Physical exercise and epigenetic modifications in skeletal muscle
Abstract
Physical activity and sports play major roles in the overall health status of humans. It is well known that regular exercise helps to lower the risk for a broad variety of health problems, such as cardiovascular disease, type 2 diabetes, and cancer. Being physically active induces a wide variety of molecular adaptations, for example fiber type switches or other metabolic alterations, in skeletal muscle tissue. These adaptations are based on exercise-induced changes to the skeletal muscle transcriptome. Understanding their nature is crucial to improve the development of exercise-based therapeutic strategies. Recent research indicates that specifically epigenetic mechanisms, i.e., pathways that induce changes in gene expression patterns without altering the DNA base sequence, might play a major role in controlling skeletal muscle transcriptional patterns. Epigenetic mechanisms include DNA and histone modifications, as well as expression of specific microRNAs. They can be modulated by environmental factors or external stimuli, such as exercise, and eventually induce specific and fine-tuned changes to the transcriptional response. In this review, we highlight current knowledge on epigenetic changes induced in exercising skeletal muscle, their target genes, and resulting phenotypic changes. In addition, we raise the question of whether epigenetic modifications might serve as markers for the design and management of optimized and individualized training protocols, as prognostic tools to predict training adaptation, or even as targets for the design of "exercise mimics".
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Human studies suggest repeated resistance loading may be associated with reduced methylation at rDNA loci and lower expression of specific DNMTs.
“Human studies examining resistance training adaptations suggest that repeated loading may be associated with reduced methylation at rDNA loci and with lower expression of specific DNMTs [121,182].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [182]
A more permissive epigenetic profile could facilitate renewed transcriptional activation during retraining, which has been discussed in relation to muscle memory.
“This mechanism has been discussed in relation to the concept of muscle memory, insofar as a more permissive epigenetic profile could facilitate renewed transcriptional activation during retraining [124,182].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [182]
Cites
Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation
Vasudevan, S., Tong, Y., & STEITZ, J. A. (2007) · Science · doi:10.1126/science.1149460 · Cited by 2,806 · see citing works
Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle
Barrès, R., Yan, J., Egan, B., Treebak, J. T., Rasmussen, M., Fritz, T., Caidahl, K., Krook, A., O'Gorman, D. J., & Zierath, J. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.001 · Cited by 965 · see citing works
Non-coding RNAs as regulators in epigenetics
Wei, J., Huang, K., Yang, C., & Kang, C. (2016) · Oncology Reports · doi:10.3892/or.2016.5236 · Cited by 750 · see citing works
Muscle-specific microRNAs in skeletal muscle development
Horak, M., Novák, J., & Vašků, J. B. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.12.013 · Cited by 476 · see citing works
Exercise acts as a drug; the pharmacological benefits of exercise
Vina, J., Sanchis‐Gomar, F., Martinez‐Bello, V, & Gomez‐Cabrera, M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01970.x · Cited by 443 · see citing works
Baggish, A. L., Hale, A., Weiner, R. B., Lewis, G. D., Systrom, D., Wang, F., Wang, T. J., & Chan, S. Y. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.213363 · Cited by 431 · see citing works
MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy
McCarthy, J. J., & Esser, K. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00932.2006 · Cited by 423 · see citing works
Interplay between miRNAs and human diseases
Paul, P., Chakraborty, A., Sarkar, D., Langthasa, M., Rahman, M., Bari, M., Singha, R. S., Malakar, A. K., & Chakraborty, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25854 · Cited by 420 · see citing works
Histone deacetylase degradation andMEF2 activation promote the formation of slow-twitch myofibers
Potthoff, M. J., Wu, H., Arnold, M., Shelton, J. M., Backs, J., McAnally, J., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31960 · Cited by 416 · see citing works
Nitert, M. D., Dayeh, T., Volkov, P., Elgzyri, T., Hall, E., Nilsson, E., Yang, B. T., Lang, S., Parikh, H. M., Wessman, Y., et al. (2012) · Diabetes · doi:10.2337/db11-1653 · Cited by 405 · see citing works
Davidsen, P. K., Gallagher, I. J., Hartman, J. W., Tarnopolsky, M. A., Dela, F., Helge, J. W., Timmons, J. A., & Phillips, S. M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00901.2010 · Cited by 385 · see citing works
Profiling genome-wide DNA methylation
Yong, W.-S., Hsu, F.-M., & Chen, P.-Y. (2016) · Epigenetics & Chromatin · doi:10.1186/s13072-016-0075-3 · Cited by 374 · see citing works
Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle
Nielsen, S. J., Schéele, C., Yfanti, C., Akerstrom, T. C. A., Nielsen, A. R., Pedersen, B. K., & Laye, M. J. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.189860 · Cited by 340 · see citing works
Human skeletal muscle possesses an epigenetic memory of hypertrophy
