Brown Adipose Tissue: Function and Physiological Significance
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- Involvement of thermosensitive TRP channels in energy metabolismKunitoshi Uchida, Katsuya Dezaki, Takeshi Yoneshiro, Tatsuo Watanabe, Jun Yamazaki, Masayuki Saito, Toshihiko Yada, Makoto Tominaga, Yusaku Iwasaki · 2017 · The Journal of Physiological Sciences
- Emerging Roles of Adipose Progenitor Cells in Tissue Development, Homeostasis, Expansion and ThermogenesisDaniel C. Berry, Yuwei Jiang, Jonathan M. Graff · 2016 · Trends in Endocrinology and Metabolism
- UCP1: A transporter for H+ and fatty acid anionsAmbre M. Bertholet, Yuriy Kirichok · 2016 · Biochimie
- Role of Cannabinoids in ObesityFrancesca Rossi, Francesca Punzo, Giuseppina Rosaria Umano, Maura Argenziano, Emanuele Miraglia del Giudice · 2018 · International Journal of Molecular Sciences
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- Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their CrosstalkKasiphak Kaikaew, Aldo Grefhorst, Jenny A. Visser · 2021 · Frontiers in Endocrinology
- Plasma bile acids show a positive correlation with body mass index and are negatively associated with cognitive restraint of eating in obese patientsPhilip Prinz, Tobias Hofmann, Anne Ahnis, Ulf Elbelt, Miriam Goebel‐Stengel, Burghard F. Klapp, Matthias Rose, Andreas Stengel · 2015 · Frontiers in Neuroscience
- Dorsomedial hypothalamic NPY and energy balance controlSheng Bi, Yonwook Justin Kim, Fenping Zheng · 2012 · Neuropeptides
- Pediatric Brown Adipose Tissue: Detection, Epidemiology, and Differences from AdultsLaura A. Drubach, Edwin L. Palmer, Leonard P. Connolly, Amanda Baker, David Zurakowski, Aaron Martin Cypess · 2011 · The Journal of Pediatrics
- Brown adipose tissue thermogenesis heats brain and body as part of the brain-coordinated ultradian basic rest-activity cycleYouichirou Ootsuka, Rodrigo Cunha Alvim de Menezes, Dmitry V. Zaretsky, Abbas Alimoradian, Joseph L. Hunt, Aneta Stefanidis, Brian J. Oldfield, William Walter Blessing · 2009 · Neuroscience
- Assessment of brown adipose tissue functionSam Virtue, Antonio Vidal‐Puig · 2013 · Frontiers in Physiology
- Sex-related differences in energy balance in response to caloric restrictionAdamo Valle, Antoni Català-Niell, Bartomeu Colom, Francisco García-Palmer, Jordi Oliver, Pilar Roca · 2005 · American Journal of Physiology-Endocrinology and Metabolism
- Serotonin potentiates sympathetic responses evoked by spinal NMDAChristopher J. Madden, Shaun F. Morrison · 2006 · The Journal of Physiology
- Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanismsEdward T. Chouchani, Lawrence Kazak, Bruce M. Spiegelman · 2017 · Journal of Biological Chemistry
- Understanding the Biology of Thermogenic Fat: Is Browning A New Approach to the Treatment of Obesity?Ariana Vargas‐Castillo, Rebeca Fuentes‐Romero, Leonardo A. Rodríguez-López, Nimbe Torres, Armando Roberto Tovar · 2017 · Archives of Medical Research
- Brown adipose tissue and lipid metabolismJöerg Heeren, Ludger Scheja · 2018 · Current Opinion in Lipidology
- Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive agingEmre U Seli, Tianren Wang, Tamás L. Horváth · 2019 · Fertility and Sterility
- Cold and Exercise: Therapeutic Tools to Activate Brown Adipose Tissue and Combat ObesityCarmem Peres Valgas da Silva, Diego Hernández‐Saavedra, Joseph D. White, Kristin Stanford · 2019 · Biology
- Resveratrol enhances brown adipose tissue activity and white adipose tissue browning in part by regulating bile acid metabolism via gut microbiota remodelingSuocheng Hui, Yang Liu, Li Huang, Lin Zheng, Min Zhou, Hedong Lang, Xiaolan Wang, Long Yi, Mantian Mi · 2020 · International Journal of Obesity
- Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiationMinhui Chen, Guanxi Qiao, Bonnie Lee Hylander, Hemn Mohammadpour, Xiang‐Yang Wang, John R. Subjeck, Anurag K. Singh, Elizabeth A. Repasky · 2020 · Nature Communications
- Mitochondrial Uncoupling Proteins in the Central Nervous SystemJeong Sook Kim‐Han, Laura L. Dugan · 2005 · Antioxidants and Redox Signaling
- Relevance of brown adipose tissue in infancy and adolescenceVicente Gilsanz, Peng Hu, Shingo Kajimura · 2012 · Pediatric Research
- Adipose tissue engineering: state of the art, recent advances and innovative approachesMaria Cristina Tanzi, Silvia Farè · 2009 · Expert Review of Medical Devices
- Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold ExposureAmeka, Magdalene, Markan, Kathleen R., Morgan, Donald A., BonDurant, Lucas D., Idiga, Sharon O., Naber, Meghan C., Zhu, Zhiyong, Zingman, Leonid V., Grobe, Justin L., Rahmouni, Kamal et al. · 2019 · Scientific Reports
- Cooling-Sensitive TRPM8 Is Thermostat of Skin Temperature against CoolingKoji Tajino, Hiroshi Hosokawa, Shingo Maegawa, Kiyoshi Matsumura, Ajay K. Dhaka, Shígeo Kobayashi · 2011 · PLoS ONE
- Oxytocin Receptor in the Hypothalamus Is Sufficient to Rescue Normal Thermoregulatory Function in Male Oxytocin Receptor Knockout MiceYoshiyuki Kasahara, Keisuke Sato, Yuki Takayanagi, Hiroaki Mizukami, Keiya Ozawa, Shizu Hidema, Kyoung-Ha So, Teruo Kawada, Nao Inoue, Ikuo Ikeda et al. · 2013 · Endocrinology
- A ketogenic diet increases brown adipose tissue mitochondrial proteins and UCP1 levels in miceShireesh Srivastava, Ulrich Baxa, Gang Niu, Xiaoyuan Shawn Chen, Richard L. Veech · 2012 · IUBMB Life
- Metabolic activity of brown, “beige,” and white adipose tissues in response to chronic adrenergic stimulation in male miceSébastien M. Labbé, Alexandre Caron, Kanta Chechi, Mathieu Laplante, Roger Lecomte, Denis Richard · 2016 · American Journal of Physiology-Endocrinology and Metabolism
- PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newbornsSandra Côté, Valérie Gagné‐Ouellet, Simon‐Pierre Guay, Catherine Allard, Andrée-Anne Houde, Patrice Perron, Jean‐Patrice Baillargeon, Daniel Gaudet, Renée Guérin, Diane Brisson et al. · 2016 · Clinical Epigenetics
- Effects of thyroid hormones on thermogenesis and energy partitioningKarl Alexander Iwen, Rebecca Oelkrug, Georg E. Brabant · 2018 · Journal of Molecular Endocrinology
- Batokines: Mediators of Inter-Tissue Communication (a Mini-Review)Felix T. Yang, Kristin I. Stanford · 2022 · Current Obesity Reports
- Sexual dimorphism in white and brown adipose tissue with obesity and inflammationIan D. Bloor, Michael Edward Symonds · 2014 · Hormones and Behavior
- The Effects of Rimonabant on Brown Adipose Tissue in Rat: Implications for Energy ExpenditureAaron N.A. Verty, Andrew Mark Allen, Brian J. Oldfield · 2008 · Obesity
- Thyroid hormones as molecular determinants of thermogenesisElena Silvestri, Luigi Schiavo, Assunta Lombardi, Fernando Goglia · 2005 · Acta Physiologica Scandinavica
- Molecular and neural bases underlying roles of BDNF in the control of body weightFilip Vanevski, Baoji Xu · 2013 · Frontiers in Neuroscience
- Uncoupling protein-1 is not leakyIrina G. Shabalina, Mario Ost, Nataša Petrovič, Marek Vrbacký, Jan Nedergaard, Barbara Cannon · 2010 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
- PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1Satoshi Iida, Wei Chen, Tomoyoshi Nakadai, Yoshiaki Ohkuma, Robert G. Roeder · 2015 · Genes & Development
- Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissueSamms, Ricardo J., Zhang, GuoFang, He, Wentao, Ilkayeva, Olga, Droz, Brian A., Bauer, Steven M., Stutsman, Cynthia, Pirro, Valentina, Collins, Kyla A., Furber, Ellen C. et al. · 2022 · Molecular Metabolism
- Adipose tissue NAD + biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in miceShintaro Yamaguchi, Michael P. Franczyk, Maria Chondronikola, Nathan Qi, Subhadra C. Gunawardana, Kelly L. Stromsdorfer, Lane C. Porter, David F. Wozniak, Yo Sasaki, Nicholas R. Rensing et al. · 2019 · Proceedings of the National Academy of Sciences
- Skeletal interoception in bone homeostasis and painXiao Lv, Feng Gao, Xu Cao · 2022 · Cell Metabolism
- Molecular Mechanisms of Lipid-Based Metabolic Adaptation Strategies in Response to ColdGang Wu, Ralf Baumeister, Thomas Heimbucher · 2023 · Cells
- Cachexia: a problem of energetic inefficiencyJosep María Adell Argilés, Cibely Cristine Fontes de Oliveira, Míriam Toledo, Francisco Javier López-Soriano, Sı́lvia Busquets · 2014 · Journal of Cachexia Sarcopenia and Muscle
- Receptor Interacting Protein 140 Regulates Expression of Uncoupling Protein 1 in Adipocytes through Specific Peroxisome Proliferator Activated Receptor Isoforms and Estrogen-Related Receptor αDarja Debevec, Mark Christian, Daniel L. Morganstein, Asha Seth, Birger Herzog, Malcolm G. Parker, Roger White · 2007 · Molecular Endocrinology
- Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in miceMarika Ziętak, Leslie P. Kozak · 2015 · American Journal of Physiology-Endocrinology and Metabolism
- Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in miceJuliane Weiner, Mathias Kranz, Nora Klöting, Anne Kunath, Karen Geva Steinhoff, Eddy Rijntjes, Josef Köhrle, Vilia Zeisig, Mohammed K. Hankir, Claudia Gebhardt et al. · 2016 · Scientific Reports
- Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activationXing Zeng, Mark P. Jedrychowski, Yi Chen, Sara Serag, Gareth Geoffrey Lavery, Steven P. Gygi, Bruce M. Spiegelman · 2016 · Genes & Development
- Sex Steroid Receptor Expression Profile in Brown Adipose Tissue. Effects of Hormonal StatusRodriguez-Cuenca, Sergio, Monjo, Marta, Frontera, Marga, Gianotti, Magdalena, Proenza, Ana Maria, Roca, Pilar · 2007 · Cellular Physiology and Biochemistry
- Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic diseaseGao, Zhanguo, Daquinag, Alexes C., Fussell, Cale, Zhao, Zhongming, Dai, Yulin, Rivera, Angielyn, Snyder, Brad E., Eckel-Mahan, Kristin L., Kolonin, Mikhail G. · 2020 · Nature Metabolism
- Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activationYuan, Yexian, Xu, Pingwen, Jiang, Qingyan, Cai, Xingcai, Wang, Tao, Peng, Wentong, Sun, Jiajie, Zhu, Canjun, Zhang, Cha, Yue, Dong et al. · 2020 · The EMBO Journal
- Oxygen Deprivation and the Cellular Response to Hypoxia in Adipocytes – Perspectives on White and Brown Adipose Tissues in ObesityPaul Trayhurn, Suliman Yousef Alomar · 2015 · Frontiers in Endocrinology
- The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein MetabolismWei Chen, Guoxun Chen · 2014 · Journal of Clinical Medicine
- Activation and recruitment of brown adipose tissue as anti-obesity regimens in humansTakeshi Yoneshiro, Masayuki Saito · 2014 · Annals of Medicine
- Transcriptomic Analysis of Brown Adipose Tissue across the Physiological Extremes of Natural HibernationMarshall E. Hampton, Richard G. Melvin, Matthew T. Andrews · 2013 · PLoS ONE
- Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respirationJiyoung Bae, Carolyn J. Ricciardi, Débora Esposito, Slavko Komarnytsky, Pan Hu, Benjamin J. Curry, Patricia L. Brown, Zhan‐Guo Gao, John Biggerstaff, Jiangang Chen et al. · 2014 · American Journal of Physiology-Cell Physiology
- Effects of exercise on brown and beige adipocytesDewal, Revati S., Stanford, Kristin I. · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein PrenylationMiroslav Baláž, Anton S. Becker, Lucia Balážová, Leon Gabriel Straub, Julian Müller, Gani Gashi, Claudia Irene Maushart, Wenfei Sun, Hua Dong, Caroline Moser et al. · 2018 · Cell Metabolism
- Housing temperature affects the acute and chronic metabolic adaptations to exercise in miceGreg L. McKie, Kyle D. Medak, Carly M. Knuth, Hesham Shamshoum, Logan K. Townsend, Willem T. Peppler, David Charles Wright · 2019 · The Journal of Physiology
- Mitochondrial H + Leak and ThermogenesisAmbre M. Bertholet, Yuriy Kirichok · 2021 · Annual Review of Physiology
- Adipokines and the Endocrine Role of Adipose TissuesMarta Giralt, Rubén Cereijo, Francesc Villarroya · 2015 · Handbook of experimental pharmacology
- Efficacy and Function of Feathers, Hair, and Glabrous Skin in the Thermoregulation Strategies of Domestic AnimalsDaniel Mota‐Rojas, Cristiane Gonçalves Titto, Ana Carina Alves Pereira de Mira Geraldo, Julio Martı́nez-Burnes, Jocelyn Gómez-Prado, Ismael Hernández-Ávalos, Alejandro Casas-Alvarado, Adriana Domínguez-Oliva, Nancy José-Pérez, Aldo Bertoni et al. · 2021 · Animals
- Interactions between central nervous system and peripheral metabolic organsWenwen Zeng, Fan Yang, Wei L. Shen, Cheng Zhan, Peng Zheng, Ji Hu · 2022 · Science China Life Sciences
- Brain-adipose tissue neural crosstalkTimothy J. Bartness, C. Kay Song · 2007 · Physiology & Behavior
- Gene expression in human brown adipose tissuePer‐Arne Svensson · 2010 · International Journal of Molecular Medicine
- Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectivelyIrina G. Shabalina, Tatiana V. Kramarova, Jan Nedergaard, Barbara Cannon · 2006 · Biochemical Journal
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- Orexin Restores Aging-Related Brown Adipose Tissue Dysfunction in Male MiceDyan Sellayah, Devanjan S. Sikder · 2013 · Endocrinology
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- Association of circulating neuregulin 4 with metabolic syndrome in obese adults: a cross-sectional studyChengfu Cai, Mingzhu Lin, Yanfang Xu, Xuejun Li, Shuyu Yang, Huijie Zhang · 2016 · BMC Medicine
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- Central Serotonergic Neurons Activate and Recruit Thermogenic Brown and Beige Fat and Regulate Glucose and Lipid HomeostasisJacob McGlashon, Michelle C. Gorecki, Amanda E. Kozlowski, Caitlin K. Thirnbeck, Kathleen R. Markan, Kirstie L. Leslie, Maya E. Kotas, Matthew J. Potthoff, George Bradley Richerson, Matthew Paul Gillum · 2015 · Cell Metabolism
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- Adipocyte-specific hypoxia-inducible factor 2α deficiency exacerbates obesity-induced brown adipose tissue dysfunction and metabolic dysregulationGarcía-Martín, Rubén, Alexaki, Vasileia I., Qin, Nan, Rubín de Celis, María F., Economopoulou, Matina, Ziogas, Athanasios, Gercken, Bettina, Kotlabova, Klara, Phieler, Julia, Ehrhart-Bornstein, Monika et al. · 2016 · Molecular and Cellular Biology
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- Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetesde Ligt, Marlies, Bruls, Yvonne M.H., Hansen, Jan, Habets, Marie-Fleur, Havekes, Bas, Nascimento, Emmani B.M., Moonen-Kornips, Esther, Schaart, Gert, Schrauwen-Hinderling, Vera B., van Marken Lichtenbelt, Wouter et al. · 2018 · Molecular Metabolism