The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Antioxidant responses to oxidant-mediated lung diseases
Abstract
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated throughout the human body. Enzymatic and nonenzymatic antioxidants detoxify ROS and RNS and minimize damage to biomolecules. An imbalance between the production of ROS and RNS and antioxidant capacity leads to a state of “oxidative stress” that contributes to the pathogenesis of a number of human diseases by damaging lipids, protein, and DNA. In general, lung diseases are related to inflammatory processes that generate increased ROS and RNS. The susceptibility of the lung to oxidative injury depends largely on its ability to upregulate protective ROS and RNS scavenging systems. Unfortunately, the primary intracellular antioxidants are expressed at low levels in the human lung and are not acutely induced when exposed to oxidative stresses such as cigarette smoke and hyperoxia. However, the response of extracellular antioxidant enzymes, the critical primary defense against exogenous oxidative stress, increases rapidly and in proportion to oxidative stress. In this paper, we review how antioxidants in the lung respond to oxidative stress in several lung diseases and focus on the mechanisms that upregulate extracellular glutathione peroxidase.
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Cites
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Cited by
Biomarkers of Oxidative Damage in Human Disease
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Mediators of Chronic Obstructive Pulmonary Disease
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Superoxide Dismutases in the Lung and Human Lung Diseases
Kinnula, V. L., & Crapo, J. D. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200212-1479so · Cited by 620
Cho, S. J., & Stout-Delgado, H. W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034610 · Cited by 458
Metadata
- Authors
- Comhair, S. A. A., & Erzurum, S. C.
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2002-08-01
- Volume
- 283
- Issue
- 2
- Pages
- L246-L255
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W2120659958
- Cited by
- 309
- References
- 9
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Comhair, S. A. A., & Erzurum, S. C. (2002). Antioxidant responses to oxidant-mediated lung diseases. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.00491.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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