Cited by 489Muscle Physiology and DisordersNutrition and Health in AgingMuscle metabolism and nutrition

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Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly

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Verdijk, Lex B., Koopman, René, Schaart, Gert, Meijer, Kenneth, Savelberg, Hans H. C. M., van Loon, Luc J. C.·2007·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00278.2006

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Abstract

Satellite cells (SC) are essential for skeletal muscle growth and repair. Because sarcopenia is associated with type II muscle fiber atrophy, we hypothesized that SC content is specifically reduced in the type II fibers in the elderly. A total of eight elderly (E; 76 ± 1 yr) and eight young (Y; 20 ± 1 yr) healthy males were selected. Muscle biopsies were collected from the vastus lateralis in both legs. ATPase staining and a pax7-antibody were used to determine fiber type-specific SC content (i.e., pax7-positive SC) on serial muscle cross sections. In contrast to the type I fibers, the proportion and mean cross-sectional area of the type II fibers were substantially reduced in E vs. Y. The number of SC per type I fiber was similar in E and Y. However, the number of SC per type II fiber was substantially lower in E vs. Y (0.044 ± 0.003 vs. 0.080 ± 0.007; P < 0.01). In addition, in the type II fibers, the number of SC relative to the total number of nuclei and the number of SC per fiber area were also significantly lower in E. This study is the first to show type II fiber atrophy in the elderly to be associated with a fiber type-specific decline in SC content. The latter is evident when SC content is expressed per fiber or per fiber area. The decline in SC content might be an important factor in the etiology of type II muscle fiber atrophy, which accompanies the loss of skeletal muscle with aging.

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Authors: Verdijk, L. B., Koopman, R., Schaart, G., Meijer, K., Savelberg, H. H. C. M., & van Loon, L. J. C.
Affiliations: Maastricht University (NL)
ORCID: Verdijk, Lex B.
Koopman, René
Schaart, Gert
Meijer, Kenneth
Savelberg, Hans H. C. M.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2007-01
Volume: 292
Issue: 1
Pages: E151-E157
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00278.2006
OpenAlex: W2113612408
Cited by: 489
References: 51
Citations by year: 2026: 14 · 2025: 17 · 2024: 21 · 2023: 20 · 2022: 35 · 2021: 33 · 2020: 27 · 2019: 27 · 2018: 35 · 2017: 25 · 2016: 28 · 2015: 28 · 2014: 35 · 2013: 36 · 2012: 27
FWCI: 4.48
Type: journal article
Language: en
Open access: green
cris.maastrichtuniversity.nl
Licence: other-oa
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: satellite cells, sarcopenia, muscle atrophy, aging, older adults, Pax7, vastus lateralis, muscle fiber cross-sectional area
MeSH terms: Adult, Aged, Atrophy, Biopsy, Cell Count, Cell Nucleus, Humans, Male, Muscle Fibers, Fast-Twitch, Satellite Cells, Skeletal Muscle

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Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly

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