Influence of carbohydrate ingestion on fuel substrate turnover and oxidation during prolonged exercise

Bosch, A. N.; Dennis, S. C.; Noakes, T. D.

doi:10.1152/jappl.1994.76.6.2364

Cited by 109Muscle metabolism and nutritionCardiovascular and exercise physiologySports Performance and Training

Influence of carbohydrate ingestion on fuel substrate turnover and oxidation during prolonged exercise

Bosch, A. N., Dennis, S. C., Noakes, T. D.·1994·Journal of Applied Physiology

DOI 10.1152/jappl.1994.76.6.2364

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Abstract

This study examined effects of ingesting a 10% carbohydrate (CHO) drink (CI) or placebo (PI) at 500 ml/h on total (splanchnic) glucose appearance (endogenous+exogenous; Ra), blood glucose oxidation, and muscle glycogen utilization in 14 male endurance-trained cyclists who rode for 180 min at 70% of maximal O2 uptake after CHO loading [starting muscle glycogen 203 +/- 7 (SE) mmol/kg wet wt]. Total CHO oxidation was similar in CI and PI, but Ra increased significantly during the trial in both groups with CI reaching a plateau after 75 min. Ra was significantly greater in CI than in PI at the end of exercise. Blood glucose oxidation also increased significantly during the trial to a plateau in CI and was significantly higher in CI than in PI at the end of exercise. However, mean endogenous Ra was significantly lower in CI than in PI throughout exercise, as was oxidation of endogenous blood glucose, which remained almost constant in CI and reached 43 +/- 8 and 73 +/- 13 mumol.min-1.kg fat-free mass-1 in CI and PI, respectively, at the end of exercise. At 0.83 g/min of CHO ingestion, 0.77 +/- 0.03 g/min was oxidized. Muscle glycogen utilization was identical in both groups and was higher during the 1st h of exercise.(ABSTRACT TRUNCATED AT 250 WORDS)

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Carbohydrate ingestion increases skeletal muscle glucose uptake and plasma glucose oxidation rates.
“This increases skeletal muscle glucose uptake and therefore plasma glucose oxidation rates (66)”
From Carbohydrate ingestion during prolonged exercise and net skeletal muscle glycogen utilization: A meta-analysis. (2026) · cites this paper as [66]

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Authors: Bosch, A. N., Dennis, S. C., & Noakes, T. D.
Affiliations: University of Cape Town (ZA)
ORCID: Bosch, A. N.
Dennis, S. C.
Noakes, T. D.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1994-06-01
Volume: 76
Issue: 6
Pages: 2364-2372
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1994.76.6.2364
OpenAlex: W4241097296
Cited by: 107
References: 0
Citations by year: 2026: 3 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
FWCI: 1.38
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: carbohydrate intake, glucose appearance, muscle glycogen utilization, endurance exercise, endurance cyclists, carbohydrate oxidation, substrate metabolism
MeSH terms: Adult, Bicycling, Blood Glucose, Carbon Dioxide, Dietary Carbohydrates, Energy Metabolism, Fats, Glucose, Glycogen, Humans, Kinetics, Lactates, Liver, Male, Muscles, Oxidation-Reduction, Oxygen Consumption, Physical Endurance, Exercise, Lactic Acid

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Influence of carbohydrate ingestion on fuel substrate turnover and oxidation during prolonged exercise

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