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Cited by 34Schizophrenia research and treatmentVisual perception and processing mechanismsMotor Control and Adaptation

Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia

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Rösler, Lara, Rolfs, Martin, van der Stigchel, Stefan, Neggers, Sebastiaan F. W., Cahn, Wiepke, Kahn, René S., Thakkar, Katharine N.·2015·Journal of Neurophysiology
DOI 10.1152/jn.00155.2015PMC PMC4541139
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Abstract

Corollary discharge (CD) refers to "copies" of motor signals sent to sensory areas, allowing prediction of future sensory states. They enable the putative mechanisms supporting the distinction between self-generated and externally generated sensations. Accordingly, many authors have suggested that disturbed CD engenders psychotic symptoms of schizophrenia, which are characterized by agency distortions. CD also supports perceived visual stability across saccadic eye movements and is used to predict the postsaccadic retinal coordinates of visual stimuli, a process called remapping. We tested whether schizophrenia patients (SZP) show remapping disturbances as evidenced by systematic transsaccadic mislocalizations of visual targets. SZP and healthy controls (HC) performed a task in which a saccadic target disappeared upon saccade initiation and, after a brief delay, reappeared at a horizontally displaced position. HC judged the direction of this displacement accurately, despite spatial errors in saccade landing site, indicating that their comparison of the actual to predicted postsaccadic target location relied on accurate CD. SZP performed worse and relied more on saccade landing site as a proxy for the presaccadic target, consistent with disturbed CD. This remapping failure was strongest in patients with more severe psychotic symptoms, consistent with the theoretical link between disturbed CD and phenomenological experiences in schizophrenia.

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  • The symptomatology of schizophrenia-such as thought insertion-has been understood in terms of a failure of sensory attenuation mechanisms.

    “For instance, the symptomatology of schizophrenia—such as thought insertion, where patients report feeling that their thoughts are not their own—have been understood in terms of a failure of these sensory attenuation mechanisms (Ford and Mathalon 2005; Frith 2005; Rösler et al. 2015; Thakkar et al. 2021).”

    From Consciousness in active inference: Deep self-models, other minds, and the challenge of psychedelic-induced ego-dissolution (2021) · cites this paper as Rösler et al. 2015

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Authors
Rösler, L., Rolfs, M., van der Stigchel, S., Neggers, S. F. W., Cahn, W., Kahn, R. S., & Thakkar, K. N.
Affiliations
  • Goethe University Frankfurt (DE)
  • Humboldt-Universität zu Berlin (DE)
  • Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands; and
  • University Medical Center Utrecht (NL)
Corresponding author
Thakkar, Katharine N.
ORCID
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
2015-08
Volume
114
Issue
2
Pages
1129-1136
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.00155.2015
PMC
PMC4541139
OpenAlex
W2176081155
Cited by
34
References
38
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 1
FWCI
4.05
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurophysiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • Utrecht University Repository (Utrecht University) (submittedVersion)
Funders
  • Nederlands Organisation for Scientific Research (Rubicon grant)
  • DFG Emmy Noether grant (RO 3579/2-1)
  • Dutch Health Resesarch Council (ZON-MW 10-000-1001)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Keywords
corollary discharge, schizophrenia, psychotic symptoms, saccades, agency, visual stability
MeSH terms
Adult, Biomechanical Phenomena, Female, Humans, Judgment, Longitudinal Studies, Male, Neuropsychological Tests, Photic Stimulation, Psychiatric Status Rating Scales, Saccades, Schizophrenia, Schizophrenic Psychology, Space Perception, Antipsychotic Agents

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