Healthy community‐living older men differ from women in associations between myostatin levels and skeletal muscle mass
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Background: Myostatin is a negative regulator of muscle growth but the relationship between serum myostatin levels and muscle mass is unclear. This study investigated the association between serum myostatin levels and skeletal muscle mass among healthy older community residents in Taiwan, to evaluate the potential of serum myostatin as a biomarker for diagnosing sarcopenia and/or evaluating the effect of its treatment. Methods: Study data were excerpted from a random subsample of the I‐Lan Longitudinal Aging Study population. Serum myostatin levels were determined and categorized into tertiles (low, medium, high). Relative appendicular skeletal muscle mass (RASM) was calculated as appendicular lean body mass by dual‐energy X‐ray absorptiometry divided by height squared (kg/m 2). Low muscle mass was defined as recommended by the Asian Working Group for Sarcopenia. Results: The analytic study sample comprised 463 adults (mean age: 69.1 years; 49.5% men). Compared with subjects with normal RASM, those with lower RASM were older and frailer, with significantly higher prevalence of malnutrition, lower serum dehydroepiandrosterone (DHEA) levels, and were more likely to have low serum myostatin status. Multivariable logistic regression analysis showed that male sex (OR 3.60, 95% CI 1.30–9.92), malnutrition (OR 4.39, 95% CI 1.56–12.36), DHEA (OR 0.99, 95% CI 0.99–1.00), and low myostatin (OR 3.23, 95% CI 1.49–7.01) were all independent risk factors for low RASM (all P < 0.05). In men, DHEA (OR 0.99, 95% CI 0.98–1.00) and low myostatin (OR 4.89, 95% CI 1.79–13.37) were significantly associated with low RASM (both P < 0.05); however, only malnutrition was associated with low RASM in women (OR 13.59, 95% CI 2.22–83.25, P < 0.05). Conclusions: Among healthy community‐living older adults, low serum myostatin levels were associated with low skeletal muscle mass in men, but not in women. Our results do not support using serum myostatin levels to diagnose sarcopenia, or to monitor how it responds to treatments. Further research is needed to understand why men apparently differ from women in the interrelationship between their myostatin levels and muscle mass.
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Positive correlations between myostatin and lean mass as well as changes in myostatin and lean mass during physical activity were reported.
“Positive correlations between myostatin and lean mass 34 as well as changes in myostatin and lean mass during physical activity were reported. 35”
From A Phase 1 study for safety and pharmacokinetics of BIO101 (20‐hydroxyecdysone) in healthy young and older adults (2023) · cites this paper as [34]
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Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742 · see citing works
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907 · see citing works
Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia
Chen, L.-K., Liu, L.-K., Woo, J., Assantachai, P., Auyeung, T.-W., Bahyah, K. S., Chou, M.-Y., Chen, L.-Y., Hsu, P.-S., Krairit, O., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.11.025 · Cited by 4,051 · see citing works
Self-citationRegulation of skeletal muscle mass in mice by a new TGF-p superfamily member
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013 · see citing works
Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr
Janssen, I., Heymsfield, S. B., Wang, Z., & Ross, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.81 · Cited by 3,087 · see citing works
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · cited 1× · see citing works
“over 3 years, with greater proportional and absolute lean mass diminution in men.(41) This evidence suggests that male sex is a potential risk factor for low muscle mass, possibly”
BackgroundAging of skeletal muscle: a 12-yr longitudinal study
Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1321 · Cited by 1,443 · see citing works
Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child
Schuelke, M., Wagner, K. R., Stolz, L. E., Hübner, C., Riebel, T., Kömen, W., Braun, T., Tobin, J. F., & Lee, S.-J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040933 · Cited by 1,399 · see citing works
ORENTREICH, N., BRIND, J. L., RIZER, R. L., & VOGELMAN, J. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-551 · Cited by 1,349 · see citing works
The Mini Nutritional Assessment (MNA) review of the literature--What does it tell us?
