Cited by 427Cardiovascular and exercise physiologyExercise and Physiological ResponsesMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle

Gibala, Martin J., McGee, Sean L., Garnham, Andrew P., Howlett, Kirsten F., Snow, Rodney J., Hargreaves, Mark·2009·Journal of Applied Physiology

DOI 10.1152/japplphysiol.90880.2008

Open this paper in CoChat — free account

Abstract

From a cell signaling perspective, short-duration intense muscular work is typically associated with resistance training and linked to pathways that stimulate growth. However, brief repeated sessions of sprint or high-intensity interval exercise induce rapid phenotypic changes that resemble traditional endurance training. We tested the hypothesis that an acute session of intense intermittent cycle exercise would activate signaling cascades linked to mitochondrial biogenesis in human skeletal muscle. Biopsies (vastus lateralis) were obtained from six young men who performed four 30-s “all out” exercise bouts interspersed with 4 min of rest (<80 kJ total work). Phosphorylation of AMP-activated protein kinase (AMPK; subunits α1 and α2) and the p38 mitogen-activated protein kinase (MAPK) was higher ( P ≤ 0.05) immediately after bout 4 vs. preexercise. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) mRNA was increased approximately twofold above rest after 3 h of recovery ( P ≤ 0.05); however, PGC-1α protein content was unchanged. In contrast, phosphorylation of protein kinase B/Akt (Thr308 and Ser473) tended to decrease, and downstream targets linked to hypertrophy (p70 ribosomal S6 kinase and 4E binding protein 1) were unchanged after exercise and recovery. We conclude that signaling through AMPK and p38 MAPK to PGC-1α may explain in part the metabolic remodeling induced by low-volume intense interval exercise, including mitochondrial biogenesis and an increased capacity for glucose and fatty acid oxidation.

Integrity signals

Registry

Crossref · 10.1152/japplphysiol.90880.2008

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,400
Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans
Burgomaster, K. A., Howarth, K. R., Phillips, S. M., Rakobowchuk, M., MacDonald, M. J., McGee, S. L., & Gibala, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142109 · Cited by 1,257
Self-citation
Short‐term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance
Gibala, M. J., Little, J. P., Van Essen, M., Wilkin, G. P., Burgomaster, K. A., Safdar, A., Raha, S., & Tarnopolsky, M. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.112094 · Cited by 1,082
Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle
Pilegaard, H., Saltin, B., & Neufer, P. D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034850 · Cited by 885
Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans
Burgomaster, K. A., Hughes, S. C., Heigenhauser, G. J. F., Bradwel, S. N., & Gibala, M. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01095.2004 · Cited by 856
Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin
Brunn, G. J., Hudson, C. C., Sekulić, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., & Abraham, R. T. (1997) · Science · doi:10.1126/science.277.5322.99 · Cited by 846
Phosphorylation and Activation of p70 s6k by PDK1
Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., & Thomas, G. (1998) · Science · doi:10.1126/science.279.5351.707 · Cited by 826
The Molecular Bases of Training Adaptation
Coffey, V. G., & Hawley, J. A. (2007) · Sports Medicine · doi:10.2165/00007256-200737090-00001 · Cited by 756
Metabolic Adaptations to Short-term High-Intensity Interval Training: A Little Pain for a Lot of Gain?
Gibala, M. J., & McGee, S. L. (2008) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e318168ec1f · Cited by 682
Self-citation