Seaborne, R. A., Strauss, J., Cocks, M., Shepherd, S., O’Brien, T. D., van Someren, K. A., Bell, P. G., Murgatroyd, C., Morton, J. P., Stewart, C. E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20287-3 · Cited by 334 · see citing works
The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training
Nielsen, S. J., Akerstrom, T. C. A., Rinnov, A., Yfanti, C., Schéele, C., Pedersen, B. K., & Laye, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087308 · Cited by 299 · see citing works
Exercise-induced histone modifications in human skeletal muscle
McGee, S. L., Fairlie, E., Garnham, A. P., & Hargreaves, M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181065 · Cited by 296 · see citing works
Russell, A. P., Lamon, S., Boon, H., Wada, S., Güller, I., Brown, E. L., Chibalin, A., Zierath, J. R., Snow, R. J., Stepto, N. K., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.255695 · Cited by 272 · see citing works
A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype
Keller, P., Vollaard, N. B. J., Gustafsson, T., Gallagher, I. J., Sundberg, C. J., Rankinen, T., Britton, S. L., Bouchard, C., Koch, L. G., & Timmons, J. A. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00634.2010 · Cited by 261 · see citing works
Drummond, M. J., McCarthy, J. J., Fry, C. S., Esser, K. A., & Rasmussen, B. B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90562.2008 · Cited by 256 · see citing works
Lindholm, M. E., Marabita, F., Gómez-Cabrero, D., Rundqvist, H., Ekström, T. J., Tegner, J. N., & Sundberg, C. J. (2014) · Epigenetics · doi:10.4161/15592294.2014.982445 · Cited by 250 · see citing works
Safdar, A., Abadi, A., Akhtar, M., Hettinga, B. P., & Tarnopolsky, M. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005610 · Cited by 238 · see citing works
Circulating micrornas as potential biomarkers of aerobic exercise capacity
Mooren, F. C., Viereck, J., Krüger, K., & Thum, T. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00711.2013 · Cited by 229 · see citing works
The microRNA miR-696 regulates PGC-1α in mouse skeletal muscle in response to physical activity
Aoi, W., Naito, Y., Mizushima, K., Takanami, Y., Kawai, Y., Ichikawa, H., & Yoshikawa, T. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00448.2009 · Cited by 206 · see citing works
Laker, R., Lillard, T. S., Okutsu, M., Zhang, M., Hoehn, K. L., Connelly, J., & Yan, Z. (2014) · Diabetes · doi:10.2337/db13-1614 · Cited by 205 · see citing works
Circulating microRNA-126 increases after different forms of endurance exercise in healthy adults
Uhlemann, M., Möbius‐Winkler, S., Fikenzer, S., Adam, J., Redlich, M., Möhlenkamp, S., Hilberg, T., Schuler, G. C., & Adams, V. (2012) · European Journal of Preventive Cardiology · doi:10.1177/2047487312467902 · Cited by 199 · see citing works
Molecular networks in skeletal muscle plasticity
Hoppeler, H. H. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.128207 · Cited by 194 · see citing works
The MyomiR Network in Skeletal Muscle Plasticity
McCarthy, J. J. (2011) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31821c01e1 · Cited by 182 · see citing works
Sharples, A. P., Stewart, C. E., & Seaborne, R. A. (2016) · Aging Cell · doi:10.1111/acel.12486 · Cited by 180 · see citing works
Muscle-enriched microRNA miR-486 decreases in circulation in response to exercise in young men
Aoi, W., Ichikawa, H., Mune, K., Tanimura, Y., Mizushima, K., Naito, Y., & Yoshikawa, T. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00080 · Cited by 172 · see citing works
Histone Marks in the ‘Driver’s Seat’: Functional Roles in Steering the Transcription Cycle
Gates, L. A., Foulds, C. E., & O’Malley, B. W. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.10.004 · Cited by 169 · see citing works
Circulating MicroRNAs and Aerobic Fitness – The HUNT-Study
Bye, A., Røsjø, H. R., Aspenes, S. T., Condorelli, G., Omland, T., & Wisløff, U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057496 · Cited by 166 · see citing works
MicroRNAs Involved in Skeletal Muscle Differentiation
Luo, W., Nie, Q., & Zhang, X. (2013) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2013.02.002 · Cited by 164 · see citing works
MicroRNAs as Important Regulators of Exercise Adaptation
da Silva, G. J. J., Bye, A., el Azzouzi, H., & Wisløff, U. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.06.003 · Cited by 156 · see citing works
Exercise: Putting Action into Our Epigenome
Denham, J., Marques, F. Z., O’Brien, B. J., & Charchar, F. J. (2013) · Sports Medicine · doi:10.1007/s40279-013-0114-1 · Cited by 142 · see citing works
Epigenetic regulation on gene expression induced by physical exercise.
Ntanasis‐Stathopoulos, I., Tzanninis, J. G., Philippou, Α., & Koutsilieris, M. (2013) · PubMed · Cited by 132 · see citing works
Ringholm, S., Biensø, R. S., Kiilerich, K., Guadalupe‐Grau, A., Aachmann‐Andersen, N. J., Saltin, B., Plomgaard, P., Lundby, C., Wojtaszewski, J. F. P., Calbet, J. A. L., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00230.2011 · Cited by 130 · see citing works
Profiling of Circulating MicroRNAs after a Bout of Acute Resistance Exercise in Humans
Sawada, S., Kon, M., Wada, S., Ushida, T., Suzuki, K., & Akimoto, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070823 · Cited by 123 · see citing works