Guigoz, Y. (2006) · PubMed · Cited by 971 · see citing works
Induction of Cachexia in Mice by Systemically Administered Myostatin
Zimmers, T. A., Davies, M. V., Koniaris, L. G., Haynes, P. A., Esquela‐Kerscher, A., Tomkinson, K. N., McPherron, A. C., Wolfman, N. M., & Lee, S. (2002) · Science · doi:10.1126/science.1069525 · Cited by 908 · see citing works
Visser, M., Kritchevsky, S. B., Goodpaster, B. H., Newman, A. B., Nevitt, M., Stamm, E., & Harris, T. B. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50217.x · Cited by 845 · see citing works
Development and Testing of a Five‐Item Version of the Geriatric Depression Scale
Trinidad Hoyl, M., Alessi, C., Harker, J. O., Josephson, K. R., Pietruszka, F. M., Koelfgen, M., Mervis, J. R., Fitten, L. J., & Rubenstein, L. Z. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb03848.x · Cited by 838 · see citing works
Strength is a major factor in balance, gait, and the occurrence of falls
Fukagawa, N. K., Wolfson, L., Judge, J., Whipple, R., & King, M. (1995) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/50a.special_issue.64 · Cited by 617 · see citing works
III, L. J. M., Khosla, S., Crowson, C. S., O'Connor, M. K., O'Fallon, W. M., & Riggs, B. L. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04719.x · Cited by 598 · see citing works
DHEA in elderly women and DHEA or testosterone in elderly men.
Nair, K. S., Rizza, R. A., O'Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054629 · Cited by 566 · see citing works
Balagopal, P., Rooyackers, O., Adey, D., Ades, P. A., & Nair, K. S. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.4.e790 · Cited by 541 · see citing works
Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men
Bèlanger, A., Candas, B., Dupont, A., Cusan, L., Diamond, P., Gomez, J.-L., & Labrie, F. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962278 · Cited by 437 · see citing works
Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men
Orentreich, N., Brind, J. L., Vogelman, J. H., Andres, R., & Baldwin, H. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400863 · Cited by 417 · see citing works
Muscle Mass Index As a Predictor of Longevity in Older Adults
Srikanthan, P., & Karlamangla, A. S. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.02.007 · Cited by 382 · see citing works
Ethical guidelines for publishing in the journal of cachexia, sarcopenia and muscle: update 2017
von Haehling, S., Morley, J. E., Coats, A. J. S., & Anker, S. D. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12261 · Cited by 351 · see citing works
Huh, J. Y., Dincer, F., Mesfum, E., & Mantzoros, C. S. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.42 · Cited by 309 · see citing works
Yarasheski, K. E., Bhasin, S., Sinha‐Hikim, I., Pak-Loduca, J., & González-Cadavid, N. F. (2002) · PubMed · Cited by 293 · see citing works
Testosterone, body composition and aging.
Vermeulen, A. T., Goemaere, S., & Kaufman, J. (1999) · PubMed · Cited by 280 · see citing works
Qu, N.-N., & Li, K. (2004) · PubMed · Cited by 248 · see citing works
Dong, J., Dong, Y., Dong, Y., Chen, F., Mitch, W. E., & Zhang, L. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.200 · Cited by 212 · see citing works
Artaza, J. N., Bhasin, S., Magee, T. R., Reisz‐Porszasz, S., Shen, R., Groome, N. P., Fareez, M. M., & González-Cadavid, N. F. (2005) · Endocrinology · doi:10.1210/en.2005-0362 · Cited by 207 · see citing works
Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopenia
Argilés, J. M. A., Busquets, S., Felipe, A., & López-Soriano, F. J. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.003 · Cited by 177 · see citing works
Effects of DHEA replacement on bone mineral density and body composition in elderly women and men
Villareal, D. T., Holloszy, J. O., & Kohrt, W. M. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01131.x · Cited by 169 · see citing works
Lenk, K., Erbs, S., Höllriegel, R., Beck, E. B., Linke, A. H.-P., Gielen, S., Winkler, S. M., Sandri, M., Hambrecht, R., Schuler, G. C., et al. (2011) · European Journal of Preventive Cardiology · doi:10.1177/1741826711402735 · Cited by 140 · see citing works
Holloszy, J. O. (2000) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(19)30634-2 · Cited by 136 · see citing works
Holloszy, J. O. (2000) · PubMed · Cited by 117 · see citing works
Effect of DHEAS on skeletal muscle over the life span: the InCHIANTI study.