Flagged first, then by citations

Show all 37 references

Sorted by citations

Items 101–200 of 424

Regular postexercise cooling enhances mitochondrial biogenesis through AMPK and p38 MAPK in human skeletal muscle.
Ihsan, M., Markworth, J. F., Watson, G., Choo, H., Govus, A., Pham, T., Hickey, A., Cameron-Smith, D., & Abbiss, C. (2015) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00031.2015 · Cited by 66
The Effect of a Short-Term High-Intensity Circuit Training Program on Work Capacity, Body Composition, and Blood Profiles in Sedentary Obese Men: A Pilot Study
Miller, M. B., Pearcey, G. E. P., Cahill, F., McCarthy, H., Stratton, S. B. D., Noftall, J. C., Buckle, S., Basset, F. A., Sun, G., & Button, D. C. (2014) · BioMed Research International · doi:10.1155/2014/191797 · Cited by 68
Nutrition and the Adaptation to Endurance Training
Baar, K. (2014) · Sports Medicine · doi:10.1007/s40279-014-0146-1 · Cited by 72
Similar Anti-Inflammatory Acute Responses from Moderate-Intensity Continuous and High-Intensity Intermittent Exercise.
Cabral‐Santos, C., Gerosa-Neto, J., Inoue, D. S., Panissa, V. L. G., Gobbo, L. A., Zagatto, A. M., Campos, E. Z., & Lira, F. S. (2015) · Europe PMC (PubMed Central) · Cited by 65
Optimizing Intramuscular Adaptations to Aerobic Exercise: Effects of Carbohydrate Restriction and Protein Supplementation on Mitochondrial Biogenesis
Margolis, L. M., & Pasiakos, S. M. (2013) · Advances in Nutrition · doi:10.3945/an.113.004572 · Cited by 63
Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men
Miyamoto‐Mikami, E., Tsuji, K., Horii, N., Hasegawa, N., Fujie, S. J., Homma, T., Uchida, M., Hamaoka, T., Kanehisa, H., Tabata, I., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-35115-x · Cited by 66
Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities
Mesquita, P. H. C., Vann, C. G., Phillips, S. M., McKendry, J., Young, K. C., Kavazis, A. N., & Roberts, M. D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.725866 · Cited by 62
Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle
Cho, Y., Hazen, B. C., Gandra, P. G., Ward, S. R., Schenk, S., Russell, A. P., & Kralli, A. (2015) · The FASEB Journal · doi:10.1096/fj.15-276360 · Cited by 64
Mitochondrial gene expression in elite cyclists: effects of high-intensity interval exercise
Psilander, N., Wang, L., Westergren, J., Tonkonogi, M., & Sahlin, K. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1544-1 · Cited by 66
AMPK, a key regulator of metabolic/energy homeostasis and mitochondrial biogenesis in cancer cells
Chaube, B., & Bhat, M. K. (2016) · Cell Death and Disease · doi:10.1038/cddis.2015.404 · Cited by 63
Acute sprint exercise transcriptome in human skeletal muscle
Rundqvist, H., Montelius, A., Österlund, T., Norman, B., Esbjörnsson, M., & Jansson, E. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223024 · Cited by 62
Does Lactate-Guided Threshold Interval Training within a High-Volume Low-Intensity Approach Represent the “Next Step” in the Evolution of Distance Running Training?
Casado, A., Foster, C., Bakken, M., & Tjelta, L. I. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20053782 · Cited by 66
High Intensity Interval and Endurance Training Have Opposing Effects on Markers of Heart Failure and Cardiac Remodeling in Hypertensive Rats
Holloway, T. M., Bloemberg, D., da Silva, M. L., Simpson, J. A., Quadrilatero, J., & Spriet, L. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121138 · Cited by 60
MAP kinase phosphatase DUSP1 is overexpressed in obese humans and modulated by physical exercise
Khadir, A., Tiss, A., Abubaker, J. A., Abu‐Farha, M., Al‐Khairi, I., Cherian, P., John, J., Kavalakatt, S., Warsame, S., Madhoun, A. S. A., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00577.2013 · Cited by 60
Transcriptional adaptations following exercise in Thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy
McGivney, B. A., Eivers, S. S., MacHugh, D. E., MacLeod, J. N., O’Gorman, G. M., Park, S. D. E., Katz, L. M., & Hill, E. W. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-638 · Cited by 59
Autophagic Cellular Responses to Physical Exercise in Skeletal Muscle
Tam, B. T., & Siu, P. M. (2014) · Sports Medicine · doi:10.1007/s40279-013-0140-z · Cited by 60
Modified sprint interval training protocols. Part I. Physiological responses
