A motor area rostral to the supplementary motor area (presupplementary motor area) in the monkey: Neuronal activity during a learned motor task
Abstract
1. The rostromesial agranular frontal cortex of macaque monkey (Macaca fuscata), traditionally defined as the supplementary motor area (SMA), was studied using various physiological techniques to delineate two different areas rostrocaudally. 2. Field and unitary responses to electrical stimulation of the primary motor cortex were distinct in the caudal part, but minimal or absent in the rostral part. Intracortical microstimulation readily evoked limb or orofacial movements in the caudal part, but only infrequently in the rostral part. Neuronal responses to visual stimuli prevailed in the rostral part, but somatosensory responses were rare. The opposite was true in the caudal part. 3. The rostral part, roughly corresponding to area 6a beta, was operationally defined as the presupplementary motor area (pre-SMA). The caudal part was redefined as the SMA proper. 4. Single-cell activity in the pre-SMA was quantitatively compared with that in the SMA proper in relation to a trained motor task. 5. Phasic responses to visual cue signals indicating the direction of forthcoming arm-reaching movement were more abundant in the pre-SMA. 6. Activity changes during the preparatory period, which lasted until the occurrence of the trigger signal for the reaching movement, were more frequent in the pre-SMA. 7. Phasic, movement-related activity was more frequent in the SMA, and its onset was often time locked to the movement onset. In the pre-SMA, the occurrences of response time locked to the movement-trigger signal were more frequent than in the SMA. 8. Among neurons in both areas, directional selectivity was found in all the cue, preparatory, and movement-related responses.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Findings from electrophysiology, human lesion and functional neuroimaging studies support the crucial role of the pre-SMA in response inhibition.
“Findings from electrophysiology, human lesion and functional neuroimaging studies support the crucial role of the pre-SMA in response inhibition.”
From Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent (2008) · cites this paper as Matsuzaka et al., 1992
Cited by
Sorted by citations
The representing brain: Neural correlates of motor intention and imagery
Jeannerod, M. (1994) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00034026 · Cited by 2,562 · see citing works
Functional role of the supplementary and pre-supplementary motor areas
Nachev, P., Kennard, C., & Husain, M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2478 · Cited by 1,928 · see citing works
Motor Areas of the Medial Wall: A Review of Their Location and Functional Activation
Picard, N., & Strick, P. L. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.3.342 · Cited by 1,712 · see citing works
“Conversely, SMA neurons are characterized by their sensitivity to somatosensory stimuli rather than to instructional cues (Matsuzaka et al., 1992).”
BackgroundInfluentialRizzolatti, G., & Luppino, G. (2001) · Neuron · doi:10.1016/s0896-6273(01)00423-8 · Cited by 1,356 · see citing works
Petrides, M., & Pandya, D. N. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00518.x · Cited by 1,068 · see citing works
“…European Neuroscience Association,European Journal of Neuroscience, 11, 1011–1036 clusters of neurons in medial area 6, both in its caudal and rostral p rts, corresponding to the supplementary motor area proper (SMA) (F3) and pre-SMA (F6), respectively (Luppinoet al., 1991; Matsuzaka et al., 1992).”
BackgroundGrafton, S., Arbib, M., Fadiga, L., & Rizzolatti, G. (1996) · Experimental Brain Research · doi:10.1007/bf00227183 · Cited by 1,045 · see citing works
“Anatomical and physiological data indicate that in the monkey, mesial area 6 (SMA) constitutes two separate areas, F3 (SMA-proper) and F6 (pre-SMA; Luppino et al. 1991; Matelli et al. 1991; Matsuzaka et al. 1992).”
BackgroundSimmonds, D. J., Pekar, J. J., & Mostofsky, S. H. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.07.015 · Cited by 1,015 · see citing works
Functional anatomy of the mental representation of upper extremity movements in healthy subjects
Stephan, K. M., Fink, G. R., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C., & Frackowiak, R. S. J. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.1.373 · Cited by 939 · see citing works
Neural Circuits Underlying Imitation Learning of Hand Actions
Buccino, G., Vogt, S., Ritzl, A., Fink, G. R., Zilles, K., Freund, H.-J., & Rizzolatti, G. (2004) · Neuron · doi:10.1016/s0896-6273(04)00181-3 · Cited by 926 · see citing works
Lewis, P. A., & Miall, R. C. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00036-9 · Cited by 837 · see citing works
“This timing could be accomplished using cortically modulated central pattern generators in the spinal cord, motor cortex based temporal pattern generation [11-13], or temporally predictable changes in activity of buildup cells [14;15].”