Yamamoto, H., Morino, K., Nishio, Y., Ugi, S., Yoshizaki, T., Kashiwagi, A., & Maegawa, H. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00097.2012 · Cited by 123 · see citing works
Rowlands, D., Page, R., Sukala, W., Giri, M., Ghimbovschi, S., Hayat, I., Cheema, B., Lys, I., Leikis, M., Sheard, P., et al. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00024.2014 · Cited by 120 · see citing works
Histone modifications and exercise adaptations
McGee, S. L., & Hargreaves, M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00979.2010 · Cited by 120 · see citing works
Thalacker-Mercer, A., Stec, M., Cui, X., Cross, J., Windham, S., & Bamman, M. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00167.2012 · Cited by 119 · see citing works
Playing TETris with DNA modifications
Delatte, B., Deplus, R., & Fuks, F. (2014) · The EMBO Journal · doi:10.15252/embj.201488290 · Cited by 116 · see citing works
Smith, J. A. H., Kohn, T. A., Chetty, A. K., & Ojuka, E. O. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00747.2007 · Cited by 115 · see citing works
Epigenetic adaptation to regular exercise in humans
Ling, C., & Rönn, T. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.03.006 · Cited by 114 · see citing works
Circulating MicroRNAs as Potential Biomarkers of Exercise Response
Polakovičová, M., Musil, P., Laczo, E., Hamar, D., & Kyselovič, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101553 · Cited by 113 · see citing works
Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion
Hong, S., Zhou, W., Fang, B., Lu, W., Loro, E., Damle, M., Ding, G., Jager, J., Zhang, S., Zhang, Y., et al. (2016) · Nature Medicine · doi:10.1038/nm.4245 · Cited by 110 · see citing works
Genomic and transcriptomic predictors of response levels to endurance exercise training
Sarzynski, M. A., Ghosh, S., & Bouchard, C. (2017) · The Journal of Physiology · doi:10.1113/jp272559 · Cited by 107 · see citing works
山元, 宏. (2013) · Medical Entomology and Zoology · Cited by 103 · see citing works
Effects of sleeping with reduced carbohydrate availability on acute training responses
Lane, S. C., Camera, D. M., Lassiter, D. G., Areta, J. L., Bird, S. R., Yeo, W. K., Jeacocke, N. A., Krook, A., Zierath, J. R., Burke, L. M., et al. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00857.2014 · Cited by 102 · see citing works
Brown, W. M. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2014-094073 · Cited by 100 · see citing works
Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity
Ecker, S., Pancaldi, V., Valencia, A., Beck, S., & Paul, D. S. (2017) · BioEssays · doi:10.1002/bies.201700148 · Cited by 90 · see citing works
Fyfe, J. J., Bishop, D. J., Zacharewicz, E., Russell, A. P., & Stepto, N. K. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00479.2015 · Cited by 87 · see citing works
Plasma MicroRNA Levels Differ between Endurance and Strength Athletes
Wardle, S. L., Bailey, M. E. S., Kilikevičius, A., Malkova, D., Wilson, R. H., Venckūnas, T., & Moran, C. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122107 · Cited by 86 · see citing works
Physical Exercise and Epigenetic Modulation: Elucidating Intricate Mechanisms
Pareja-Galeano, H., Sanchis‐Gomar, F., & García‐Giménez, J. L. (2014) · Sports Medicine · doi:10.1007/s40279-013-0138-6 · Cited by 84 · see citing works
Mueller, M., Breil, F., Lurman, G. J., Klossner, S., Flück, M., Billeter-Clark, R., Däpp, C., & Hoppeler, H. H. (2011) · Gerontology · doi:10.1159/000323267 · Cited by 84 · see citing works
Seaborne, R. A., Strauss, J., Cocks, M., Shepherd, S., O'Brien, T. D., van Someren, K., Bell, P., Murgatroyd, C., Morton, J. P., Stewart, C., et al. (2018) · Scientific Data · doi:10.1038/sdata.2018.213 · Cited by 81 · see citing works
Ehlert, T., Simon, P. D., & Moser, D. (2013) · Sports Medicine · doi:10.1007/s40279-012-0012-y · Cited by 79 · see citing works
Pandorf, C. E., Haddad, F., Wright, C. E., Bodell, P. W., & Baldwin, K. M. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00075.2009 · Cited by 78 · see citing works
Ramos, A. E., Lo, C. T., Estephan, L. E., Tai, Y.-Y., Tang, Y. M., Zhao, J., Sugahara, M., Gorcsan, J., Brown, M. G., Lieberman, D. E., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00741.2017 · Cited by 77 · see citing works
Noncoding RNAs: Stress, Glucocorticoids, and Posttraumatic Stress Disorder
Daskalakis, N. P., Provost, A. C., Hunter, R. G., & Guffanti, G. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.009 · Cited by 66 · see citing works
Genetic polymorphisms of the enzymes involved in DNA methylation and synthesis in elite athletes
Terruzzi, I. M., Senesi, P., Montesano, A., Torre, A. L., Alberti, G., Benedini, S., Caumo, A., Fermo, I., & Luzi, L. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00040.2010 · Cited by 63 · see citing works
Exercise-induced circulating microRNA changes in athletes in various training scenarios
Horak, M., Zlámal, F., Iliev, R., Kucera, J., Cacek, J., Svobodová, L., Hlavoňová, Z., Kalina, T., Slabý, O., & Vašků, J. B. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191060 · Cited by 62 · see citing works
Exercise Immunology Meets MiRNAs
Makarova, J. A., Grigoriev, A. I., Galatenko, V., Abbasi, A., Maximenko, D. G., Grigoriev, A. I., Tonevitsky, A., & Northoff, H. (2026) · PubMed · doi:10.22029/eir.2014.1692 · Cited by 59 · see citing works
The impact of endurance exercise on global and AMPK gene-specific DNA methylation
