Role of oxytocin in energy metabolism

Chaves, Valéria Ernestânia; Tilelli, Cristiane Queixa; Brito, Nilton Almeida; Brito, Márcia Nascimento

doi:10.1016/j.peptides.2013.04.010

Cited by 90Regulation of Appetite and ObesityNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

Role of oxytocin in energy metabolism

Chaves, Valéria Ernestânia, Tilelli, Cristiane Queixa, Brito, Nilton Almeida, Brito, Márcia Nascimento·2013·Peptides

DOI 10.1016/j.peptides.2013.04.010

Open this paper in CoChat — free account

Abstract

The basic mechanisms that lead obesity are not fully understood; however, several peptides undoubtedly play a role in regulating body weight. Obesity, a highly complex metabolic disorder, involves central mechanisms that control food intake and energy expenditure. Previous studies have shown that central or peripheral oxytocin administration induces anorexia. Recently, in an apparent discrepancy, rodents that were deficient in oxytocin or the oxytocin receptor were shown to develop late-onset obesity without changing their total food intake, which indicates the physiological importance of oxytocin to body metabolism. Oxytocin is synthesized not only within magnocellular and parvocellular neurons but also in several organs, including the ovary, uterus, placenta, testis, thymus, kidney, heart, blood vessels, and skin. The presence of oxytocin receptors in neurons, the myometrium and myoepithelial cells is well recognized; however, this receptor has also been identified in other tissues, including the pancreas and adipose tissue. The oxytocin receptor is a typical class I G protein-coupled receptor that is primarily linked to phospholipase C-β via Gq proteins but can also be coupled to other G proteins, leading to different functional effects. In this review, we summarize the present knowledge of the effects of oxytocin on controlling energy metabolism, focusing primarily on the role of oxytocin on appetite regulation, thermoregulation, and metabolic homeostasis.

Integrity signals

Registry

Crossref · 10.1016/j.peptides.2013.04.010

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Oxytocin regulates feeding and metabolism at several sites, and its receptors are present throughout the gastrointestinal tract and on gastric vagal nerve endings.
“Oxytocin regulates feeding and metabolism at multiple sites (34,35).Its receptors are expressed throughout the gastrointestinal tract, and on gastric vagal nerve endings (36).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [34]

Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150 · see citing works
Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure
Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,122 · see citing works
On some physiological actions of ergot
Dale, H. H. (1906) · The Journal of Physiology · doi:10.1113/jphysiol.1906.sp001148 · Cited by 1,011 · see citing works
Deconstruction of a neural circuit for hunger
Atasoy, D., Betley, J. N., Su, H. H., & Sternson, S. M. (2012) · Nature · doi:10.1038/nature11270 · Cited by 969 · see citing works
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856 · see citing works
Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin
Poulain, D. A., & Wakerley, J. B. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90044-6 · Cited by 813 · see citing works
Oxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798 · see citing works
Evidence for a Neuroendocrinological Foundation of Human Affiliation: Plasma Oxytocin Levels Across Pregnancy and the Postpartum Period Predict Mother-Infant Bonding
Feldman, R., Weller, A., Zagoory-Sharon, O., & Levine, A. (2007) · Psychological Science · doi:10.1111/j.1467-9280.2007.02010.x · Cited by 787 · see citing works
Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system
Romanovsky, A. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00668.2006 · Cited by 786 · see citing works
THE SEQUENCE OF AMINO ACIDS IN OXYTOCIN, WITH A PROPOSAL FOR THE STRUCTURE OF OXYTOCIN
du Vigneaud, V., Ressler, C., & Trippett, S. (1953) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49238-1 · Cited by 603 · see citing works
Neuromodulation by Oxytocin and Vasopressin
Stoop, R. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.025 · Cited by 506 · see citing works
Development of neuroendocrine lineages requires the bHLH–PAS transcription factor SIM1Preprint
Michaud, J. L., Rosenquist, T. A., May, N. R., & Fan, C. (1998) · Genes & Development · doi:10.1101/gad.12.20.3264 · Cited by 391 · see citing works
Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): Half-times of disappearance of these neuropeptides from CSF
Mens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)90478-x · Cited by 360 · see citing works
Oxytocin Secretion in Response to Cholecystokinin and Food: Differentiation of Nausea from Satiety
Verbalis, J. G., McCann, M. J., McHale, C. M., & Stricker, E. M. (1986) · Science · doi:10.1126/science.3715453 · Cited by 354 · see citing works
Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
Blevins, J. E., Schwartz, M. W., & Baskin, D. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00604.2003 · Cited by 332 · see citing works
Influence of oxytocin on feeding behavior in the rat
Arletti, R., Benelli, A., & Bertolini, A. (1989) · Peptides · doi:10.1016/0196-9781(89)90082-x · Cited by 328 · see citing works
The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
Oldfield, B. J., Giles, M., Watson, A. M. D., Anderson, C. R., Colvill, L. M., & McKinley, M. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00555-3 · Cited by 317 · see citing works
Oxytocin receptor-deficient mice developed late-onset obesity
Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., & Nishimori, K. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3283021ca9 · Cited by 294 · see citing works
The grooming analysis algorithm discriminates between different levels of anxiety in rats: potential utility for neurobehavioural stress research.
Kalueff, A., & Tuohimaa, P. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.10.001 · Cited by 284 · see citing works
Neuronal circuitries involved in thermoregulation
Nagashima, K., Nakai, S., Tanaka, M., & Kanosue, K. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00216-2 · Cited by 279 · see citing works
Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats
Deblon, N., Veyrat-Durebex, C., Bourgoin, L., Caillon, A., Bussier, A.-L., Petrosino, S., Piscitelli, F., Legros, J.-J., Geenen, V., Foti, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025565 · Cited by 254 · see citing works
Oxytocin inhibits food and fluid intake in rats
Arletti, R., Benelli, A., & Bertolini, A. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90234-u · Cited by 246 · see citing works
Low sympathetic tone and obese phenotype in oxytocin-deficient mice
Camerino, C. (2009) · Obesity · doi:10.1038/oby.2009.12 · Cited by 235 · see citing works
Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass
Maejima, Y., Iwasaki, Y., Yamahara, Y., Kodaira, M., Sedbazar, U., & Yada, T. (2011) · Aging · doi:10.18632/aging.100408 · Cited by 220 · see citing works
Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats
Morton, G. J., Thatcher, B. S., Reidelberger, R. D., Ogimoto, K., Wolden-Hanson, T., Baskin, D. G., Schwartz, M. W., & Blevins, J. E. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2011 · Cited by 213 · see citing works
Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance
Zhang, G., Bai, H., Zhang, H., Dean, C., Wu, Q., Li, J., Guariglia, S., Meng, Q., & Cai, D. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.036 · Cited by 208 · see citing works
Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells
Szeto, A., Nation, D. A., Mendez, A. J., Domínguez‐Bendala, J., Brooks, L., Schneiderman, N., & McCabe, P. M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90718.2008 · Cited by 207 · see citing works
Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically
Stanley, S. A., Pinto, S., Segal, J., Pérez, C. A., Viale, A. J., DeFalco, J., Cai, X., Heisler, L. K., & Friedman, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002790107 · Cited by 203 · see citing works
Evidence for differential regulation of corticotropin-releasing factor and vasopressin immunoreactivities in parvocellular neurosecretory and autonomic-related projections of the paraventricular nucleus
Sawchenko, P. E. (1987) · Brain Research · doi:10.1016/0006-8993(87)91641-6 · Cited by 184 · see citing works
Oxytocin and its receptors are synthesized in the rat vasculature
Jankowski, M., Wang, D., Hajjar, F., Mukaddam-Daher, S., McCann, S. M., & Gutkowska, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110137497 · Cited by 175 · see citing works
Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment
Zhang, G., & Cai, D. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00196.2011 · Cited by 171 · see citing works
Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin
Blevins, J. E., Eakin, T. J., Murphy, J. A., Schwartz, M. W., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.036 · Cited by 164 · see citing works
Mapping oxytocin receptor gene expression in the mouse brain and mammary gland using an oxytocin receptor-LacZ reporter mouse
Gould, B. R., & Zingg, H. H. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00283-5 · Cited by 138 · see citing works
Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions
Sclafani, A. J., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00826.2006 · Cited by 131 · see citing works
Central oxytocin and reproductive behaviours
Insel, T. R. (1997) · Reviews of Reproduction · doi:10.1530/ror.0.0020028 · Cited by 129 · see citing works
Several agents and pathways regulate lipolysis in adipocytes.
Chaves, V., Frasson, D., & Kawashita, N. (2011) · Biochimie · doi:10.1016/j.biochi.2011.05.018 · Cited by 126 · see citing works
Self-citation
Oxytocin Secretion Is Associated with Severity of Disordered Eating Psychopathology and Insular Cortex Hypoactivation in Anorexia Nervosa
Lawson, E. A., Holsen, L. M., Santin, M., Meenaghan, E. M., Eddy, K. T., Becker, A. E., Herzog, D. B., Goldstein, J. M., & Klibanski, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1702 · Cited by 121 · see citing works
Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion
Amico, J. A., Vollmer, R. R., Cai, H.-M., Miedlar, J. A., & Rinaman, L. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00558.2005 · Cited by 120 · see citing works
Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin
Ghamari‐Langroudi, M., Srisai, D., & Cone, R. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016785108 · Cited by 113 · see citing works
Central administration of peptides alters thermoregulation in the rabbit
Lipton, J. M., & Glyn, J. R. (1980) · Peptides · doi:10.1016/0196-9781(80)90029-7 · Cited by 111 · see citing works
Molecular, immunohistochemical, and pharmacological evidence of oxytocin’s role as inhibitor of carbohydrate but not fat intake
Olszewski, P. K., Klockars, A., Olszewska, A. M., Fredriksson, R., Schiöth, H. B., & Levine, A. S. (2010) · Endocrinology · doi:10.1210/en.2010-0151 · Cited by 104 · see citing works
Ablation of Sim1 Neurons Causes Obesity through Hyperphagia and Reduced Energy Expenditure
Xi, D., Gandhi, N. M., Lai, M., & Kublaoui, B. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036453 · Cited by 100 · see citing works
Dual modulation of inward rectifier potassium currents in olfactory neuronal cells by promiscuous G protein coupling of the oxytocin receptor
Gravati, M., Busnelli, M., Bulgheroni, E., Reversi, A., Spaiardi, P., Parenti, M. D., Toselli, M., & Chini, B. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06861.x · Cited by 92 · see citing works
Insulin, oxytocin, and vasopressin stimulate protein kinase C activity in adipocyte plasma membranes.
Egan, J. J., Saltis, J., Wek, S. A., Simpson, I. A., & Londos, C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.3.1052 · Cited by 88 · see citing works
Evidence of a Peripheral and a Central Effect of Oxytocin on Pancreatic Hormone Release in Rats
Björkstrand, E., Eriksson, M., & Uvnäs‐Moberg, K. (2008) · Neuroendocrinology · doi:10.1159/000126978 · Cited by 83 · see citing works
Oxytocin gene deletion mice overconsume palatable sucrose solution but not palatable lipid emulsions
Miedlar, J. A., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00228.2007 · Cited by 82 · see citing works
Amygdala-lesion obesity: what is the role of the various amygdaloid nuclei?
Rollins, B. L., & King, B. M. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1348 · Cited by 77 · see citing works
A New Oxytocin-Saporin Cytotoxin for Lesioning Oxytocin-Receptive Neurons in the Rat Hindbrain
Baskin, D. G., Kim, F., Gelling, R. W., Russell, B. J., Schwartz, M. W., Morton, G. J., Simhan, H. N., Moralejo, D. H., & Blevins, J. E. (2010) · Endocrinology · doi:10.1210/en.2010-0295 · Cited by 72 · see citing works
