The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm
Abstract
To determine whether glucose and insulin responses to a mixed meal are influenced by time of day irrespective of duration of prior fast, eight normal subjects (4 males, 4 females) were studied on two separate occasions, involving ingestion of identical meals at either 6- or 12-h intervals. The 24-h profiles of plasma glucose, serum insulin, and plasma C-peptide were obtained at 20-min intervals. Plasma cortisol levels were measured on each sample to evaluate possible relationship between diurnal variations in metabolic responses and circadian rhythm of cortisol. Rates of secretion of insulin and cortisol were mathematically derived from peripheral concentrations by deconvolution using two-compartment models for clearance kinetics. Postmeal responses of glucose, insulin, and insulin secretion rate were evaluated by calculating maximum postmeal increment, total area under curve, area under curve for 2 h after meal ingestion, and total duration of response. Postmeal cortisol responses were quantified by increment in plasma level and amount secreted in postmeal pulse. For glucose responses, irrespective of duration of prior fast, all four parameters characterizing the response were significantly greater in the evening than in the morning, with total area under curve and 2-h area under curve being approximately twofold larger in the evening than in the morning. Time of day did not significantly influence maximum postmeal increment in insulin secretion rate or duration of insulin secretory response, but total and 2-h areas under curve were 25-50% greater in the evening than in the morning. Meal ingestion was followed by a significant pulse of cortisol secretion in 37 of 40 cases.(ABSTRACT TRUNCATED AT 250 WORDS)
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and other studies have shown that insulin sensitivity and glucose tolerance fall gradually during the day with insulin sensitivity reaching the lowest level in the evening (11,36) .”
From Effects of consuming later evening meal v. earlier evening meal on weight loss during a weight loss diet: a randomised clinical trial (2021) · cites this paper as [36]
Citations
Cites
Morgan, C. R., & Lazarow, A. (1963) · Diabetes · doi:10.2337/diab.12.2.115 · Cited by 2,197
Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.
Polonsky, K. S., Given, B. D., & Van Cauter, E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113339 · Cited by 763
Self-citationCircadian Rhythms of Epinephrine and Norepinephrine in Man*
LINSELL, C. R., LIGHTMAN, S. L., MULLEN, P. E., BROWN, M. J., & CAUSON, R. C. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-6-1210 · Cited by 399
Circadian rhythms of the spontaneous meal pattern, macronutrient intake, and mood of humans
de Castro, J. M. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90028-x · Cited by 185
Estimating false-positive and false-negative errors in analyses of hormonal pulsatility
Cauter, E. V. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.6.e786 · Cited by 177
Circadian variations of blood sugar and plasma insulin levels in man
Malherbe, C., Marc De Gasparo, B., Hertogh, R. D., & Hoem, J. J. (1969) · Diabetologia · doi:10.1007/bf00427978 · Cited by 167
A MID-DAY SURGE IN CORTISOL LEVELS
QUIGLEY, M. E., & YEN, S. S. C. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-6-945 · Cited by 135
Shapiro, E. T., TILLIL, H., Polonsky, K. S., Fang, V. S., Rubenstein, A. H., & Cauter, E. V. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-307 · Cited by 131
Self-citationService, F. J., Hall, L. D., Westland, R. E., O’Brien, P. C., Go, V. L. W., Haymond, M. W., & Rizza, R. A. (1983) · Diabetologia · doi:10.1007/bf00253193 · Cited by 98
Ahmed, M., Gannon, M. C., & Nuttall, F. Q. (1976) · Diabetologia · doi:10.1007/bf01221966 · Cited by 92
Research works printed but not linked: 1
- Eaton R. P., Metub., 51, 520
Cited by
Sorted by citations
Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetes
Hovorka, R., Canonico, V., Chassin, L. J., Haueter, U., Massi-Benedetti, M., Federici, M. O., Pieber, T. R., Schaller, H. C., Schaupp, L., Vering, T., et al. (2004) · Physiological Measurement · doi:10.1088/0967-3334/25/4/010 · Cited by 1,274
Rajaratnam, S. M., & Arendt, J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06108-6 · Cited by 711
Circadian regulation of glucose, lipid, and energy metabolism in humans
Poggiogalle, E., Jamshed, H., & Peterson, C. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.017 · Cited by 743
Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 632
Self-citationJakubowicz, D., Barnea, M., Wainstein, J., & Froy, O. (2013) · Obesity · doi:10.1002/oby.20460 · Cited by 593
Metadata
- Authors
- Van Cauter, E., Shapiro, E. T., Tillil, H., & Polonsky, K. S.
- Affiliations
- Department of Medicine, University of Chicago, Illinois 60637.
- University of Chicago (US)
- ORCID
- Tillil, H.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1992-04-01
- Volume
- 262
- Issue
- 4
- Pages
- E467-E475
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1921767431
- Cited by
- 240
- References
- 13
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 16 · 2021: 9 · 2020: 11 · 2019: 13 · 2018: 8 · 2017: 13 · 2016: 6 · 2015: 12 · 2014: 13 · 2013: 14 · 2012: 8
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-31842, DK 20595, DK-41814, R01DK041814)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- circadian rhythm, cortisol, insulin secretion, glycemic response, mixed meal, time of day, fasting duration, C-peptide, insulin secretion rate, diurnal variation
- MeSH terms
- Insulin Secretion, Adult, Blood Glucose, Circadian Rhythm, Eating, Female, Humans, Hydrocortisone, Insulin, Male, Osmolar Concentration, Sex Characteristics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