King-Himmelreich, T. S., Schramm, S., Wolters, M. C., Schmetzer, J., Möser, C. V., Knothe, C., Resch, E., Peil, J., Geißlinger, G., & Niederberger, E. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.04.078 · Cited by 59 · see citing works
Bajpeyi, S., Covington, J. D., Taylor, E. M., Stewart, L. K., Galgani, J. E., & Henagan, T. M. (2017) · Endocrinology · doi:10.1210/en.2017-00051 · Cited by 59 · see citing works
Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans
Laker, R. C., Garde, C., CAMERA, D. M., Smiles, W. J., Zierath, J. R., Hawley, J. A., & Barrès, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-15420-7 · Cited by 58 · see citing works
Kanzleiter, T., Jähnert, M., Schulze, G., Selbig, J., Hallahan, N., Schwenk, R., & Schürmann, A. (2015) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00289.2014 · Cited by 57 · see citing works
Epigenetic Modifications of the PGC-1α Promoter during Exercise Induced Expression in Mice
Lochmann, T. L., Thomas, R. R., Bennett, J. P., & Taylor, S. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129647 · Cited by 54 · see citing works
Exercise and the Skeletal Muscle EpigenomePreprint
McGee, S. L., & Walder, K. R. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029876 · Cited by 54 · see citing works
Fisher, A. G., Seaborne, R. A., Hughes, T. M., Gutteridge, A., Stewart, C., Coulson, J., Sharples, A., & Jarvis, J. (2017) · The FASEB Journal · doi:10.1096/fj.201700089rr · Cited by 54 · see citing works
Physical Exercise and Epigenetic Modulation: Elucidating Intricate Mechanisms
Sanchis-Gomar, H. P.-G., & a-Gimenez, J. G. ́. (2014) · Cited by 51 · see citing works
Drug Discovery and Chemical Biology of Cancer Epigenetics
Ribich, S. A., Harvey, D. M., & Copeland, R. A. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.08.020 · Cited by 49 · see citing works
Stephens, N. A., Brouwers, B., Eroshkin, A. M., Yi, F., Cornnell, H. H., Meyer, C., Goodpaster, B. H., Pratley, R. E., Smith, S. R., & Sparks, L. M. (2018) · Diabetes Care · doi:10.2337/dc18-0296 · Cited by 48 · see citing works
Barreiro, E., & Sznajder, J. I. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01027.2012 · Cited by 47 · see citing works
Soci, Ú. P. R., Melo, S. F. S., Gomes, J. L. P., Silveira, A. C., Nóbrega, C., & de Oliveira, E. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4304-8_16 · Cited by 42 · see citing works
Muscle Contraction Induces Acute Hydroxymethylation of the Exercise-Responsive Gene Nr4a3
Pattamaprapanont, P., Garde, C., Fabre, O., & Barrès, R. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00165 · Cited by 40 · see citing works
Kawano, F., Nimura, K., Ishino, S., Nakai, N., Nakata, K., & Ohira, Y. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00289.2015 · Cited by 36 · see citing works
Effect of contractile activity on PGC-1α transcription in young and aged skeletal muscle.
Carter, H. N., Pauly, M., Tryon, L. D., & Hood, D. (2018) · Journal of applied physiology · doi:10.1152/japplphysiol.01110.2017 · Cited by 36 · see citing works
Joseph, J. S., Ayeleso, A. O., & Mukwevho, E. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.03.002 · Cited by 32 · see citing works
Kasch, J., Kanzleiter, I., Saussenthaler, S., Schürmann, A., Keijer, J., van Schothorst, E. M., Klaus, S., & Schumann, S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.03.015 · Cited by 30 · see citing works
New insights on the role of DNA methylation from a global view
Recillas‐Targa, F. (2016) · Frontiers in bioscience · doi:10.2741/4508 · Cited by 29 · see citing works
Circulating Small Non-coding RNAs as Biomarkers for Recovery After Exhaustive or Repetitive Exercise
Håkansson, K. E. J., Sollie, O., Simons, K. H., Quax, P. H. A., Jensen, J., & Nossent, A. Y. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01136 · Cited by 29 · see citing works
Nguyen, A., Duquette, N., Mamarbachi, M., & Thorin, É. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151526 · Cited by 25 · see citing works
Willkomm, L., Gehlert, S., Jacko, D., Schiffer, T., & Bloch, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176609 · Cited by 18 · see citing works
Masuzawa, R., Konno, R., Ohsawa, I., Watanabe, A., & Kawano, F. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00202.2018 · Cited by 18 · see citing works
Hechanova, R. L., Wegler, J. L., & Forest, C. P. (2017) · JAAPA · doi:10.1097/01.jaa.0000513344.52255.cc · Cited by 17 · see citing works
Ohsawa, I., Konno, R., Masuzawa, R., & Kawano, F. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00074.2018 · Cited by 16 · see citing works
Oikawa, S., Lee, M., Motohashi, N., Maeda, S., & Akimoto, T. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00278.2018 · Cited by 15 · see citing works
Penna, F., & Costelli, P. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1557634 · Cited by 12 · see citing works
Flagged first, then by citations
1 of the 90 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Momma, H., Kawakami, R., Honda, T., & Sawada, S. S. (2022) · British Journal of Sports Medicine · doi:10.1136/bjsports-2021-105061 · Cited by 265 · see citing works
Roberts, M. D., McCarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, A. L., Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., et al. (2023) · Physiological Reviews · doi:10.1152/physrev.00039.2022 · Cited by 214 · see citing works
