Altered Hippocampal Synaptic Plasticity in the Fmr1 Gene Family Knockout Mouse Models

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481

The mGluR theory of fragile X mental retardation

Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349

Fmr1 knockout mice: A model to study fragile X mental retardation

THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,108

Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits

Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046

Correction of Fragile X Syndrome in Mice

Dölen, G., Osterweil, E., Rao, B. S. S., Smith, G. B., Auerbach, B. D., Chattarji, S., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.12.001 · Cited by 979

The FMR–1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation

Devys, D., Lutz, Y., Rouyer, N., Bellocq, J., & Mandel, J. (1993) · Nature Genetics · doi:10.1038/ng0893-335 · Cited by 781

Fear conditioning induces a lasting potentiation of synaptic currents in vitro

McKernan, M. G., & Shinnick-Gallagher, P. (1997) · Nature · doi:10.1038/37605 · Cited by 771

Drosophila Fragile X-Related Gene Regulates the MAP1B Homolog Futsch to Control Synaptic Structure and Function

Zhang, Y., Bailey, A. M., Matthies, H. J. G., Renden, R., Smith, M. A., Speese, S. D., Rubin, G. M., & Broadie, K. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00589-x · Cited by 651

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

Weiler, I. J., Irwin, S. A., Klintsova, A. Y., Spencer, C. M., Brazelton, A. D., Miyashiro, K., Comery, T. A., Patel, B., Eberwine, J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5395 · Cited by 644

Dysregulation of mTOR signaling in fragile X syndrome

Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3696-09.2010 · Cited by 557

The translation of translational control by FMRP: therapeutic targets for FXS

Darnell, J. C., & Klann, E. (2013) · Nature Neuroscience · doi:10.1038/nn.3379 · Cited by 491

The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)

Bhakar, A. L., Dölen, G., & Bear, M. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153138 · Cited by 370

Fragile X mental retardation protein and synaptic plasticity

Sidorov, M. S., Auerbach, B. D., & Bear, M. F. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-15 · Cited by 255

Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops

Mullins, C., Fishell, G., & Tsien, R. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.017 · Cited by 167

Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs

Darnell, J. C., Fraser, C., Mostovetsky, O., & Darnell, R. B. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp255 · Cited by 160

Early developmental alterations in GABAergic protein expression in fragile X knockout mice

Adusei, D. C., Pacey, L. K. K., Chen, D., & Hampson, D. R. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.05.002 · Cited by 139

Abnormal Presynaptic Short-Term Plasticity and Information Processing in a Mouse Model of Fragile X Syndrome

Deng, P., Sojka, D., & Klyachko, V. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2021-11.2011 · Cited by 139

The GABAA Receptor Agonist THIP Ameliorates Specific Behavioral Deficits in the Mouse Model of Fragile X Syndrome

Olmos-Serrano, J. L., Corbin, J. G., & Burns, M. P. (2011) · Developmental Neuroscience · doi:10.1159/000332884 · Cited by 134

Of Men and Mice: Modeling the Fragile X Syndrome

Dahlhaus, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00041 · Cited by 133

Proteomics, Ultrastructure, and Physiology of Hippocampal Synapses in a Fragile X Syndrome Mouse Model Reveal Presynaptic Phenotype

Klemmer, P., Meredith, R. M., Holmgren, C. D., Klychnikov, O. I., Stahl-Zeng, J., Loos, M., van der Schors, R. C., Wortel, J., de Wit, H., Spijker, S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.210260 · Cited by 103

RNA-Binding Protein FXR2 Regulates Adult Hippocampal Neurogenesis by Reducing Noggin Expression

Guo, W., Zhang, L., Christopher, D. M., Teng, Z., Fausett, S. R., Liu, C.-M., George, O. L., Klingensmith, J., Jin, P., & Zhao, X. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.027 · Cited by 96

Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition

Deliu, E., Arecco, N., Morandell, J., Dotter, C. P., Contreras, X., Girardot, C., Käsper, E.-L., Kozlova, A., Kishi, K., Chiaradia, I., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0266-2 · Cited by 89

Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms

Guo, W., Polich, E. D., Su, J., Gao, Y., Christopher, D. M., Allan, A. M., Wang, M., Wang, F., Wang, G., & Zhao, X. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.013 · Cited by 84

Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats

Tian, Y., Yang, C., Shang, S., Cai, Y., Deng, X., Zhang, J., Shao, F., Zhu, D., Liu, Y., Chen, G., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00269 · Cited by 82

Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions

Akins, M. R., LeBlanc, H. F., Stackpole, E. E., Chyung, E., & Fallon, J. R. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23123 · Cited by 78

Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome

Bostrom, C. A., Yau, S., Majaess, N. M., Vetrici, M. A., Gil‐Mohapel, J., & Christie, B. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.033 · Cited by 87

Activity-dependent modulation of neural circuit synaptic connectivity

Tessier, C. R. (2009) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.008.2009 · Cited by 80

RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation

Nakayama, K., Ohashi, R., Shinoda, Y., Yamazaki, M., Abe, M., Fujikawa, A., Shigenobu, S., Futatsugi, A., Noda, M., Mikoshiba, K., et al. (2017) · eLife · doi:10.7554/elife.29677 · Cited by 73

The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia

Enríquez-Barreto, L., & Morales, M. (2016) · Journal of Green Engineering · doi:10.1186/s40591-016-0047-9 · Cited by 73

Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1

Dvořák, D., Radwan, B., Sparks, F. T., Talbot, Z. N., & Fenton, A. A. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2003354 · Cited by 78

Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P

Coffee, R. L., Tessier, C. R., Woodruff, E. A., & Broadie, K. S. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004598 · Cited by 71

Antipsychotic Drug Responsiveness and Dopamine Receptor Signaling; Old Players and New Prospects

Rampino, A., Marakhovskaia, A., Soares-Silva, T., Torretta, S., Veneziani, F., & Beaulieu, J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00702 · Cited by 72

Signals, synapses, and synthesis: how new proteins control plasticity

Zukin, R. S. (2009) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.014.2009 · Cited by 75

Behavioral and Synaptic Circuit Features in a Zebrafish Model of Fragile X Syndrome

Ng, M.-C., Yang, Y.-L., & Lu, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0051456 · Cited by 70

Genetic and cognitive windows into circuit mechanisms of psychiatric disease

Arguello, P. A., & Gogos, J. A. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.007 · Cited by 70

Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins

Chen, E., & Joseph, S. (2015) · Biochimie · doi:10.1016/j.biochi.2015.02.005 · Cited by 66

Homeostatic Responses Fail to Correct Defective Amygdala Inhibitory Circuit Maturation in Fragile X Syndrome

Vislay, R. L., Martin, B. S., Olmos-Serrano, J. L., Kratovac, S., Nelson, D. L., Corbin, J. G., & Huntsman, M. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2764-12.2013 · Cited by 62

Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome

Costa, L., Sardone, L. M., Lacivita, E., Leopoldo, M., & Ciranna, L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00065 · Cited by 57

Concise Review: Fragile X Proteins in Stem Cell Maintenance and Differentiation

Li, Y., & Zhao, X. (2014) · Stem Cells · doi:10.1002/stem.1698 · Cited by 57

Short- and Long-Term Memory Are Modulated by Multiple Isoforms of the Fragile X Mental Retardation Protein

Banerjee, P., Schoenfeld, B. P., Bell, A. J., Choi, C. H., Bradley, M. P., Hinchey, P., Kollaros, M., Park, J. H., McBride, S. M. J., & Dockendorff, T. C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6369-09.2010 · Cited by 55

Revisiting the flip side: Long-term depression of synaptic efficacy in the hippocampus

Pinar, C., Fontaine, C. J., Triviño-Paredes, J., Lottenberg, C. P., Gil‐Mohapel, J., & Christie, B. R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.001 · Cited by 60

Fragile X mental retardation protein (FMRP) interacting proteins exhibit different expression patterns during development

Bonaccorso, C. M., Spatuzza, M., Di Marco, B., Gloria, A., Barrancotto, G., Cupo, A., Musumeci, S. A., D'Antoni, S., Bardoni, B., & Catania, M. V. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.02.004 · Cited by 52

Pharmacological Rescue of Cortical Synaptic and Network Potentiation in a Mouse Model for Fragile X Syndrome

