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Cited by 92Cardiovascular and exercise physiologyHeart Rate Variability and Autonomic ControlBlood Pressure and Hypertension Studies

Modest weight gain is associated with sympathetic neural activation in nonobese humans

Gentile, Christopher L., Orr, Jeb S., Davy, Brenda M., Davy, Kevin P.·2007·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.00876.2006
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Abstract

We tested the hypothesis that modest, overfeeding-induced weight gain would increase sympathetic neural activity in nonobese humans. Twelve healthy males (23 ± 2 years; body mass index, 23.8 ± 0.7) were overfed ∼1,000 kcal/day until a 5-kg weight gain was achieved. Muscle sympathetic nerve activity (MSNA, microneurography), blood pressure, body composition (dual energy X-ray absorptiometry), and abdominal fat distribution (computed tomography) were measured at baseline and following 4 wk of weight stability at each individual's elevated body weight. Overfeeding increased body weight (73.5 ± 3.1 vs. 78.4 ± 3.2 kg, P < 0.001) and body fat (14.9 ± 1.2 vs. 18 ± 1.1 kg, P < 0.001) in 42 ± 8 days. Total abdominal fat increased (220 ± 22 vs. 266 ± 22 cm 2, P < 0.001) with weight gain, due to increases in both subcutaneous (158 ± 15 vs. 187 ± 12 cm 2, P < 0.001) and visceral fat (63 ± 8 vs. 79 ± 12 cm 2, P = 0.004). As hypothesized, weight gain elicited increases in MSNA burst frequency (32 ± 2 vs. 38 ± 2 burst/min, P = 0.002) and burst incidence (52 ± 4 vs. 59 ± 3 bursts/100 heart beats, P = 0.026). Systolic, but not diastolic blood pressure increased significantly with weight gain. The change in MSNA burst frequency was correlated with the percent increase in body weight ( r = 0.59, P = 0.022), change in body fat ( r = 0.52, P = 0.043) and percent change in body fat ( r = 0.51, P = 0.045). The results of the current study indicate that modest diet-induced weight gain elicits sympathetic neural activation in nonobese males. These findings may have important implications for understanding the link between obesity and hypertension.

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  • In humans, skeletal muscle sympathetic nerve activity measured by microneurography increases even with modest weight gain.

    “In humans, skeletal MSNA, measured by microneurography, increases even with modest weight gain153.”

    From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [153]

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Authors
Gentile, C. L., Orr, J. S., Davy, B. M., & Davy, K. P.
Affiliations
Virginia Tech (US)
ORCID
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2007-05
Volume
292
Issue
5
Pages
R1834-R1838
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.00876.2006
OpenAlex
W2081478664
Cited by
92
References
39
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 6
FWCI
18.87
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (K02HL067227, HL67227)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
sympathetic nervous system, muscle sympathetic nerve activity, overfeeding, fat mass, visceral fat, abdominal fat distribution, blood pressure, hypertension, obesity, sympathetic activation, weight gain, subcutaneous adipose tissue, body composition, microneurography, dual-energy X-ray absorptiometry, computed tomography, males
MeSH terms
Adult, Diet, Humans, Male, Sympathetic Nervous System, Weight Gain

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