Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions
Open accessAbstract
The prevalence of diabetes increases with age, driven in part by an absolute increase in incidence among adults aged 65 years and older. Individuals with diabetes are at higher risk for cardiovascular disease, and age strongly predicts cardiovascular complications. Inflammation and oxidative stress appear to play some role in the mechanisms underlying aging, diabetes, cardiovascular disease, and other complications of diabetes. However, the mechanisms underlying the age-associated increase in risk for diabetes and diabetes-related cardiovascular disease remain poorly understood. Moreover, because of the heterogeneity of the older population, a lack of understanding of the biology of aging, and inadequate study of the effects of treatments on traditional complications and geriatric conditions associated with diabetes, no consensus exists on the optimal interventions for older diabetic adults. The Association of Specialty Professors, along with the National Institute on Aging, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Heart, Lung, and Blood Institute, and the American Diabetes Association, held a workshop, summarized in this Perspective, to discuss current knowledge regarding diabetes and cardiovascular disease in older adults, identify gaps, and propose questions to guide future research.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Type 2 diabetes is a strong risk factor for cardiovascular disease, and both CVD mortality and the effect of diabetes on CVD risk increase with older age and frailty.
“Type 2 diabetes is a strong risk factor for CVD, and both CVD mortality and the effect of diabetes on the risk of CVD increase sharply with older age and frailty status”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [176]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300 · see citing works
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333 · see citing works
The Pathobiology of Diabetic Complications
Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339 · see citing works
Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292 · see citing works
The Emerging Risk Factors Collaboration (2010) · The Lancet · doi:10.1016/s0140-6736(10)60484-9 · Cited by 5,125 · see citing works
Diabetes Prevention Program Research Group (2009) · The Lancet · doi:10.1016/s0140-6736(09)61457-4 · Cited by 3,020 · see citing works
DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016 · see citing works
Heart disease and stroke statistics--2013 update: a report from the American Heart Association.
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., Dai, S., Ford, E. S., Fox, C. S., Franco, S., et al. (2013) · eScholarship (California Digital Library) · Cited by 2,601 · see citing works
A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805796 · Cited by 1,939 · see citing works
Strategies for Multivessel Revascularization in Patients with Diabetes
Farkouh, M. E., Domanski, M., Sleeper, L. A., Siami, F. S., Dangas, G., Mack, M., Yang, M., Cohen, D. J., Rosenberg, Y., Solomon, S. D., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211585 · Cited by 1,922 · see citing works
The intersection between aging and cardiovascular disease
North, B. J., & Sinclair, D. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246876 · Cited by 1,585 · see citing works
Severe hypoglycemia and risks of vascular events and death
Zoungas, S., Patel, A., Chalmers, J., de Galan, B. E., Li, Q., Billot, L., Woodward, M., Ninomiya, T., Neal, B., MacMahon, S., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003795 · Cited by 1,471 · see citing works
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415 · see citing works
Kidney disease and increased mortality risk in type 2 diabetes
Afkarian, M., Sachs, M. C., Kestenbaum, B., Hirsch, I. B., Tuttle, K. R., Himmelfarb, J., & de Boer, I. H. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012070718 · Cited by 1,298 · see citing works
Kirkman, M. S., Briscoe, V. J., Clark, N., Florez, H., Haas, L. B., Halter, J. B., Huang, E. S., Korytkowski, M. T., Munshi, M. N., Odegard, P. S., et al. (2012) · Diabetes Care · doi:10.2337/dc12-1801 · Cited by 1,274 · see citing works
Self-citationCraft, S. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.233 · Cited by 1,253 · see citing works
Handbook of the Biology of Aging
Finch, C. E., & Schneider, E. L. (1990) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,210 · see citing works
Weight loss, exercise, or both and physical function in obese older adults
Villareal, D. T., Chode, S., Parimi, N., Sinacore, D. R., Hilton, T., Armamento-Villareal, R., Napoli, N., Qualls, C., & Shah, K. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1008234 · Cited by 1,096 · see citing works
Temporal trends in the prevalence of diabetic kidney disease in the United States
de Boer, I. H. (2011) · JAMA · doi:10.1001/jama.2011.861 · Cited by 1,036 · see citing works
Insulin Resistance, Hyperglycemia, and Atherosclerosis
Bornfeldt, K., & Tabas, I. A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.015 · Cited by 1,002 · see citing works
Bomfim, T. R., Forny‐Germano, L., Sathler, L. B., Brito‐Moreira, J., Houzel, J., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57256 · Cited by 830 · see citing works
Association of an intensive lifestyle intervention with remission of type 2 diabetes
Gregg, E. W., Chen, H., Wagenknecht, L. E., Clark, J. M., Delahanty, L. M., Bantle, J., Pownall, H. J., Johnson, K. C., Safford, M. M., Kitabchi, A. E., et al. (2012) · JAMA · doi:10.1001/jama.2012.67929 · Cited by 752 · see citing works
