Cited by 135Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorSleep and Wakefulness Research

Appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons

Zheng, Huiyuan, Corkern, Michele, Stoyanova, Irina, Patterson, Laurel M., Tian, Rui, Berthoud, Hans-Rudolf·2003·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Abstract

Corticolimbic circuits involving the prefrontal cortex, amygdala, and ventral striatum determine the reward value of food and might play a role in environmentally induced obesity. Chemical manipulation of the nucleus accumbens shell (AcbSh) has been shown to elicit robust feeding and Fos expression in the hypothalamus and other brain areas of satiated rats. To determine the neurochemical phenotype of hypothalamic neurons receiving input from the AcbSh, we carried out c-Fos/peptide double-labeling immunohistochemistry in various hypothalamic areas known to contain feeding peptides, from rats that exhibited a significant feeding response after AcbSh microinjection of the GABA(A) agonist muscimol. In the perifornical area, a significantly higher percentage of orexin neurons expressed Fos after muscimol compared with saline injection. In contrast, Fos expression was not induced in melanin-concentrating hormone and cocaine-amphetamine-related transcript (CART) neurons. In the arcuate nucleus, Fos activation was significantly lower in neurons coexpressing CART and proopiomelanocortin, and there was a tendency for higher Fos expression in neuropeptide Y neurons. In the paraventricular nucleus, no significant activation of oxytocin and CART neurons was found. Thus AcbSh manipulation may elicit food intake through coordinated stimulation of hypothalamic neurons expressing orexigenic peptides and suppression of neurons expressing anorexigenic peptides. However, activation of many neurons not expressing these peptides suggests that additional peptides/transmitters in the lateral hypothalamus and accumbens projections to other brain areas might also be involved.

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Crossref · 10.1152/ajpregu.00781.2002

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  • Chemical manipulation of the nucleus accumbens in rats resulted in stimulation of orexigenic neurons and inhibition of anorexigenic neurons in the hypothalamus.

    “the chemical manipulation of the nucleus accumbens in rats resulted in the stimulation of orexigenic neurons and inhibition of anorexigenic neurons in the hypothalamus (35)”

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Authors
Zheng, H., Corkern, M., Stoyanova, I., Patterson, L. M., Tian, R., & Berthoud, H.-R.
Affiliations
Pennington Biomedical Research Center (US)
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Published
2003-06-01
Volume
284
Issue
6
Pages
R1436-R1444
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
OpenAlex
W2040689703
Cited by
135
References
63
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 7
FWCI
4.41
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK-47348, R01DK047348)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
nucleus accumbens shell, hypothalamus, orexin neurons, proopiomelanocortin neurons, melanin-concentrating hormone neurons, neuropeptide Y neurons, oxytocin neurons, feeding behavior, food reward, corticolimbic circuits, muscimol microinjection, Fos expression, lateral hypothalamus
MeSH terms
Orexins, Cocaine- and Amphetamine-Regulated Transcript Protein, Animals, Appetite Regulation, Arcuate Nucleus of Hypothalamus, Carrier Proteins, Feeding Behavior, Gene Expression Regulation, Hypothalamic Hormones, Hypothalamus, Male, Melanins, Muscimol, Nerve Tissue Proteins, Neurons, Neuropeptide Y, Neuropeptides, Nucleus Accumbens, Oxytocin, Paraventricular Hypothalamic Nucleus, Pituitary Hormones, Pro-Opiomelanocortin, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, GABA Agonists, Intracellular Signaling Peptides and Proteins, Rats

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