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Ryanodine Receptor Calcium Release Channels
Abstract
The ryanodine receptors (RyRs) are a family of Ca 2+release channels found on intracellular Ca 2+storage/release organelles. The RyR channels are ubiquitously expressed in many types of cells and participate in a variety of important Ca 2+signaling phenomena (neurotransmission, secretion, etc.). In striated muscle, the RyR channels represent the primary pathway for Ca 2+release during the excitation-contraction coupling process. In general, the signals that activate the RyR channels are known (e.g., sarcolemmal Ca 2+influx or depolarization), but the specific mechanisms involved are still being debated. The signals that modulate and/or turn off the RyR channels remain ambiguous and the mechanisms involved unclear. Over the last decade, studies of RyR-mediated Ca 2+release have taken many forms and have steadily advanced our knowledge. This robust field, however, is not without controversial ideas and contradictory results. Controversies surrounding the complex Ca 2+regulation of single RyR channels receive particular attention here. In addition, a large body of information is synthesized into a focused perspective of single RyR channel function. The present status of the single RyR channel field and its likely future directions are also discussed.
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Metadata
- Authors
- Fill, M., & Copello, J. A.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2002-01-10
- Volume
- 82
- Issue
- 4
- Pages
- 893-922
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2137283585
- Cited by
- 1,099
- References
- 1
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
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