Chen, T., Lu, J.-S., Song, Q., Liu, M.-G., Koga, K., Descalzi, G., Li, Y.-Q., & Zhuo, M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.44 · Cited by 52

Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome

Costa, L., Sardone, L. M., Bonaccorso, C. M., D’Antoni, S., Spatuzza, M., Gulisano, W., Tropea, M. R., Puzzo, D., Leopoldo, M., Lacivita, E., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00353 · Cited by 49

The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling

Blair, L. J., Criado‐Marrero, M., Zheng, D., Wang, X., Kamath, S. G., Nordhues, B. A., Weeber, E. J., & Dickey, C. A. (2019) · eNeuro · doi:10.1523/eneuro.0242-18.2019 · Cited by 48

Molecular and Cellular Aspects of Mental Retardation in the Fragile X Syndrome: From Gene Mutation/s to Spine Dysmorphogenesis

De Rubeis, S., Fernández, E., Buzzi, A., Di Marino, D., & Bagni, C. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-7091-0932-8_23 · Cited by 48

How Do Short-Term Changes at Synapses Fine-Tune Information Processing?

Klug, A., Borst, J. G. G., Carlson, B. A., Kopp‐Scheinpflug, C., Klyachko, V. A., & Xu‐Friedman, M. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3348-12.2012 · Cited by 47

Defects in translational regulation contributing to human cognitive and behavioral disease

Darnell, J. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.05.002 · Cited by 43

FXR1P Limits Long-Term Memory, Long-Lasting Synaptic Potentiation, and De Novo GluA2 Translation

Cook, D., Nuro, E., Jones, E. V., Altimimi, H. F., Farmer, W. T., Gandin, V., Hanna, E., Zong, R.-T., Barbon, A., Nelson, D. L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.028 · Cited by 42

Abnormal Sleep Architecture and Hippocampal Circuit Dysfunction in a Mouse Model of Fragile X Syndrome

Boone, C. E., Davoudi, H., Harrold, J. B., & Foster, D. J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.012 · Cited by 45

Altered Connectivity and Synapse Maturation of the Hippocampal Mossy Fiber Pathway in a Mouse Model of the Fragile X Syndrome

Scharkowski, F., Frotscher, M., Lutz, D., Körte, M., & Michaelsen‐Preusse, K. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw408 · Cited by 40

Molecular biomarkers predictive of sertraline treatment response in young children with fragile X syndrome

AlOlaby, R. R., Sweha, S. R., Silva, M., Durbin-Johnson, B. P., Yrigollen, C. M., Pretto, D. I., Hagerman, R. J., & Tassone, F. (2017) · Brain and Development · doi:10.1016/j.braindev.2017.01.012 · Cited by 41

Abnormal neuronal morphology and neurochemistry in the auditory brainstem of Fmr1 knockout rats.

Ruby, K., Falvey, K., & Kulesza, R. J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.061 · Cited by 41

Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder

Long, J., Li, H., Liu, Y., Liao, X., Tang, Z., Han, K., Chen, J., & Zhang, H. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1364858 · Cited by 43

Serotonin dysregulation in Fragile X Syndrome: implications for treatment

Hanson, A. C., & Hagerman, R. J. (2014) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2014.01027 · Cited by 40

Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury

Zhu, Z., Huang, X., Du, M., Wu, C., Fu, J., Tan, W., Wu, B., Zhang, J., & Liao, Z. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02126-8 · Cited by 41

Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders

Kim, K. C., Gonzales, E. L., Lázaro, M. T., Choi, C. S., Bahn, G. H., Yoo, H. J., & Shin, C. Y. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.061 · Cited by 44

Fmr1 KO and Fenobam Treatment Differentially Impact Distinct Synapse Populations of Mouse Neocortex

Wang, G. X., Smith, S. J., & Mourrain, P. (2014) · Neuron · doi:10.1016/j.neuron.2014.11.016 · Cited by 36

Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse

Fujiwara, K., Fujita, Y., Kasai, A., Onaka, Y., Hashimoto, H., Okada, H., & Yamashita, T. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.31 · Cited by 35

Functional rescue of excitatory synaptic transmission in the developing hippocampus in Fmr1-KO mouse