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy
Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.050 · Cited by 677 · see citing works
De Felice, F. G., Vieira, M. N. N., Bomfim, T. R., Decker, H., Velasco, P. T., Lambert, M. P., Viola, K. L., Zhao, W.-Q., Ferreira, S. T., & Klein, W. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809158106 · Cited by 657 · see citing works
Baker, L. D., Cross, D. J., Minoshima, S., Belongia, D., Watson, G. S., & Craft, S. (2011) · Archives of Neurology · doi:10.1001/archneurol.2010.225 · Cited by 639 · see citing works
Chang, A. M., & Halter, J. B. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00366.2002 · Cited by 585 · see citing works
Self-citationThe Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia: Two Roads Converged
Craft, S. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.27 · Cited by 547 · see citing works
Takeda, S., Sato, N., Uchio‐Yamada, K., Sawada, K., Kunieda, T., Takeuchi, D., Kurinami, H., Shinohara, M., Rakugi, H., & Morishita, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000645107 · Cited by 506 · see citing works
Mitochondria and Cardiovascular Aging
Dai, D., Rabinovitch, P. S., & Ungvari, Z. I. (2012) · Circulation Research · doi:10.1161/circresaha.111.246140 · Cited by 435 · see citing works
Andersen, S. L., Paola Sebastiani, B., Dworkis, D. A., Feldman, L., & Perls, T. T. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr223 · Cited by 382 · see citing works
Poor Cognitive Function and Risk of Severe Hypoglycemia in Type 2 Diabetes
Punthakee, Z., Miller, M. E., Launer, L. J., Williamson, J. D., Lazar, R. M., Cukierman-Yaffee, T., Seaquist, E. R., Ismail-Beigi, F., Sullivan, M. D., Lovato, L. C., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1855 · Cited by 337 · see citing works
Lifestyle change and mobility in obese adults with type 2 diabetes
Rejeski, W. J., Ip, E. H., Bertoni, A. G., Bray, G. A., Evans, G., Gregg, E. W., & Zhang, Q. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110294 · Cited by 301 · see citing works
Race/Ethnicity, Quality of Care, and Outcomes in Ischemic Stroke
Schwamm, L. H., Reeves, M. J., Pan, W., Smith, E. E., Frankel, M. R., Olson, D., Zhao, X., Peterson, E., & Fonarow, G. C. (2010) · Circulation · doi:10.1161/circulationaha.109.881490 · Cited by 292 · see citing works
Wannamethee, S. G., Shaper, A. G., Whincup, P. H., Lennon, L., & Sattar, N. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.2 · Cited by 281 · see citing works
The Diabetes Prevention Program Research Group [Prepared by Jill Crandall, D. S. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1075 · Cited by 254 · see citing works
Elevated Rates of Diabetes in Pacific Islanders and Asian Subgroups
Karter, A., Schillinger, D., Adams, A., Moffet, H., Liu, J., Adler, N., & Kanaya, A. (2013) · Diabetes Care · doi:10.2337/dc12-0722 · Cited by 241 · see citing works
Pierce, G. L., Beske, S. D., Lawson, B. R., Southall, K. L., Benay, F. J., Donato, A. J., & Seals, D. R. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.111427 · Cited by 167 · see citing works
Huang, E. S., Zhang, Q., Gandra, N., Chin, M. H., & Meltzer, D. O. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-1-200807010-00005 · Cited by 165 · see citing works
Self-citationBouchonville, M., Armamento-Villareal, R., Shah, K., Napoli, N., Sinacore, D. R., Qualls, C., & Villareal, D. T. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.122 · Cited by 163 · see citing works
Kamalesh, M., Sharp, T. G., Tang, X. C., Shunk, K., Ward, H. B., Walsh, J., King, S. B., Colling, C. L., MORITZ, T. E., Stroupe, K. T., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.044 · Cited by 162 · see citing works
Changes in Diastolic Dysfunction in Diabetes Mellitus Over Time
From, A. M., Scott, C. G., & Chen, H. H. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.01.358 · Cited by 152 · see citing works
HDL and LDL cholesterol significantly influence β-cell function in type 2 diabetes mellitus
Kruit, J. K., Brunham, L. R., Verchere, C. B., & Hayden, M. R. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328339387b · Cited by 145 · see citing works
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
de Cavanagh, E. M. V., Inserra, F., & Ferder, L. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq285 · Cited by 136 · see citing works
Ghosh, S., Lertwattanarak, R., Lefort, N., Molina-Carrion, M., Joya-Galeana, J., Bowen, B. P., Garduno-Garcia, J. D. J., Abdul-Ghani, M., Richardson, A., DeFronzo, R. A., et al. (2011) · Diabetes · doi:10.2337/db11-0121 · Cited by 128 · see citing works
Self-citationKuller, L. H. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.1.71 · Cited by 110 · see citing works
The Population Burden of Heart Failure Attributable to Modifiable Risk Factors
Avery, C. L., Loehr, L. R., Baggett, C. D., Chang, P. P., Kucharska‐Newton, A., Matsushita, K., Rosamond, W. D., & HEISS, G. M. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.07.022 · Cited by 105 · see citing works
Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes
Cryer, P. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28735 · Cited by 100 · see citing works
Clinical Complexity in Middle-Aged and Older Adults With Diabetes: The Health and Retirement Study
Blaum, C. S., Cigolle, C. T., Boyd, C., Wolff, J. L., Tian, Z., Langa, K. M., & Weir, D. R. (2010) · Medical Care · doi:10.1097/mlr.0b013e3181ca4035 · Cited by 99 · see citing works
Insulin Resistance and Aging: A Cause or a Protective Response?
