The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Combined Unilateral Lesions of the Amygdala and Orbital Prefrontal Cortex Impair Affective Processing in Rhesus Monkeys
Abstract
The amygdala and orbital prefrontal cortex (PFo) interact as part of a system for affective processing. To assess whether there is a hemispheric functional specialization for the processing of emotion or reward or both in nonhuman primates, rhesus monkeys ( Macaca mulatta) with combined lesions of the amygdala and PFo in one hemisphere, either left or right, were compared with unoperated controls on a battery of tasks that tax affective processing, including two tasks that tax reward processing and two that assess emotional reactions. Although the two operated groups did not differ from each other, monkeys with unilateral lesions, left and right, showed altered reward-processing abilities as evidenced by attenuated reinforcer devaluation effects and an impairment in object reversal learning relative to controls. In addition, both operated groups showed blunted emotional reactions to a rubber snake. By contrast, monkeys with unilateral lesions did not differ from controls in their responses to an unfamiliar human (human “intruder”). Although the results provide no support for a hemispheric specialization of function, they yield the novel finding that unilateral lesions of the amygdala-orbitofrontal cortical circuit in monkeys are sufficient to significantly disrupt affective processing.
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Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00411.1998 · Cited by 2,205
Preliminary analysis of functions of the temporal lobes in monkeys
KLÜVER, H. (1939) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1939.02270240017001 · Cited by 1,696
Conscious and unconscious emotional learning in the human amygdala
Morris, J. S., Öhman, A., & Dolan, R. J. (1998) · Nature · doi:10.1038/30976 · Cited by 1,665 · cited 1×
“1994) and functional imaging data (Morris et al. 1998; Whalen et al. 1998) in humans also suggest that the right hemisphere is more important than the”
Dissociation in prefrontal cortex of affective and attentional shifts
Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Nature · doi:10.1038/380069a0 · Cited by 1,527
Baxter, M. G., & Murray, E. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn875 · Cited by 1,200
Self-citationEncoding Predictive Reward Value in Human Amygdala and Orbitofrontal Cortex
Gottfried, J. A., O'Doherty, J., & Dolan, R. J. (2003) · Science · doi:10.1126/science.1087919 · Cited by 1,165
Rolls, E. T., Hornak, J., Wade, D., & McGrath, J. (1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.12.1518 · Cited by 1,005
Fellows, L. K. (2003) · Brain · doi:10.1093/brain/awg180 · Cited by 631
Amygdala circuitry in attentional and representational processes
Holland, P. C., & Gallagher, M. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01271-6 · Cited by 618
Orbitofrontal Cortex and Representation of Incentive Value in Associative Learning
Gallagher, M., McMahan, R. W., & Schoenbaum, G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06610.1999 · Cited by 593
Cited by
Izquierdo, A., Suda, R. K., & Murray, E. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1921-04.2004 · Cited by 588
Self-citationLimbic systems for emotion and for memory, but no single limbic system
Rolls, E. T. (2015) · Cortex · doi:10.1016/j.cortex.2013.12.005 · Cited by 428
Croxson, P. L., Johansen-Berg, H., Behrens, T. E. J., Robson, M. D., Pinsk, M. A., Gross, C. G., Richter, W., Richter, M. C., Kastner, S., & Rushworth, M. F. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1311-05.2005 · Cited by 410
A Role for the Macaque Anterior Cingulate Gyrus in Social Valuation
Rudebeck, P. H., Buckley, M. J., Walton, M. E., & Rushworth, M. F. S. (2006) · Science · doi:10.1126/science.1128197 · Cited by 312
Contributions of the Amygdala to Reward Expectancy and Choice Signals in Human Prefrontal Cortex
Hampton, A. N., Adolphs, R., Tyszka, J. M., & O'Doherty, J. P. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.022 · Cited by 213
Metadata
- Authors
- Izquierdo, A., & Murray, E. A.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2004-05
- Volume
- 91
- Issue
- 5
- Pages
- 2023-2039
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2048637258
- Cited by
- 167
- References
- 16
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Izquierdo, A., & Murray, E. A. (2004). Combined Unilateral Lesions of the Amygdala and Orbital Prefrontal Cortex Impair Affective Processing in Rhesus Monkeys. Journal of Neurophysiology. https://doi.org/10.1152/jn.00968.2003
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