BackgroundCorticocortical connections of area F3 (SMA‐proper) and area F6 (pre‐SMA) in the macaque monkey
Luppino, G., Matelli, M., Camarda, R., & Rizzolatti, G. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903380109 · Cited by 795 · see citing works
Self-initiated versus externally triggered movements
Jenkins, I. H., Jahanshahi, M., Jueptner, M., Passingham, R. E., & Brooks, D. J. (2000) · Brain · doi:10.1093/brain/123.6.1216 · Cited by 746 · see citing works
Mayka, M. A., Corcos, D. M., Leurgans, S. E., & Vaillancourt, D. E. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.004 · Cited by 731 · see citing works
“These two regions have been previously differentiated in the monkey (Dum and Strick, 1991;Matelli et al., 1991;Matsuzaka et al., 1992).”
BackgroundUllsperger, M., & von Cramon, D. Y. (2001) · NeuroImage · doi:10.1006/nimg.2001.0935 · Cited by 702 · see citing works
“In contrast to the SMA, which is more closely related to movement execution and effector-specific modulations, the pre-SMA seems to be involved in higher hierarchical roles of motor control (Matsuzaka et al., 1992; Tanji, 1994; Picard and Strick, 1996; Lee et al., 1999; Schubotz and von Cramon, 2001).”
BackgroundChanges in connectivity profiles define functionally distinct regions in human medial frontal cortex
Johansen‐Berg, H., Behrens, T. E. J., Robson, M. D., Drobnjak, I., Rushworth, M. F. S., Brady, J. M., Smith, S. M., Higham, D. J., & Matthews, P. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403743101 · Cited by 684 · see citing works
Johnson, P. B., Ferraina, S., Bianchi, L., & Caminiti, R. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.2.102 · Cited by 705 · see citing works
“Interestingly, similar trends have been observed in other studies (Alexander and Crutcher, 1990; Matsuzaka et al., 1992) of SMA.”
ResultRole for supplementary motor area cells in planning several movements ahead
Tanji, J., & Shima, K. (1994) · Nature · doi:10.1038/371413a0 · Cited by 683 · see citing works
Self-citationKrakauer, J. W., Hadjiosif, A. M., Xu, J., Wong, A. L., & Haith, A. M. (2019) · Comprehensive physiology · doi:10.1002/cphy.c170043 · Cited by 832 · see citing works
Cortical motor reorganization in akinetic patients with Parkinson's disease
Sabatini, U., Boulanouar, K., Fabre, N., Martin, F., Carel, C., Colonnese, C., Bozzao, L., Berry, I., Montastruc, J., Chollet, F., et al. (2000) · Brain · doi:10.1093/brain/123.2.394 · Cited by 592 · see citing works
“…by anatomical (Dum and Strick, 1991; Luppino et al., 1993; Morecraft and Van Hoesen, 1993; Tokuno and Tanji, 1993), electrophysiological (Luppino et al., 1991; Shima et al., 1991; Matsuzaka et al., 1992; for a review, see Devinsky et al., 1995) and clinical observations (Devinsky et al., 1995).”
BackgroundResultThe supplementary motor area in the cerebral cortex
Tanji, J. (1994) · Neuroscience Research · doi:10.1016/0168-0102(94)90038-8 · Cited by 583 · see citing works
Self-citationAn fMRI investigation of syllable sequence production
Bohland, J. W., & Guenther, F. H. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.04.173 · Cited by 545 · see citing works
“These areas included the medial premotor cortices (SMA / pre- SMA / cingulate sulcus), the junction of the frontal operculum and anterior insula bilaterally, the left posterior parietal cortex, the anterior thalamus, the superior cerebellum, and regions of the”
BackgroundInfluentialMotor learning in man: A review of functional and clinical studies
Halsband, U., & Lange, R. K. (2006) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2006.03.007 · Cited by 536 · see citing works
“Furthermore, it was found, that the pre-SMA contains a significantly higher proportion of neuron with cue responses, preparatory activity and time-logged activity to movement trigger signals than the SMA proper when the animal has to select a single movement according to a visual cue (Matsuzaka et al., 1992).”