Barzilai, N., & Ferrucci, L. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls145 · Cited by 95 · see citing works
Racial Differences in Risks for First Cardiovascular Events and Noncardiovascular Death
Feinstein, M. J., Ning, H., Kang, J., Bertoni, A. G., Carnethon, M. R., & Lloyd‐Jones, D. M. (2012) · Circulation · doi:10.1161/circulationaha.111.057232 · Cited by 93 · see citing works
The Economic Costs of Diabetes: Is It Time for a New Treatment Paradigm?
Herman, W. H. (2013) · Diabetes Care · doi:10.2337/dc13-0270 · Cited by 90 · see citing works
Diabetes and Cardiovascular Disease Prevention in Older Adults
Cigolle, C. T., Blaum, C. S., & Halter, J. B. (2009) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.09.001 · Cited by 50 · see citing works
Self-citationGeriatric Conditions Develop in Middle-Aged Adults with Diabetes
Cigolle, C. T., Lee, P., Langa, K. M., Lee, Y. Y., Tian, Z., & Blaum, C. S. (2010) · Journal of General Internal Medicine · doi:10.1007/s11606-010-1510-y · Cited by 47 · see citing works
Vascular health in the ageing athlete
DeVan, A. E., & Seals, D. R. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2011.058792 · Cited by 46 · see citing works
Racial and Ethnic Differences in Incident Hospitalized Heart Failure in Postmenopausal Women
Eaton, C. B., Abdulbaki, A. M., Margolis, K. L., Manson, J. E., Limacher, M. C., Klein, L., Allison, M., Robinson, J. G., Curb, J. D., Martin, L. W., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.066688 · Cited by 44 · see citing works
Forearm vascular control during acute hyperglycemia in healthy humans
Reed, A. S., Charkoudian, N., Vella, A. V., Shah, P., Rizza, R. A., & Joyner, M. J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00348.2003 · Cited by 32 · see citing works
Exercise attenuates the premature cardiovascular aging effects of type 2 diabetes mellitus
Huebschmann, A. G., Kohrt, W. M., & Regensteiner, J. G. (2011) · Vascular Medicine · doi:10.1177/1358863x11419996 · Cited by 22 · see citing works
Halter, J. B. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00017-8 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works
Cardiovascular Risks Associated with Gender and Aging
Rodgers, J. L., Jones, J., Bolleddu, S. I., Vanthenapalli, S., Rodgers, L. E., Shah, K., Karia, K., & Panguluri, S. K. (2019) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd6020019 · Cited by 1,081 · see citing works
Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline
LeRoith, D., Biessels, G. J., Braithwaite, S. S., Casanueva, F. F., Draznin, B., Halter, J. B., Hirsch, I. B., McDonnell, M. E., Molitch, M. E., Murad, M. H., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00198 · Cited by 586 · see citing works
Self-citationThe humanistic and economic burden of chronic wounds: a protocol for a systematic review
Järbrink, K., Ni, G., Sönnergren, H., Schmidtchen, A., Pang, C., Bajpai, R. C., & Car, J. (2017) · Systematic Reviews · doi:10.1186/s13643-016-0400-8 · Cited by 538 · see citing works
Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases
Kane, A. E., & Sinclair, D. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312498 · Cited by 490 · see citing works
Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease
Liberale, L., Montecucco, F., Tardif, J., Libby, P., & Camici, G. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz961 · Cited by 347 · see citing works
Ciumărnean, L., Milaciu, M. V., Negrean, V., Orasan, O. H., Vesa, Ș. C., Sălăgean, O., Iluţ, S., & Vlaicu, S. I. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19010207 · Cited by 231 · see citing works
The Pathophysiology of Hyperglycemia in Older Adults: Clinical Considerations
Lee, P., & Halter, J. B. (2017) · Diabetes Care · doi:10.2337/dc16-1732 · Cited by 211 · see citing works
Self-citationSulforaphane Protects against Cardiovascular Disease via Nrf2 Activation
Bai, Y., Wang, X., Zhao, S., Ma, C., Cui, J., & Zheng, Y. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/407580 · Cited by 204 · see citing works
Diabetes and Aging: From Treatment Goals to Pharmacologic Therapy