Shorter, E., Sannicandro, A. J., Poulet, B., & Goljanek‐Whysall, K. (2019) · Current Rheumatology Reports · doi:10.1007/s11926-019-0839-4 · Cited by 152 · see citing works
Exercise mimetics: harnessing the therapeutic effects of physical activity
Gubert, C., & Hannan, A. J. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00217-1 · Cited by 153 · see citing works
Sarcopenia and Cognitive Function: Role of Myokines in Muscle Brain Cross-Talk
Scisciola, L., Fontanella, R. A., Surina, S., Cataldo, V., Paolisso, G., & Barbieri, M. (2021) · Life · doi:10.3390/life11020173 · Cited by 148 · see citing works
Epigenetic changes in healthy human skeletal muscle following exercise– a systematic review
Jacques, M., Hiam, D., Craig, J. M., Barrès, R., Eynon, N., & Voisin, S. A. C. (2019) · Epigenetics · doi:10.1080/15592294.2019.1614416 · Cited by 137 · see citing works
Effect of physical activity on the risk of frailty: A systematic review and meta-analysis
Zhao, W., Hu, P., Sun, W., Wu, W., Zhang, J., Deng, H., Huang, J., Ukawa, S., Lu, J., Tamakoshi, A., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278226 · Cited by 121 · see citing works
Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age
Rezuş, E., Burlui, A., Cardoneanu, A., Rezuș, C., Codreanu, C., Parvu, M., Zota, G. R., & Tamba, B.-I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020592 · Cited by 117 · see citing works
Plaza‐Díaz, J., Izquierdo, D., Torres‐Martos, Á., Baig, A. T., Aguilera, C. M., & Ruiz‐Ojeda, F. J. (2022) · Biomedicines · doi:10.3390/biomedicines10010126 · Cited by 114 · see citing works
Scaricamazza, S., Salvatori, I., Giacovazzo, G., Loeffler, J., René, F., Rosina, M., Quessada, C., Proietti, D., Heil, C., Rossi, S., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101087 · Cited by 95 · see citing works
Resveratrol regulates muscle fiber type conversion via miR-22-3p and AMPK/SIRT1/PGC-1α pathway
Wen, W., Chen, X., Huang, Z., Chen, D., Chen, H., Luo, Y., He, J., Zheng, P., Yu, J., & Yu, B. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108297 · Cited by 88 · see citing works
Overtraining Syndrome as a Complex Systems Phenomenon
Armstrong, L. E., Bergeron, M. F., Lee, E. C., Mershon, J. E., & Armstrong, E. M. (2022) · Frontiers in Network Physiology · doi:10.3389/fnetp.2021.794392 · Cited by 101 · see citing works
Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis
Chen, L., Zhang, M., Yang, X., Wang, Y., Huang, T., Li, X., Ban, Y., Li, Q., Yang, Q., Zhang, Y., et al. (2024) · Theranostics · doi:10.7150/thno.94738 · Cited by 83 · see citing works
Lloyd, E. M., Pinniger, G. J., Murphy, R. M., & Grounds, M. D. (2023) · Acta Physiologica · doi:10.1111/apha.14012 · Cited by 65 · see citing works
Upstream and downstream regulators of Klotho expression in chronic kidney disease
Li, S., Sheng, M.-J., Sun, Z.-Y., Liang, Y., Yu, L., & Liu, Q. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155530 · Cited by 62 · see citing works
Exercise-induced circulating microRNA changes in athletes in various training scenarios
Horak, M., Zlámal, F., Iliev, R., Kucera, J., Cacek, J., Svobodová, L., Hlavoňová, Z., Kalina, T., Slabý, O., & Vašků, J. B. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191060 · Cited by 62 · see citing works
Physical Activity Behavior from a Transdisciplinary Biopsychosocial Perspective: a Scoping Review
John, J. M., Haug, V., & Thiel, A. (2020) · Sports Medicine - Open · doi:10.1186/s40798-020-00279-2 · Cited by 57 · see citing works
Li, J., Zhang, S., Li, C., Zhang, X., Shan, Y., Zhang, Z., Hai, B., & Zhang, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-72088-6 · Cited by 57 · see citing works
Brun, J.-F., Myzia, J., Varlet-Marie, E., Raynaud de Mauverger, E., & Mercier, J. (2022) · Nutrients · doi:10.3390/nu14081605 · Cited by 48 · see citing works
A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine
Corrêa, H. D. L., Raab, A. T. O., Araújo, T. M., Deus, L. A., Reis, A. L., Honorato, F. S., Rodrigues-Silva, P. L., Neves, R. V. P., Brunetta, H. S., Mori, M. A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-22123-1 · Cited by 44 · see citing works
A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1‐mediated oxidative stress
Villivalam, S. D., Ebert, S. M., Lim, H., Kim, J., You, D., Jung, B. C., Palacios, H. H., Tcheau, T., Adams, C. M., & Kang, S. (2021) · The EMBO Journal · doi:10.15252/embj.2020106491 · Cited by 45 · see citing works
Sexton, C., Godwin, J. S., McIntosh, M. C., Ruple, B. A., Osburn, S. C., Hollingsworth, B., Kontos, N. J., Agostinelli, P., Kavazis, A., Ziegenfuss, T., et al. (2023) · Cells · doi:10.3390/cells12020263 · Cited by 31 · see citing works
Livshits, G., & Kalinkovich, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102267 · Cited by 42 · see citing works
Physical exercise and epigenetic modifications in skeletal muscle, brain, and heart
Zheng, X., Liu, X., Guo, Y., Lv, Y., Lin, C.-S., Wang, D., Wang, S., Liu, Y.-P., & Hu, X.-F. (2025) · Epigenetics & Chromatin · doi:10.1186/s13072-025-00576-8 · Cited by 37 · see citing works
Epigenetics of Skeletal Muscle-Associated Genes in the ASB, LRRC, TMEM, and OSBPL Gene Families
Ehrlich, K. C., Lacey, M. R., & Ehrlich, M. (2020) · Epigenomes · doi:10.3390/epigenomes4010001 · Cited by 42 · see citing works
Healthy Aging Interventions Reduce Repetitive Element Transcripts