BackgroundResponse Inhibition and Response Selection: Two Sides of the Same Coin
Mostofsky, S. H., & Simmonds, D. J. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20500 · Cited by 514 · see citing works
“…the pre-SMA, on the other hand, is interconnected with prefrontal and nonprimary motor cortical regions, indicating that its role is upstream of motor execution, namely, in preparing and selecting motor actions (Rizzolatti, Luppino, & Matelli, 1996; Matsuzaka et al., 1992; Dum & Strick, 1991).”
BackgroundRole of the Human Medial Frontal Cortex in Task Switching: A Combined fMRI and TMS Study
Rushworth, M. F. S., Hadland, K. A., Paus, T., & Sipilä, P. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.87.5.2577 · Cited by 516 · see citing works
“…response conflict studies, they have sometimes been assigned to cingulate cortex, but they may be in a human equivalent of the presupplementary motor area (pre-SMA) (Crosson et al. 1999; Deiber et al. 1999; Luppino et al. 1991; Matsuzaka et al. 1992; Picard and Strick 1996; Sakai et al. 1998–2000).”
BackgroundInterconnections between the prefrontal cortex and the premotor areas in the frontal lobe
Lu, M., Preston, J. B., & Strick, P. L. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903410308 · Cited by 501 · see citing works
Rizzolatti, G., Cattaneo, L., Fabbri‐Destro, M., & Rozzi, S. (2014) · Physiological Reviews · doi:10.1152/physrev.00009.2013 · Cited by 496 · see citing works
Coull, J. T., Frith, C., Büchel, C., & Nobre, A. C. (2000) · Neuropsychologia · doi:10.1016/s0028-3932(99)00132-3 · Cited by 479 · see citing works
“Furthermore, the medial premotor activation is just anterior to the anterior commissure, and so may correspond to a `preSMA' area which is associated more with preparation than execution of a motor act [24,35,36].”
BackgroundTransition of Brain Activation from Frontal to Parietal Areas in Visuomotor Sequence Learning
Sakai, K., Hikosaka, O., Miyauchi, S., Takino, R., Sasaki, Y., & Pütz, B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01827.1998 · Cited by 468 · see citing works
“This suggests that the pre-SM A receives declarative information from the DLPFC, via corticocortical connections (Dum and Strick, 1991; Matsuzaka et al., 1992; Luppino et al., 1993), and uses it to generate a procedure for sequential button presses.”
MethodBrain activation patterns during measurement of sub- and supra-second intervals
Lewis, P. A., & Miall, R. C. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(03)00118-0 · Cited by 466 · see citing works
Functional neuroanatomy of the primate isocortical motor system
Geyer, S., Matelli, M., Luppino, G., & Zilles, K. (2000) · Anatomy and Embryology · doi:10.1007/s004290000127 · Cited by 450 · see citing works
“…activity long before the onset of a movement is present almost exclusively in the pre-SMA (Rizzolatti et al. 1990; Alexander and Crutcher 1990; Matsuzaka et al. 1992), whereas phasic activity, more frequently time locked to the movement onset is more common in the SMA proper (Alexander and…”
BackgroundAkkal, D., Dum, R. P., & Strick, P. L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3134-07.2007 · Cited by 437 · see citing works
“…included within the SMA has been subdivided into two distinct areas: the SMA proper (SMA) and a more rostrally located presupplementary motor area (pre-SMA) (Luppino et al., 1991; Matsuzaka et al., 1992; Picard and Strick, 1996, 2001) [for additional references and review, see Tanji (1994, 1996)].”
BackgroundThe role of the pre-supplementary motor area in the control of action
Nachev, P., Wydell, H., O’Neill, K., Husain, M., & Kennard, C. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.034 · Cited by 430 · see citing works
Switching from automatic to controlled action by monkey medial frontal cortex
Isoda, M., & Hikosaka, O. (2007) · Nature Neuroscience · doi:10.1038/nn1830 · Cited by 430 · see citing works
Sequential Organization of Multiple Movements: Involvement of Cortical Motor Areas
Tanji, J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.631 · Cited by 425 · see citing works
“Transient Chemical Inactivation Two recent studies attempted to inactivate the portions of the medial frontal cortex now defined as the presupplementary motor area (pre-SMA) (see Matsuzaka et al 1992; cf Luppino et al 1991) and the newly defined SMA (Tanji 1996) transiently.”