Longo, M., Bellastella, G., Maiorino, M. I., Meier, J. J., Esposito, K., & Giugliano, D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00045 · Cited by 193 · see citing works
Hurlow, J., & Bowler, P. G. (2022) · Journal of Wound Care · doi:10.12968/jowc.2022.31.5.436 · Cited by 190 · see citing works
Risk of Progression to Diabetes Among Older Adults With Prediabetes
Rooney, M. R., Rawlings, A. M., Pankow, J. S., Echouffo-Tcheugui, J. B., Coresh, J., Sharrett, A. R., & Selvin, E. (2021) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.8774 · Cited by 178 · see citing works
Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases
Bleve, A., Motta, F., Durante, B., Pandolfo, C., Selmi, C., & Sica, A. (2022) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08909-7 · Cited by 179 · see citing works
An, J., Nichols, G., Qian, L., Munis, M., Harrison, T. N., Li, Z., Wei, R., Weiss, T., Rajpathak, S., & Reynolds, K. (2021) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001847 · Cited by 138 · see citing works
Black Esophagus: New Insights and Multicenter International Experience in 2014
Gurvits, G. E., Cherian, K., Shami, M. N., Korabathina, R., El-Nader, E. M. A., Rayapudi, K., Gandolfo, F. J., Alshumrany, M., Patel, H. G., Chowdhury, D. N., et al. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3382-1 · Cited by 140 · see citing works
Siam, N. H., Snigdha, N. N., Tabasumma, N., & Parvin, I. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2512436 · Cited by 162 · see citing works
Age-related cerebral small vessel disease and inflammaging
Li, T., Huang, Y., Cai, W., Chen, X., Men, X., Lü, T., Wu, A., & Lu, Z. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03137-x · Cited by 127 · see citing works
Inoue, T., Tanaka, M., Masuda, S., Ohue‐Kitano, R., Yamakage, H., Muranaka, K., Wada, H., Kusakabe, T., Shimatsu, A., Hasegawa, K., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.02.010 · Cited by 117 · see citing works
Barinda, A. J., Ikeda, K., Nugroho, D. B., Wardhana, D. A., Sasaki, N., Honda, S., Urata, R., Matoba, S., Hirata, K., & Emoto, N. (2020) · Nature Communications · doi:10.1038/s41467-020-14387-w · Cited by 112 · see citing works
Hossain, M. E., Uddin, S., & Khan, A. M. (2020) · Expert Systems with Applications · doi:10.1016/j.eswa.2020.113918 · Cited by 107 · see citing works
Noninvasive Cardiovascular Risk Assessment of the Asymptomatic Diabetic Patient
Budoff, M. J., Raggi, P., Beller, G., Berman, D. S., Druz, R. S., Malik, S., Rigolin, V. H., Weigold, W. G., & Soman, P. (2016) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2015.11.011 · Cited by 103 · see citing works
Nguimkeu, P., & Tadadjeu, S. (2020) · World Development · doi:10.1016/j.worlddev.2020.105251 · Cited by 99 · see citing works
Leustean, A. M., Ciocoiu, M., Sava, A. C., Costea, C. F., Floria, M., Tărniceriu, C. C., & Tănase, D. M. (2018) · Journal of Diabetes Research · doi:10.1155/2018/5205126 · Cited by 92 · see citing works
Wound models for periodontal and bone regeneration: the role of biologic research
Sculean, A., Chapple, I., & Giannobile, W. V. (2015) · Periodontology 2000 · doi:10.1111/prd.12091 · Cited by 88 · see citing works
Kundu, J., & Kundu, S. (2021) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2021.100937 · Cited by 86 · see citing works
Silva‐Palacios, A., Königsberg, M., & Zazueta, C. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.12.005 · Cited by 84 · see citing works
Correlation of physical and cognitive impairment in diabetic and hypertensive frail older adults
Mone, P., Gambardella, J., Lombardi, A., Pansini, A., Gennaro, S. D., Leo, A. L., Famiglietti, M., Marro, A., Morgante, M., Frullone, S., et al. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01442-z · Cited by 78 · see citing works
Egg consumption and heart health: A review
Clayton, Z. S., Fusco, E., & Kern, M. (2016) · Nutrition · doi:10.1016/j.nut.2016.12.014 · Cited by 75 · see citing works
Li, S., Peng, Y., Wang, X., Qian, Y., Xiang, P., Wade, S. W., Guo, H., López, J. A. G., Herzog, C. A., & Handelsman, Y. (2019) · Clinical Cardiology · doi:10.1002/clc.23160 · Cited by 75 · see citing works
Lipid-Induced Mechanisms of Metabolic Syndrome