Islam, H., Townsend, L. K., & Hazell, T. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0478 · Cited by 60
Exercise and the Skeletal Muscle EpigenomePreprint
McGee, S. L., & Walder, K. R. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029876 · Cited by 56
The effect of Tabata-style functional high-intensity interval training on cardiometabolic health and physical activity in female university students
Lu, Y., Wiltshire, H., Baker, J. S., Wang, Q., & Ying, S. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1095315 · Cited by 62
Aerobic exercise interventions for promoting cardiovascular health and mobility after stroke: a systematic review with Bayesian network meta-analysis
Moncion, K., Rodrigues, L., Wiley, E., Noguchi, K. S., Negm, A. M., Richardson, J. A., MacDonald, M. J., Roig, M., & Tang, A. (2024) · British Journal of Sports Medicine · doi:10.1136/bjsports-2023-107956 · Cited by 52
Resistance Training to Momentary Muscular Failure Improves Cardiovascular Fitness in Humans: A Review of Acute Physiological Responses and Chronic Physiological Adaptations
Steele, J., Fisher, J. P., McGuff, D., Bruce‐Low, S., & Smith, D. (2012) · Solent University Research Portal (Solent University) · Cited by 52
Dietary stimulators of GLUT4 expression and translocation in skeletal muscle: A mini‐review
Gannon, N. P., Conn, C. A., & Vaughan, R. A. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400414 · Cited by 53
Exercise twice‐a‐day potentiates markers of mitochondrial biogenesis in men
Andrade‐Souza, V. A., Ghiarone, T., Sansonio, A., Silva, K. A. S., Tomazini, F., Arcoverde, L., Fyfe, J. J., Perri, E., Saner, N. J., Kuang, J., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901207rr · Cited by 53
Mechanisms Involved in 3′,5′-Cyclic Adenosine Monophosphate-Mediated Inhibition of the Ubiquitin-Proteasome System in Skeletal Muscle
Gonçalves, D. A. P., Lira, E. C., Baviera, A. M., Cao, P., Zanon, N. M., Arany, Z. P., Bedard, N., Tanksale, P., Wing, S. S., Lecker, S. H., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0428 · Cited by 51
The PKCδ-Nrf2-ARE signalling pathway may be involved in oxidative stress in arsenic-induced liver damage in rats
Hu, Y., Yu, C. W., Yao, M., Wang, L., Liang, B., Zhang, B., Huang, X., & Zhang, A. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.05.012 · Cited by 51
Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle
Percival, M. E., Martin, B. J., Gillen, J. B., Skelly, L. E., MacInnis, M. J., Green, A. E., Tarnopolsky, M. A., & Gibala, M. J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00048.2015 · Cited by 50
Self-citation
‘Fit for surgery’: the relationship between cardiorespiratory fitness and postoperative outcomes
Rose, G. A., Davies, R. G., Appadurai, I. R., Williams, I. M., Bashir, M., Berg, R. M. G., Poole, D. C., & Bailey, D. M. (2022) · Experimental Physiology · doi:10.1113/ep090156 · Cited by 55
Repeated Sprints Alter Signaling Related to Mitochondrial Biogenesis in Humans
Serpiello, F. R., McKenna, M. J., Bishop, D. J., Aughey, R. J., Caldow, M. K., Cameron‐Smith, D., & Stepto, N. K. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318240067e · Cited by 48
Regulators of blood lipids and lipoproteins? PPARδ and AMPK, induced by exercise, are correlated with lipids and lipoproteins in overweight/obese men and women
Greene, N. P., Fluckey, J. D., Lambert, B. S., Greene, E. S., Riechman, S. E., & Crouse, S. F. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00309.2012 · Cited by 50
Exercise snacks and physical fitness in sedentary populations
Wang, T., Laher, I., & Li, S. (2024) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2024.02.006 · Cited by 48
High-intensity interval training (HIIT) alleviated NAFLD feature via miR-122 induction in liver of high-fat high-fructose diet induced diabetic rats
Kalaki-Jouybari, F., Shanaki, M., Delfan, M., Gorgani-Firouzjae, S., & Khakdan, S. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1510968 · Cited by 48
High-intensity interval training increases intrinsic rates of mitochondrial fatty acid oxidation in rat red and white skeletal muscle
Hoshino, D., Yoshida, Y., Kitaoka, Y., Hatta, H., & Bonen, A. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0257 · Cited by 51
Exercise-specific adaptations in human skeletal muscle: Molecular mechanisms of making muscles fit and mighty
Thomas, A. C. Q., Stead, C. A., Burniston, J. G., & Phillips, S. M. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.010 · Cited by 57
Similar Expression of Oxidative Genes after Interval and Continuous Exercise
Wang, L., Psilander, N., Tonkonogi, M., Ding, S., & Sahlin, K. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181abc1ec · Cited by 47
Rapidly elevated levels of PGC-1α-b protein in human skeletal muscle after exercise: exploring regulatory factors in a randomized controlled trial
Gidlund, E., Ydfors, M., Appel, S., Rundqvist, H., Sundberg, C. J., & Norrbom, J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01000.2014 · Cited by 44
PGC-1α and exercise in the control of body weight
Summermatter, S., & Handschin, C. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.12 · Cited by 45
From Tissue to System: What Constitutes an Appropriate Response to Loading?
Gabbett, T. J., & Oetter, E. (2024) · Sports Medicine · doi:10.1007/s40279-024-02126-w · Cited by 48
Epigenetic modulation by life–style: advances in diet, exercise, and mindfulness for disease prevention and health optimization
Ostaiza-Cardenas, J., Tobar, A. C., Costa, S. C., Calero, D. S., López-Carrera, A., Bermúdez, F. G., & Orellana‐Manzano, A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1632999 · Cited by 51
Exercise and the Regulation of Mitochondrial Turnover
Hood, D. A., Tryon, L. D., Vainshtein, A., Memme, J. M., Chen, C., Pauly, M., Crilly, M. J., & Carter, H. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.007 · Cited by 44
Exercise, fasting, and mimetics: toward beneficial combinations?
Jaspers, R. T., Zillikens, M. C., Friesema, E. C. H., Paoli, G. D., Bloch, W., Uitterlinden, A. G., Goglia, F., Lanni, A., & de Lange, P. (2016) · The FASEB Journal · doi:10.1096/fj.201600652r · Cited by 44
CrossTalk proposal: Exercise training intensity is more important than volume to promote increases in human skeletal muscle mitochondrial content
MacInnis, M. J., Skelly, L. E., & Gibala, M. J. (2019) · The Journal of Physiology · doi:10.1113/jp277633 · Cited by 41
Aquatic High Intensity Interval Training for Cardiometabolic Health
Nagle, E. F., Sanders, M. E., & Franklin, B. A. (2015) · American Journal of Lifestyle Medicine · doi:10.1177/1559827615583640 · Cited by 46
A 31-day time to surgery compliant exercise training programme improves aerobic health in the elderly
Boereboom, C., Phillips, B. E., Williams, J. P., & Lund, J. N. (2016) · Techniques in Coloproctology · doi:10.1007/s10151-016-1455-1 · Cited by 39
Exercise duration-matched interval and continuous sprint cycling induce similar increases in AMPK phosphorylation, PGC-1α and VEGF mRNA expression in trained individuals
Taylor, C. W., Ingham, S. A., Hunt, J. E. A., Martin, N. R. W., PRINGLE, J. S. M., & Ferguson, R. A. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3402-2 · Cited by 40
High Intensity Training Improves Health and Physical Function in Middle Aged Adults
Adamson, S., Lorimer, R., Cobley, J. N., Lloyd, R., & Babraj, J. (2014) · Biology · doi:10.3390/biology3020333 · Cited by 41
Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance
Tang, X., Zhuang, J., Chen, J., Yu, L., Hu, L., Jiang, H., & Shen, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024224 · Cited by 42
Combined speed endurance and endurance exercise amplify the exercise‐induced PGC‐1 α and PDK4 mRNA response in trained human muscle
Skovgaard, C., Brandt, N., Pilegaard, H., & Bangsbo, J. (2016) · Physiological Reports · doi:10.14814/phy2.12864 · Cited by 40
The effect of acute and chronic sprint-interval training on LRP130, SIRT3, and PGC-1α expression in human skeletal muscle
Edgett, B. A., Bonafiglia, J. T., Baechler, B. L., Quadrilatero, J., & Gurd, B. J. (2016) · Physiological Reports · doi:10.14814/phy2.12879 · Cited by 41
Skeletal Muscle Mitochondrial Dysfunction in Chronic Obstructive Pulmonary Disease: Underlying Mechanisms and Physical Therapy Perspectives
Wang, Y., Li, P., Cao, Y., Liu, C., Wang, J., & Wu, W. (2022) · Aging and Disease · doi:10.14336/ad.2022.0603 · Cited by 41
The exercised skeletal muscle: a review
Marini, M., & Veicsteinas, A. (2010) · European Journal of Translational Myology · doi:10.4081/bam.2010.3.105 · Cited by 39
Mechanism of continuous high temperature affecting growth performance, meat quality, and muscle biochemical properties of finishing pigs