BackgroundSelf-citationNeural representations and mechanisms for the performance of simple speech sequences
Bohland, J. W., Bullock, D., & Guenther, F. H. (2010) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21306 · Cited by 393 · see citing works
“The left prefrontal cortex, specifically in and surrounding the ventral inferior frontal sulcus (IFS), showed increased activity in a memory-guided speaking task when the serial complexity of the utterance was increased (Bohland & Guenther, 2006).”
Rouiller, E. M., Babalian, A. L., Kazennikov, O. V., Moret, V., Yu, X.-H., & Wiesendanger, M. (1994) · Experimental Brain Research · doi:10.1007/bf00227511 · Cited by 392 · see citing works
“For example, a distinction was made between a rostral and a caudal division of the SMA (Wiesendanger 1981,1986), which have also been referred to as "preSMA" and "SMA-proper" (Matsuzaka et al. 1992) or areas "F6" and "F3" (Luppino et al. 1991).”
BackgroundTHE ORGANIZATION OF BEHAVIORAL REPERTOIRE IN MOTOR CORTEX
Graziano, M. S. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112924 · Cited by 364 · see citing works
“The animal’s behavioral repertoire is diverse, different behaviors require different control strategies, and at every level the motor networks are built and trained to produce those actions important to the animal.”
BackgroundThe Cortical Control of Movement Revisited
Graziano, M. S. A., Taylor, C. S. R., Moore, T., & Cooke, D. F. (2002) · Neuron · doi:10.1016/s0896-6273(02)01003-6 · Cited by 364 · see citing works
Ball, T., Schreiber, A., Feige, B., Wagner, M., Lücking, C. H., & Kristeva-Feige, R. (1999) · NeuroImage · doi:10.1006/nimg.1999.0507 · Cited by 351 · see citing works
“Further, we argue hat the intermediate part of the SMA triggers the ctual motor act via the release of inhibition of the rimary motor area.”
BackgroundShima, K., & Tanji, J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.4.2148 · Cited by 351 · see citing works
“We used previously established criteria to differentiate the SMA and pre-SMA (Matsuzaka et al. 1992) based on neuronal responses and the effects of ICMS.”
BackgroundMethodInfluentialSelf-citationOrienting attention to instants in time
Nobre, A. C. (2001) · Neuropsychologia · doi:10.1016/s0028-3932(01)00120-8 · Cited by 339 · see citing works
fMRI evidence that the neural basis of response inhibition is task-dependent
Mostofsky, S. H., Schafer, J. G. B., Abrams, M. T., Goldberg, M. C., Flower, A. A., Boyce, A., Courtney, S. M., Calhoun, V. D., Kraut, M. A., Denckla, M. B., et al. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(03)00144-7 · Cited by 320 · see citing works
Complexity affects regional cerebral blood flow change during sequential finger movements
Sadato, N., Campbell, G., Ibanez, V., Deiber, M., & Hallett, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02691.1996 · Cited by 322 · see citing works
Mapping Behavioral Repertoire onto the Cortex
Graziano, M. S. A., & Aflalo, T. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.013 · Cited by 319 · see citing works
“Yet after the use of a dimensionality reduction to model the primary visual cortex, little work was done to determine whether the same principle might explain the topographic details of other cortical areas.”
BackgroundMethodInfluentialLaryngeal Motor Cortex and Control of Speech in Humans
Simonyan, K., & Horwitz, B. (2011) · The Neuroscientist · doi:10.1177/1073858410386727 · Cited by 310 · see citing works
“We hypothesize that this neuro anatomical difference may underlie the very limited abil ity of nonhuman primates to learn and control their vocalizations voluntarily.”
