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Interleukin 1 alters rat sleep: temporal and dose-related effects
Abstract
Rats received various doses of interleukin 1 (IL-1) (range, 0.5-25.0 ng) or pyrogen-free saline intracerebroventricularly during the rest (light) and the active (dark) cycles of the day, and sleep-wake activity and brain temperature were determined for 6 h. Low doses of IL-1 (0.5 ng at night, 2.5 ng during the day) increased both the duration of non-rapid-eye-movement sleep (NREMS) and electroencephalogram (EEG) slow-wave activity during NREMS episodes. Increasing doses of IL-1 had divergent effects on NREMS duration and EEG slow-wave activity, and the direction of the changes depended on the diurnal cycle. Thus NREMS duration was promoted at night and EEG slow-wave amplitudes during the day, whereas NREMS duration during the day and EEG slow-wave amplitudes at night were suppressed after higher doses of IL-1. High doses of IL-1 also induced decreases in rapid-eye-movement sleep during both phases of the day. Each dose of IL-1 that promoted NREMS also tended to increase brain temperature. These results demonstrate that IL-1 promotes NREMS in the rat. However, unlike previously reported findings in rabbits, the circadian rhythm of sleep regulation strongly interferes with the sleep-promoting activity of IL-1 in rats.
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“These findings established both cytokines, IL-1 and TNF, as substances involved in the homeostatic regulation of sleep (for review, see Refs. 299, 411).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [411]
In the citing paper
“increasing the availability of those cytokines promoted NREM sleep amount and intensity and suppressed REM sleep amount.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [411]
In the citing paper
“blocking the biological actions of the cytokines IL-1 and TNF resulted in a reduction of physiological NREM sleep amount or NREM sleep rebound after sleep deprivation.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [411]
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“Thus, in rats injection of IL1 during the dark enhances NREMS while the same dose given during light hours reduces NREMS (Opp et al., 1991).”
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“Of importance to this present study, some doses of IL-1 administered directly into rat brain reduce EEG delta power, even when NREMS duration is enhanced (28, 39).”
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“Many of these symptoms are regulated by the circadian clock; for example, the increase in body temperature and the sleep modulation after Il-1 or Il-6 injection in mice differ depending on the time of administration (Morrow & Opp, 2005; Opp & Toth, 1998; Opp et al., 1991).”
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Cytokine Involvement in Sleep Responses to Infection and Physiological Sleep
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Self-citationSynthetic Alleles at Position 121 Define a Functional Domain of Human Interleukin‐1β
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Interleukin-1 receptor (IL-1R) mediates epilepsy-induced sleep disruption
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“Low doses of IL-1 increase NREM sleep during the night and slow wave activity during the day; in contrast, high doses of IL-1 suppress NREM sleep during the day and slow wave activity at night [19].”
BackgroundInterleukin-1β induces CREB-binding protein (CBP) mRNA in brain and the sequencing of rat CBP
Tang, C. Z., Sula, M. J. M., Bohnet, S. G., Rehman, A., Taishi, P., & Krueger, J. M. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.03.009 · Cited by 5
Self-citationCharacterization of Interleukin-1α Binding to Mouse Brain Endothelial Cells
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The role of sleep in multiple sclerosis
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CSF levels of diazepam-binding inhibitor correlate with REM latency in schizophrenia, a pilot study
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“1992a), interleukins and other peptides (Opp et al. 1991; Krueger 1985).”
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Self-citation
Metadata
- Authors
- Opp, M. R., Obal, F., & Krueger, J. M.
- Affiliations
- University of Tennessee Health Science Center (US)
- Department of Physiology and Biophysics, University of Tennessee,Memphis 38163.
- ORCID
- Opp, M. R.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1991-01-01
- Volume
- 260
- Issue
- 1
- Pages
- R52-R58
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2286922506
- Cited by
- 232
- References
- 0
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 7
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-27250, NS-25378, R01NS027250, R01NS025378)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- interleukin-1, sleep regulation, NREM sleep, REM sleep, EEG slow-wave activity, circadian rhythm, dose-dependent effects, brain temperature, intracerebroventricular administration, rats
- MeSH terms
- Animals, Brain, Circadian Rhythm, Dose-Response Relationship, Drug, Electroencephalography, Interleukin-1, Light, Male, Rats, Inbred Strains, Sleep, REM, Temperature, Rats
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