Valenti, G., Denti, L., Maggio, M., Ceda, G., Volpato, S., Bandinelli, S., Ceresini, G., Cappola, A., Guralnik, J., & Ferrucci, L. (2004) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/59.5.m466 · Cited by 116 · see citing works
DHEA enhances effects of weight training on muscle mass and strength in elderly women and men
Villareal, D. T., & Holloszy, J. O. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00100.2006 · Cited by 116 · see citing works
Serum myostatin levels and skeletal muscle wasting in chronic obstructive pulmonary disease
Ju, C., & Chen, R. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.07.016 · Cited by 114 · see citing works
Christensen, H. M., Kistorp, C., Schou, M., Keller, N., Zerahn, B., Frystyk, J., Schwarz, P., & Faber, J. O. (2012) · Endocrine · doi:10.1007/s12020-012-9836-3 · Cited by 109 · see citing works
Corona, G., Rastrelli, G., Giagulli, V. A., Sila, A., Sforza, A., Forti, G., Mannucci, E., & Maggi, M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1358 · Cited by 105 · see citing works
Ning-nin, Q. (2004) · Zhonghua liuxingbingxue zazhi · Cited by 101 · see citing works
The Function of Myostatin in the Regulation of Fat Mass in Mammals
Deng, B., Zhang, F., Wen, J., Ye, S., Wang, L., Yang, Y., Gong, P., & Jiang, S. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0179-1 · Cited by 98 · see citing works
Bopp, M. J., Houston, D. K., Lenchik, L., Easter, L., Kritchevsky, S. B., & Nicklas, B. J. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.04.017 · Cited by 93 · see citing works
Bahat, G., Saka, B., Tufan, F., Akın, S., Sivrikaya, S., Yücel, N., Erten, N., & Karan, M. A. (2010) · The Aging Male · doi:10.3109/13685538.2010.489130 · Cited by 90 · see citing works
Abbasi, A. A., Duthie, E. H., Sheldahl, L. M., Wilson, C. R., Sasse, E. A., Rudman, I. W., & Mattson, D. E. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb01036.x · Cited by 88 · see citing works
Chew, J., Tay, L., Lim, J. P., Leung, B. P., Yeo, A., Yew, S., Ding, Y. Y., & Lim, W. S. (2019) · The Journal of nutrition, health and aging · doi:10.1007/s12603-019-1255-1 · Cited by 88 · see citing works
The role of muscle mass and body fat on disability among older adults: A cross-national analysis
Tyrovolas, S., Koyanagi, A., Olaya, B., Ayuso‐Mateos, J. L., Miret, M., Chatterji, S., Tobiasz‐Adamczyk, B., Koskinen, S. V. P., Leonardi, M., & Haro, J. M. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.06.002 · Cited by 77 · see citing works
Muscle distribution: Variations with body weight, gender, and age
Gallagher, D., & Heymsfield, S. (1998) · Applied Radiation and Isotopes · doi:10.1016/s0969-8043(97)00096-1 · Cited by 72 · see citing works
Velázquez-Alva, M. C., Irigoyen‐Camacho, M. E., Delgadillo‐Velazquez, J., & Lazarevich, I. (2013) · PubMed · doi:10.3305/nh.2013.28.2.6180 · Cited by 69 · see citing works
Powerful Genes — Myostatin Regulation of Human Muscle Mass
McNally, E. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmp048124 · Cited by 68 · see citing works
McNelis, J., Manolopoulos, K. N., Gathercole, L., Bujalska, I. J., Stewart, P. M., Tomlinson, J., & Arlt, W. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00314.2012 · Cited by 66 · see citing works
Saitoh, M., dos Santos, M. R., Ebner, N., Emami, A., Konishi, M., Ishida, J., Valentová, M., Sandek, A., Doehner, W., Anker, S. D., et al. (2016) · Wiener klinische Wochenschrift · doi:10.1007/s00508-016-1112-8 · Cited by 62 · see citing works
Furihata, T., Kinugawa, S., Fukushima, A., Takada, S., Homma, T., Masaki, Y., Abe, T., Yokota, T., Oba, K., Okita, K., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.06.231 · Cited by 59 · see citing works
Strength is a major factor in balance, gait, and the occurrence of falls
WOLFSON, L. I. (1995) · The Journals of Gerontology Series A · Cited by 57 · see citing works
Frailty in patients with heart failure
Vitale, C., & Uchmanowicz, I. (2019) · European Heart Journal Supplements · doi:10.1093/eurheartj/suz238 · Cited by 40 · see citing works
Muscle wasting in heart failure
Saitoh, M., dos Santos, M. R., & von Haehling, S. (2016) · Wiener klinische Wochenschrift · doi:10.1007/s00508-016-1100-z · Cited by 25 · see citing works
Significance of serum Myostatin in hemodialysis patients
Esposito, P. B., Battaglia, Y., Porta, E. L., Grignano, M. A., Caramella, E., Avella, A., Peressini, S., Sessa, N., Albertini, R., Natali, G. D., et al. (2019) · BMC Nephrology · doi:10.1186/s12882-019-1647-9 · Cited by 24 · see citing works
Role of Serum Myostatin during the Lactation Period
Hosoyama, T., Yamanouchi, K., & Nishihara, M. (2006) · Journal of Reproduction and Development · doi:10.1262/jrd.18009 · Cited by 17 · see citing works
Jeanplong, F., Osepchook, C. C., Falconer, S. J., Smith, H. K., Bass, J. J., McMahon, C. D., & Oldham, J. M. (2015) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2015.01.002 · Cited by 11 · see citing works
The Journal of Cachexia, Sarcopenia and Muscle stays the front‐runner in geriatrics and gerontology
Anker, M. S., Anker, S. D., Coats, A. J. S., & von Haehling, S. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12518 · Cited by 11 · see citing works
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Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 262 · see citing works
Inflammaging: Implications in Sarcopenia
Antuña, E., Cachán-Vega, C., Bermejo-Millo, J. C., Potes, Y., Caballero, B., Vega‐Naredo, I., Coto‐Montes, A. M., & García-González, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315039 · Cited by 223 · see citing works
Myostatin as a Biomarker of Muscle Wasting and other Pathologies-State of the Art and Knowledge Gaps
Bączek, J., Silkiewicz, M., & Wojszel, Z. B. (2020) · Nutrients · doi:10.3390/nu12082401 · Cited by 159 · see citing works
Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies
Baig, M. H., Ahmad, K., Moon, J. S., Park, S.-Y., Ho Lim, J., Chun, H. J., Qadri, A. F., Hwang, Y. C., Jan, A. T., Ahmad, S. S., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.876078 · Cited by 135 · see citing works
Praktiknjo, M., Clees, C., Pigliacelli, A., Fischer, S., Jansen, C., Lehmann, J., Pohlmann, A., Lattanzi, B., Krabbe, V., Strassburg, C. P., et al. (2019) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000025 · Cited by 120 · see citing works
Kwon, J. H., Moon, K. M., & Min, K.-W. (2020) · Healthcare · doi:10.3390/healthcare8040378 · Cited by 116 · see citing works
Sex Differences in Inflammation and Muscle Wasting in Aging and Disease
Peruta, C. D., Lozanoska‐Ochser, B., Renzini, A., Moresi, V., Riera, C. S., Bouché, M., & Coletti, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054651 · Cited by 108 · see citing works
Chew, J., Tay, L., Lim, J. P., Leung, B. P., Yeo, A., Yew, S., Ding, Y. Y., & Lim, W. S. (2019) · The Journal of nutrition, health and aging · doi:10.1007/s12603-019-1255-1 · Cited by 88 · see citing works
Jo, D., Yoon, G., Kim, O. Y., & Song, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112636 · Cited by 83 · see citing works
Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83 · see citing works
Planella-Farrugia, C., Comas, F., Sabater, M., Moreno, M., Moreno‐Navarrete, J. M., Rovira, O., Ricart, W., & Fernández‐Real, J. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00871 · Cited by 74 · see citing works
Sheng, R., Cao, M., Song, M., Wang, M., Zhang, Y., Shi, L., Xie, T., Li, Y., Wang, J., & Rui, Y. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.09.007 · Cited by 74 · see citing works
Zhou, Y., Hellberg, M., Hellmark, T., Höglund, P., & Clyne, N. (2019) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfz210 · Cited by 71 · see citing works
Choi, K., Jang, H. Y., Ahn, J. M., Hwang, S. H., Chung, J. W., Choi, Y. S., Kim, J., Jang, E. S., Choi, G. H., & Jeong, S. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0005 · Cited by 71 · see citing works
Yu, P., Hsu, C., Lee, W., Liang, C., Chou, M., Lin, M., Hsiao, F., Peng, L., & Chen, L. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12877 · Cited by 70 · see citing works
Self-citationSubtypes of physical frailty and their long‐term outcomes: a longitudinal cohort study
Huang, S., Tange, C., Otsuka, R., Nishita, Y., Peng, L., Hsiao, F., Tomida, M., Shimokata, H., Arai, H., & Chen, L. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12577 · Cited by 68 · see citing works
Self-citationIf my muscle could talk: Myokines as a biomarker of frailty
Coelho‐Júnior, H. J., Picca, A., Calvani, R., Uchida, M. C., & Marzetti, E. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110715 · Cited by 69 · see citing works
Arrieta, H., Hervás, G., Rezola-Pardo, C., Ruiz-Litago, F., Iturburu, M., Yanguas, J. J., Gil, S. M., Rodriguez-Larrad, A., & Irazusta, J. (2019) · Gerontology · doi:10.1159/000494137 · Cited by 66 · see citing works
Paris, M. T., Bell, K. E., & Mourtzakis, M. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.06.003 · Cited by 62 · see citing works
Antimyostatin Treatment in Health and Disease: The Story of Great Expectations and Limited Success
Nielsen, T. L., Vissing, J., & Krag, T. O. B. (2021) · Cells · doi:10.3390/cells10030533 · Cited by 52 · see citing works
Sarcopenia: Tilting the Balance of Protein Homeostasis
Tan, K. T., Ang, S. T., & Tsai, S. (2019) · PROTEOMICS · doi:10.1002/pmic.201800411 · Cited by 49 · see citing works
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs
Rodgers, B. D., & Ward, C. W. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab030 · Cited by 111 · see citing works
Khalafi, M., Aria, B., Symonds, M. E., & Rosenkranz, S. K. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114272 · Cited by 48 · see citing works
Micielska, K., Gmiat, A., Żychowska, M., Flis, M., Walentukiewicz, A., Łysak, A., Jaworska, J., Rodziewicz-Flis, E. A., Duda-Biernacka, B., & Ziemann, E. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.05.009 · Cited by 43 · see citing works
Zamboni, M. M., Mazzali, G., Brunelli, A., Saatchi, T., Urbani, S., Giani, A., Rossi, A. P., Zoico, E., & Fantin, F. (2022) · Cells · doi:10.3390/cells11213361 · Cited by 42 · see citing works
Dioh, W., Tourette, C., Del Signore, S., Daudigny, L., Dupont, P., Balducci, C., Dilda, P. J., Lafont, R., & Veillet, S. (2023) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.13195 · Cited by 40 · see citing works
Frailty in patients with heart failure
Vitale, C., & Uchmanowicz, I. (2019) · European Heart Journal Supplements · doi:10.1093/eurheartj/suz238 · Cited by 40 · see citing works
Shero, J. A., Lindholm, M. E., Sandri, M. F., & Stanford, K. I. (2025) · Circulation Research · doi:10.1161/circresaha.124.325614 · Cited by 43 · see citing works
Energy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review
Barros, D. G. M., Marques, E. A., Magalhães, J., & Carvalho, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101780 · Cited by 36 · see citing works
Muscle-derived factors influencing bone metabolism
Gries, K. J., Zysik, V. S., Jobe, T. K., Griffin, N., Leeds, B. P., & Lowery, J. W. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.10.009 · Cited by 34 · see citing works
Cui, C., Mackey, R. H., Shaaban, C. E., Kuller, L. H., López, O. L., & Sekikawa, A. M. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12125 · Cited by 32 · see citing works
Zhang, N., Chim, Y. N., Wang, J., Wong, R. M. Y., Chow, S. K., & Cheung, W. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24477 · Cited by 29 · see citing works
Cannavò, A., Carandina, A., Corbi, G., Tobaldini, E., Montano, N., & Arosio, B. (2022) · Life · doi:10.3390/life12122139 · Cited by 28 · see citing works
Kurose, S., Onishi, K., Takao, N., Miyauchi, T., Takahashi, K., & Kimura, Y. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245678 · Cited by 26 · see citing works
Significance of serum Myostatin in hemodialysis patients
Esposito, P. B., Battaglia, Y., Porta, E. L., Grignano, M. A., Caramella, E., Avella, A., Peressini, S., Sessa, N., Albertini, R., Natali, G. D., et al. (2019) · BMC Nephrology · doi:10.1186/s12882-019-1647-9 · Cited by 24 · see citing works
Kruszewski, M., & Aksenov, M. O. (2022) · Genes · doi:10.3390/genes13112055 · Cited by 22 · see citing works
Li, J., Shen, Z., Lin, Y., Wang, Z., Li, M., Sun, H., Wang, Q., Zhao, C., Xu, J., Lü, X., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13472 · Cited by 20 · see citing works
Seo, M.-W., Jung, S.-W., Kim, S.-W., Jung, H. C., Kim, D., & Song, J.-K. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186581 · Cited by 23 · see citing works
Xue, J., Xi, H., Zheng, Y., Zhang, Q., & Kong, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1385902 · Cited by 19 · see citing works
O’Hara, V., Cowan, A., Riddell, D. O., Massey, C., Martin, J., & Piercy, R. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-86783-1 · Cited by 18 · see citing works
Mechanisms of sarcopenia in liver cirrhosis and the role of myokines
Geladari, E. V. (2023) · Annals of Gastroenterology · doi:10.20524/aog.2023.0804 · Cited by 17 · see citing works
Peng, L., Lin, M., Tseng, S., Yen, K.-H., Lee, H., Hsiao, F., & Chen, L. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13481 · Cited by 17 · see citing works
Self-citationPeng, L., Chou, M.-Y., Liang, C., Lee, W., Kojima, T., Lin, M.-H., Loh, C., & Chen, L. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.07.020 · Cited by 17 · see citing works
Self-citationSerum Amino Acids Patterns and 4-Year Sarcopenia Risk in Community-Dwelling Chinese Older Adults
Yeung, S. S. Y., Zhu, Z. L. Y., Kwok, T. C. Y., & Woo, J. (2021) · Gerontology · doi:10.1159/000518412 · Cited by 15 · see citing works
The role of activin: the other side of chronic kidney disease–mineral bone disorder?