BackgroundPrimary motor cortex is involved in bimanual coordination
Donchin, O., Gribova, A., Steinberg, O., Bergman, H., & Vaadia, E. (1998) · Nature · doi:10.1038/26220 · Cited by 305 · see citing works
Deiber, M.-P., Ibañez, V., Honda, M., Sadato, N., Raman, R., & Hallett, M. (1998) · NeuroImage · doi:10.1006/nimg.1997.0314 · Cited by 304 · see citing works
“In contrast with the SMA proper, which is mostly active with movement execution, the pre-SMA is thought to be involved in higher motor control (Dum and Strick, 1991; Matsuzaka et al., 1992; Luppino et al., 1993; Halsband et al., 1994; Hikosaka et al., 1996).”
ResultInterval time coding by neurons in the presupplementary and supplementary motor areas
Mita, A., Mushiake, H., Shima, K., Matsuzaka, Y., & Tanji, J. (2009) · Nature Neuroscience · doi:10.1038/nn.2272 · Cited by 301 · see citing works
Self-citationNeural computations underlying action-based decision making in the human brain
Wunderlich, K., Rangel, A., & O'Doherty, J. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901077106 · Cited by 301 · see citing works
Eye fields in the frontal lobes of primates
Tehovnik, E. J., Sommer, M. A., Chou, I.-H., Slocum, W. M., & Schiller, P. H. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00092-2 · Cited by 294 · see citing works
How self-initiated memorized movements become automatic: A functional MRI study
Wu, T., Kansaku, K., & Hallett, M. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01052.2003 · Cited by 286 · see citing works
“Neurons in the SMA-proper were more active when the sequence was remembered and self-determined.”
BackgroundInfluentialThe preparation, execution and suppression of copied movements in the human brain
Krams, M., Rushworth, M. F. S., Deiber, M., Frackowiak, R. S. J., & Passingham, R. E. (1998) · Experimental Brain Research · doi:10.1007/s002210050412 · Cited by 283 · see citing works
“…Crammond 1995; Crammond and Kalaska 1996; Johnson et al. 1996); the supplementary motor area (SMA) and the pre-SMA (Alexander and Crutcher 1990a, b; Matsuzaka et al. 1992; Romo and Schulz 1992); Brodmann area 5 (Riehle et al. 1994; Kalaska and Crammond 1995; Riehle and Requin 1995); middle…”
InfluentialOveractive prefrontal and underactive motor cortical areas in idiopathic dystonia
Ceballos-Baumann, A., Passingham, R. E., Warner, T. T., et al. (1995) · Annals of Neurology · doi:10.1002/ana.410370313 · Cited by 284 · see citing works
Flexible Sensorimotor Computations through Rapid Reconfiguration of Cortical Dynamics
Remington, E. D., Narain, D., Hosseini, E. A., & Jazayeri, M. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.020 · Cited by 273 · see citing works
Decoding a Perceptual Decision Process across Cortex
Hernández, A., Nácher, V., Luna, R., Zainos, A., Lemus, L., Álvarez, M., Vázquez, Y., Camarillo, L., & Romo, R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.031 · Cited by 269 · see citing works
“Pre-SMA is located rostral to a line passing from the midline to the posterior edge of the arcuate sulcus (Matsuzaka et al., 1992).”
BackgroundShima, K., & Tanji, J. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.6.3247 · Cited by 272 · see citing works
“Anesthesia in the monkeys was induced used previously established criteria to differentiate the SMA and with ketamine hydrochloride ( 8 mg / kg im) with atropine sulfate, pre-SMA ( Matsuzaka et al. 1992 ) on the basis of neuronal refollowed by pentobarbital sodium ( 30 mg / kg im) .”
MethodSelf-citationMiyachi, S., Hikosaka, O., & Lu, X. (2002) · Experimental Brain Research · doi:10.1007/s00221-002-1213-7 · Cited by 262 · see citing works
“This difference is similar to the difference in cortical neurons: delay activities are abundant in the DLPC and the pre-SMA neurons, while movement-related activities are more common in SMA and M1 (Funahashi et al. 1989; Mushiake et al. 1991; Matsuzaka et al. 1992).”
BackgroundHikosaka, O., Sakai, K., Miyauchi, S., Takino, R., Sasaki, Y., & Pütz, B. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.1.617 · Cited by 263 · see citing works
“Neurons in the pre-SMA frequently show preparatory activity before a forthcoming movement, whereas neurons in the SMA are more likely to show phasic activities locked with individual movements (Matsuzaka et al. 1992).”
BackgroundNeuronal Activity in Medial Frontal Cortex During Learning of Sequential Procedures
Nakamura, K., Sakai, K., & Hikosaka, O. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.5.2671 · Cited by 262 · see citing works
“In fact, found, however, few neurons in the pre-SMA that fired selec-Matsuzaka et al. (1992) showed that cells with visual retively after errors.sponse were more abundant in the pre-SMA than in the SMA.”
BackgroundTemporal Evolution of a Decision-Making Process in Medial Premotor Cortex
Hernández, A., Zainos, A., & Romo, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00613-x · Cited by 253 · see citing works
“%) varied from the pre-SMA and the SMA-proper of the two”
BackgroundInfluentialRole for cells in the presupplementary motor area in updating motor plans.
Shima, K., Mushiake, H., Saito, N., & Tanji, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8694 · Cited by 245 · see citing works
Self-citationLee, K.-M., Chang, K.-H., & Roh, J.-K. (1999) · NeuroImage · doi:10.1006/nimg.1998.0393 · Cited by 241 · see citing works
McFarland, N. R., & Haber, S. N. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03798.2000 · Cited by 238 · see citing works
“Primary, supplementary, premotor, and cingulate motor areas mediate different aspects of motor control (Alexander and Crutcher, 1990; Shima et al., 1991; Matsuzaka et al., 1992; Dum and Strick, 1993; Kurata, 1993; Rizzolatti et al., 1996; Graziano et al., 1997).”
BackgroundThe Role of Rostral Brodmann Area 6 in Mental-operation Tasks: an Integrative Neuroimaging Approach
Hanakawa, T. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.11.1157 · Cited by 240 · see citing works
“More recent studies in animals show that the SMA, PMd and PMv each have distinct rostral and caudal subdivisions (Matelli et al., 1985; Matsuzaka et al., 1992; Luppino et al., 1993; Lu et al., 1994; Preuss et al., 1996; Geyer et al., 1998).”
BackgroundMorecraft, R. J., Stilwell‐Morecraft, K. S., Cipolloni, P. B., Ge, J., McNeal, D. W., & Pandya, D. Ν. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.12.005 · Cited by 237 · see citing works
Bayesian Computation through Cortical Latent Dynamics
Sohn, H., Narain, D., Meirhaeghe, N., & Jazayeri, M. (2019) · Neuron · doi:10.1016/j.neuron.2019.06.012 · Cited by 226 · see citing works
Brain Activation during Anticipation of Sound Sequences
Leaver, A. M., Lare, J. V., Zielinski, B. A., Halpern, A. R., & Rauschecker, J. P. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4921-08.2009 · Cited by 229 · see citing works
Roles of supplementary motor areas in auditory processing and auditory imagery
Lima, C. F., Krishnan, S., & Scott, S. K. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.06.003 · Cited by 227 · see citing works
Zilles, K., Gottfried Schlaug, A., Matelli, M., Luppino, G., Schleicher, A., Qü, M., Dabringhaus, A., Seitz, R. J., & Roland, P. E. (1995) · PubMed · Cited by 232 · see citing works
Shen, L., & Alexander, G. E. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.3.1195 · Cited by 229 · see citing works
“AND SHEN, L. Phasic responses to sensory cues in the1993; Matsuzaka et al. 1992; Steinmetz and Constantinidis dorsal premotor area reflect abstract features of the instructed movement 1995), and these are differentiated by varying amounts and rather than specific details such as movement trajectory.”
Inase, M., Tokuno, H., Nambu, A., Akazawa, T., & Takada, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01531-0 · Cited by 227 · see citing works
Boecker, H., Dagher, A., Ceballos-Baumann, A., Passingham, R. E., Samuel, M., Friston, K. J., Poline, J.-B., Dettmers, C., Conrad, B., & Brooks, D. J. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.2.1070 · Cited by 227 · see citing works
“…of disturbed motor se- unit activity in rostral SMA (i.e., pre-SMA) during preparatory periods before performance of prelearned movementquence performance after repetitive transcranial magnetic stimulation over the ipsilateral primary motor cortex (Chen (Matsuzaka et al. 1992; Tanji 1994).”
BackgroundTalati, A., & Joy Hirsch, C. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929054475226 · Cited by 225 · see citing works
Percheron, G., François, C., Talbi, B., Yelnik, J., & Fénelon, G. (1996) · Brain Research Reviews · doi:10.1016/0165-0173(96)00003-3 · Cited by 230 · see citing works
Halsband, U., Matsuzaka, Y., & Tanji, J. (1994) · Neuroscience Research · doi:10.1016/0168-0102(94)90032-9 · Cited by 225 · see citing works
Self-citationSupplementary motor area as key structure for domain-general sequence processing: A unified account
Cona, G., & Semenza, C. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.033 · Cited by 218 · see citing works
Organization of Action Sequences and the Role of the Pre-SMA
Kennerley, S. W., Sakai, K., & Rushworth, M. F. S. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00651.2003 · Cited by 217 · see citing works
“was a result of the TMS’ greater proximity to the SMA region which might be more closely concerned with the execution of individual movements (Lee et al. 1999; Matsuzaka et al. 1992).”
BackgroundResultFunctional Anatomy of a Prelearned Sequence of Horizontal Saccades in Humans
Petit, L., Orssaud, C., Tzourio‐Mazoyer, N., Crivello, F., Berthoz, A., & Mazoyer, B. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-11-03714.1996 · Cited by 214 · see citing works
“Electro- physiological findings have provided sufficient evidence that two separate motor areas exist in the SMA traditionally defined as a single motor area corresponding to the medial part of Brodmann’s area 6 (for review, see Tanji, 1994).”
BackgroundInfluentialNew concepts of the supplementary motor area
Tanji, J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80028-6 · Cited by 216 · see citing works
Self-citationNeurocognitive mechanisms of action control: resisting the call of the Sirens.
Richard Ridderinkhof, K., Forstmann, B. U., Wylie, S. A., Burle, B., & van den Wildenberg, W. P. M. (2011) · WIREs Cognitive Science · doi:10.1002/wcs.99 · Cited by 215 · see citing works
Premotor cortex is involved in restoration of gait in stroke
Miyai, I., Yagura, H., Oda, I., Konishi, I., Eda, H., Suzuki, T., & Kubota, K. (2002) · Annals of Neurology · doi:10.1002/ana.10274 · Cited by 214 · see citing works
“Neurons in the pre-SMAs are activated during the skill acquisition in the monkey.(39,40) In our study, all patients had severe hemiplegia requiring maximal assistance in gait.”
BackgroundfMRI studies of temporal attention: allocating attention within, or towards, time
Coull, J. T. (2004) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2004.02.011 · Cited by 205 · see citing works
“More specifically, the SMA activation was in the region of preSMA which has been associated more with preparation than execution of a motor act [21,28,36] as well as in sequencing of motor acts [7,64,66].”
BackgroundInterval and Ordinal Properties of Sequences Are Associated with Distinct Premotor Areas
Schubotz, R. I. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.3.210 · Cited by 211 · see citing works
Movement-related change of electrocorticographic activity in human supplementary motor area proper
Ohara, S. (2000) · Brain · doi:10.1093/brain/123.6.1203 · Cited by 209 · see citing works
Rouiller, E. M., Liang, F., Babalian, A. L., Moret, V., & Wiesendanger, M. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903450204 · Cited by 209 · see citing works
Cortical correlates of learning in monkeys adapting to a new dynamical environment
Gandolfo, F., Li, C.-S. R., Benda, B. J., Schioppa, C. P., & Bizzi, E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040567097 · Cited by 209 · see citing works
Nagahama, Y., Okada, T., Katsumi, Y., Hayashi, T., Yamauchi, H., Sawamoto, N., Toma, K., Nakamura, K., Hanakawa, T., Konishi, J., et al. (1999) · NeuroImage · doi:10.1006/nimg.1999.0451 · Cited by 203 · see citing works
Cortical connections of the anterior (F5a) subdivision of the macaque ventral premotor area F5
Gerbella, M., Belmalih, A., Borra, E., Rozzi, S., & Luppino, G. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0293-6 · Cited by 198 · see citing works
“F5a displays a very dense ‘‘intrinsic’’ connectivity with F5c and F5p, premotor connections limited to F4 and F6/pre-SMA, relatively robust prefrontal connections with areas 46v and 12, and dense connections with rostral opercular frontal areas.”
InfluentialKemmerer, D. L., & González-Castillo, J. (2008) · Brain and Language · doi:10.1016/j.bandl.2008.09.010 · Cited by 197 · see citing works
Crosson, B., Benefield, H., Cato, A., Sadek, J. R., MOORE, A. B., Wierenga, C. E., Gopinath, K., Soltysik, D. A., Bauer, R. M., Auerbach, E. J., et al. (2003) · Journal of the International Neuropsychological Society · doi:10.1017/s135561770397010x · Cited by 194 · see citing works
“Pre-SMA is the anterior portion of medial Brodmann’s area 6 (Matsuzaka et al., 1992; Paus, 2001; Picard & Strick 1996, 2001).”
BackgroundNakahara, H., Doya, K., & Hikosaka, O. (2001) · Journal of Cognitive Neuroscience · doi:10.1162/089892901750363208 · Cited by 192 · see citing works
“The current coordinator output is closely related to the current visual input; The neural activity in the pre-SMA tends to be more active after receiving sensory inputs and before starting movement, that is, is closely related to the current visual input (Matsuzaka et al. 1992; Halsband et al. 1994; Sakai et al. 1999).”
BackgroundInfluentialThe Place of the Thalamus in Frontal Cortical-Basal Ganglia Circuits
Haber, S. N., & McFarland, N. R. (2001) · The Neuroscientist · doi:10.1177/107385840100700408 · Cited by 187 · see citing works
Fontaine, D., Capelle, L., & Duffau, H. (2002) · Neurosurgery · doi:10.1097/00006123-200202000-00011 · Cited by 193 · see citing works
The functions of the medial premotor cortex
Thaler, D., Chen, Y.-C., Nixon, P. D., Stern, C. E., & Passingham, R. E. (1995) · Experimental Brain Research · doi:10.1007/bf00230649 · Cited by 193 · see citing works
Tokuno, H., & Tanji, J. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903330206 · Cited by 190 · see citing works
Self-citationFrontal and Parietal Lobe Activation during Transitive Inference in Humans
Acuna, B. D. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.12.1312 · Cited by 188 · see citing works
“Activation of SMA in the HT–VIS comparison, in turn, may result from one of several support processes (Matsuzaka et al., 1992; Halsband et al., 1994; Tanji, 1994).”
ResultCortical control of motor sequences
Ashe, J., Lungu, O. V., Basford, A. T., & Lu, X. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.03.008 · Cited by 185 · see citing works
Hoshi, E., & Tanji, J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00547.2004 · Cited by 181 · see citing works
“From caudal to rostral in the SMA, we found somatotopic representation arranged in the order leg, hip, trunk, arm, and face, as reported previously (Luppino et al. 1991; Matsuzaka et al. 1992; Mitz and Wise 1987).”
BackgroundResultInfluentialSelf-citationKrakauer, J. W., Hadjiosif, A. M., Xu, J., Wong, A. L., & Haith, A. M. (2019) · Comprehensive physiology · doi:10.1002/j.2040-4603.2019.tb00069.x · Cited by 189 · see citing works
Conversion of sensory signals into perceptual decisions
Romo, R., & de Lafuente, V. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.03.007 · Cited by 181 · see citing works
- Authors
- Matsuzaka, Y., Aizawa, H., & Tanji, J.
- Affiliations
- Tohoku University (JP)
- ORCID
- Matsuzaka, Y.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1992-09-01
- Volume
- 68
- Issue
- 3
- Pages
- 653-662
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2253058536
- Cited by
- 500
- References
- 0
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 5 · 2023: 23 · 2022: 7 · 2021: 11 · 2020: 10 · 2019: 14 · 2018: 11 · 2017: 9 · 2016: 10 · 2015: 13 · 2014: 12 · 2013: 10 · 2012: 15
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- pre-supplementary motor area, supplementary motor area, macaque, primary motor cortex, single-unit activity, arm reaching, movement-related activity, preparatory period, direction selectivity, intracortical microstimulation
- MeSH terms
- Animals, Arm, Cues, Electric Stimulation, Eye Movements, Female, Learning, Macaca, Male, Motor Activity, Motor Cortex, Movement, Neurons, Sensation, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
