Cited by 108Dietary Effects on HealthMuscle metabolism and nutritionAdipose Tissue and Metabolism

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Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men

Stannard, S. R., Thompson, M. W., Fairbairn, K., Huard, B., Sachinwalla, T., Thompson, C. H.·2002·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00108.2002

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Abstract

The purpose of this study was to determine changes in intramyocellular lipid (IMCL) content in the vastus lateralis of nondiabetic, physically fit males over 72 h of fasting. Six men, mean age 35 yr (range 23–55 yr), body mass index 23.7 kg/m 2(21.2–27.4 kg/m 2), undertook a water-only fast for 84 h. Vastus lateralis IMCL content was determined using proton magnetic resonance spectroscopy after 12 and 84 h of fasting. Venous blood was sampled at 12-h intervals throughout the fast. IMCL-(CH 2)n/water and IMCL-(CH 2)n/total creatine ratios increased from 0.00623 ± 0.00065 to 0.0142 ± 0.0015 ( P = 0.002) and 6.82 ± 0.87 to 14.96 ± 1.73 ( P = 0.001), respectively. Plasma free fatty acid (FFA), serum triglyceride, and whole blood 3-hydroxybutyrate concentrations increased ( P < 0.001, <0.05, <0.03, respectively), whereas plasma glucose and serum insulin concentrations decreased (both P < 0.001) during fasting. In conclusion, 72-h water-only fasting produces a large increase in plasma FFA concentration, a drop in serum insulin concentration, and accumulation of IMCL in the vastus lateralis muscle of nondiabetic, physically fit men.

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Authors: Stannard, S. R., Thompson, M. W., Fairbairn, K., Huard, B., Sachinwalla, T., & Thompson, C. H.
Affiliations: The University of Sydney (AU)
Rayscan Imaging, Liverpool 2170, New South Wales, Australia
ORCID: Stannard, S. R.
Huard, B.
Thompson, C. H.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2002-12-01
Volume: 283
Issue: 6
Pages: E1185-E1191
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00108.2002
OpenAlex: W2115449275
Cited by: 108
References: 48
Citations by year: 2026: 6 · 2024: 2 · 2023: 9 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 4
FWCI: 3.60
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: water-only fasting, intramyocellular lipid, vastus lateralis, plasma free fatty acids, insulin, ketone bodies, beta-hydroxybutyrate, serum triglycerides, muscle lipid accumulation, caloric restriction, physical fitness
MeSH terms: Adult, Blood Glucose, Fasting, Fatty Acids, Nonesterified, Humans, Insulin, Intracellular Fluid, Leg, Magnetic Resonance Imaging, Male, Middle Aged, Magnetic Resonance Spectroscopy, Physical Fitness, Reference Values, Time Factors, Triglycerides, Muscle, Skeletal, 3-Hydroxybutyric Acid, Lipid Metabolism

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Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men

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