Meredith, R. M., de Jong, R., & Mansvelder, H. D. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.08.026 · Cited by 35

Fragile X Syndrome and Alzheimers Disease: Another Story About APP and β -Amyloid

Malter, J. S., Ray, B. C., Westmark, P. R., & Westmark, C. J. (2010) · Current Alzheimer Research · doi:10.2174/156720510791050957 · Cited by 34

The Fragile X proteins Fmrp and Fxr2p cooperate to regulate glucose metabolism in mice

Lumaban, J. G., & Nelson, D. L. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu737 · Cited by 37

Annual Research Review: Transgenic mouse models of childhood‐onset psychiatric disorders

Robertson, H. R., & Feng, G. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02380.x · Cited by 33

Fragile X Related Protein 1 Clusters with Ribosomes and Messenger RNAs at a Subset of Dendritic Spines in the Mouse Hippocampus

Cook, D., Sánchez‐Carbente, M. D. R., Lachance, C., Radzioch, D., Tremblay, S., Khandjian, É. W., DesGroseillers, L., & Murai, K. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026120 · Cited by 33

Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampusPreprint

Connor, S. A., Hoeffer, C. A., Klann, E., & Nguyen, P. (2011) · Learning & Memory · doi:10.1101/lm.2043811 · Cited by 32

Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission

Khlghatyan, J., Evstratova, A., Chamberland, S., Marakhovskaia, A., Bahremand, A., Tóth, K., & Beaulieu, J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00119 · Cited by 31

Impaired GABA neural circuits are critical for fragile X syndrome.

Gao, F., Qi, L., Yang, Z., Yang, T., Zhang, Y., Xu, H., & Zhao, H. (2018) · Neural Plasticity · doi:10.1155/2018/8423420 · Cited by 30

A presynaptic role for FMRP during protein synthesis–dependent long-term plasticity in AplysiaPreprint

Till, S. M., Li, H.-L., Miniaci, M. C., Kandel, E. R., & Choi, Y. (2010) · Learning & Memory · doi:10.1101/lm.1958811 · Cited by 30

New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model

Busquets-García, A., Maldonado, R. J., & Ozaita, A. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.05.004 · Cited by 28

Parental origin impairment of synaptic functions and behaviors in cytoplasmic FMRP interacting protein 1 (Cyfip1) deficient mice

Chung, L., Wang, X., Zhu, L., Towers, A. J., Cao, X., Kim, I. H., & Jiang, Y. (2015) · Brain Research · doi:10.1016/j.brainres.2015.10.015 · Cited by 25

FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression

Fernandez, E., Li, K. W., Rajan, N., Rubeis, S. D., Fiers, M. W. E. J., Smit, A. B., Achsel, T., & Bagni, C. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4800-14.2015 · Cited by 23

A comparative study of the performance of individuals with fragile X syndrome and Fmr1 knockout mice on Hebb‐Williams mazes

MacLeod, L. S., Kogan, C. S., Collin, C. A., Berry‐Kravis, E., Messier, C., & Gandhi, R. M. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00534.x · Cited by 22

Dynamic Regulation of Synaptic Maturation State by Voltage-Gated A-Type K+Channels in CA1 Hippocampal Pyramidal Neurons

Kim, E., & Hoffman, D. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2373-12.2012 · Cited by 21

Activity‐dependent regulation of release probability at excitatory hippocampal synapses: a crucial role of fragile X mental retardation protein in neurotransmission

Wang, X., Peng, C., Cai, W., Xia, J., Jin, D., Dai, Y., Luo, X., Klyachko, V. A., & Deng, P. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12546 · Cited by 21

Transient Enhanced GluA2 Expression in Young Hippocampal Neurons of a Fragile X Mouse Model

Banke, T. G., & Barría, A. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.588295 · Cited by 20

Increasing our understanding of human cognition through the study of fragile X syndrome

Cook, D., Nuro, E., & Murai, K. K. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22096 · Cited by 22

miR-132 Regulates PTSD-like Behaviors in Rats Following Single-Prolonged Stress Through Fragile X-Related Protein 1

Nie, P.-Y., Ji, L.-L., Fu, C.-H., Peng, J., Wang, Z., & Tong, L. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00854-x · Cited by 19