Ma, X., Wang, L., Shi, Z., Chen, W., Yang, X., Hu, Y., Zheng, C., & Jiang, Z. (2019) · Genes & Nutrition · doi:10.1186/s12263-019-0643-9 · Cited by 43
Fast regulation of the NF-κB signalling pathway in human skeletal muscle revealed by high-intensity exercise and ischaemia at exhaustion: Role of oxygenation and metabolite accumulation
Gallego-Selles, Á., Galván-Álvarez, V., Martinez‐Canton, M., García-Gonzalez, E., Morales‐Álamo, D., Santana, A., González, J. J., Dorado, C., Calbet, J. A. L., & Martín-Rincón, M. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102398 · Cited by 38
High-intensity interval training has beneficial effects on cardiac remodeling through local renin-angiotensin system modulation in mice fed high-fat or high-fructose diets
Sá, G. D. O., Neves, V. D. S., Fraga, S. R. D. O., Souza‐Mello, V., & Barbosa‐da‐Silva, S. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.09.012 · Cited by 38
Untitled work
Baar (2009) · doi:10.1139/h09-035 · Cited by 36
Skeletal muscle signaling response to sprint exercise in men and women
Fuentes, T., Guerra, B., Ponce-González, J. G., Morales-Alamo, D., Guadalupe-Grau, A., Olmedillas, H., Rodríguez-García, L., Feijoo, D., De Pablos-Velasco, P., Fernández-Pérez, L., et al. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2164-0 · Cited by 36
Effect of formoterol, a long-acting β2-adrenergic agonist, on muscle strength and power output, metabolism, and fatigue during maximal sprinting in men
Kalsen, A., Hostrup, M., Backer, V., & Bangsbo, J. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00364.2015 · Cited by 36
Sprint exercise enhances skeletal muscle p70S6k phosphorylation and more so in females than in males
Esbjörnsson, M., Rundqvist, H., Mascher, H., Österlund, T., Rooyackers, O., Blomstrand, E., & Jansson, E. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02404.x · Cited by 36
The effect of exercise-intensity on skeletal muscle stress kinase and insulin protein signaling
Parker, L., Trewin, A. J., Levinger, I., Shaw, C. S., & Stepto, N. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171613 · Cited by 36
Postexercise cold water immersion modulates skeletal muscle PGC-1α mRNA expression in immersed and nonimmersed limbs: evidence of systemic regulation
Allan, R., Sharples, A. P., Close, G. L., Drust, B., Shepherd, S. O., Dutton, J. J., Morton, J. P., & Gregson, W. A. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00096.2017 · Cited by 41
High-Intensity Interval Training Attenuates Insulin Resistance Induced by Sleep Deprivation in Healthy Males
de Souza, J. F. T., Dáttilo, M., de Mello, M. T., Tufik, S., & Antunes, H. K. M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00992 · Cited by 35
Molecular aspects of the cardioprotective effect of exercise in the elderly
Rengo, G., Parisi, V., Femminella, G. D., Pagano, G., de Lucia, C., Cannavò, A., Liccardo, D., Giallauria, F., Scala, O., Zincarelli, C., et al. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0117-7 · Cited by 32
The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle
Pecorella, S. R. H., Potter, J. V. F., Cherry, A. D., Peacher, D. F., Welty‐Wolf, K. E., Moon, R. E., Piantadosi, C. A., & Suliman, H. B. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00104.2015 · Cited by 35
Brief report of the effects of the aerobic, resistance, and high-intensity interval training in type 2 diabetes mellitus individuals
Sousa, R. A. L. D. (2017) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-017-0582-1 · Cited by 36
Dietary stimulators of the PGC-1 superfamily and mitochondrial biosynthesis in skeletal muscle. A mini-review
Vaughan, R. A., Mermier, C. M., Bisoffi, M., Trujillo, K. A., & Conn, C. A. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0301-4 · Cited by 34
The Effects of Sprint Interval Training on Physical Performance: A Systematic Review and Meta-Analysis
Hall, A. J., Aspe, R., Craig, T. P., Kavaliauskas, M., Babraj, J., & Swinton, P. A. (2022) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000004257 · Cited by 41
A novel gravity-induced blood flow restriction model augments ACC phosphorylation and PGC-1α mRNA in human skeletal muscle following aerobic exercise: a randomized crossover study