Cianciolo, G., Manna, G. L., Capelli, I., Gasperoni, L., Galassi, A., Ciceri, P., & Cozzolino, M. G. (2020) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa203 · Cited by 15 · see citing works
Shin, H. E., Won, C. W., & Kim, M. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105115 · Cited by 14 · see citing works
Cao, Y., Lü, Q., Zhuang, B., Zhang, L., Wang, Y., Jin, S., Xiao, S., Jin, S., Zheng, B., & Sun, Y. P. (2021) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2021.101943 · Cited by 14 · see citing works
Choi, S. J., Lee, M. S., Kang, D., Ko, G. J., Lim, H., Yu, B. C., Park, M. Y., Kim, J. K., Kim, C., Hwang, S. D., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18147344 · Cited by 14 · see citing works
Myostatin as a Biomarker for Diagnosis or Prognosis of Frailty and Sarcopenia: Current Knowledge
Arrieta, H., Rodriguez‐Larrad, A., & Irazusta, J. (2019) · Gerontology · doi:10.1159/000496469 · Cited by 14 · see citing works
Sharma, A. R., Chatterjee, S., Lee, Y., & Lee, S. (2023) · Aging and Disease · doi:10.14336/ad.2023.00903 · Cited by 15 · see citing works
Chien, W., Lee, W., Liang, C., Yen, K.-H., Peng, L., Lin, M., Loh, C., Hsiao, F., & Chen, L. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70078 · Cited by 12 · see citing works
Self-citationRole of irisin and myostatin on sarcopenia in malnourished patients diagnosed with GLIM criteria.
de Luis, D., Primo, D., Izaola, O., & Gomez, J. J. L. (2023) · Nutrition (Burbank, Los Angeles County, Calif.) · doi:10.1016/j.nut.2023.112348 · Cited by 13 · see citing works
LeDrew, M., Sadri, P., Peil, A., & Farahnak, Z. (2025) · Nutrients · doi:10.3390/nu17172758 · Cited by 12 · see citing works
Implications of maraviroc and/or rapamycin in a mouse model of fragility
Pérez‐Martínez, L., Romero, L., Muñoz-Galván, S., Verdugo‐Sivianes, E. M., Rubio-Mediavilla, S., Oteo, J. A., Carnero, A., & Blanco, J. R. (2020) · Aging · doi:10.18632/aging.103167 · Cited by 11 · see citing works
The Journal of Cachexia, Sarcopenia and Muscle stays the front‐runner in geriatrics and gerontology
Anker, M. S., Anker, S. D., Coats, A. J. S., & von Haehling, S. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12518 · Cited by 11 · see citing works
Kim, J., Park, K., & Lee, J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17134900 · Cited by 11 · see citing works
Lu, Y., Chou, R., Liu, L.-K., Chen, L., Huang, P., & Lin, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-75391-0 · Cited by 11 · see citing works
Self-citationMyostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis
González-Ponce, F., Gámez-Nava, J. I., Gómez-Ramírez, E. E., Ramírez-Villafaña, M., Jacobo-Cuevas, H., Rodriguez-Jimenez, N. A., Olivas-Flores, E. M., Esparza-Guerrero, Y., Martelli-García, A., Santiago-Garcia, A. P., et al. (2022) · Journal of Immunology Research · doi:10.1155/2022/7258152 · Cited by 11 · see citing works
Sex differences in the frailty phenotype and mortality in the I-Lan longitudinal aging study cohort
Lu, Y., Chang, C., Chou, R., Lee, W., Chen, L., Huang, P., & Lin, S. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-04785-w · Cited by 10 · see citing works
Self-citationMyostatin and Activin A as Biomarkers of Sarcopenia in Inflammatory Bowel Disease Patients
Godala, M. M., Gaszyńska, E., Walczak, K., & Małecka-Wojciesko, E. (2024) · Nutrients · doi:10.3390/nu16060810 · Cited by 9 · see citing works
Aging, Body Composition, and Cognitive Decline: Shared and Unique Characteristics
Chen, L. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-2022-x · Cited by 9 · see citing works
Self-citationSerum Myostatin and Follistatin Levels in Patients With Dermatomyositis and Polymyositis
de Sordi, C. M., dos Reis-Neto, E. T., Keppeke, G. D., Shinjo, S. K., & Sato, E. I. (2021) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000001806 · Cited by 8 · see citing works
Moghadam, M. R. S. F., Vaezi, A., Jandari, S., Araste, A., & Rezvani, R. (2024) · Aging Medicine · doi:10.1002/agm2.12287 · Cited by 7 · see citing works
Li, W., Chen, M., Chen, F., Li, Y., Zhong, Y., Lu, Y., Zhang, K., & Yang, F. (2024) · Trials · doi:10.1186/s13063-024-08498-8 · Cited by 6 · see citing works
Skeletal muscle health: A key determinant of healthy aging
Chen, L. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105011 · Cited by 6 · see citing works
Self-citationYang, P., Song, Y., Jing, X., Ge, Y., Liu, M., Tang, F., Chen, Y., Li, Q., Wei, F., Mao, Y., et al. (2023) · Nutrition and Cancer · doi:10.1080/01635581.2023.2220167 · Cited by 5 · see citing works
Myokines: A potential key factor in development, treatment, and biomarker of sarcopenia
Aoi, W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822146-4.00006-5 · Cited by 4 · see citing works
Alonso-Puyo, J., Izagirre-Fernandez, O., Crende, O., Seco‐Calvo, J., Fernández‐Atutxa, A., Fernández‐Lázaro, D., García-Gallastegui, P., & Sanz, B. (2024) · Proteomes · doi:10.3390/proteomes12040034 · Cited by 3 · see citing works
Aryana, I. G. P. S., Astika, I. N., Kuswardhani, R. A. T., Putrawan, I. B. P., Purnami, N. K. R., Semaradana, W. G. P., Lestari, A. A. W., & Wande, I. N. (2019) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v11i3.822 · Cited by 3 · see citing works
Changes in Serum Myostatin Levels in Alcoholic Hepatitis Correlate with Improvement in MELD
Shamseddeen, H., Madathanapalli, A., Are, V. S., Shah, V. H., Sanyal, A. J., Tang, Q., Liang, T., Gelow, K., Zimmers, T. A., Chalasani, N., et al. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06632-5 · Cited by 3 · see citing works
Marulanda-Díaz, N., Estrada, A., Milán, A. F., Narváez-Sánchez, R., Calderón, J. C., & Giraldo, N. A. G. (2025) · Nutrition · doi:10.1016/j.nut.2025.112767 · Cited by 2 · see citing works
МЕТААНАЛИЗ АССОЦИАЦИИ ПОЛИМОРФИЗМА ГЕНА MSTN RS1805086 С СИЛОВЫМИ ПОКАЗАТЕЛЯМИ СПОРТСМЕНОВ
Aksenov, M. O. (2021) · Siberian Journal of Life Sciences and Agriculture · doi:10.12731/2658-6649-2021-13-2-303-335 · Cited by 2 · see citing works
Endo, K., Sato, T., Yoshida, Y., Kakisaka, K., Miyasaka, A., & Takikawa, Y. (2022) · Nutrition · doi:10.1016/j.nut.2022.111699 · Cited by 2 · see citing works
James, E., Goodall, S., Nichols, S., Walker, K., Carroll, S., O’Doherty, A. F., & Ingle, L. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1094733 · Cited by 2 · see citing works
Myostatin Serum Related with Sarcopenia Among Elderly Population
Kartika, R. W. (2022) · Berkala Ilmiah Kedokteran Duta Wacana · doi:10.21460/bikdw.v7i2.530 · Cited by 1 · see citing works
Association of nut consumption and sarcopenia in Chinese older adults
Xu, J., Pu, K., Sun, W., Pang, C., Li, D., & Zang, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-02389-x · Cited by 1 · see citing works
Li, Y., Lu, Y., Li, W., & Yang, F. (2025) · MethodsX · doi:10.1016/j.mex.2025.103655 · Cited by 1 · see citing works
Wong, J. J., Gao, F., Lakatta, E. G., Simonsick, E., Ferrucci, L., Tan, R., AlGhatrif, M., & Koh, A. S.-M. (2026) · BMC Medicine · doi:10.1186/s12916-026-04829-5 · Cited by 1 · see citing works
Lei, C., Jiang, H., Yang, X., Ding, S., Yu, Y., Zhang, Z., Wang, L., Gao, C., Lü, A., Qin, L., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27093836 · Cited by 1 · see citing works