Translational control of synaptic plasticity

Richter, J. D. (2010) · Biochemical Society Transactions · doi:10.1042/bst0381527 · Cited by 19

Disrupted inhibitory plasticity and homeostasis in Fragile X syndrome

Rio, C. A. C.-D., Nunez-Parra, A., Freedman, S., Kushner, J. K., Alexander, A., Restrepo, D., & Huntsman, M. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104959 · Cited by 19

FMRP Mediates Chronic Ethanol‐Induced Changes in NMDA, Kv4.2, and KChIP3 Expression in the Hippocampus

Spencer, K. B., Mulholland, P. J., & Chandler, L. J. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13060 · Cited by 17

Are FXR Family Proteins Integrators of Dopamine Signaling and Glutamatergic Neurotransmission in Mental Illnesses?

Khlghatyan, J., & Beaulieu, J. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00022 · Cited by 19

FMRP ribonucleoprotein complexes and RNA homeostasis

Suardi, G. A. M., & Haddad, L. A. (2020) · Advances in genetics · doi:10.1016/bs.adgen.2020.01.001 · Cited by 18

Serotonin 5‐HT7 receptors require cyclin‐dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome

Costa, L., Tempio, A., Lacivita, E., Leopoldo, M., & Ciranna, L. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15246 · Cited by 16

Mechanisms regulating input-output function and plasticity of neurons in the absence of FMRP

Booker, S. A., & Kind, P. C. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.06.025 · Cited by 16

Comparative Behavioral Phenotypes of Fmr1 KO, Fxr2 Het, and Fmr1 KO/Fxr2 Het Mice

Saré, R. M., Figueroa, C., Lemons, A. H. S., Loutaev, I., & Smith, C. B. (2019) · Brain Sciences · doi:10.3390/brainsci9010013 · Cited by 16

Developmental onset of enduring long‐term potentiation in mouse hippocampus

Ostrovskaya, O. I., Cao, G., Eroğlu, Ç., & Harris, K. M. (2020) · Hippocampus · doi:10.1002/hipo.23257 · Cited by 15

Do group I metabotropic glutamate receptors mediate LTD?

Jones, O. D. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.010 · Cited by 16

The Genetic Control of Stoichiometry Underlying Autism

Darnell, R. B. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100119-024851 · Cited by 12

Fragile X syndrome

Pietropaolo, S., & Subashi, E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.014 · Cited by 12

Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice

Callaerts‐Vegh, Z., Ahmed, T., Vermaercke, B., Marynen, P., Balschun, D., Froyen, G., & D’Hooge, R. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00179 · Cited by 11

Intellectual and developmental disabilities research centers: Fifty years of scientific accomplishments

Walkley, S. U., Abbeduto, L., Batshaw, M. L., Bhattacharyya, A., Bookheimer, S. Y., Christian, B. T., Constantino, J. N., de Vellis, J., Doherty, D., Nelson, D. L., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25531 · Cited by 11

Acamprosate rescues neuronal defects in the Drosophila model of Fragile X Syndrome

Hutson, R. L., Thompson, R. L., Bantel, A. P., & Tessier, C. R. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.01.007 · Cited by 9

From wings to whiskers to stem cells: why every model matters in fragile X syndrome research

Sandoval, S. O., Méndez-Albelo, N. M., Xu, Z., & Zhao, X. (2024) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-024-09545-w · Cited by 9

Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone

Wang, Y., Fisahn, A., Sinha, I., Nguyen, D. P., Sterzenbach, U., Lallemend, F., & Hadjab, S. (2016) · Scientific Reports · doi:10.1038/srep18617 · Cited by 7

Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures

Lo, A. C., Rajan, N., Gastaldo, D., Telley, L., Hilal, M. L., Buzzi, A., Simonato, M., Achsel, T., & Bagni, C. (2021) · EMBO Reports · doi:10.15252/embr.202051404 · Cited by 7

Cage effects on synaptic plasticity and its modulation in a mouse model of fragile X syndrome

Volianskis, R., Lundbye, C. J., Petroff, G. N., Jane, D. E., Georgiou, J., & Collingridge, G. L. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2023.0484 · Cited by 6

