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Cited by 256Muscle metabolism and nutritionHormonal and reproductive studiesMuscle Physiology and Disorders

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Testosterone injection stimulates net protein synthesis but not tissue amino acid transport

Ferrando, Arny A., Tipton, Kevin D., Doyle, David, Phillips, Stuart M., Cortiella, Joaquin, Wolfe, Robert R.·1998·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1998.275.5.e864
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Abstract

Testosterone administration (T) increases lean body mass and muscle protein synthesis. We investigated the effects of short-term T on leg muscle protein kinetics and transport of selected amino acids by use of a model based on arteriovenous sampling and muscle biopsy. Fractional synthesis (FSR) and breakdown (FBR) rates of skeletal muscle protein were also directly calculated. Seven healthy men were studied before and 5 days after intramuscular injection of 200 mg of testosterone enanthate. Protein synthesis increased twofold after injection ( P < 0.05), whereas protein breakdown was unchanged. FSR and FBR calculations were in accordance, because FSR increased twofold ( P < 0.05) without a concomitant change in FBR. Net balance between synthesis and breakdown became more positive with both methodologies ( P< 0.05) and was not different from zero. T injection increased arteriovenous essential and nonessential nitrogen balance across the leg ( P < 0.05) in the fasted state, without increasing amino acid transport. Thus T administration leads to an increased net protein synthesis and reutilization of intracellular amino acids in skeletal muscle.

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Crossref · 10.1152/ajpendo.1998.275.5.e864

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Citations

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Show all 22 references

Research works printed but not linked: 13

  1. Bhasin S., 1997, J. Clin. Endocrinol. Metab., 82, 407
  2. Biolo G., 1995, Am. J. Physiol., 268, E75
  3. Biolo G., 1997, Am. J. Physiol., 273, E122
  4. Brodsky I. G., 1996, J. Clin. Endocrinol. Metab., 81, 3469
  5. Ferrando A. A., 1996, Am. J. Physiol., 270, E627
  6. Fryburg D. A., 1994, Am. J. Physiol., 267, E331
  7. Fryburg D. A., 1991, Am. J. Physiol., 260, E499
  8. Hobbs C. J., 1993, J. Endocrinol. Metab., 77, 776
  9. Katznelson L., 1996, J. Clin. Endocrinol. Metab., 81, 4358
  10. Tenover J. S., 1992, J. Clin. Endocrinol. Metab., 75, 1092
  11. Urban R. J., 1995, Am. J. Physiol., 269, E820
  12. Welle S., 1992, J. Clin. Endocrinol. Metab., 74, 332
  13. Zhang X.-J., 1996, Am. J. Physiol., 270, E759

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Metadata

Authors
Ferrando, A. A., Tipton, K. D., Doyle, D., Phillips, S. M., Cortiella, J., & Wolfe, R. R.
Affiliations
  • Departments of Surgery and
  • The University of Texas Medical Branch at Galveston (US)
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1998-11-01
Volume
275
Issue
5
Pages
E864-E871
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1998.275.5.e864
OpenAlex
W2122493788
Cited by
256
References
22
Citations by year
2026: 2 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 13 · 2021: 9 · 2020: 8 · 2019: 12 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 13 · 2014: 5 · 2013: 14 · 2012: 6
FWCI
2.39
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
Funders
  • National Institutes of Health (5r01dk033952-14)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 33952)
  • National Center for Research Resources (M01RR000073)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
testosterone, testosterone enanthate, muscle protein synthesis, protein degradation, amino acid transport, nitrogen balance, lower limb muscles, lean body mass, muscle hypertrophy, muscle biopsy
MeSH terms
Adult, Alanine, Amino Acids, Biological Transport, Carbon Isotopes, Femoral Artery, Humans, Injections, Intramuscular, Kinetics, Leucine, Lysine, Male, Models, Biological, Nitrogen Isotopes, Phenylalanine, Regional Blood Flow, Regression Analysis, Testosterone, Time Factors, Protein Biosynthesis, Tritium, Muscle, Skeletal

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