Preobrazenski, N., Islam, H., Drouin, P. J., Bonafiglia, J. T., Tschakovsky, M. E., & Gurd, B. J. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0641 · Cited by 38
Is sprint exercise a leptin signaling mimetic in human skeletal muscle?
Guerra, B., Olmedillas, H., Guadalupe‐Grau, A., Ponce‐González, J. G., Morales‐Álamo, D., Fuentes, T., Chapinal, E., Fernández‐Pérez, L., de Pablos-Velasco, P. L., Santana, A., et al. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00805.2010 · Cited by 34
Very low volume sprint interval exercise suppresses subjective appetite, lowers acylated ghrelin, and elevates GLP-1 in overweight individuals: A pilot study
Holliday, A., & Blannin, A. (2017) · Nutrients · doi:10.3390/nu9040362 · Cited by 34
Acute Response of Circulating Vascular Regulating MicroRNAs during and after High-Intensity and High-Volume Cycling in Children
Kilian, Y., Wehmeier, U. F., Wahl, P., Mester, J., Hilberg, T., & Sperlich, B. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00092 · Cited by 34
Irisin and myostatin responses to acute high-intensity interval exercise in humans
Kabak, B., Belviranlı, M., & Okudan, N. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0008 · Cited by 33
Factors Influencing AMPK Activation During Cycling Exercise: A Pooled Analysis and Meta-Regression
Rothschild, J. A., Islam, H., Bishop, D. J., Kilding, A. E., Stewart, T. I., & Plews, D. J. (2021) · Sports Medicine · doi:10.1007/s40279-021-01610-x · Cited by 32
Exercise and Gene Expression
Hargreaves, M. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.006 · Cited by 32
Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA
Gurd, B. J., Menezes, E. S., Arhen, B. B., & Islam, H. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.05.016 · Cited by 31
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases
Swalsingh, G., Pani, P., & Bal, N. C. (2022) · Clinical Science · doi:10.1042/cs20220636 · Cited by 35
Effects of different types of exercise intensity on improving health-related physical fitness in children and adolescents: a systematic review
Zhou, X., Li, J., & Jiang, X. (2024) · Scientific Reports · doi:10.1038/s41598-024-64830-x · Cited by 31
Impact of adrenaline and metabolic stress on exercise‐induced intracellular signaling and PGC‐1α mRNA response in human skeletal muscle
Brandt, N., Gunnarsson, T. P., Hostrup, M., Tybirk, J., Nybo, L., Pilegaard, H., & Bangsbo, J. (2016) · Physiological Reports · doi:10.14814/phy2.12844 · Cited by 32
Cold-water immersion following sprint interval training does not alter endurance signaling pathways or training adaptations in human skeletal muscle
Broatch, J. R., Petersen, A. C., & Bishop, D. J. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00434.2016 · Cited by 36
Beetroot-based gel supplementation improves handgrip strength and forearm muscle O 2 saturation but not exercise tolerance and blood volume in jiu-jitsu athletes
de Oliveira, G. V., do Nascimento, L. A. D., Volino‐Souza, M., Mesquita, J. S., & Álvares, T. S. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0828 · Cited by 35
ADP is the dominant controller of AMP-activated protein kinase activity dynamics in skeletal muscle during exercise
Coccimiglio, I. F., & Clarke, D. C. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008079 · Cited by 32
The effects of combined resveratrol and high intensity interval training on the hippocampus in aged male rats: An investigation into some signaling pathways related to mitochondria.
Amirazodi, M., Mehrabi, A., Rajizadeh, M. A., Bejeshk, M. A., Esmaeilpour, K., Daryanoosh, F., & Gaeini, A. A. (2022) · PubMed Central · doi:10.22038/ijbms.2022.57780.12853 · Cited by 31
Influence of Short vs. Long Repetition Sprint Training on Selected Fitness Components in Young Soccer Players
Meckel, Y., Gefen, Y., Nemet, D., & Eliakim, A. (2011) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318236d0f0 · Cited by 31
Induction of oxidative metabolism by the p38α/MK2 pathway
Trempolec, N., Muñoz, J. P., Slobodnyuk, K., Marín, S., Cascante, M., Zorzano, A., & Nebreda, Á. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-11309-7 · Cited by 30
High Intensity Training (HIT) für die Verbesserung der Ausdauerleistungsfähigkeit von Normalpersonen und im Präventions- & Rehabilitationsbereich
Wahl, P., Hägele, M., Zinner, C., Bloch, W., & Mester, J. (2010) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-010-0857-3 · Cited by 31
