The unfolded protein response and cellular senescence. A Review in the Theme: Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477

Signal integration in the endoplasmic reticulum unfolded protein response

Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,431

The limited in vitro lifetime of human diploid cell strains

Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876

Telomeres shorten during ageing of human fibroblasts

Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., & Mori, K. (2001) · Cell · doi:10.1016/s0092-8674(01)00611-0 · Cited by 4,054

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1×

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M. A., Sadri, N., Yun, C., Popko, B., Paules, R. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,336

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

Schröder, M., & Kaufman, R. J. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074134 · Cited by 3,099

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

Urano, F., Wang, X.-Z., Bertolotti, A., Zhang, Y.-H., Chung, P., Harding, H., & Ron, D. (2000) · Science · doi:10.1126/science.287.5453.664 · Cited by 3,081

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

Calfon, M. A., Zeng, H., Urano, F., Till, J. H., Hubbard, S. R., Harding, H. P., Clark, S. G., & Ron, D. (2002) · Nature · doi:10.1038/415092a · Cited by 2,907

Intracellular Functions of N-Linked Glycans

Helenius, A., & Aebi, A. M. (2001) · Science · doi:10.1126/science.291.5512.2364 · Cited by 2,405

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379 · cited 3×

Mediators of endoplasmic reticulum stress-induced apoptosis

Szegezdi, E., Logue, S. E., Gorman, A. M., & Samali, A. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400779 · Cited by 2,345

Cellular response to oxidative stress: Signaling for suicide and survival*

Martindale, J. L., & Holbrook, N. J. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10119 · Cited by 2,314

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · cited 3×

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsPreprint

Kaufman, R. J. (1999) · Genes & Development · doi:10.1101/gad.13.10.1211 · Cited by 2,250

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160

The essence of senescence: Figure 1.

Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038

Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01453-06 · Cited by 1,832

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482

Plasma cell differentiation requires the transcription factor XBP-1

Reimold, A., Iwakoshi, N., Manis, J., Vallabhajosyula, P., Szomolanyi-Tsuda, E., Gravallese, E., Friend, D., Grusby, M., Alt, F., & Glimcher, L. (2001) · Nature · doi:10.1038/35085509 · Cited by 1,371

Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response

Hollien, J., & Weissman, J. S. (2006) · Science · doi:10.1126/science.1129631 · Cited by 1,319

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

Cullinan, S. B., Zhang, D. D., Hannink, M., Arvisais, E. W., Kaufman, R. J., & Diehl, J. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7198-7209.2003 · Cited by 1,233

Senescence is a developmental mechanism that contributes to embryonic growth and patterning

Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

Obeng, E. A., Carlson, L. M., Gutman, D. M., Harrington, W. J., Lee, K. P., & Boise, L. (2006) · Blood · doi:10.1182/blood-2005-08-3531 · Cited by 1,176

Living on a break: cellular senescence as a DNA-damage response

d'Adda di Fagagna, F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2440 · Cited by 1,170

Senescence in tumours: evidence from mice and humans

Collado, M., & Serrano, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2772 · Cited by 1,124

Fat tissue, aging, and cellular senescence

Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094

ER stress and diseases

Yoshida, H. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05639.x · Cited by 1,086

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responsePreprint

Lee, K., Tirasophon, W., Shen, X., Michalak, M., Prywes, R., Okada, T., Yoshida, H., Mori, K., & Kaufman, R. J. (2002) · Genes & Development · doi:10.1101/gad.964702 · Cited by 1,085

Autophagy mediates the mitotic senescence transition

Young, A. R. J., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, J. F. J., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F. M., et al. (2009) · Genes & Development · doi:10.1101/gad.519709 · Cited by 1,078

XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

Shaffer, A. L., Shelef, M. A., Iwakoshi, N. N., Lee, A., Qian, S., Zhao, H., Yu, X., Yang, L., Tan, B. K., Rosenwald, A., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.010 · Cited by 1,060

Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response

Bernales, S., McDonald, K. L., & Walter, P. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040423 · Cited by 1,047

The signals and pathways activating cellular senescence

Ben-Porath, I., & Weinberg, R. A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.013 · Cited by 1,046

Oxidative protein folding in eukaryotes

Tu, B. P., & Weissman, J. S. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200311055 · Cited by 1,041

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

Hollien, J., Lin, J. H., Li, H., Stevens, N. S., Walter, P., & Weissman, J. S. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200903014 · Cited by 1,021

ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

Kouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., Ogawa, S., Kaufman, R. J., Kominami, E., & Momoi, T. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401984 · Cited by 934

Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?

von Zglinicki, T., Saretzki, G., Döcke, W., & Lotze, C. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1305 · Cited by 856

Cellular senescence and its effector programs

Salama, R., Sadaie, M., Hoare, M., & Narita, M. (2014) · Genes & Development · doi:10.1101/gad.235184.113 · Cited by 855

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

Fumagalli, M., Rossiello, F., Clerici, M., Barozzi, S., Cittaro, D., Kaplunov, J. M., Bucci, G., Dobreva, M., Matti, V., Beausejour, C. M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2466 · Cited by 851

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40027 · Cited by 829

Microarray analysis of replicative senescence

Shelton, D. N., Chang, E., Whittier, P. S., Choi, D., & Funk, W. D. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80420-5 · Cited by 764

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

Salminen, A., Kauppinen, A., & Kaarniranta, K. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.006 · Cited by 763

Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes

Toussaint, O., Medrano, E. E., & von Zglinicki, T. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00180-7 · Cited by 713

DNA damage response and cellular senescence in tissues of aging mice

Wang, C., Jurk, D., Maddick, M., Nelson, G., Martin‐Ruiz, C., & Von Zglinicki, T. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00481.x · Cited by 696

ATF6α Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress

Wu, J., Rutkowski, D. T., Dubois, M., Swathirajan, J., Saunders, T. L., Wang, J., Song, B., Yau, G. D.-Y., & Kaufman, R. J. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.07.005 · Cited by 680

ATF4-dependent transcription mediates signaling of amino acid limitation

Kilberg, M. S., Shan, J., & Su, N. Y. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.05.008 · Cited by 614

ER-associated degradation: Protein quality control and beyond

Ruggiano, A., Foresti, O., & Carvalho, P. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201312042 · Cited by 599

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

Shoulders, M. D., Ryno, L. M., Genereux, J. C., Moresco, J. J., Tu, P. G., Wu, C., Yates, J. R., Su, A. I., Kelly, J. W., & Wiseman, R. L. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.024 · Cited by 558

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

Dörr, J. R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J. H. M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., et al. (2013) · Nature · doi:10.1038/nature12437 · Cited by 541

A negative feedback signaling network underlies oncogene-induced senescence

Courtois-Cox, S., Genther Williams, S. M., Reczek, E. E., Johnson, B. W., McGillicuddy, L. T., Johannessen, C. M., Hollstein, P. E., MacCollin, M., & Cichowski, K. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.10.003 · Cited by 501

Untitled work

(1995) · PubMed · Cited by 496

Endoplasmic Reticulum Stress in Malignancy

Clarke, H. J., Chambers, J. E., Liniker, E., & Marciniak, S. J. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.015 · Cited by 473

Integrated Endoplasmic Reticulum Stress Responses in Cancer

Moenner, M., Pluquet, O., Bouchecareilh, M., & Chevet, É. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1705 · Cited by 434

The FAD- and O2-Dependent Reaction Cycle of Ero1-Mediated Oxidative Protein Folding in the Endoplasmic Reticulum

Tu, B. P., & Weissman, J. S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00696-2 · Cited by 433

Cellular senescence: a link between cancer and age-related degenerative disease?

