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Cited by 266Neural dynamics and brain functionSleep and Wakefulness ResearchNeuroscience and Neuropharmacology Research

Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation

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Chauvette, Sylvain, Volgushev, Maxim, Timofeev, Igor·2010·Cerebral Cortex
DOI 10.1093/cercor/bhq009PMC PMC2951844
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Abstract

Slow-wave sleep is characterized by spontaneous alternations of activity and silence in corticothalamic networks, but the causes of transition from silence to activity remain unknown. We investigated local mechanisms underlying initiation of activity, using simultaneous multisite field potential, multiunit recordings, and intracellular recordings from 2 to 4 nearby neurons in naturally sleeping or anesthetized cats. We demonstrate that activity may start in any neuron or recording location, with tens of milliseconds delay in other cells and sites. Typically, however, activity originated at deep locations, then involved some superficial cells, but appeared later in the middle of the cortex. Neuronal firing was also found to begin, after the onset of active states, at depths that correspond to cortical layer V. These results support the hypothesis that switch from silence to activity is mediated by spontaneous synaptic events, whereby any neuron may become active first. Due to probabilistic nature of activity onset, the large pyramidal cells from deep cortical layers, which are equipped with the most numerous synaptic inputs and large projection fields, are best suited for switching the whole network into active state.

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  • High-density EEG recordings in humans as well as depth recordings in epileptic patients and cats indicate that the slow oscillation behaves like a travelling wave, which originates most frequently in the frontal regions and propagates towards posterior regions, although other origins and directions of propagation occur.

    “High-density EEG recordings in humans as well as depth recordings in epileptic patients and cats indicate that the slow oscillation behaves like a travelling wave, which originates most frequently in the frontal regions and propagates towards posterior regions, although other origins and directions of propagation occur (188, 748, 791, 841, 859, 1261, 1314).”

    From About Sleep's Role in Memory (2013) · cites this paper as [188]

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  • Virtually every cortical neuron, both excitatory and inhibitory, engages in the slow oscillation with firing patterns showing high synchrony across cellular populations.

    “Virtually every cortical neuron, both excitatory as well as inhibitory neuron, engages in the slow oscillation with the firing patterns showing high synchrony across cellular populations (33,188,1139,1146,1261,1268).”

    From About Sleep's Role in Memory (2013) · cites this paper as [188]

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Authors
Chauvette, S., Volgushev, M., & Timofeev, I.
Affiliations
  • Université Laval (CA)
  • University of Connecticut (US)
Corresponding author
Timofeev, Igor
ORCID
Venue
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Published
2010-03-03
Volume
20
Issue
11
Pages
2660-2674
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
DOI
10.1093/cercor/bhq009
PMC
PMC2951844
OpenAlex
W2144398166
Cited by
266
References
9
Citations by year
2026: 9 · 2025: 13 · 2024: 13 · 2023: 10 · 2022: 15 · 2021: 15 · 2020: 10 · 2019: 26 · 2018: 16 · 2017: 19 · 2016: 21 · 2015: 21 · 2014: 15 · 2013: 26 · 2012: 12
FWCI
12.22
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Cerebral Cortex (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Corpus Université Laval (Université Laval) (submittedVersion)
Funders
  • National Institutes of Health (5r01ns060870-04)
  • Canadian Institutes of Health Research (/MOP-67175, /MOP-37862)
  • National Institute of Neurological Disorders and Stroke (R01-NS-060870, 1R01NS060870-01)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
slow-wave sleep, corticothalamic network, spontaneous neuronal activity, activity onset, cortical layer V, pyramidal neurons, sleep spindles, cats
MeSH terms
Action Potentials, Animals, Biological Clocks, Cats, Female, Male, Nerve Net, Neurons, Sleep, Neocortex

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