Denisenko, Y., Kytikovа, O. Y., Novgorodtseva, T. P., Antonyuk, M. V., Gvozdenko, T. A., & Анатольевна, К. Т. (2020) · Journal of Obesity · doi:10.1155/2020/5762395 · Cited by 78 · see citing works
Hezel, M. P., Peleli, M., Liu, M. R., Zollbrecht, C., Jensen, B. L., Checa, A., Giulietti, A., Wheelock, C. E., Lundberg, J. O., Weitzberg, E., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.07.025 · Cited by 73 · see citing works
Management of diabetes mellitus in older people with comorbidities
Huang, E. S. (2016) · BMJ · doi:10.1136/bmj.i2200 · Cited by 73 · see citing works
Self-citationEpidemiology of Cardiovascular Diseases in the Elderly
Noale, M., Limongi, F., & Maggi, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-33330-0_4 · Cited by 70 · see citing works
Normal and defective pathways in biogenesis and maintenance of the insulin storage pool
Liu, M. R., Huang, Y., Xu, X., Li, X., Alam, M., Arunagiri, A., Haataja, L., Ding, L., Wang, S., Itkin‐Ansari, P., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142240 · Cited by 70 · see citing works
Cardiovascular safety of anti-diabetic drugs
Kumar, R. B., Kerins, D. M., & Walther, T. (2015) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvv035 · Cited by 67 · see citing works
Aldafas, R., Crabtree, T. S. J., Alkharaiji, M. A., Vinogradova, Y., & IDRIS, I. R. (2023) · Age and Ageing · doi:10.1093/ageing/afad254 · Cited by 71 · see citing works
Yokota, R. T. D. C., der Heyden, J. V., Nusselder, W. J., Robine, J., Tafforeau, J., Deboosere, P., & Oyen, H. J. V. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv234 · Cited by 66 · see citing works
Bellettiere, J., Healy, G. N., LaMonte, M. J., Kerr, J., Evenson, K. R., Rillamas‐Sun, E., Di, C., Büchner, D. M., Hovell, M. F., & LaCroix, A. Z. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly101 · Cited by 63 · see citing works
Adiposity‐Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans
Ehrhardt, N., Cui, J., Dağdeviren, S., Saengnipanthkul, S., Goodridge, H. S., Kim, J. K., Lantier, L., Guo, X., Chen, Y. I., Raffel, L. J., et al. (2019) · Obesity · doi:10.1002/oby.22418 · Cited by 63 · see citing works
Cigolle, C. T., Blaum, C. S., Lyu, C., Ha, J., Kabeto, M. U., & Zhong, J. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.32766 · Cited by 62 · see citing works
On-demand transdermal insulin delivery system for type 1 diabetes therapy with no hypoglycemia risks
Fu, Y. Z., Liu, P., Chen, M., Jin, T., Wu, H., Hei, M., Wang, C., Xu, Y. F., Qian, X. H., & Zhu, W. P. (2021) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2021.07.126 · Cited by 61 · see citing works
Workplace Strategies to Prevent Sitting-induced Endothelial Dysfunction
Kruse, N. T., Hughes, W. E., Benzo, R. M., Carr, L. J., & Casey, D. P. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001484 · Cited by 56 · see citing works
Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology
Dubois, V., Staels, B., Lefebvre, P., Verzi, M., & Eeckhoute, J. (2020) · Cells · doi:10.3390/cells9102185 · Cited by 63 · see citing works
Exploring the dual character of metformin in Alzheimer's disease
Ning, P., Luo, A., Mu, X. L., Xu, Y., & Li, T. X. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.108966 · Cited by 51 · see citing works
Gut microbiota: a promising target against cardiometabolic diseases
Warmbrunn, M. V., Herrema, H., Aron‐Wisnewsky, J., Soeters, M. R., van Raalte, D. H., & Nieuwdorp, M. (2020) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2020.1720511 · Cited by 48 · see citing works
Update on the management of diabetes in long-term care facilities
Idrees, T., CASTRO-REVOREDO, I. A., Migdal, A. L., MORENO, E. M., & Umpierrez, G. E. (2022) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2021-002705 · Cited by 46 · see citing works
Wan, X., Li, X., Liu, D., Gao, X., Chen, Y., Chen, Z., Fu, C., Lin, L., Liu, B., & Zhao, C. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.010 · Cited by 45 · see citing works
Jensen, P. S., Petersen, J., Kirketerp‐Møller, K., Poulsen, I., & Andersen, O. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-016030 · Cited by 44 · see citing works