High-intensity interval training increases in vivo oxidative capacity with no effect on Pi→ATP rate in resting human muscle
Larsen, R. G., Befroy, D. E., & Kent‐Braun, J. A. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00409.2012 · Cited by 31
No effect of acute and chronic supramaximal exercise on circulating levels of the myokine SPARC
Songsorn, P., Ruffino, J. S., & Vollaard, N. B. J. (2016) · European Journal of Sport Science · doi:10.1080/17461391.2016.1266392 · Cited by 30
High-intensity high-volume swimming induces more robust signaling through PGC-1α and AMPK activation than sprint interval swimming in m. triceps brachii
Casuso, R. A., Plaza‐Díaz, J., Ruiz‐Ojeda, F. J., Aragón‐Vela, J., Robles-Sánchez, C., Nordsborg, N. B., Hebberecht, M., Salmerón, L. M., & Huertas, J. R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185494 · Cited by 30
Hourly 4-s Sprints Prevent Impairment of Postprandial Fat Metabolism from Inactivity
Wolfe, A. S., Burton, H. M., Vardarli, E., & Coyle, E. F. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002367 · Cited by 31
Adaptation of Skeletal Muscles to Contractile Activity of Varying Duration and Intensity: The Role of PGC-1α
Popov, D. V. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918060019 · Cited by 30
The Molecular Signature of High-intensity Training in the Human Body
Wahl, P., Bloch, W., & Proschinger, S. (2021) · International Journal of Sports Medicine · doi:10.1055/a-1551-9294 · Cited by 37
High-intensity interval training enhances oxidative capacity and substrate availability in skeletal muscle
Hoshino, D., Kitaoka, Y., & Hatta, H. (2016) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.5.13 · Cited by 31
Skeletal muscle mechanisms contributing to improved glycemic control following intense interval exercise and training
Islam, H., & Gillen, J. B. (2023) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2023.01.002 · Cited by 36
High Intensity Interval Training: A Potential Method for Treating Sarcopenia
Liu, Q., Xie, W., Luo, Y., Li, Y., Huang, W., Wu, Y., & Li, Y. (2022) · Clinical Interventions in Aging · doi:10.2147/cia.s366245 · Cited by 34
Effect of High-Protein Feeding on Performance and Nitrogen Balance in Female Cyclists
ROWLANDS, D. S., & Wadsworth, D. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181e93316 · Cited by 30
Intensive training and reduced volume increases muscle FXYD1 expression and phosphorylation at rest and during exercise in athletes
Thomassen, M., Gunnarsson, T. P., Christensen, P. M., Pavlović, D., Shattock, M. J., & Bangsbo, J. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00081.2015 · Cited by 29
The Effects of Acute and Chronic Sprint-Interval Training on Cytokine Responses Are Independent of Prior Caffeine Intake
Ferreira, G. A., Felippe, L. C., Bertuzzi, R., Bishop, D. J., Barreto, E., De-Oliveira, F. R., & Lima‐Silva, A. E. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00671 · Cited by 28
Effect of feeding regimen on meat quality, MyHC isoforms, AMPK, and PGC‐1α genes expression in the biceps femoris muscle of Mongolia sheep
Hou, Y., Su, L. C., Su, R., Luo, Y., Wang, B., Yao, D., Zhao, L., & Jin, Y. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1494 · Cited by 27
Mitochondrial function in metabolic health: A genetic and environmental tug of war
Stephenson, E. J., & Hawley, J. A. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.12.004 · Cited by 28
Inclusion of sprints in moderate intensity continuous training leads to muscle oxidative adaptations in trained individuals
Gunnarsson, T. P., Brandt, N., Fiorenza, M., Hostrup, M., Pilegaard, H., & Bangsbo, J. (2019) · Physiological Reports · doi:10.14814/phy2.13976 · Cited by 26
The time course of physiological adaptations to high‐intensity interval training in older adults
Herrod, P., Blackwell, J., Boereboom, C., Atherton, P., Williams, J. P., Lund, J., & Phillips, B. (2020) · Aging Medicine · doi:10.1002/agm2.12127 · Cited by 20
High-intensity interval and endurance training are associated with divergent skeletal muscle adaptations in a rodent model of hypertension
Holloway, T. M., Bloemberg, D., da Silva, M. L., Quadrilatero, J., & Spriet, L. L. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00048.2015 · Cited by 27

