Cited by 256Muscle metabolism and nutritionHormonal and reproductive studiesMuscle Physiology and Disorders

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Testosterone injection stimulates net protein synthesis but not tissue amino acid transport

Ferrando, Arny A., Tipton, Kevin D., Doyle, David, Phillips, Stuart M., Cortiella, Joaquin, Wolfe, Robert R.·1998·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.1998.275.5.e864

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Abstract

Testosterone administration (T) increases lean body mass and muscle protein synthesis. We investigated the effects of short-term T on leg muscle protein kinetics and transport of selected amino acids by use of a model based on arteriovenous sampling and muscle biopsy. Fractional synthesis (FSR) and breakdown (FBR) rates of skeletal muscle protein were also directly calculated. Seven healthy men were studied before and 5 days after intramuscular injection of 200 mg of testosterone enanthate. Protein synthesis increased twofold after injection ( P < 0.05), whereas protein breakdown was unchanged. FSR and FBR calculations were in accordance, because FSR increased twofold ( P < 0.05) without a concomitant change in FBR. Net balance between synthesis and breakdown became more positive with both methodologies ( P< 0.05) and was not different from zero. T injection increased arteriovenous essential and nonessential nitrogen balance across the leg ( P < 0.05) in the fasted state, without increasing amino acid transport. Thus T administration leads to an increased net protein synthesis and reutilization of intracellular amino acids in skeletal muscle.

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Authors: Ferrando, A. A., Tipton, K. D., Doyle, D., Phillips, S. M., Cortiella, J., & Wolfe, R. R.
Affiliations: Departments of Surgery and
The University of Texas Medical Branch at Galveston (US)
ORCID: Ferrando, Arny A.
Tipton, Kevin D.
Phillips, Stuart M.
Cortiella, Joaquin
Wolfe, Robert R.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 1998-11-01
Volume: 275
Issue: 5
Pages: E864-E871
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.1998.275.5.e864
OpenAlex: W2122493788
Cited by: 256
References: 22
Citations by year: 2026: 2 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 13 · 2021: 9 · 2020: 8 · 2019: 12 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 13 · 2014: 5 · 2013: 14 · 2012: 6
FWCI: 2.39
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
Funders: National Institutes of Health (5r01dk033952-14)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 33952)
National Center for Research Resources (M01RR000073)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: testosterone, testosterone enanthate, muscle protein synthesis, protein degradation, amino acid transport, nitrogen balance, lower limb muscles, lean body mass, muscle hypertrophy, muscle biopsy
MeSH terms: Adult, Alanine, Amino Acids, Biological Transport, Carbon Isotopes, Femoral Artery, Humans, Injections, Intramuscular, Kinetics, Leucine, Lysine, Male, Models, Biological, Nitrogen Isotopes, Phenylalanine, Regional Blood Flow, Regression Analysis, Testosterone, Time Factors, Protein Biosynthesis, Tritium, Muscle, Skeletal

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Testosterone injection stimulates net protein synthesis but not tissue amino acid transport

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