Itsiopoulos, C., Marx, W., Mayr, H. L., Tatucu-Babet, O. A., Dash, S. R., George, E. S., Trakman, G. L., Kelly, J. T., Thomas, C. J., & Brazionis, L. (2018) · Journal of Nutrition & Intermediary Metabolism · doi:10.1016/j.jnim.2018.02.002 · Cited by 37 · see citing works
Barreira, E., Novo, A., Vaz, J. A., & Pereira, A. J. B. C. (2017) · Atención Primaria · doi:10.1016/j.aprim.2017.06.012 · Cited by 36 · see citing works
Inorganic nitrate alleviates the senescence-related decline in liver function
Wang, H., Hu, L., Li, L., Wu, X., Fan, Z., Zhang, C., Wang, J., Jia, J., & Wang, S. (2018) · Science China Life Sciences · doi:10.1007/s11427-017-9207-x · Cited by 36 · see citing works
Novel targets for delaying aging: The importance of the liver and advances in drug delivery
Hunt, N. J., McCourt, P., Couteur, D. G. L., & Cogger, V. C. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.006 · Cited by 36 · see citing works
Bansal, S., Canziani, M. E. F., Birne, R., Anker, S. D., Bakris, G. L., Filippatos, G. S., Rossing, P. R., Ruilope, L. M., Farjat, A. E., Kolkhof, P., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-076444 · Cited by 37 · see citing works
Kohanski, R. A., Deeks, S. G., Gravekamp, C., Halter, J. B., High, K. P., Hurria, A., Fuldner, R., Green, P. A., Huebner, R. E., Macchiarini, F., et al. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13297 · Cited by 33 · see citing works
Self-citationAging, the Medical Subspecialties, and Career Development: Where We Were, Where We Are Going
Hurria, A., High, K. P., Mody, L., Horne, F. M., Escobedo, M. R., Halter, J. B., Hazzard, W. R., Schmader, K. E., Klepin, H. D., Lee, S., et al. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14708 · Cited by 34 · see citing works
Self-citationKawanishi, N., Kato, Y., Yokozeki, K., Sawada, S., Sakurai, R., Fujiwara, Y., Shinkai, S., Goda, N., & Suzuki, K. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0785-6 · Cited by 34 · see citing works
Chadwick, P., & Ousey, K. J. (2019) · Journal of Wound Care · doi:10.12968/jowc.2019.28.6.370 · Cited by 33 · see citing works
Lee, A. K., Woodward, M., Wang, D., Ohkuma, T., Warren, B., Sharrett, A. R., Williams, B., Marre, M., Hamet, P., Harrap, S. B., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz045 · Cited by 32 · see citing works
Wu, M. S., Carballo‐Jane, E., Zhou, H., Zafian, P., Dai, G., Liu, M., Lao, J. Z., Kelly, T. M., Shao, D., Gorski, J. N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28561-9 · Cited by 31 · see citing works
Li, T., Li, H., Li, W., Chen, S., Feng, T., Jiao, W., Wu, C., Dong, J., Li, Y., Li, S., et al. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.06.008 · Cited by 31 · see citing works
Cardiovascular events, diabetes and guidelines: the virtue of simplicity
Esper, R. J., & Nordaby, R. A. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0844-y · Cited by 30 · see citing works
Rosland, A.-M. M., Piette, J. D., TRIVEDI, R. B., Kerr, E. A., STOLL, S. C., Tremblay, A. S., & Heisler, M. (2018) · Trials · doi:10.1186/s13063-018-2785-2 · Cited by 29 · see citing works
Considering Cause and Effect of Immune Cell Aging on Cardiac Repair after Myocardial Infarction
Tobin, S. W., Alibhai, F. J., Weisel, R. D., & Li, R. (2020) · Cells · doi:10.3390/cells9081894 · Cited by 30 · see citing works
Baek, J. H., Yang, Y., Ko, S., Han, K., Kim, J. H., Moon, M. K., Park, J. S., Lee, B., Oh, T. J., Chon, S., et al. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2022.0002 · Cited by 29 · see citing works
Kapil, U., Khandelwal, R., Ramakrishnan, L., Khenduja, P., Gupta, A., Sareen, N., Pandey, R. M., Sati, H. C., & Belwal, R. S. (2018) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_261_17 · Cited by 27 · see citing works
ANGPTL2 ― A New Causal Player in Accelerating Heart Disease Development in the Aging ―
Oike, Y., Tian, Z., Miyata, K., Morinaga, J., Endo, M., & Kadomatsu, T. (2017) · Circulation Journal · doi:10.1253/circj.cj-17-0854 · Cited by 27 · see citing works
Rao, M., Bairy, S., Edla, S. R., Manthena, S., & Tatavarti, N. G. D. (2020) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_32_19 · Cited by 25 · see citing works
