Individualized model of human thermoregulation for the simulation of heat stress response
Abstract
A population-based dynamic model of human thermoregulation was expanded with control equations incorporating the individual person's characteristics (body surface area, mass, fat%, maximal O 2 uptake, acclimation). These affect both the passive (heat capacity, insulation) and active systems (sweating and skin blood flow function). Model parameters were estimated from literature data. Other data, collected for the study of individual differences {working at relative or absolute workloads in hot-dry [45°C, 20% relative humidity (rh)], warm-humid [35°C, 80% rh], and cool [21°C, 50% rh] environments}, were used for validation. The individualized model provides an improved prediction [mean core temperature error, −0.21 → −0.07°C ( P< 0.001); mean squared error, 0.40 → 0.16°C, ( P < 0.001)]. The magnitude of improvement varies substantially with the climate and work type. Relative to an empirical multiple-regression model derived from these specific data sets, the analytical simulation model has between 54 and 89% of its predictive power, except for the cool climate, in which this ratio is zero. In conclusion, individualization of the model allows improved prediction of heat strain, although a substantial error remains.
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Existing thermophysiological models do not incorporate physiological or psychological adaptive mechanisms.
“while the existing thermophysiological models offer the potential to look at differences due to physiological characteristics (either metabolic heat production, body composition or thermoregulatory function) [27,28]; they do not incorporate physiological or psychological adaptive mechanisms.”
From Drivers of diversity in human thermal perception – A review for holistic comfort models (2018) · cites this paper as [27]
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- Authors
- Havenith, G.
- Affiliations
- Loughborough University (GB)
- Corresponding author
- Havenith, George
- ORCID
- Havenith, George
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2001-05-01
- Volume
- 90
- Issue
- 5
- Pages
- 1943-1954
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2253010661
- Cited by
- 299
- References
- 43
- Citations by year
- 2026: 18 · 2025: 12 · 2024: 11 · 2023: 10 · 2022: 15 · 2021: 26 · 2020: 17 · 2019: 12 · 2018: 12 · 2017: 6 · 2016: 12 · 2015: 26 · 2014: 19 · 2013: 15 · 2012: 9
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Effects of Environmental Stressors on Livestock
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- human thermoregulation, heat stress, heat strain, sweating, skin blood flow, body surface area, body fat percentage, VO2max, acclimation, individual differences, hot arid climate, hot and humid climate, cool climate, heat capacity, thermal insulation
- MeSH terms
- Acclimatization, Adipose Tissue, Body Temperature Regulation, Hot Temperature, Humans, Humidity, Models, Biological, Physical Fitness, Regression Analysis, Stress, Physiological, Temperature, Models, Statistical
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