. A., Wang, B., & Demaria, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00668-4 · Cited by 794
Skin Aging, Cellular Senescence and Natural Polyphenols
Csekes, E., & Račková, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312641 · Cited by 352
Melanocytic nevi and melanoma: unraveling a complex relationship
Damsky, W., & Bosenberg, M. (2017) · Oncogene · doi:10.1038/onc.2017.189 · Cited by 263
Role of oxidative stress and antioxidants in daily nutrition and human health
Bjørklund, G., & Chirumbolo, S. (2016) · Nutrition · doi:10.1016/j.nut.2016.07.018 · Cited by 254
Fibronectin in Cancer: Friend or Foe
Lin, T.-C., Yang, C.-H., Cheng, L.-H., Chang, W., Lin, Y.-R., & Cheng, H.-C. (2019) · Cells · doi:10.3390/cells9010027 · Cited by 241
Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies
Wyld, L., Bellantuono, I., Tchkonia, T., Morgan, J., Turner, O., Foss, F., George, J., Danson, S., & Kirkland, J. L. (2020) · Cancers · doi:10.3390/cancers12082134 · Cited by 235
“Metabolic stress may also induce senescence and trigger the unfolded protein response (UPR).”
Background
The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions
Secomandi, L., Borghesan, M., Velarde, M., & Demaria, M. (2022) · Human Reproduction Update · doi:10.1093/humupd/dmab038 · Cited by 208
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo
Omori, S., Wang, T.-W., Johmura, Y., Kanai, T., Nakano, Y., Kido, T., Susaki, E. A., Nakajima, T., Shichino, S., Ueha, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.09.006 · Cited by 194
Oxidative Stress and Diseases Associated with High-Altitude Exposure
Pena, E., Alam, S. E., Siqués, P., & Brito, J. (2022) · Antioxidants · doi:10.3390/antiox11020267 · Cited by 194
Cellular senescence in cancer: from mechanisms to detection
Ou, H., Hoffmann, R. J., González‐López, C., Doherty, G. J., Korkola, J. E., & Muñoz‐Espín, D. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12807 · Cited by 208
Senescence as a therapeutic target in cancer and age-related diseases
McHugh, D., Durán, I., & Gil, J. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01074-4 · Cited by 197
Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions
Soto-Gamez, A., Quax, W. J., & Demaria, M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.05.036 · Cited by 175
Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility
Lin, X., Dai, Y., Tong, X., Xu, W., Huang, Q., Jin, X., Li, C., Zhou, F., Zhou, H., Lin, X., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101431 · Cited by 181
Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury
Yan, M., Shu, S., Guo, C., Tang, C., & Dong, Z. (2018) · Annals of Medicine · doi:10.1080/07853890.2018.1489142 · Cited by 177
ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling
Zheng, W., Xie, W., Yin, D., Luo, R., Liu, M., & Guo, F. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0353-3 · Cited by 167
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Lucas, V., Cavadas, C., & Aveleira, C. A. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000622 · Cited by 172
Senescence and senotherapeutics: a new field in cancer therapy
Myrianthopoulos, V., Evangelou, K., Vasileiou, P. V. S., Cooks, T., Vassilakopoulos, T. P., Pangalis, G. A., Kouloukoussa, M., Kittas, C., Georgakilas, A. G., & Gorgoulis, V. G. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.08.006 · Cited by 160
ENDOPLASMIC RETICULUM STRESS IN SEPSIS
Khan, M. M., Yang, W.-L., & Wang, P. (2015) · Shock · doi:10.1097/shk.0000000000000425 · Cited by 147
Targeting Proteotoxic Stress in Cancer: A Review of the Role that Protein Quality Control Pathways Play in Oncogenesis
Ho, M., Kavanagh, E. L., Dunne, L., Dowling, P., Zhang, L., Lindsay, S., Bazou, D., Goh, C. Y., Hanley, C., Bianchi, G., et al. (2019) · Cancers · doi:10.3390/cancers11010066 · Cited by 132
Role of Cellular Senescence in Type II Diabetes
Narasimhan, A., Flores, R. R., Robbins, P. D., & Niedernhofer, L. J. (2021) · Endocrinology · doi:10.1210/endocr/bqab136 · Cited by 133
The Fountain of Youth by Targeting Senescent Cells?
de Keizer, P. L. J. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.11.006 · Cited by 127
Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1
Guha, P., Kaptan, E., Gade, P., Kalvakolanu, D. V., & Ahmed, H. (2017) · Oncotarget · doi:10.18632/oncotarget.19277 · Cited by 117
Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy
Huang, Z., Gan, S., Zhuang, X., Chen, Y., Lu, L., Wang, Y., Qi, X., Feng, Q., Huang, Q., Du, B., et al. (2022) · Cells · doi:10.3390/cells11162472 · Cited by 124
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Uddin, M. S., Yu, W. S., & Lim, L. W. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101417 · Cited by 123
Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence
Ogrodnik, M., Salmonowicz, H., Jurk, D., & Passos, J. F. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2019.06.011 · Cited by 104
Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress
Fang, J., Yuan, Y., Teng, X., Wen, X., Li, N., Peng, S., Liu, W., Donadeu, F. X., Zhao, S., & Hua, J. (2018) · Aging · doi:10.18632/aging.101602 · Cited by 108
Longxuetongluo Capsule protects against cerebral ischemia/reperfusion injury through endoplasmic reticulum stress and MAPK-mediated mechanisms
Pan, B., Sun, J., Liu, Z., Wang, L., Huo, H.-X., Zhao, Y., Tu, P., Xiao, W., Zheng, J., & Li, J. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.01.016 · Cited by 107
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Hubáčková, S., Davidová, E., Rohlenová, K., Štursa, J., Werner, L., Anděra, L., Dong, L., Terp, M. G., Hodný, Z., Ditzel, H. J., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0118-3 · Cited by 102
Olive Oil and the Hallmarks of Aging
Fernández-del-Río, L., Gutiérrez-Casado, E., Varela‐López, A., & Villalba, J. M. (2016) · Molecules · doi:10.3390/molecules21020163 · Cited by 100
ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01904-z · Cited by 99
Cellular senescence of renal tubular epithelial cells in acute kidney injury
Chen, J., Zhang, H., Yi, X., Dou, Q., Yang, X., Chen, J., Chen, J., & Chen, K. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01831-9 · Cited by 103
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Danford, I. D., Verkuil, L. D., Choi, D., Collins, D. W., Gudiseva, H. V., Uyhazi, K. E., Lau, M. K., Kanu, L. N., Grant, G. R., Chavali, V. R. M., et al. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.02.001 · Cited by 91
Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury
Chen, X., Wang, Y., Xie, X., Chen, H., Zhu, Q., Ge, Z., Wei, H., Deng, J., Xia, Z., & Lian, Q. (2018) · Mediators of Inflammation · doi:10.1155/2018/9413876 · Cited by 89
ATF6α regulates morphological changes associated with senescence in human fibroblasts
Druelle, C., Drullion, C., Deslé, J., Martin, N., Saas, L., Cormenier, J., Malaquin, N., Huot, L., Slomianny, C., Bouali, F., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11505 · Cited by 87
Self-citation
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Senescent Microglia: The Key to the Ageing Brain?
Greenwood, E. K., & Brown, D. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094402 · Cited by 84
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Amaya-Montoya, M., Pérez-Londoño, A., Guatibonza-García, V., Vargas-Villanueva, A., & Mendivil, C. O. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01287-0 · Cited by 82
Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-κB pathway
Su, J., Yan, Y., Qu, J., Xue, X., Liu, Z., & Cai, H. (2017) · Oncology Reports · doi:10.3892/or.2017.5428 · Cited by 81
Dicot-specific ATG8-interacting ATI3 proteins interact with conserved UBAC2 proteins and play critical roles in plant stress responses
Zhou, J., Wang, Z., Wang, X., Li, X., Zhang, Z., Fan, B., Zhu, C., & Chen, Z. (2018) · Autophagy · doi:10.1080/15548627.2017.1422856 · Cited by 78
Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses?
Abbadie, C., Pluquet, O., & Pourtier, A. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2587-9 · Cited by 77
Self-citation
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Sun, H., Yang, Y., Shao, H., Sun, W., Gu, M., Wang, H., Jiang, L., Qu, L., Sun, D., & Gao, Y. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00286 · Cited by 75
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Self-citation
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Musci, R., Hamilton, K., & Linden, M. (2019) · Sports · doi:10.3390/sports7070170 · Cited by 73
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Bešše, L., Bešše, A., Mendez-Lopez, M. A., Vašíčková, K., Sedláčková, M., Vaňhara, P., Kraus, M., Bader, J. E., Ferreira, R. B., Castellano, R. K., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.207704 · Cited by 72
Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease
Lynch, S. M., Guo, G., Gibson, D. S., Bjourson, A. J., & Singh, T. (2021) · Cells · doi:10.3390/cells10123367 · Cited by 70
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Cosolo, A., Jaiswal, J., Csordás, G., Grass, I., Uhlířová, M., & Classen, A.-K. (2019) · eLife · doi:10.7554/elife.41036 · Cited by 72
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Tóth, A., Balogh, E., & Jeney, V. (2020) · Antioxidants · doi:10.3390/antiox9100963 · Cited by 75
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Wang, L., Zhu, X.-M., & Yao, Y.-M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02797 · Cited by 68
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Zhang, S., Xia, W., Xu, J., Xu, H., Lu, C., Zhao, Y.-Z., & Wu, X.-Q. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s137237 · Cited by 66
Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
Machado-Oliveira, G., Ramos, C., Marques, A. R. A., & Vieira, O. V. (2020) · Cells · doi:10.3390/cells9102146 · Cited by 70
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The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells
Alessio, N., Aprile, D., Squillaro, T., Bernardo, G. D., Finicelli, M., Melone, M. A. B., Peluso, G., & Galderisi, U. (2019) · Aging · doi:10.18632/aging.102172 · Cited by 67
The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E 2 intracrine pathway
Cormenier, J., Martin, N., Deslé, J., Salazar-Cardozo, C., Pourtier, A., Abbadie, C., & Pluquet, O. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.003 · Cited by 64
Self-citation
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Liu, Z., Shi, Q., Song, X., Wang, Y., Wang, Y., Song, E., & Song, Y. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00181 · Cited by 62
Naringenin Attenuates Myocardial Ischemia-Reperfusion Injury via cGMP-PKGI α Signaling and In Vivo and In Vitro Studies
Yu, L., Dong, X., Zhang, J., Li, Z., Xue, X., Wu, H.-J., Yang, Z., Yang, Y., & Wang, H. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7670854 · Cited by 62
Pancreatic Cancer and Cellular Senescence: Tumor Microenvironment under the Spotlight
Cortesi, M., Zanoni, M., Pirini, F., Tumedei, M. M., Ravaioli, S., Rapposelli, I. G., Frassineti, G. L., & Bravaccini, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010254 · Cited by 62
The p38‐activated ER stress‐ATF6α axis mediates cellular senescence
Kim, H. S., Kim, Y.-J., Lim, M. J., Park, Y.-G., Park, S. I., & Sohn, J. (2018) · The FASEB Journal · doi:10.1096/fj.201800836r · Cited by 65
Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks
Abbadie, C., & Pluquet, O. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.02.005 · Cited by 67
Self-citation
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He, Q., Zhou, X., Liu, Y., Gou, W., Cui, J., Li, Z., Wu, Y., & Zuo, D. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.08.003 · Cited by 58
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Huang, J., Meng, P., Wang, C., Zhang, Y., & Zhou, L. (2022) · Theranostics · doi:10.7150/thno.70588 · Cited by 54
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Yap, K. N., Yamada, K. Y. H., Zikeli, S., Kiaris, H., & Hood, W. R. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12667 · Cited by 47
Time for the systems-level integration of aging: Resilience enhancing strategies to prevent Alzheimer’s disease
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Aging, Senescence, and Dementia
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Gao, L., Chen, H., Li, C., Xiao, Y., Yang, D., Zhang, M., Zhou, D., Liu, W., Wang, A., & Jin, Y. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.01.008 · Cited by 47
Endoplasmic reticulum stress in human chronic wound healing: Rescue by 4‐phenylbutyrate
Bachar-Wikström, E., Manchanda, M., Bansal, R., Karlsson, M. G., Pettersson, P. K., Sköldenberg, O. G., & Wikström, J. D. (2020) · International Wound Journal · doi:10.1111/iwj.13525 · Cited by 45
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Self-citation
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Authors: Pluquet, O., Pourtier, A., & Abbadie, C.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Pluquet, Olivier
ORCID: Pluquet, Olivier
Pourtier, Albin
Abbadie, Corinne
Venue: American Journal of Physiology-Cell Physiology
Publisher: American Physiological Society
Published: 2015-03-15
Volume: 308
Issue: 6
Pages: C415-C425
ISSN: 0363-6143 (ISSN-L)
1522-1563
DOI: 10.1152/ajpcell.00334.2014
OpenAlex: W2093398011
Semantic Scholar: 28aee3c356339845b8920cf8fc965b9d001ce341
Cited by: 305
References: 143
Citations by year: 2026: 21 · 2025: 24 · 2024: 25 · 2023: 29 · 2022: 28 · 2021: 45 · 2020: 38 · 2019: 33 · 2018: 26 · 2017: 21 · 2016: 13 · 2015: 2
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Cell Physiology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Association pour la recherche contre le cancer
Ligue Contre le Cancer
Centre national de la recherche scientifique
Chaire d'excellence Lille2/CNRS
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: unfolded protein response, cellular senescence, endoplasmic reticulum stress, ER stress signaling, protein misfolding, proteotoxicity, senescence-associated secretome, age-related diseases, cell cycle arrest, extracellular matrix
MeSH terms: Aging, Animals, Endoplasmic Reticulum, Humans, Phenotype, Signal Transduction, Cellular Senescence, Unfolded Protein Response, Endoplasmic Reticulum Stress

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The unfolded protein response and cellular senescence. A Review in the Theme: Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease

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