CoChat
Sign Up
Cited by 35Pancreatic function and diabetesDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and Management

Glucose Metabolism in Older Adults: A Study Including Subjects More Than 80 Years of Age

Garcia, Gloria V., Freeman, Rosario V., Supiano, Mark A., Smith, Maria J., Galecki, Andrzej T., Halter, Jeffrey B.·1997·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.1997.tb01507.x
Open this paper in CoChat — free account

Abstract

OBJECTIVE : This study was undertaken to understand the dynamics of glucose metabolism in healthy non‐diabetic subjects older than age 80 (old‐old) compared with subjects aged 61 to 79 (young‐old), as well as to compare healthy older subjects with impaired glucose tolerance (IGT) with older subjects with normal glucose tolerance (NGT). DESIGN : A cross sectional, observational study. SETTING : A university hospital clinical research center. PARTICIPANTS : There were 28 community‐dwelling adults, 10 older than age 80 and 18 aged 61 to 79. Thirteen of these people had NGT and 15 had IGT. Subjects were not taking any medication that interfered with glucose tolerance. MEASUREMENTS : Status of glucose tolerance was determined by an oral glucose tolerance test categorized as NGT or IGT according to WHO criteria. Insulin sensitivity (S I and glucose effectiveness (S G ) were assessed using a tolbutamide‐assisted intravenous glucose tolerance test (IVGTT). The data were analyzed using the Minmod modeling program. Glucose tolerance (K g ) and the acute insulin response to glucose (AIR g ) were calculated from the IVGTT. RESULTS : There were no significant differences between the young‐old and old‐old in body mass index or in plasma glucose, insulin, or C‐peptide levels in the fasting state or during the OGTT. Values for K g , S I S G , and AIRg from the IVGTT were similar in the two age groups. When the subjects were classified by glucose tolerance status, the subjects with NGT had age, gender, and body mass index similar to the subjects with IGT. Older people with IGT had a lower Kg and tended to have higher fasting glucose and similar fasting insulin compared with people with NGT. IGT subjects had lower S] and tended to have lower S G . The AIRg in IGT subjects tended to be low rather than high when compared with older people with NGT. CONCLUSION : Otherwise healthy adults more than 80 years of age have measures of glucose metabolism similar to people aged 61 to 79. The presence of IGT in older adults is associated with insulin resistance, regardless of patient age. We hypothesize that the lack of pancreatic islet compensation for insulin resistance may contribute to impaired glucose tolerance in older adults.

Integrity signals

Registry

Crossref · 10.1111/j.1532-5415.1997.tb01507.x

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • During ivGTT, glucose tolerance was decreased by more than 40% in sleep debt and reached values typical for older adults with impaired glucose tolerance.

    “Glucose tolerance during this ivGTT was decreased by more than 40% when the subjects were in a state of sleep debt and reached values typical for older adults with impaired glucose tolerance [54].”

    From Sleep and metabolic function (2012) · cites this paper as [54]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Garcia, G. V., Freeman, R. V., Supiano, M. A., Smith, M. J., Galecki, A. T., & Halter, J. B.
Affiliations
University of Michigan (US)
Corresponding author
Halter, Jeffrey B.
ORCID
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
1997-07
Volume
45
Issue
7
Pages
813-817
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.1997.tb01507.x
OpenAlex
W2066746642
Cited by
35
References
18
Citations by year
2024: 1 · 2023: 2 · 2021: 1 · 2018: 3 · 2013: 2 · 2012: 2
FWCI
1.92
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6509 d)
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (acceptedVersion)
Funders
  • National Institute on Aging (AG-08808)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK20572)
  • National Center for Research Resources (RR00042, M01RR000042)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
glucose metabolism, older adults, impaired glucose tolerance, insulin resistance, insulin sensitivity, glucose effectiveness, acute insulin response, oral glucose tolerance test, intravenous glucose tolerance test, tolbutamide
MeSH terms
Aged, Aged, 80 and over, Aging, Blood Pressure, C-Peptide, Catecholamines, Glucose, Glucose Tolerance Test, Humans, Insulin, Middle Aged, Glucose Intolerance

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review