Authors: Gibala, M. J., McGee, S. L., Garnham, A. P., Howlett, K. F., Snow, R. J., & Hargreaves, M.
Affiliations: McMaster University (CA)
ORCID: Gibala, Martin J.
McGee, Sean L.
Garnham, Andrew P.
Howlett, Kirsten F.
Snow, Rodney J.
Hargreaves, Mark
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2009-03
Volume: 106
Issue: 3
Pages: 929-934
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.90880.2008
OpenAlex: W2163772556
Cited by: 427
References: 37
Citations by year: 2026: 15 · 2025: 30 · 2024: 22 · 2023: 19 · 2022: 21 · 2021: 23 · 2020: 17 · 2019: 21 · 2018: 23 · 2017: 29 · 2016: 31 · 2015: 33 · 2014: 30 · 2013: 25 · 2012: 25
FWCI: 61.49
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Victoria University Research Repository (Victoria University) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: high-intensity interval exercise, AMPK, p38 MAPK, PGC-1α, mitochondrial biogenesis, skeletal muscle, acute exercise, Akt signaling, vastus lateralis
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Bicycling, Heat-Shock Proteins, Humans, Male, Phosphorylation, Transcription Factors, Exercise, Gene Expression, Muscle, Skeletal, MAP Kinase Signaling System, p38 Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins c-akt, AMP-Activated Protein Kinases, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks