Brown Adipose Tissue: Function and Physiological Significance

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Towards a molecular understanding of adaptive thermogenesis

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Increased adipose tissue in male and female estrogen receptor-α knockout mice

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Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies

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Thyroid hormone (T 3 ) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy

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Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling

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The anti-obesity effects of green tea in human intervention and basic molecular studies

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Biosynthetic Pathway and Health Benefits of Fucoxanthin, an Algae-Specific Xanthophyll in Brown Seaweeds

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Increased maternal nutrition alters development of the appetite‐regulating network in the brain

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The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions

Nedergaard, J., & Cannon, B. (2003) · Experimental Physiology · doi:10.1113/eph8802502 · Cited by 229

Overview of Adipose Tissue and Its Role in Obesity and Metabolic Disorders

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A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate

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Adiposity and human regional body temperature

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Human Brown Adipose Tissue: What We Have Learned So Far

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Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

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Ebf2 is a selective marker of brown and beige adipogenic precursor cells

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GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure

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Browning of White Fat: Novel Insight Into Factors, Mechanisms, and Therapeutics: FAT BROWNING AND THEIR POTENTIAL AS THERAPEUTICS

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Integration of body temperature into the analysis of energy expenditure in the mouse

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The renaissance of mitochondrial pH

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Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases

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The role of skeletal‐muscle‐based thermogenic mechanisms in vertebrate endothermy

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O tecido adiposo como centro regulador do metabolismo

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Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes

Blondin, D. P., Labbé, S. M., Noll, C., Kunach, M., Phoenix, S., Guérin, B., Turcotte, É. E., Haman, F., Richard, D., & Carpentier, A. C. (2015) · Diabetes · doi:10.2337/db14-1651 · Cited by 229

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Kunkel, S. D., Elmore, C., Bongers, K. S., Ebert, S. M., Fox, D. K., Dyle, M. C., Bullard, S. A., & Adams, C. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039332 · Cited by 225

Adipose tissue plasticity from WAT to BAT and in between

Lee, Y., Mottillo, E. P., & Granneman, J. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.011 · Cited by 236

Twist-1 Is a PPARδ-Inducible, Negative-Feedback Regulator of PGC-1α in Brown Fat Metabolism

Pan, D., Fujimoto, M., Lopes, A., & Wang, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.051 · Cited by 224

Emerging Complexities in Adipocyte Origins and Identity

Sánchez-Gurmaches, J., Hung, C., & Guertin, D. A. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.01.004 · Cited by 225

Heterogeneity of adipose tissue in development and metabolic function

Schöttl, T., Kapser-Fischer, I., & Ussar, S. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.162958 · Cited by 228

Orphan nuclear receptor estrogen-related receptor α is essential for adaptive thermogenesis

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Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans

Berry, D. C., Jiang, Y., Arpke, R. W., Close, E. L., Uchida, A., Reading, D., Berglund, E. D., Kyba, M., & Graff, J. M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.023 · Cited by 214

The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity

Zhao, Y., Chen, B., Shen, J., Wan, L., Zhu, Y., Yi, T., & Xiao, Z. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1459497 · Cited by 216

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

Wang, G., Meyer, J. G., Cai, W., Softic, S., Li, M. E., Verdin, E. M., Newgard, C. B., Schilling, B., & Kahn, C. R. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.03.021 · Cited by 216

Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?

McElwain, C. J., Tuboly, E., McCarthy, F. P., & McCarthy, C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00655 · Cited by 236

Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

Kiefer, F. W., Vernochet, C., O’Brien, P., Spoerl, S., Brown, J. D., Nallamshetty, S., Zeyda, M., Stulnig, T. M., Cohen, D. E., Kahn, C. R., et al. (2012) · Nature Medicine · doi:10.1038/nm.2757 · Cited by 210

Central neural control of thermoregulation and brown adipose tissue

Morrison, S. F. (2016) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.02.010 · Cited by 220

Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes

Lo, K. A., & Sun, L. (2013) · Bioscience Reports · doi:10.1042/bsr20130046 · Cited by 225

Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects

Vijgen, G. H. E. J., Bouvy, N. D., Teule, G. J. J., Brans, B. T., Hoeks, J., Schrauwen, P., & Lichtenbelt, W. D. V. M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1289 · Cited by 218

Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism

Schéele, C., & Wolfrum, C. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz007 · Cited by 224

Early origins of obesity: programming the appetite regulatory system

McMillen, I. C., Adam, C. L., & Mühlhäusler, B. S. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.081992 · Cited by 216

Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues

Dong, J., Dong, Y., Dong, Y., Chen, F., Mitch, W. E., & Zhang, L. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.200 · Cited by 212

Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes

González, N., Moreno-Villegas, Z., González-Bris, A., Egido, J., & Lorenzo, Ó. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0528-4 · Cited by 211

In vivo measurement of energy substrate contribution to cold‐induced brown adipose tissue thermogenesis

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Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance

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Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of the Sirt3 Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype

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Adult Epicardial Fat Exhibits Beige Features

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Beyond the Sympathetic Tone: The New Brown Fat Activators

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The energy hypothesis of sleep revisited

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Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

Sánchez-Gurmaches, J., Tang, Y., Jespersen, N. Z., Wallace, M., Calejman, C. M., Gujja, S., Li, H., Edwards, Y. J. K., Wolfrum, C., Metallo, C. M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.008 · Cited by 204

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

Bartelt, A., Widenmaier, S. B., Schlein, C., Johann, K., Gonçalves, R. L. S., Eguchi, K., Fischer, A. W., Parlakgül, G., Snyder, N., Nguyen, T. B., et al. (2018) · Nature Medicine · doi:10.1038/nm.4481 · Cited by 212

Brown Adipose Tissue in Adult Humans: A Metabolic Renaissance

Lee, P. C., Swarbrick, M. M., & Ho, K. K. Y. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1081 · Cited by 224

Knockdown of NPY Expression in the Dorsomedial Hypothalamus Promotes Development of Brown Adipocytes and Prevents Diet-Induced Obesity

Chao, P.-T., Yang, L., Aja, S. M., Moran, T. H., & Bi, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.019 · Cited by 213

Exercise as a new physiological stimulus for brown adipose tissue activity

Matteis, R. D., Lucertini, F., Guescini, M., Polidori, E., Zeppa, S. D., Stocchi, V., Cinti, S., & Cuppini, R. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.01.013 · Cited by 204

The brown fat secretome: metabolic functions beyond thermogenesis

Wang, G.-X., Zhao, X.-Y., & Lin, J. D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.03.002 · Cited by 212

Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice

Guo, H., Jin, D., Zhang, Y., Wright, W. S., Bazuine, M., Brockman, D. A., Bernlohr, D., & Chen, X. (2010) · Diabetes · doi:10.2337/db09-1735 · Cited by 214

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat

Leiria, L. O., Wang, C., Lynes, M. D., Yang, K., Shamsi, F., Sato, M. M., Sugimoto, S., Chen, E. Y.-S., Bussberg, V., Narain, N. R., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.001 · Cited by 205

Brain insulin signalling in metabolic homeostasis and disease

Scherer, T., Sakamoto, K., & Buettner, C. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00498-x · Cited by 205

Long-term effects of nutritional programming of the embryo and fetus: mechanisms and critical windows

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Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications

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Neurotrophic factor control of satiety and body weight

Xu, B., & Xie, X. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.24 · Cited by 203

PTEN in cancer, metabolism, and aging

Ortega-Molina, A., & Serrano, M. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.11.002 · Cited by 207

Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion

Arruda, A. P., Milanski, M., Coope, A., Torsoni, A. S., Ropelle, E. R., de Carvalho, D. P., Carvalheira, J. B. C., & Velloso, L. A. (2011) · Endocrinology · doi:10.1210/en.2010-0659 · Cited by 207

Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1

Gavva, N. R. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.08.003 · Cited by 203

Adipose tissue at single-cell resolution

Maniyadath, B., Zhang, Q., Gupta, R. K., & Mandrup, S. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.002 · Cited by 218

PTP1B and TCPTP – nonredundant phosphatases in insulin signaling and glucose homeostasis

Tiganis, T. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08563.x · Cited by 209

Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons

Dietrich, M. O., & Horváth, T. L. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3739 · Cited by 205

Brown adipose tissue transplantation ameliorates polycystic ovary syndrome

Yuan, X., Hu, T., Zhao, H., Huang, Y., Ye, R., Lin, J., Zhang, C., Zhang, H., Wei, G., Zhou, H., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523236113 · Cited by 203

UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity

Madsen, L., Pedersen, L. M., Lillefosse, H. H., Fjære, E., Brønstad, I., Hao, Q., Petersen, R. K., Hallenborg, P., Ma, T., Matteis, R. D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011391 · Cited by 204

Browning of white adipose tissue: lessons from experimental models

Bargut, T. C. L., Souza‐Mello, V., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0051 · Cited by 212

PPARγ in the control of brown adipocyte differentiation

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Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α

Scimè, A., Grenier, G., Huh, M. S., Gillespie, M. A., Bevilacqua, L., Harper, M.-E., & Rudnicki, M. A. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.002 · Cited by 199

UCP1: its involvement and utility in obesity

Kozak, L. P., & Anunciado‐Koza, R. P. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.236 · Cited by 200

Energy balance regulation by thyroid hormones at central level

López, M., Álvarez, C. V., Nogueiras, R., & Diéguez, C. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.04.004 · Cited by 207