Bączek, J., Charkiewicz, M., Kasiukiewicz, A., Witkowska, A. M., Magnuszewski, Ł., Bączek, M., & Wojszel, Z. B. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13061741 · Cited by 1 · see citing works
Moghadam, M. R. S. F., Jandari, S., Vaezi, A., & Rezvani, R. (2023) · Qeios · doi:10.32388/g24my5 · Cited by 1 · see citing works
Modern use of biomarkers in geriatric medicine
Walter, S. (2022) · Pathy's Principles and Practice of Geriatric Medicine · doi:10.1002/9781119484288.ch109
Каретникова, В. Н., Геннадьевна, Н. А., Carpova, E. I., & Барбараш, О. Л. (2024) · Cardiosomatics · doi:10.17816/cs624809
Hayashi, M., Abe, K., Sugaya, T., Takahata, Y., Fujita, M., Takahashi, A., & Ohira, H. (2024) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16639
Moghadam, M. R. S. F., Jandari, S., Vaezi, A., & Rezvani, R. (2023) · Qeios · doi:10.32388/g24my5.2
Lu, Y.-W., Chang, C.-C., Chou, R.-H., Lee, W.-J., Chen, L.-K., Huang, P.-H., & Lin, S.-J. (2024) · Figshare · doi:10.6084/m9.figshare.25282924
Self-citationLu, Y.-W., Chang, C.-C., Chou, R.-H., Lee, W.-J., Chen, L.-K., Huang, P.-H., & Lin, S.-J. (2024) · Figshare · doi:10.6084/m9.figshare.25282837
Self-citationSilva, J. M. D. S., Santo, R. C. D. E., Dias, D. N. G., Braz, N. F. T., Vieira, É. L. M., Freitas, E. C., Chakr, R. M. D. S., Kakehasi, A. M., & Xavier, R. S. F. (2026) · Revista Brasileira de Reumatologia · doi:10.1186/s42358-025-00505-z
Genetic polymorphisms and genes associated with muscle strength and quality of life
Verde, Z., & Fernández-Araque, A. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-28842-5.00019-3
Novel biomarkers for sarcopenia: a narrative review
Chen, X., Wu, F., Shi, S., Xia, L., Wang, Y., Wei, Y., Wang, J., Li, J., Zhu, M., Zhang, X. W., et al. (2026) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-026-06880-7
Hormonal dimorphism in sarcopenia disease
Menard, R., & Madelaine, R. (2026) · Aging · doi:10.18632/aging.206392
Süzer, K., Oflazoğlu, U., Demir, L., Unal, S., Guc, Z., Yildiz, Y., Karalar, F. O., Kucukzeybek, Y., & Alacacıoğlu, A. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1800359
Tan, X., Ma, C., Sheikh, A. M., Nagai, A., & Yano, S. (2026) · Biomolecules · doi:10.3390/biom16101469
- Authors
- Peng, L., Lee, W., Liu, L., Lin, M., & Chen, L.
- Affiliations
- Taipei Veterans General Hospital (TW)
- Corresponding author
- Chen, Liang‐Kung
- Venue
- Journal of Cachexia, Sarcopenia and Muscle
- Publisher
- Wiley
- Published
- 2018-04-13
- Volume
- 9
- Issue
- 4
- Pages
- 635-642
- ISSN
- 2190-5991 (ISSN-L)
- 2190-6009
- PMC
- PMC6104118
- OpenAlex
- W2796837022
- Semantic Scholar
- 18a05c349844f9f239d1d6f433ec8e2ca0fcbd04
- Cited by
- 93
- References
- 58
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 13 · 2023: 14 · 2022: 12 · 2021: 12 · 2020: 13 · 2019: 13 · 2018: 2
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Cachexia Sarcopenia and Muscle (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Science and Technology, Taiwan (MOST 105‐3011‐B‐010‐001, MOST 104‐2633‐B‐400‐001)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- myostatin, skeletal muscle mass, sarcopenia, sex differences, older adults, malnutrition, dehydroepiandrosterone, frailty, biomarkers, Asian Working Group for Sarcopenia criteria, community-dwelling older adults
- MeSH terms
- Aged, Aged, 80 and over, Body Composition, Female, Humans, Longitudinal Studies, Male, Middle Aged, Organ Size, Biomarkers, Absorptiometry, Photon, Geriatric Assessment, Odds Ratio, Muscle, Skeletal, Myostatin, Sarcopenia
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