Pavela, G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0168481 · Cited by 24 · see citing works
Yang, W., Li, Y., Tian, T., Wang, L., Lee, P., & Hua, Q. (2017) · BMC Endocrine Disorders · doi:10.1186/s12902-017-0216-0 · Cited by 24 · see citing works
Protein and Peptides for Elderly Health
Shang, N., Chalamaiah, M., Bandara, N., & Wu, J. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.03.003 · Cited by 24 · see citing works
Hossain, M. E., Uddin, S., Khan, A. M., & Moni, M. A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17020596 · Cited by 24 · see citing works
Kadam, U. T., Roberts, I., White, S. J., Bednall, R., Khunti, K. K., Nilsson, P. M., & Lawson, C. A. (2018) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2018.10.014 · Cited by 23 · see citing works
Visaria, J., Iyer, N. N., Raval, A. D., Kong, S. X., Hobbs, T. M., Bouchard, J. R., Kern, D. M., & Willey, V. J. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.05.012 · Cited by 23 · see citing works
Brain insulin responsiveness is linked to age and peripheral insulin sensitivity
Wagner, L., Veit, R., Kübler, C., Fritsche, A., Häring, H., Birkenfeld, A. L., Heni, M., Preissl, H., & Kullmann, S. (2023) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15094 · Cited by 22 · see citing works
The Cardiac Dysfunction Caused by Metabolic Alterations in Alzheimer's Disease
Murphy, J., Le, T. N. V., Fedorova, J., Yang, Y., Krause‐Hauch, M., Davitt, K., Zoungrana, L. I., Fatmi, M. K., Lesnefsky, E. J., Li, J., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.850538 · Cited by 22 · see citing works
Recent advancements on novel approaches of insulin delivery
Karmakar, S., Bhowmik, M., Laha, B., & Manna, S. (2023) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2023.100253 · Cited by 23 · see citing works
Idrees, T., Castro-Revoredo, I. A., Oh, H. D., Gavaller, M. D., Zabala, Z., Moreno, E., Moazzami, B., Galindo, R. J., Vellanki, P., Cabb, E., et al. (2024) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2024.01.031 · Cited by 22 · see citing works
Han, X., Wu, Y., Liu, X., Ma, L., Lv, T., Sun, Q., Xu, W., Zhang, S., Wang, K., Wang, W., et al. (2017) · Bioscience Reports · doi:10.1042/bsr20170282 · Cited by 22 · see citing works
Robson, B., & Boray, S. (2018) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2018.02.013 · Cited by 22 · see citing works
Qiu, Y., Deng, X., Sha, Y., Wu, X., Zhang, P., Chen, K., Zhao, Z., Wei, W., Yang, L., Yuan, G., et al. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s284420 · Cited by 21 · see citing works
Srivastava, S., Anwar, T., Patel, R., & Chauhan, S. (2020) · International Journal of Scientific Reports · doi:10.18203/issn.2454-2156.intjscirep20203116 · Cited by 21 · see citing works
Protective effect of resveratrol on methylglyoxal-induced endothelial dysfunction in aged rats
Taşatargil, A., Tanriover, G., Barutcigil, A., & Turkmen, E. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-0986-x · Cited by 21 · see citing works
Jensen, J., Schou, M., Kistorp, C., Faber, J. O., Hansen, T. W., Jensen, M. T., Andersen, H. U., Rossing, P. R., Vilsbøll, T., & Jørgensen, P. G. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13583 · Cited by 21 · see citing works
Artificial intelligence in preventive cardiology
Sherbini, A. E., Rosenson, R. S., Rifai, M. A., Virk, H. U. H., Wang, Z., Virani, S. S., Glicksberg, B. S., Lavie, C. J., & Krittanawong, C. (2024) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2024.03.002 · Cited by 28 · see citing works
Kobayashi, A., Hirano, K., Okuda, T., Ikenoue, T., Yokoo, T., & Fukuma, S. (2024) · Clinical and Experimental Nephrology · doi:10.1007/s10157-024-02570-y · Cited by 19 · see citing works
Gokhale, M., Buse, J. B., Funk, M. J., Lund, J. L., Pate, V., Simpson, R. J., & Stürmer, T. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12906 · Cited by 19 · see citing works
Quashie, N. T., D’Este, C. A., Agrawal, S., Naidoo, N., & Kowal, P. R. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.02.068 · Cited by 19 · see citing works
Yang, W., Li, Y., Tian, T., & Wang, L. (2017) · BioMed Research International · doi:10.1155/2017/4875026 · Cited by 19 · see citing works
González‐Juanatey, C., Anguita-Sánchez, M. P., Barrios, V., Nuñez-Gil, I. J., Gómez‐Doblas, J. J., García–Moll, X., Gormaz, C. L., Rollán-Gómez, M. J., Peral-Disdier, V., Martínez‐Dolz, L., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12165218 · Cited by 18 · see citing works
Biomarkers of Airway Type-2 Inflammation and Integrating Complex Phenotypes to Endotypes in Asthma
Peters, M. C., Nguyen, M. T., & Dunican, E. M. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-016-0651-4 · Cited by 17 · see citing works
Whipple, M. O., Masters, K. S., Huebschmann, A. G., Scalzo, R. L., Reusch, J. E. B., Bergouignan, A., & Regensteiner, J. G. (2021) · Vascular Medicine · doi:10.1177/1358863x211009307 · Cited by 18 · see citing works
Alario, M. L. B., Ferri, J., Civera, M., Martínez‐Hervás, S., Ascaso, J. F., & Real, J. T. (2015) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2015.10.005 · Cited by 15 · see citing works
Moradi, M., Daneshzad, E., Najafabadi, M. M., Bellissimo, N., Suitor, K., & Azadbakht, L. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.09.032 · Cited by 15 · see citing works
Goswami, A., Huda, N., Yasmin, T., Hosen, M. I., Hasan, A. K. M. M., & Nabi, A. N. (2021) · Molecular Biology Reports · doi:10.1007/s11033-020-06045-7 · Cited by 15 · see citing works
Inpatient Management of T2DM and Hyperglycemia in Older Adults
DeCarlo, K., & Wallia, A. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1209-3 · Cited by 15 · see citing works
Shah, R., Yang, Y., Bentley, J. P., & Banahan, B. F. (2016) · Current Medical Research and Opinion · doi:10.1080/03007995.2016.1219708 · Cited by 14 · see citing works
Ulambayar, B., Ghanem, A. S., Kovács, N., Trefán, L., Móré, M., & Nagy, A. C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1263365 · Cited by 14 · see citing works
Fluca, A. L., Pani, B., Janjusevic, M., Zwas, D. R., Abraham, Y., Calligaris, M., Beltrami, A. P., Corgosinho, F. C., Marketou, M. E., D’Errico, S., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122911 · Cited by 14 · see citing works
Bayesian adaptive lasso for additive hazard regression with current status data
Wang, C., Li, Q., Song, X., & Dong, X. (2019) · Statistics in Medicine · doi:10.1002/sim.8137 · Cited by 14 · see citing works
- Authors
- Halter, J. B., Musi, N., McFarland Horne, F., Crandall, J. P., Goldberg, A., Harkless, L., Hazzard, W. R., Huang, E. S., Kirkman, M. S., Plutzky, J., Schmader, K. E., Zieman, S., & High, K. P.
- Affiliations
- University of Michigan (US)
- The University of Texas at San Antonio Health Science Center (US)
- Association of Specialty Professors, Alexandria, VA
- Albert Einstein College of Medicine (US)
- University of Maryland, Baltimore (US)
- Western University of Health Sciences (US)
- University of Washington (US)
- University of Chicago (US)
- University of North Carolina at Chapel Hill (US)
- Brigham and Women's Hospital (US)
- Duke University (US)
- National Institutes of Health (US)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Halter, Jeffrey B.
- Musi, Nicolas
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2014-07-17
- Volume
- 63
- Issue
- 8
- Pages
- 2578-2589
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC4113072
- OpenAlex
- W2158639332
- Cited by
- 255
- References
- 58
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 29 · 2023: 28 · 2022: 28 · 2021: 20 · 2020: 28 · 2019: 19 · 2018: 27 · 2017: 25 · 2016: 13 · 2015: 12 · 2014: 2
- FWCI
- 13.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (UL1TR001073)
- Wake Forest School of Medicine
- National Institute on Aging (U13AG040938, P30AG028716)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK092949, P30DK020572)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- cardiovascular disease, older adults, aging, inflammation, oxidative stress, diabetes complications, geriatric conditions, research priorities
- MeSH terms
- Adult, Aged, Aging, Blood Glucose, Cardiovascular Diseases, Humans, Hyperglycemia, Middle Aged, United States, Diabetes Complications, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