Wahl, D., Cavalier, A. N., Smith, M., Seals, D. R., & LaRocca, T. J. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa302 · Cited by 42 · see citing works
Pickering, C., & Kiely, J. (2019) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk4020025 · Cited by 43 · see citing works
Functionally Annotating Regulatory Elements in the Equine Genome Using Histone Mark ChIP-Seq
Kingsley, N. B., Kern, C., Creppe, C., Hales, E. N., Zhou, H., Kalbfleisch, T., MacLeod, J. N., Petersen, J. L., Finno, C. J., & Bellone, R. R. (2019) · Genes · doi:10.3390/genes11010003 · Cited by 37 · see citing works
Solsona, R., Pavlin, L., Bernardi, H., & Sanchez, A. M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052741 · Cited by 39 · see citing works
Telles, G. D., Libardi, C. A., Conceição, M. S., VECHIN, F. C., Lixandrão, M. E., de Andrade, A. L. L., Guedes, D. N., Ugrinowitsch, C., & CAMERA, D. M. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002632 · Cited by 33 · see citing works
Gevaert, A. B., Wood, N., Boen, J. R. A., Davos, C. H., Hansen, D., Hanssen, H., Krenning, G., Moholdt, T. T., Osto, E., Paneni, F., et al. (2022) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwac179 · Cited by 34 · see citing works
Li, J., Zhang, Z., Hai, B., & Zhang, Y. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.036 · Cited by 33 · see citing works
Exercise Ameliorates Spinal Cord Injury by Changing DNA Methylation
Davaa, G., Hong, J. Y., Kim, T. U., Lee, S. J., Kim, S., Hong, K., & Hyun, J. K. (2021) · Cells · doi:10.3390/cells10010143 · Cited by 32 · see citing works
Impact of Cancer Cachexia on Cardiac and Skeletal Muscle: Role of Exercise Training
Bordignon, C., dos Santos, B. S., & Rosa, D. D. (2022) · Cancers · doi:10.3390/cancers14020342 · Cited by 32 · see citing works
Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases
Xu, Y., Zhang, Y., Luo, Y., Qiu, G., Lu, J., He, M., & Wang, Y. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01435-9 · Cited by 31 · see citing works
Wan, R., Liu, S., Feng, X., Luo, W., Zhang, H., Wu, Y., Chen, S., & Shang, X. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.01.001 · Cited by 31 · see citing works
Transcriptional memory in skeletal muscle. Don't forget (to) exercise
Beiter, T., Niess, A. M., & Moser, D. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29535 · Cited by 29 · see citing works
Exercise and physical activity in cirrhosis: opportunities or perils
Bellar, A., Welch, N., & Dasarathy, S. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00798.2019 · Cited by 32 · see citing works
Hart, D. A., & Zernicke, R. F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00156 · Cited by 30 · see citing works
Hashida, R., Matsuse, H., Kawaguchi, T., Yoshio, S., Bekki, M., Iwanaga, S., Sugimoto, T., Hara, K., Koya, S., Hirota, K., et al. (2021) · Hepatology Research · doi:10.1111/hepr.13670 · Cited by 29 · see citing works
miR-22-3p regulates muscle fiber-type conversion through inhibiting AMPK/SIRT1/PGC-1α pathway
Wen, W., Chen, X., Huang, Z., Chen, D., Zheng, P., He, J., Chen, H., Yu, J., Luo, Y., & Yu, B. (2020) · Animal Biotechnology · doi:10.1080/10495398.2020.1763375 · Cited by 26 · see citing works
Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity
Wang, Y., Xie, H., Liu, Q., Wang, N., Luo, X., Sun, F., Zhu, J., Dong, R., Wang, Y., Gao, J. L., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01210-9 · Cited by 25 · see citing works
Pedretti, R. F. E., Asteggiano, R., Gevaert, A. B., Bowen, T. S., Caselli, S., Cornelissen, V., Christodorescu, R., Derosa, G., Diévart, F., Kurpas, D., et al. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf175 · Cited by 31 · see citing works
Li, Y., Zhao, W., & Yang, Q. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1554222 · Cited by 23 · see citing works
Mallett, G. S. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-025-05704-6 · Cited by 22 · see citing works
Genetic test for the personalization of sport training.
Naureen, Z., Perrone, M. A., Paolacci, S., Maltese, P. E., Dhuli, K., Kurti, D., Dautaj, A., Miotto, R., Casadei, A., Fioretti, B., et al. (2020) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v91i13-s.10593 · Cited by 22 · see citing works
Mubarak, G., & Zahir, F. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12020199 · Cited by 22 · see citing works
Schmitt, A., Herzog, P., Röchner, F., Brändle, A.-L., Fragasso, A., & Munz, B. (2020) · Physiological Reports · doi:10.14814/phy2.14609 · Cited by 20 · see citing works
Self-citationSankova, M. V., Beeraka, N. M., Oganesyan, M. V., Rizaeva, N. A., Sankov, A. V., Shelestova, O. S., Bulygin, K. V., Hemanth Vikram, P. R., Barinov, A. N., Khalimova, A. K., et al. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.08.024 · Cited by 23 · see citing works
Modulation of microRNAs through Lifestyle Changes in Alzheimer’s Disease
Pinto-Hernández, P., Castilla-Silgado, J., Coto-Vilcapoma, A., Fernández-Sanjurjo, M., Fernández-García, B., Tomás-Zapico, C., & Iglesias-Gutiérrez, E. (2023) · Nutrients · doi:10.3390/nu15173688 · Cited by 20 · see citing works
Associations between Daily Step Counts and Physical Fitness in Preschool Children
Fang, C., Zhang, J., Zhou, T., Li, L., Yao-fei, L., Gao, Z., & Quan, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010163 · Cited by 20 · see citing works
Brown Adipose Tissue: New Challenges for Prevention of Childhood Obesity. A Narrative Review
