Cited by 13Exercise and Physiological ResponsesMuscle metabolism and nutritionCardiovascular and exercise physiology

Small peptides: Could they have a big role in metabolism and the response to exercise?

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Atakan, Muhammed M., Türkel, İbrahim, Özerkliğ, Berkay, Koşar, Şükran N., Taylor, Dale F., Yan, Xu, Bishop, David J.·2024·The Journal of Physiology

Abstract

Exercise is a powerful non-pharmacological intervention for the treatment and prevention of numerous chronic diseases. Contracting skeletal muscles provoke widespread perturbations in numerous cells, tissues and organs, which stimulate multiple integrated adaptations that ultimately contribute to the many health benefits associated with regular exercise. Despite much research, the molecular mechanisms driving such changes are not completely resolved. Technological advancements beginning in the early 1960s have opened new avenues to explore the mechanisms responsible for the many beneficial adaptations to exercise. This has led to increased research into the role of small peptides (<100 amino acids) and mitochondrially derived peptides in metabolism and disease, including those coded within small open reading frames (sORFs; coding sequences that encode small peptides). Recently, it has been hypothesized that sORF-encoded mitochondrially derived peptides and other small peptides play significant roles as exercise-sensitive peptides in exercise-induced physiological adaptation. In this review, we highlight the discovery of mitochondrially derived peptides and newly discovered small peptides involved in metabolism, with a specific emphasis on their functions in exercise-induced adaptations and the prevention of metabolic diseases. In light of the few studies available, we also present data on how both single exercise sessions and exercise training affect expression of sORF-encoded mitochondrially derived peptides. Finally, we outline numerous research questions that await investigation regarding the roles of mitochondrially derived peptides in metabolism and prevention of various diseases, in addition to their roles in exercise-induced physiological adaptations, for future studies.

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Authors
Atakan, M. M., Türkel, İ., Özerkliğ, B., Koşar, Ş. N., Taylor, D. F., Yan, X., & Bishop, D. J.
Affiliations
  • Hacettepe University (TR)
  • Victoria University (AU)
  • Australian Institute for Musculoskeletal Science (AU)
Corresponding author
Bishop, David J.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2024-01-09
Volume
602
Issue
4
Pages
545-568
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
OpenAlex
W4390700673
Cited by
13
References
157
Citations by year
2026: 2 · 2025: 8 · 2024: 3
FWCI
0.56
Type
journal article
Language
en
Open access
Locations
  • The Journal of Physiology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Victoria University
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
small peptides, small open reading frames, exercise-induced adaptations, metabolism, exercise training, metabolic disorders, skeletal muscle, disease prevention
MeSH terms
Peptides, Open Reading Frames

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