The Prognostic and Therapeutic Potential of Fragile X Mental Retardation 1 (FMR1) Gene Expression in Prostate Adenocarcinoma: Insights into Survival Outcomes and Oncogenic Pathway Modulation

Baldi, S., Amer, B., Alnadari, F., AL-Mogahed, M., Gao, Y., & Gamallat, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137290 · Cited by 4

Septotemporal Variation of Information Processing in the Hippocampus of Fmr1 KO Rat

Leontiadis, L. J., Felemegkas, P., Trompoukis, G., Tsotsokou, G., Miliou, A., Karagianni, E., Rigas, P., & Papatheodoropoulos, C. (2024) · Developmental Neuroscience · doi:10.1159/000537879 · Cited by 4

Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome

Donahue, M. M., Robson, E., & Colgin, L. L. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1978-24.2025 · Cited by 7

Hippocampal gamma-band oscillopathy in a mouse model of Fragile X SyndromePreprint

Pollali, E., Hollnagel, J., & Çalışkan, G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.24.441239 · Cited by 4

Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models

Pollali, E., Donaire, D. F., del Ángel, M., Demiray, Y. E., Lacalle, S. E., Hollnagel, J., Annamneedi, A., & Çalışkan, G. (2025) · Molecular Autism · doi:10.1186/s13229-025-00687-9 · Cited by 9

Delayed Development of Dendritic Spines in Fxr2 Knockout Mouse

Deng, J., & Dunaevsky, A. (2014) · The Open Neuroscience Journal · doi:10.2174/1874082000903010148 · Cited by 3

FMRP-mediated spatial regulation of physiologic NMD targets in neuronal cells

Kurosaki, T., Rambout, X., & Maquat, L. E. (2024) · Genome biology · doi:10.1186/s13059-023-03146-x · Cited by 4

Quantitative proteomics reveals the therapeutic effects of RFAP against depression via pathway regulation of long-term depression and potentiation

Wu, Y., Hao, Y., Yu, G., Li, L., Wang, S., Li, X., Zhang, Z., Zou, S., Liu, Z., Fan, P., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13429 · Cited by 3

Fragile X Mental Retardation Protein: Regulator of Specific mRNAs or Master Regulator of Global Translation?

Cook, D., Cameron, S. A., & Jones, E. V. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1298-10.2010 · Cited by 3

Hippocampal glial alterations are associated with Lamin B1 dysregulation and abnormal nuclear morphology in a rat model of fragile X syndrome

Rava, A., Feo, A., Bagnato, G., Doria, V., Pezzullo, M., Petrini, S., Buzzelli, V., Ascone, F., Trapano, M. D., Peruzzi, B., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107304 · Cited by 2

Long-term potentiation in the brain: a synaptic memory mechanism

Moreno, A. R., & Paulsen, O. (2026) · Physiological Reviews · doi:10.1152/physrev.00028.2025 · Cited by 2

Hippocampal proteome comparison of infant and adult Fmr1 deficiency mice reveals adult-related changes associated with postsynaptic density

Yang, C., Huang, Y.-T., Yao, Y.-F., Fu, J., & Long, Y. (2024) · Journal of Proteomics · doi:10.1016/j.jprot.2024.105202 · Cited by 2

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Henry, F. E. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0829-11.2011 · Cited by 2

Loss of the Fragile X Mental Retardation Protein Decouples Metabotropic Glutamate Receptor Dependent Priming of Long-Term Potentiation From Protein Synthesis

Auerbach, B. D., & Bear, M. F. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00449.2010 · Cited by 71

Metabotropic Receptor-Dependent Long-Term Depression Persists in the Absence of Protein Synthesis in the Mouse Model of Fragile X Syndrome

Nosyreva, E. D., & Huber, K. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01316.2005 · Cited by 301

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349

A Role for the NMDA receptor in synaptic plasticity in the hippocampus of the Fmr1 transgenic mouse model of Fragile X Syndrome

Bostrom, C. A. (2012) · UVic’s Research and Learning Repository (University of Victoria)

Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampusPreprint

Connor, S. A., Hoeffer, C. A., Klann, E., & Nguyen, P. (2011) · Learning & Memory · doi:10.1101/lm.2043811 · Cited by 32