Cited by 160Neural dynamics and brain functionSleep and Wakefulness ResearchNeuroscience and Neuropharmacology Research

Extracellular Calcium Fluctuations and Intracellular Potentials in the Cortex During the Slow Sleep Oscillation

Massimini, Marcello, Amzica, Florin·2001·Journal of Neurophysiology

Abstract

During slow wave sleep the main activity of cortical neurons consists of synchronous and rhythmic alternations of the membrane potential between depolarized and hyperpolarized values. The latter are long-lasting (200–600 ms) periods of silence. The mechanisms responsible for this periodical interruption of cortical network activity are unknown. Here we report a decrease of ∼20% in the extracellular calcium concentration ([Ca]out) progressively taking place in the cortex between the onset and the offset of the depolarizing phase of the slow sleep oscillation. Since [Ca]out exerts a high gain modulation of synaptic transmission, we estimated the associated transmitter release probability and found a corresponding 50% drop. Thus the periods of silence occurring in the cortical network during slow wave sleep are promoted by recurrent [Ca]out depletions.

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Crossref · 10.1152/jn.2001.85.3.1346

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  • Extracellular Ca2+ concentrations are increased during the downstate, which enhances synaptic efficacy, such that a single spike generated in this condition may effectively excite the whole network.

    “Moreover, extracellular Ca 2ϩ concentrations are increased during the downstate, which enhances synaptic efficacy, such that a single spike generated in this condition may effectively excite the whole network (238, 790), in particular when such spikes originate from neurons in deep cortical layers with larger numbers of synaptic contacts to other neurons (188).”

    From About Sleep's Role in Memory (2013) · cites this paper as [790]

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Authors
Massimini, M., & Amzica, F.
Affiliations
Université Laval (CA)
Venue
Journal of Neurophysiology
Published
2001-03-01
Volume
85
Issue
3
Pages
1346-1350
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
OpenAlex
W2208002446
Cited by
160
References
38
Citations by year
2026: 3 · 2025: 7 · 2024: 4 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 1 · 2015: 10 · 2014: 9 · 2013: 5 · 2012: 9
FWCI
6.45
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
slow-wave sleep, extracellular calcium, hyperpolarization, synaptic transmission, calcium depletion, cortical network activity, sleep spindles
MeSH terms
Animals, Biological Clocks, Calcium, Cats, Cerebral Cortex, Electric Stimulation, Electrodes, Implanted, Electroencephalography, Extracellular Space, Membrane Potentials, Microelectrodes, Nerve Net, Neurons, Pons, Sleep, Tegmentum Mesencephali

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