The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Mechanisms and modifiers of reflex induced cutaneous vasodilation and vasoconstriction in humans
Open accessAbstract
Human skin blood flow responses to body heating and cooling are essential to the normal processes of physiological thermoregulation. Large increases in skin blood flow provide the necessary augmentation of convective heat loss during environmental heat exposure and/or exercise, just as reflex cutaneous vasoconstriction is key to preventing excessive heat dissipation during cold exposure. In humans, reflex sympathetic innervation of the cutaneous circulation has two branches: a sympathetic noradrenergic vasoconstrictor system, and a non-noradrenergic active vasodilator system. Noradrenergic vasoconstrictor nerves are tonically active in normothermic environments and increase their activity during cold exposure, releasing both norepinephrine and cotransmitters (including neuropeptide Y) to decrease skin blood flow. The active vasodilator system in human skin does not exhibit resting tone and is only activated during increases in body temperature, such as those brought about by heat exposure or exercise. Active cutaneous vasodilation occurs via cholinergic nerve cotransmission and has been shown to include potential roles for nitric oxide, vasoactive intestinal peptide, prostaglandins, and substance P (and/or neurokinin-1 receptors). It has proven both interesting and challenging that no one substance has been identified as the sole mediator of active cutaneous vasodilation. The processes of reflex cutaneous vasodilation and vasoconstriction are both modified by acute factors, such as exercise and hydration, and more long-term factors, such as aging, reproductive hormones, and disease. This review will highlight some of the recent findings in these areas, as well as interesting areas of ongoing and future work.
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Cites
Excess hospital admissions during the July 1995 heat wave in Chicago
Semenza, J. (1999) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(99)00025-2 · Cited by 619
Estrogen replacement in middle-aged women: thermoregulatory responses to exercise in the heat
Tankersley, C. G., Nicholas, W. C., Deaver, D. R., Mikita, D., & Kenney, W. L. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.4.1238 · Cited by 116 · cited 1×
“Estrogen replacement therapy (without concomitant progesterone) causes a decrease in the threshold for cutaneous vasodilation during body heating (4, 80), whereas including a progesterone component appeared to reverse this effect (4).”
BackgroundBrooks, E. M., Morgan, A. L., Pierzga, J. M., Wladkowski, S. L., O’Gorman, J. T., Derr, J. A., & Kenney, W. L. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.2.477 · Cited by 111
Effect of luteal phase elevation in core temperature on forearm blood flow during exercise
Kolka, M. A., & Stephenson, L. A. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.4.1079 · Cited by 87
Charkoudian, N., & Johnson, J. M. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.5.h1634 · Cited by 79
Self-citation
Cited by
Sawka, M. N., Leon, L. R., Montain, S. J., & Sonna, L. A. (2011) · Comprehensive Physiology · doi:10.1002/cphy.c100082 · Cited by 470
Rance, N. E., Dacks, P. A., Mittelman-Smith, M. A., Romanovsky, A. A., & Krajewski-Hall, S. J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.07.003 · Cited by 380
Reproductive Hormone Influences on Thermoregulation in Women
Charkoudian, N., & Stachenfeld, N. S. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130029 · Cited by 143
Self-citationGronlund, C. J., Sullivan, K. P., Kefelegn, Y., Cameron, L., & O’Neill, M. S. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.06.002 · Cited by 141
“[27] Furthermore, exercise training in warm environments can promote heat acclimation, causing skin blood flow and sweating to occur earlier and in greater volume.[23] As seen in cold-water and coldweather athletes, cold-weather exercise can induce acclimation to prolonged cold temperatures, as well.”
BackgroundRaynaud’s Phenomenon: A Brief Review of the Underlying Mechanisms
Fardoun, M. M., Nassif, J., Issa, K., Baydoun, E., & Eid, A. H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00438 · Cited by 80
Cutaneous innervation of the human face as assessed by skin biopsy
Nolano, M., Provitera, V., Caporaso, G., Stancanelli, A., Leandri, M., Biasiotta, A., Cruccu, G., Santoro, L., & Truini, A. (2013) · Journal of Anatomy · doi:10.1111/joa.12001 · Cited by 64
Tierney, M., Fraser, A., Purtill, H., & Kennedy, N. (2013) · Arthritis Care & Research · doi:10.1002/acr.21914 · Cited by 56
Clijsen, R., Stoop, R., Hohenauer, E., Aerenhouts, D., Clarys, P., Deflorin, C., & Taeymans, J. (2022) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2021.06.015 · Cited by 36
Reference breast temperature: Proposal of an equation
Souza, G. A. G. R. D., Brioschi, M. L., Vargas, J. V. C., Morais, K. C. C., Dalmaso Neto, C., & Neves, E. B. (2015) · Einstein (São Paulo) · doi:10.1590/s1679-45082015ao3392 · Cited by 20
Metadata
- Authors
- Charkoudian, N.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2010-10
- Volume
- 109
- Issue
- 4
- Pages
- 1221-1228
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2169095554
- Cited by
- 475
- References
- 5
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- green
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