Subchronic treatment of rats with oxytocin results in improved adipocyte differentiation and increased gene expression of factors involved in adipogenesis
Eckertova, M., Ondrejcakova, M., Krskova, K., Zorad, S., & Jezova, D. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01037.x · Cited by 68 · see citing works
Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets
Gao, Z. Y., Drews, G., & Henquin, J. (1991) · Biochemical Journal · doi:10.1042/bj2760169 · Cited by 58 · see citing works
Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport
King, B. M., Cook, J. T., Rossiter, K. N., & Rollins, B. L. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00249.2002 · Cited by 56 · see citing works
Vasopressin and oxytocin in rat brain in response to prostaglandin fever
Landgraf, R., Malkinson, T. J., Veale, W. L., Lederis, K. P., & Pittman, Q. J. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.259.5.r1056 · Cited by 56 · see citing works
Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior
Marroni, S. S., Nakano, F., Gati, C. D. C., Oliveira, J. A. C., Antunes‐Rodrigues, J., & Garcia‐Cairasco, N. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002015 · Cited by 55 · see citing works
Oxytocin is expressed in epidermal keratinocytes and released upon stimulation with adenosine 5′‐[γ‐thio]triphosphate in vitro
Denda, S., Takei, K., Kumamoto, J., Goto, M., Tsutsumi, M., & Denda, M. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01507.x · Cited by 51 · see citing works
Glyceroneogenesis Is Reduced and Glucose Uptake Is Increased in Adipose Tissue from Cafeteria Diet–Fed Rats Independently of Tissue Sympathetic Innervation
Chaves, V. E., Frasson, D., dos Santos, M. E. S. M., Boschini, R. P., ́falo, M. A. G., Festuccia, W. T., Kettelhut, Í. D. C., & Migliorini, R. H. (2006) · Journal of Nutrition · doi:10.1093/jn/136.10.2475 · Cited by 50 · see citing works
Self-citation
Integration of sensory information via central thermoregulatory leptin targets
Rezai-Zadeh, K. P., & Münzberg, H. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.014 · Cited by 48 · see citing works
The galactagogue action of the thymus and corpus luteum
Ott, I., & Scott, J. C. (1910) · Experimental Biology and Medicine · doi:10.3181/00379727-8-28 · Cited by 45 · see citing works
The Oxytocin‐induced Inward Current in Vagal Neurons of the Rat is Mediated by G Protein Activation but not by an Increase in the lntracellular Calcium Concentration
Alberi, S., Dreifuss, J. J., & Raggenbass, M. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01690.x · Cited by 44 · see citing works
Antipyretic action of centrally administered arginine vasopressin but not oxytocin in the cat
NAYLOR, A. M., Ruwe, W. D., & Veale, W. L. (1986) · Brain Research · doi:10.1016/0006-8993(86)91558-1 · Cited by 27 · see citing works
Oxytocin-Gly-Lys-Arg: A Novel Cardiomyogenic Peptide
Danalache, B. A., Gutkowska, J., Ślusarz, M. J., Berezowska, I., & Jankowski, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013643 · Cited by 24 · see citing works
Interactive effects of intracisternal oxytocin and other centrally active substances on colonic temperatures of mice
Mason, G., Caldwell, J. D., Stanley, D. A., Hatley, O. L., Prange, A. J., & Pedersen, C. A. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90008-x · Cited by 24 · see citing works
Specification of the cholesterol interaction with the oxytocin receptor using a chimeric receptor approach
Wiegand, V., & Gimpl, G. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.11.041 · Cited by 23 · see citing works
Oxytocin action. Mechanisms for insulin-like activity in isolated rat adipocytes.
Hanif, K., Goren, H. J., Hollenberg, M. D., et al. (1982) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)15138-9 · Cited by 23 · see citing works
Lack of diet-induced thermogenesis following lesions of paraventricular nucleus in rats
Luca, B. D., Monda, M., Amaro, S., Pellicano, M., & CIOFFI, L. A. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90352-1 · Cited by 20 · see citing works
Catecholaminergic enzymes, vasopressin and oxytocin distribution in Siberian hamster brain
Shi, H., & Bartness, T. J. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00429-9 · Cited by 17 · see citing works
Inability of Oxytocin to Activate Pyruvate Dehydrogenase in the Brattleboro Rat
Hanif, K., Lederis, K. P., Hollenberg, M. D., et al. (1982) · Science · doi:10.1126/science.7079746 · Cited by 16 · see citing works
Effects of a Tocolytic Oxytocin Analogue on Lipid and Carbohydrate Metabolism
Eriksson, H., Björgell, P., Åkerlund, M., et al. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000293310 · Cited by 7 · see citing works
Glutamate Microinjected in the Posterodorsal Medial Amygdala Induces Subtle Increase in the Consumption of a Three‐Choice Macronutrient Self‐Selection Diet in Male Rats
Rosa, C. B., Goularte, J. F., Trindade, N. A., et al. (2011) · The Anatomical Record · doi:10.1002/ar.21419 · Cited by 7 · see citing works
Wortmannin converts insulin but not oxytocin from an antilipolytic to a lipolytic agent in the presence of forskolin
Fain, J. N., Gökmen‐Polar, Y., & Bahouth, S. W. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90169-4 · Cited by 4 · see citing works
Untitled work
Rinaman (1998) · doi:10.1002/(sici)1096-9861(19980914)399:1