Campisi, J., Andersen, J. K., Kapahi, P., & Melov, S. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.09.001 · Cited by 421

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

Wu, C.-H., van Riggelen, J., Yetil, A., Fan, A. C., Bachireddy, P., & Felsher, D. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701953104 · Cited by 417

Stress management at the ER: Regulators of ER stress-induced apoptosis

Gorman, A. M., Healy, S., Jäger, R., & Samali, A. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.02.003 · Cited by 412

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

Moiseeva, O., Bourdeau, V., Roux, A., Deschênes-Simard, X., & Ferbeyre, G. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01868-08 · Cited by 408 · cited 1×

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Lin, H.-K., Chen, Z., Wang, G., Nardella, C., Lee, S.-W., Chan, C.-H., Yang, W.-L., Wang, J., Egia, A., Nakayama, K. I., et al. (2010) · Nature · doi:10.1038/nature08815 · Cited by 400

The endoplasmic reticulum stress response in aging and age-related diseases

Brown, M. K., & Naidoo, N. N. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00263 · Cited by 388

Oncogene-Induced Cell Senescence — Halting on the Road to Cancer

Mooi, W. J., & Peeper, D. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmra062285 · Cited by 371

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

Zhang, K., Wong, H. N., Song, B., Miller, C. N., Scheuner, D., & Kaufman, R. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci21848 · Cited by 367

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway

Denoyelle, C., Abou-Rjaily, G., Bezrookove, V., Verhaegen, M., Johnson, T. M., Fullen, D. R., Pointer, J. N., Gruber, S. B., Su, L. D., Nikiforov, M. A., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1471 · Cited by 349

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

Ogrunc, M., Di Micco, R., Liontos, M., Bombardelli, L., Mione, M., Fumagalli, M., Gorgoulis, V. G., & d'Adda di Fagagna, F. (2014) · Cell Death & Differentiation · doi:10.1038/cdd.2014.16 · Cited by 328

Activation of an Unfolded Protein Response during Differentiation of Antibody-secreting B Cells

Gass, J. N., Gifford, N. M., & Brewer, J. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205011200 · Cited by 306

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · cited 2×

ATF6α induces XBP1-independent expansion of the endoplasmic reticulum

Bommiasamy, H., Back, S. H., Fagone, P., Lee, K., Meshinchi, S., Vink, E. I., Sriburi, R., Frank, M. W., Jackowski, S., Kaufman, R. J., et al. (2009) · Journal of Cell Science · doi:10.1242/jcs.045625 · Cited by 299

Replicative senescence: a critical review

Cristofalo, V. J., Lorenzini, A., Allen, R. G., Torres, C. A., & Tresini, M. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.07.010 · Cited by 285

ER and aging—Protein folding and the ER stress response

Naidoo, N. N. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.03.001 · Cited by 285

Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence

Xu, Y., Li, N., Xiang, R., & Sun, P. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.04.004 · Cited by 282

Cellular senescence and the aging brain

Chinta, S. J., Woods, G., Rane, A., Demaria, M., Campisi, J., & Andersen, J. K. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.018 · Cited by 282

Senescent cells develop a parp-1 and nuclear factor-κB-associated secretome (PNAS).

Ohanna, M., Giuliano, S., Bonet, C., Imbert, V., Hofman, V., Zangari, J., Bille, K., Robert, C., Bressac-de Paillerets, B., Hofman, P., et al. (2011) · Genes & Development · doi:10.1101/gad.625811 · Cited by 267

Coordinate Regulation of Phospholipid Biosynthesis and Secretory Pathway Gene Expression in XBP-1(S)-induced Endoplasmic Reticulum Biogenesis

Sriburi, R., Bommiasamy, H., Buldak, G. L., Robbins, G. R., Frank, M. W., Jackowski, S., & Brewer, J. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609490200 · Cited by 262

Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence

Zwerschke, W., Mazurek, S., Stöckl, P., Hütter, E., EIGENBRODT, E., & Jansen‐Dürr, P. (2003) · Biochemical Journal · doi:10.1042/bj20030816 · Cited by 248

Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

Borodkina, A. V., Shatrova, A. N., Abushik, P. A., Nikolsky, N. N., & Burova, E. (2014) · Aging · doi:10.18632/aging.100673 · Cited by 214

Apoptosis in Proliferating, Senescent, and Immortalized Keratinocytes

Chaturvedi, V., Qin, J., Denning, M. F., Choubey, D., Dı́az, M. O., & Nickoloff, B. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23358 · Cited by 213

Oleate Blocks Palmitate-Induced Abnormal Lipid Distribution, Endoplasmic Reticulum Expansion and Stress, and Insulin Resistance in Skeletal Muscle

Gong, P., Li, L., Liu, Y., Pu, J., Zhang, S., Yu, J., Zhao, J., & Liu, P. (2011) · Endocrinology · doi:10.1210/en.2010-1369 · Cited by 208

Structure-Based Design and Evaluation of Naphthalene Diimide G-Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells

Micco, M., Collie, G. W., Dale, A. G., Ohnmacht, S. A., Pazitna, I., Gunaratnam, M., Reszka, A. P., & Neidle, S. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm301899y · Cited by 189

Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling

Liu, J., Huang, K., Cai, G.-Y., Chen, X.-M., Yang, J.-R., Lin, L.-R., Yang, J., Huo, B.-G., Zhan, J., & He, Y.-N. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2013.10.002 · Cited by 181

Definition of pRB- and p53-Dependent and -Independent Steps in HIRA/ASF1a-Mediated Formation of Senescence-Associated Heterochromatin Foci

Ye, X., Zerlanko, B. J., Zhang, R., Somaiah, N., Lipinski, M., Salomoni, P., & Adams, P. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01592-06 · Cited by 177

Virus-induced ER stress and the unfolded protein response

Zhang, L., & Wang, A. (2012) · Frontiers in Plant Science · doi:10.3389/fpls.2012.00293 · Cited by 175

Redox signaling loops in the unfolded protein response

Higa, A., & Chevet, É. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.03.011 · Cited by 174

Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts.

Wei, S., Wei, S., & Sedivy, J. M. (1999) · PubMed · Cited by 166

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

Rossiello, F., Herbig, U., Longhese, M. P., Fumagalli, M., & di Fagagna, F. D. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.06.009 · Cited by 163

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

Pike, L., Singleton, D. C., Buffa, F. M., Abramczyk, O., Phadwal, K., Li, J., Simon, A. K., Murray, J. T., & Harris, A. L. (2012) · Biochemical Journal · doi:10.1042/bj20120972 · Cited by 158

Carbonylation of ER chaperone proteins in aged mouse liver

Rabek, J. P., Boylston, W. H., & Papaconstantinou, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00826-x · Cited by 148

Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors

Voghel, G., Thorin‐Trescases, N., Farhat, N., Nguyen, A. Q., Villeneuve, L. R., Mamarbachi, A. M., Fortier, A., Perrault, L. P., Carrier, M., & Thorin, É. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.09.006 · Cited by 145

The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells

Gass, J. N., Jiang, H.-Y., Wek, R. C., & Brewer, J. W. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.07.029 · Cited by 138

Posttranscriptional Regulation of PER1 Underlies the Oncogenic Function of IREα

Pluquet, O., Dejeans, N., Bouchecareilh, M., Lhomond, S., Pineau, R., Higa, A., Delugin, M., Combe, C., Loriot, S., Cubel, G., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3989 · Cited by 128

ER stress and hormetic regulation of the aging process

Salminen, A., & Kaarniranta, K. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.003 · Cited by 122

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Dagouassat, M., Gagliolo, J.-M., Chrusciel, S., Bourin, M.-C., Duprez, C., Caramelle, P., Boyer, L., Hue, S., Stern, J.-B., Validire, P., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201208-1361oc · Cited by 120

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Gosselin, K., Deruy, E., Martien, S., Vercamer, C., Bouali, F., Dujardin, T., Slomianny, C., Houel-Renault, L., Chelli, F., De Launoit, Y., et al. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080332 · Cited by 119

X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells

Panganiban, R. A. M., Mungunsukh, O., & Day, R. M. (2012) · International Journal of Radiation Biology · doi:10.3109/09553002.2012.711502 · Cited by 115

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Manié, S. N., Lebeau, J., & Chevet, É. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00292.2014 · Cited by 112

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Baraibar, M. A., Liu, L., Ahmed, E. K., & Friguet, B. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/919832 · Cited by 111

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Malaquin, N., Vercamer, C., Bouali, F., Martien, S., Deruy, E., Wernert, N., Chwastyniak, M., Pinet, F., Abbadie, C., & Pourtier, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063607 · Cited by 110

Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein

Maiuolo, J., Bulotta, S., Verderio, C., Benfante, R., & Borgese, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101379108 · Cited by 107

Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells

Patschan, S., Chen, J., Polotskaia, A., Mendelev, N., Cheng, J., Patschan, D., & Goligorsky, M. S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00713.2007 · Cited by 105

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Bernard, D., Gosselin, K., Monté, D., Vercamer, C., Bouali, F., Pourtier, A., Vandenbunder, B., & Abbadie, C. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-0005 · Cited by 105

Comparison of replicative senescence and stress‐induced premature senescence combining differential display and low‐density DNA arrays

Pascal, T., Debacq‐Chainiaux, F., Chrétien, A., Bastin, C., Dabée, A.-F., Bertholet, V., Remacle, J., & Toussaint, O. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.05.056 · Cited by 101

Molecular and Cell Biology of Replicative SenescencePreprint

Dimri, G. P., & Campisi, J. (1994) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1994.059.01.010 · Cited by 98

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Carpenter, J. E., Jackson, W., Benetti, L., & Grose, C. F. (2011) · Journal of Virology · doi:10.1128/jvi.00281-11 · Cited by 91

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Matos, L., Gouveia, A., & Almeida, H. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu129 · Cited by 91

The Endoplasmic Reticulum Stress Response and Aging

Naidoo, N. N. (2009) · Reviews in the Neurosciences · doi:10.1515/revneuro.2009.20.1.23 · Cited by 89

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Maruyama, J., Naguro, I., Takeda, K., & Ichijo, H. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709787846613 · Cited by 86

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Chambers, J. E., & Marciniak, S. J. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00183.2014 · Cited by 83

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Martino, M. E. B., Olsen, J. C., Fulcher, N. B., Wolfgang, M. C., O’Neal, W. K., & Ribeiro, C. M. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809180200 · Cited by 78

Early Dengue Virus Protein Synthesis Induces Extensive Rearrangement of the Endoplasmic Reticulum Independent of the UPR and SREBP-2 Pathway

Peña, J., & Harris, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038202 · Cited by 72

Normal or stress-induced fibroblast senescence involves COX-2 activity

Zdanov, S., Bernard, D., Debacq‐Chainiaux, F., Martien, S., Gosselin, K., Vercamer, C., Chelli, F., Toussaint, O., & Abbadie, C. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.04.033 · Cited by 68

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Deruy, E., Gosselin, K., Vercamer, C., Martien, S., Bouali, F., Slomianny, C., Bertout, J., Bernard, D., Pourtier, A., & Abbadie, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012712 · Cited by 67

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Horiguchi, M., Koyanagi, S., Okamoto, A., Suzuki, S. O., Matsunaga, N., & Ohdo, S. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1891 · Cited by 60

Differentially expressed genes that encode potential markers of goldfish macrophage development in vitro

Barreda, D. R. (2003) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2003.11.005 · Cited by 55

Acquisition of Oxidative DNA Damage during Senescence

Martien, S., & Abbadie, C. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1404.010 · Cited by 52

Cancer cell senescence: a new frontier in drug development

Cairney, C. J., Bilsland, A. E., Evans, T. R. J., Roffey, J., Bennett, D. C., Narita, M., Torrance, C. J., & Keith, W. N. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.01.019 · Cited by 50

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Martien, S., Pluquet, O., Vercamer, C., Malaquin, N., Martin, N., Gosselin, K., Pourtier, A., & Abbadie, C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.04.005 · Cited by 50

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Zhu, B., Ferry, C. H., Markell, L. K., Blazanin, N., Glick, A. B., Gonzalez, F. J., & Peters, J. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.551069 · Cited by 47

Differential Proteome Analysis of Replicative Senescence in Rat Embryo Fibroblasts

Benvenuti, S., Cramer, R., Quinn, C. C., Bruce, J., Zvelebil, M., Corless, S., Bond, J., Yang, A., Hockfield, S. J., Burlingame, A. L., et al. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m100028-mcp200 · Cited by 47

Comparison of ex vivo and in vitro human fibroblast ageing models

Boraldi, F., Annovi, G., Tiozzo, R., Sommer, P., & Quaglino, D. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.08.008 · Cited by 46

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Gunn, K., Gifford, N. M., Mori, K., & Brewer, J. W. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.04.023 · Cited by 46

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Rajesh, K., Papadakis, A. I., Kazimierczak, U., Peidis, P., Wang, S., Ferbeyre, G., Kaufman, R. J., & Koromilas, A. E. (2013) · Aging · doi:10.18632/aging.100620 · Cited by 41

Stress-induced premature senescence: from biomarkers to likeliness of in vivo occurrence

Toussaint, O., Remacle, J., Dierick, J., Pascal, T. G., Frippiat, C. C., Royer, V., Magalhacs, J. P., Zdanov, S., & Debacq‐Chainiaux, F. (2002) · Biogerontology · doi:10.1023/a:1015226524335 · Cited by 39

Protein Oxidative Modifications and Replicative Senescence of WI‐38 Human Embryonic Fibroblasts

Ahmed, E. K., Picot, C. R., Bulteau, A., & Friguet, B. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1404.020 · Cited by 38

Spatio-temporal association between mTOR and autophagy during cellular senescence

Young, A. R. J., Narita, M., & Narita, M. (2011) · Autophagy · doi:10.4161/auto.7.11.17348 · Cited by 37

Selective COX-2 inhibitor, NS-398, inhibits the replicative senescence of cultured dermal fibroblasts

Han, J. H., Roh, M. S., Park, C., Park, K. C., Cho, K. H., Kim, K. H., Eun, H. C., & Chung, J. H. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.02.002 · Cited by 35

Altered expression pattern of Nrf2/HO-1 axis during accelerated-senescence in HIV-1 transgenic rat

Davinelli, S., Scapagnini, G., Denaro, F., Calabrese, V., Benedetti, F., Krishnan, S., Curreli, S., Bryant, J., & Zella, D. (2014) · Biogerontology · doi:10.1007/s10522-014-9511-6 · Cited by 35

Cell death by bortezomib-induced mitotic catastrophe in natural killer lymphoma cells

Shen, L., Au, W., Wong, K., Shimizu, N., Tsuchiyama, J., Kwong, Y., Liang, R. H. S., & Srivastava, G. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0641 · Cited by 35

The Role of Exchange Protein Directly Activated by Cyclic AMP 2-mediated Calreticulin Expression in the Decidualization of Human Endometrial Stromal Cells

Kusama, K., Yoshie, M., Tamura, K., Nakayama, T., Nishi, H., Isaka, K., & Tachikawa, E. (2013) · Endocrinology · doi:10.1210/en.2013-1478 · Cited by 35

Selection and characterization of KDEL-specific VHH antibody fragments and their application in the study of ER resident protein expression

Klooster, R., Eman, M. R., le Duc, Q., Verheesen, P., Verrips, C. T., Roovers, R. C., & Post, J. A. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.10.009 · Cited by 29

Identification of novel candidates for replicative senescence by functional proteomics

Benvenuti, S., Cramer, R., Bruce, J., Waterfield, M. D., & Jat, P. (2002) · Oncogene · doi:10.1038/sj.onc.1205525 · Cited by 28

Phenylbutyric acid induces the cellular senescence through an Akt/p21WAF1 signaling pathway

Kim, H. D., Jang, C., Choe, J. M., Sohn, J., & Kim, J. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.04.086 · Cited by 28

Age-related decline in expression of calnexin

Choi, B.-H., & Kim, J. (2004) · Experimental & Molecular Medicine · doi:10.1038/emm.2004.63 · Cited by 27

UPR-Mediated Membrane Biogenesis in B Cells

Brewer, J. W., & Jackowski, S. (2011) · Biochemistry Research International · doi:10.1155/2012/738471 · Cited by 27

Metformin induces a senescence-associated gene signature in breast cancer cells

Williams, C. C., Singleton, B. A., Llopis, S. D., & Skripnikova, E. V. (2013) · Journal of Health Care for the Poor and Underserved · doi:10.1353/hpu.2013.0044 · Cited by 22

Low-glucose medium induces ORP150 expression and exerts inhibitory effect on apoptosis and senescence of human breast MCF7 cells.

Krętowski, R., Stypułkowska, A., & Cechowska‐Pasko, M. (2013) · Acta Biochimica Polonica · doi:10.18388/abp.2013_1967 · Cited by 21

Identification and Characterization of a Potent Activator of p53-Independent Cellular Senescence via a Small-Molecule Screen for Modifiers of the Integrated Stress Response

Sayers, C. M., Papandreou, I., Guttmann, D. M., Maas, N. L., Diehl, J. A., Witze, E. S., Koong, A. C., & Koumenis, C. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.081810 · Cited by 16

Heat Shock Protein 47 Expression in Aged Normal Human Fibroblasts: Modulation by Salix alba Extract

Nizard, C., Noblesse, E., BOISDÉ, C., Moreau, M., Faussat, A., Schnebert, S., & Mahé, C. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.037 · Cited by 16

Platelets in Alzheimer's Disease-Associated Cellular Senescence and Inflammation

Casoli, T., Balietti, M., Giorgetti, B., Solazzi, M., Scarpino, O., & Fattoretti, P. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319090020 · Cited by 15

Abstract 4732: Depletion of Tregs from PBMCs by treatment with defucosylated anti-CCR4 mAb.

Kurose, K., Eikawa, S., Mizote, Y., Ohue, Y., Isobe, M., Uenaka, A., Oka, M., & Nakayama, E. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-4732 · Cited by 11

Age-related alteration of proline hydroxylase and collagen-binding heat shock protein (HSP47) expression in human fibroblasts

Miyaishi, O., Kozaki, K., Saga, S., Sato, T., & Hashizume, Y. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01660-0 · Cited by 6

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Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605

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Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.116 · Cited by 1,284

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Almanza, A., Carlesso, A., Chintha, C., Creedican, S., Doultsinos, D., Leuzzi, B., Luís, A., McCarthy, N., Montibeller, L., More, S., et al. (2019) · The FEBS Journal · doi:10.1111/febs.14608 · Cited by 1,034

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Wang, L., Lankhorst, L., & Bernards, R. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-022-00450-9 · Cited by 867

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Schmitt, C. A., Wang, B., & Demaria, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00668-4 · Cited by 794

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Pluquet, O., & Abbadie, C. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.01.001 · Cited by 12

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Li, C. (2022) · International Conference on Biomedical Engineering and Applications (ICBEA) · doi:10.1145/3543081.3543090