Influence of endotoxin on daytime sleep in humans
Open accessAbstract
Administration of endotoxin in the evening has been shown to transiently suppress rapid eye movement (REM) and to promote non-REM sleep in humans. In a single-blind placebo-controlled crossover design, we assessed the effects of Salmonella abortus equi endotoxin administered intravenously in the morning on the primary host response and on daytime sleep by use of a multiple napping protocol in healthy volunteers. The extent of the host response achieved by 0.8 ng of endotoxin per kg of body weight given at 0900 h was comparable to that previously reported to result from the administration of 0.4 ng/kg at 1900 h. However, sleep was only slightly influenced. Endotoxin reduced the amount of REM sleep and increased REM latency. Non-REM sleep amount in the first nap, although not significantly changed, correlated negatively with the individual peak levels of interleukin-6 (r = -0.73, P < 0.05). Subjective tiredness, sleep onset latency, total sleep time, and the amounts of slow-wave and non-REM sleep were not affected by endotoxin throughout the entire experiment. Spectral analysis of the electroencephalogram obtained during non-REM sleep yielded no condition differences. We conclude that endotoxin administration in the morning to healthy volunteers, while activating the host defense to the same extent as a lower dose that has been reported to promote non-REM sleep when given in the evening, does not affect non-REM sleep. REM sleep suppression is, to date, the most consistently reported effect of endotoxin on human sleep.
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Very low doses of endotoxin (0.2 ng/kg) promoted sleep.
“For example, very low doses of endotoxin (0.2 ng/kg) promoted sleep, whereas moderate doses (0.8 ng/kg) reduced total sleep time and increased sleep onset latency (Hermann et al., 1998; Korth et al., 1996; Mullington et al., 2000).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Korth et al., 1996
Moderate doses of endotoxin (0.8 ng/kg) reduced total sleep time.
“For example, very low doses of endotoxin (0.2 ng/kg) promoted sleep, whereas moderate doses (0.8 ng/kg) reduced total sleep time and increased sleep onset latency (Hermann et al., 1998; Korth et al., 1996; Mullington et al., 2000).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Korth et al., 1996
Moderate doses of endotoxin (0.8 ng/kg) increased sleep onset latency.
“For example, very low doses of endotoxin (0.2 ng/kg) promoted sleep, whereas moderate doses (0.8 ng/kg) reduced total sleep time and increased sleep onset latency (Hermann et al., 1998; Korth et al., 1996; Mullington et al., 2000).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Korth et al., 1996
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Self-citation
- Authors
- Korth, C., Mullington, J., Schreiber, W., & Pollmächer, T.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1996-04
- Volume
- 64
- Issue
- 4
- Pages
- 1110-1115
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC173891
- OpenAlex
- W1932558162
- Cited by
- 35
- References
- 40
- Citations by year
- 2024: 2 · 2020: 1 · 2018: 2 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- endotoxin, Salmonella abortus equi, daytime sleep, REM sleep suppression, REM latency, NREM sleep, interleukin-6, host response, sleep latency
- MeSH terms
- Adult, Endotoxins, Humans, Male, Sleep, Sleep, REM, Single-Blind Method, Cross-Over Studies
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