Verduci, E., Calcaterra, V., Profio, E. D., Fiore, G., Rey, F., Magenes, V. C., Todisco, C. F., Carelli, S., & Zuccotti, G. (2021) · Nutrients · doi:10.3390/nu13051450 · Cited by 20 · see citing works
Genetics and athletic performance: a systematic SWOT analysis of non-systematic reviews
Konopka, M. J., Sperlich, B., Rietjens, G. J., & Zeegers, M. P. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1232987 · Cited by 20 · see citing works
Júnior, A. S. S., Aidar, F. J., Silva, A. M. D. O. E., Estevam, C. D. S., Carvalho, C. R. D. O., Lima, F. B., dos Santos, J. L., & Marçal, A. C. (2020) · Nutrients · doi:10.3390/nu13010124 · Cited by 17 · see citing works
Rocha-Rodrigues, S., Matos, A., Afonso, J., Mendes-Ferreira, M., Abade, E., Teixeira, E., Silva, B., Murawska-Ciałowicz, E., Oliveira, M. J., & Ribeiro, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094469 · Cited by 17 · see citing works
Psatha, A., Al-Mahayri, Z. N., Mitropoulou, C., & Patrinos, G. P. (2024) · Human Genomics · doi:10.1186/s40246-024-00621-9 · Cited by 17 · see citing works
The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women
Molina‐Molina, E., Furtado, G. E., Jones, J. G., Portincasa, P., Pedrosa, A., Teixeira, A. M., Barros, M. P., Bachi, A. L. L., & Sardão, V. A. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13731 · Cited by 17 · see citing works
Franco‐Obregón, A., Tai, Y. K., Wu, K. Y., Iversen, J. N., & Wong, C. J. K. (2023) · Bioengineering · doi:10.3390/bioengineering10080956 · Cited by 16 · see citing works
Effects of Voluntary Running Wheel Exercise-Induced Extracellular Vesicles on Anxiety
Yoon, K. J., Park, S., Kwak, S. H., & Moon, H. Y. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.665800 · Cited by 15 · see citing works
Shen, Y., Zhang, C., Cui, S., Wang, R., Cai, H., Zhao, W., Zhu, J., & Yu, Y. (2022) · Human Brain Mapping · doi:10.1002/hbm.26031 · Cited by 15 · see citing works
Mechanisms of endurance and resistance exercise in type 2 diabetes mellitus: A Narrative review
Zhao, X., Huang, F., Sun, Y., & Li, L. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151731 · Cited by 14 · see citing works
The blooming intersection of subfatin and metabolic syndrome
Huang, S., Cao, L., Cheng, H., Li, D., Li, Y. W., & Wu, Z. (2021) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2203086 · Cited by 15 · see citing works
Telles, G. D., Libardi, C. A., Conceição, M. S., VECHIN, F. C., Lixandrão, M. E., Mangone, F. R., Pavanelli, A. C., Nagai, M. A., CAMERA, D. M., Hawley, J. A., et al. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003049 · Cited by 14 · see citing works
The importance of RNA modifications: From cells to muscle physiology
Das, A. S., Alfonzo, J. D., & Accornero, F. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1700 · Cited by 14 · see citing works
Podgórski, R., Cieśla, M., Podgórska, D., Bajorek, W., Płonka, A., Czarny, W., Trybulski, R., & Król, P. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11010263 · Cited by 13 · see citing works
miRNAs as markers for the development of individualized training regimens: A pilot study
Widmann, M., Maturana, F. M., Burgstahler, C., Erz, G., Schellhorn, P., Fragasso, A., Schmitt, A., Niess, A. M., & Munz, B. (2022) · Physiological Reports · doi:10.14814/phy2.15217 · Cited by 12 · see citing works
Self-citationMolecular origin and biological effects of exercise mimetics
Zhu, Y., & Song, G. (2023) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2023.12.002 · Cited by 14 · see citing works
Chen, H., Cheng, M.-C., You, S., Zhu, Y.-Q., Sun, L., Zhang, Y., Feng, B.-B., & Wu, G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33769 · Cited by 12 · see citing works
Peterson, J. A., Crow, J. A., Johnson, A. J., Meng, L., Rani, A., Huo, Z., Foster, T. C., Fillingim, R. B., & Cruz‐Almeida, Y. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1122364 · Cited by 12 · see citing works
Leońska‐Duniec, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211175 · Cited by 11 · see citing works
Normand-Gravier, T., Solsona, R., Dablainville, V., Racinais, S., Borrani, F., Bernardi, H., & Sanchez, A. M. J. (2024) · European Journal of Applied Physiology · doi:10.1007/s00421-024-05642-9 · Cited by 12 · see citing works
Zhang, Y., Wei, Y., Liu, H., & Guo, Y. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5587 · Cited by 12 · see citing works
Denham, J., McCluskey, M. J., Denham, M. M., Sellami, M., & Davie, A. J. (2020) · Equine Veterinary Journal · doi:10.1111/evj.13320 · Cited by 11 · see citing works
Li, Y., Kong, M., Wang, J., Han, P., Zhang, N., Yang, X., Wang, J., Hu, Y., Duo, Y., & Liu, D. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e12583 · Cited by 10 · see citing works
Exercise, Epigenetics, and Body Composition: Molecular Connections
Williams, A., Wadsworth, D. D., & Geetha, T. (2025) · Cells · doi:10.3390/cells14191553 · Cited by 13 · see citing works
Zhou, L., Li, S., Zhang, Q., Yu, M., & Xiao, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.853197 · Cited by 9 · see citing works
Epigenetic control of heredity
Kachhawaha, A. S., Mishra, S., & Tiwari, A. K. (2023) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.03.006 · Cited by 9 · see citing works
Chen, L., Bai, J., & Li, Y. (2020) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2019.0169 · Cited by 9 · see citing works