Flagged first, then by citations

Sorted by citations

Oxytocin pathways and the evolution of human behavior
Carter, C. S. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115110 · Cited by 714 · see citing works
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 615 · see citing works
The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
Napso, T., Yong, H. E. J., Lopez-Tello, J., & Sferruzzi-Perri, A. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01091 · Cited by 470 · see citing works
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393 · see citing works
A comparison of methods to measure central and peripheral oxytocin concentrations in human and non-human primates
Lefevre, A., Mottolese, R., Dirheimer, M., Mottolese, C., Duhamel, J.-R., & Sirigu, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-17674-7 · Cited by 105 · see citing works
Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model
Zierer, J., Pallister, T., Tsai, P.-C., Krumsiek, J., Bell, J. T., Lauc, G., Spector, T. D., Menni, C., & Kastenmüller, G. (2016) · Scientific Reports · doi:10.1038/srep37646 · Cited by 63 · see citing works
Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response
Bordt, E. A., Smith, C. J., Demarest, T. G., Bilbo, S. D., & Kingsbury, M. A. (2019) · Neurotoxicity Research · doi:10.1007/s12640-018-9962-7 · Cited by 58 · see citing works

Blood-Brain Leptin Transport and Appetite and Reproductive Neuroendocrine Responses to Intracerebroventricular Leptin Injection in Sheep: Influence of Photoperiod
Adam, C. L., Findlay, P. A., & Miller, D. W. (2006) · Endocrinology · doi:10.1210/en.2006-0576 · Cited by 54 · see citing works
Roles of Leptin and Ghrelin in the Loss of Body Weight Caused by a Low Fat, High Carbohydrate Diet
Weigle, D. S., Cummings, D. E., Newby, P. D., Breen, P. A., Frayo, R. S., Matthys, C. C., Callahan, H. S., & Purnell, J. Q. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021262 · Cited by 212 · see citing works
Body Composition, Insulin Resistance and Mediators of Appetite and Energy Homeostasis in Hyperthyroidism
Patil, A., Vaikkakara, S., Sachan, A., et al. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab048.1682
Inhibitory Effect of Exogenous Orexin A on Gastric Emptying, Plasma Leptin, and the Distribution of Orexin and Orexin Receptors in the Gut and Pancreas in Man
Ehrström, M., Gustafsson, T. P., Finn, A., Kirchgessner, A. L., Grybäck, P., Jacobsson, H., Hellström, P. M., & Näslund, E. B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1408 · Cited by 93 · see citing works
Mice With Hyperghrelinemia Are Hyperphagic and Glucose Intolerant and Have Reduced Leptin Sensitivity
Bewick, G. A., Kent, A. S., Campbell, D., Patterson, M., Ghatei, M. A., Bloom, S. R., & Gardiner, J. (2009) · Diabetes · doi:10.2337/db08-1428 · Cited by 72 · see citing works

Authors: Chaves, V. E., Tilelli, C. Q., Brito, N. A., & Brito, M. N.
Affiliations: Federal University of São João del-Rei (BR)
Universidade Estadual de Maringá (BR)
Corresponding author: Chaves, Valéria Ernestânia
ORCID: Chaves, Valéria Ernestânia
Tilelli, Cristiane Queixa
Venue: Peptides
Publisher: Elsevier BV
Published: 2013-07
Volume: 45
Pages: 9-14
ISSN: 0196-9781 (ISSN-L)
DOI: 10.1016/j.peptides.2013.04.010
OpenAlex: W2030421266
Cited by: 90
References: 73
Citations by year: 2026: 3 · 2025: 6 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 13 · 2020: 4 · 2019: 4 · 2018: 10 · 2017: 11 · 2016: 7 · 2015: 9 · 2014: 8 · 2013: 2
FWCI: 1.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Peptides (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, energy metabolism, obesity, appetite regulation, thermoregulation, metabolic homeostasis, oxytocin receptor, G protein-coupled receptors, Gq protein, phospholipase C beta, dietary intake, energy expenditure
MeSH terms: Adipose Tissue, Appetite Regulation, Body Temperature Regulation, Body Weight, Eating, Energy Metabolism, Homeostasis, Humans, Neurons, Obesity, Oxytocin, Receptors, Oxytocin, Leptin, Phospholipase C beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of oxytocin in energy metabolism

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks