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Cited by 167Thermoregulation and physiological responsesCardiovascular and exercise physiologyEstrogen and related hormone effects

Estrogen modifies the temperature effects of progesterone

Stachenfeld, Nina S., Silva, Celso, Keefe, David L.·2000·Journal of Applied Physiology
DOI 10.1152/jappl.2000.88.5.1643
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Abstract

To test the hypothesis that progestin-mediated increases in resting core temperature and the core temperature threshold for sweating onset are counteracted by estrogen, we studied eight women (24 ± 2 yr) at 27°C rest, during 20 min of passive heating (35°C), and during 40 min of exercise at 35°C. Subjects were tested four times, during the early follicular and midluteal menstrual phases, after 4 wk of combined estradiol-norethindrone (progestin) oral contraceptive administration (OC E+P), and after 4 wk of progestin-only oral contraceptive administration (OC P). The order of the OC P and OC E+P were randomized. Baseline esophageal temperature (T es) at 27°C was higher ( P < 0.05) in the luteal phase (37.08 ± 0.21°C) and in OC P (37.60 ± 0.31°C) but not during OC E+P (37.04 ± 0.23°C) compared with the follicular phase (36.66 ± 0.21°C). T es remained above follicular phase levels throughout passive heating and exercise during OC P, whereas T es in the luteal phase was greater than in the follicular phase throughout exercise ( P < 0.05). The T es threshold for sweating was also greater in the luteal phase (38.02 ± 0.28°C) and OC P (38.07 ± 0.17°C) compared with the follicular phase (37.32 ± 0.11°C) and OC E+P (37.46 ± 0.18°C). Progestin administration raised the T es threshold for sweating during OC P, but this effect was not present when estrogen was administered with progestin, suggesting that estrogen modifies progestin-related changes in temperature regulation. These data are also consistent with previous findings that estrogen lowers the thermoregulatory operating point.

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Crossref · 10.1152/jappl.2000.88.5.1643

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  • Core body temperature was higher when taking progestin-only compared with the combined oral contraceptive.

    “In addition, core body temperature was higher when taking progestin-only compared with the combined oral contraceptive.”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [107]

  • In a randomized cross-over study, during 20 min of rest in a thermoneutral environment, esophageal temperature was higher when women were taking the progestin-only pill compared with their follicular phase.

    “During 20 min of rest in a thermoneutral environment, the esophageal temperature was higher when women were taking the progestin-only pill compared with their follicular phase.”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [107]

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Authors
Stachenfeld, N. S., Silva, C., & Keefe, D. L.
Affiliations
  • Yale University (US)
  • Brown University (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2000-05-01
Volume
88
Issue
5
Pages
1643-1649
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.2000.88.5.1643
OpenAlex
W1899639583
Cited by
167
References
34
Citations by year
2026: 13 · 2025: 7 · 2024: 8 · 2023: 11 · 2022: 5 · 2021: 12 · 2020: 11 · 2019: 9 · 2018: 5 · 2017: 4 · 2016: 13 · 2015: 9 · 2014: 11 · 2013: 2 · 2012: 4
FWCI
2.27
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
estrogen, progesterone, progestins, thermoregulation, core body temperature, sweating threshold, esophageal temperature, oral contraceptives, progestin-only contraceptives, menstrual cycle, follicular phase, luteal phase, passive heating, exercise thermoregulation
MeSH terms
Adult, Body Temperature, Contraceptives, Oral, Differential Threshold, Drug Combinations, Esophagus, Estradiol, Estrogens, Female, Follicular Phase, Humans, Luteal Phase, Norethindrone, Progesterone, Sweating, Exercise

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