Podgórska, D., Cieśla, M., Płonka, A., Bajorek, W., Czarny, W., Król, P., & Podgórski, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116107 · Cited by 10 · see citing works
Yao, Z., Jiang, Z., Liu, X., Zhang, L., Guo, S., Chen, Y., Luo, L., Ma, S., Wang, P., & Shyh‐Chang, N. (2025) · Advanced Science · doi:10.1002/advs.202505989 · Cited by 7 · see citing works
Mechanisms of the biological response cascade to exercise-induced stress: a comprehensive review
Xu, J., Zhang, J., & Sang, K. (2025) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2025.1691779 · Cited by 8 · see citing works
Genome-wide epigenetic modifications in sports horses during training as an adaptation phenomenon
Cappelli, K., Mecocci, S., Porceddu, A., Albertini, E., Giontella, A., Miglio, A., Silvestrelli, M., Supplizi, A. V., Marconi, G., & Capomaccio, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-46043-w · Cited by 7 · see citing works
Ding, L., Liu, J. Y., Zhou, L., & Xiao, X. (2023) · Nutrients · doi:10.3390/nu15122793 · Cited by 7 · see citing works
Dietary Plant Extracts in Improving Skeletal Muscle Development and Metabolic Function
Xiang, J., Du, ., & Wang, H. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2087669 · Cited by 8 · see citing works
Taukeni, S. G., Mathwasa, J., & Ntshuntshe, Z. (2022) · Advances in public policy and administration (APPA) book series · doi:10.4018/978-1-6684-6496-0.ch001 · Cited by 7 · see citing works
Schmitt, A., Brändle, A.-L., Herzog, P., Röchner, F., Fragasso, A., & Munz, B. (2020) · Redox Report · doi:10.1080/13510002.2020.1807088 · Cited by 7 · see citing works
Self-citationRang, Y., Ma, S., Yang, J., Liu, H., Suzuki, K., & Liu, C. (2021) · Metabolites · doi:10.3390/metabo11050301 · Cited by 6 · see citing works
Jakobsson, J., Cotgreave, I. A., Furberg, M., Arnberg, N., & Svensson, M. (2021) · Sports · doi:10.3390/sports9090121 · Cited by 6 · see citing works
Acevedo, L. M., Vidal, Á., Aguilera‐Tejero, E., & Rivero, J. L. L. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00306.2022 · Cited by 6 · see citing works
Zhou, Y., Liu, X., Qi, Z., Huang, C., Yang, L., & Lin, D. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31290 · Cited by 6 · see citing works
Sehn, A. P., Brand, C., Tornquist, L., Tornquist, D., Silveira, J. F. D. C., Gaya, A. R., Cristi‐Montero, C., Burns, R. D., Renner, J. D. P., & Reuter, C. P. (2024) · European Journal of Sport Science · doi:10.1002/ejsc.12070 · Cited by 5 · see citing works
Moore, A. Z., Simonsick, E. M., Landman, B. A., Schrack, J. A., Wanigatunga, A. A., & Ferrucci, L. (2024) · Aging Cell · doi:10.1111/acel.14078 · Cited by 5 · see citing works
Muscle fibre size and myonuclear positioning in trained and aged humans
Battey, E., Levy, Y., Pollock, R. D., Pugh, J. N., Close, G. L., Kalakoutis, M., Lazarus, N. R., Harridge, S. D. R., Ochala, J., & Stroud, M. J. (2024) · Experimental Physiology · doi:10.1113/ep091567 · Cited by 4 · see citing works
Yao, J., Xu, L., Zhao, Z., Dai, D., Zhan, S., Cao, J., Guo, J., Zhong, T., Wang, L., Li, L., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189804 · Cited by 4 · see citing works
Bales, K. L., Karesh, A. M., Hogan, K., Chacko, A. S., Douglas, G. L., Feola, A., Nickerson, J. M., Pybus, A. F., Wood, L. B., Boatright, J. H., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-57027-9 · Cited by 4 · see citing works
Xu, L., Jia, J., Yu, J., Miao, S., & Zhang, Y. (2024) · Free Radical Research · doi:10.1080/10715762.2024.2348789 · Cited by 4 · see citing works
Regulation of autophagy and cellular signaling through non-histone protein methylation
Bao, Y., Ma, Y., Huang, W., Bai, Y., Gao, S., Xiu, L., Xie, Y., Wan, X., Shan, S., Chen, C., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139057 · Cited by 5 · see citing works
Dong, X., Yi, X., Xiao, J., Yi, N., Wang, H., Hou, X., & Zhou, C. (2025) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2025.105525 · Cited by 4 · see citing works
dos Santos, J. L., de Araújo, S. S., Silva, A. M. D. O. E., Lima, C. A., Souza, L. M. V., Costa, R. A., Aidar, F. J., Voltarelli, F. A., Estevam, C. D. S., & Marçal, A. C. (2019) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2019-0331 · Cited by 4 · see citing works
Imura, T. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05165-9 · Cited by 4 · see citing works
- Authors
- Widmann, M., Nieß, A. M., & Munz, B.
- Affiliations
- University of Tübingen (DE)
- Corresponding author
- Munz, Barbara
- Venue
- Sports Medicine
- Published
- 2019-02-19
- Volume
- 49
- Issue
- 4
- Pages
- 509-523
- ISSN
- 0112-1642 (ISSN-L)
- 1179-2035
- OpenAlex
- W2917335963
- Cited by
- 165
- References
- 90
- Citations by year
- 2026: 19 · 2025: 26 · 2024: 27 · 2023: 17 · 2022: 22 · 2021: 24 · 2020: 21 · 2019: 8 · 2018: 1
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Minigraduiertenkolleg iReAct
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- physical activity, epigenetic modifications, skeletal muscle, exercise-induced gene expression, DNA methylation, histone modifications, microRNA, muscle fiber type shift, exercise adaptation, exercise mimetics, training protocols, exercise biomarkers
- MeSH terms
- Endurance Training, Adaptation, Physiological, Age Factors, Gene Expression Regulation, Histones, Humans, Protein Processing, Post-Translational, Exercise, Muscle, Skeletal, MicroRNAs, Epigenesis, Genetic, Resistance Training, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