C/EBPα and the Corepressors CtBP1 and CtBP2 Regulate Repression of Select Visceral White Adipose Genes during Induction of the Brown Phenotype in White Adipocytes by Peroxisome Proliferator-Activated Receptor γ Agonists

Vernochet, C., Peres, S. B., Davis, K. E., McDonald, M. E., Qiang, L., Wang, H., Scherer, P. E., & Farmer, S. R. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01899-08 · Cited by 201

Brown Adipose Tissue—A Translational Perspective

Carpentier, A. C., Blondin, D. P., Haman, F., & Richard, D. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac015 · Cited by 218

Spectral tracing of deuterium for imaging glucose metabolism

Zhang, L., Shi, L., Shen, Y., Miao, Y., Wei, M., Qian, N., Liu, Y., & Min, W. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0393-4 · Cited by 202

Nutrition, insulin resistance and dysfunctional adipose tissue determine the different components of metabolic syndrome

Paniagua, J. A. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i19.483 · Cited by 197

Toward an understanding of how immune cells control brown and beige adipobiology

Villarroya, F., Cereijo, R., Villarroya, J., Gavaldà-Navarro, A., & Giralt, M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.006 · Cited by 198

BAT: a new target for human obesity?

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Ephedrine activates brown adipose tissue in lean but not obese humans

Carey, A. L., Formosa, M. F., van Every, B., Bertovic, D. A., Eikelis, N., Lambert, G. W., Kalff, V., Duffy, S. J., Cherk, M. H., & Kingwell, B. A. (2012) · Diabetologia · doi:10.1007/s00125-012-2748-1 · Cited by 196

Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans

Blondin, D. P., Frisch, F., Phoenix, S., Guérin, B., Turcotte, É. E., Haman, F., Richard, D., & Carpentier, A. C. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.005 · Cited by 205

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge

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Thyroid Hormone Effects on Mitochondrial Energetics

Harper, M.-E., & Seifert, E. L. (2008) · Thyroid · doi:10.1089/thy.2007.0250 · Cited by 194

Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity

Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194

The Adipose Tissue as an Endocrine Organ

Adamczak, M., & Więcek, A. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2012.12.008 · Cited by 207

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning

Liu, D., Bordicchia, M., Zhang, C., Fang, H., Wei, W., Li, J., Guilherme, A., Guntur, K., Czech, M., & Collins, S. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83532 · Cited by 197

Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome

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Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity

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Adipose tissue as an endocrine organ: from theory to practice

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FAT CELLS: Afferent and Efferent Messages Define New Approaches to Treat Obesity

Lafontan, M. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095843 · Cited by 191

Central Control of Brown Adipose Tissue Thermogenesis

Morrison, S. F., Madden, C. J., & Tupone, D. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00005 · Cited by 199

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis

Lai, B., Lee, J.-E., Jang, Y., Wang, L., Peng, W., & Ge, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx234 · Cited by 191

Impact of nesting material on mouse body temperature and physiology

Gaskill, B. N., Gordon, C. J., Pajor, E. A., Lucas, J. R., Davis, J. K., & Garner, J. P. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.12.018 · Cited by 189

Bone marrow adipocytes

Horowitz, M., Berry, R., Holtrup, B., Sebo, Z. L., Nelson, T., Fretz, J. A., Lindskog, D., Kaplan, J. L., Ables, G., Rodeheffer, M. S., et al. (2017) · Adipocyte · doi:10.1080/21623945.2017.1367881 · Cited by 172

ISMRM workshop on fat–water separation: Insights, applications and progress in MRI

Hu, P., Börnert, P., Hernando, D., Kellman, P., Ma, J., Reeder, S. B., & Sirlin, C. B. (2012) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24369 · Cited by 189

Crosstalk between adipokines and myokines in fat browning

Rodríguez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 196

Factors involved in white‐to‐brown adipose tissue conversion and in thermogenesis: a review

Montanari, T., Pošćić, N., & Colitti, M. (2017) · Obesity Reviews · doi:10.1111/obr.12520 · Cited by 193

IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins

Dai, N., Zhao, L., Wrighting, D., Krämer, D., Majithia, A., Wang, Y., Cracan, V., Borges-Rivera, D., Mootha, V. K., Nahrendorf, M., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.03.006 · Cited by 188

Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues

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UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction

Kazak, L., Chouchani, E. T., Stavrovskaya, I. G., Lu, G. Z., Jedrychowski, M. P., Egan, D. F., Kumari, M., Kong, X., Erickson, B. K., Szpyt, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705406114 · Cited by 195

Recent advances in understanding the anti-obesity activity of anthocyanins and their biosynthesis in microorganisms

Xie, L., Su, H., Sun, C., Zheng, X., & Chen, W. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.12.002 · Cited by 191

Hypothalamic-autonomic control of energy homeostasis

Seoane‐Collazo, P., Fernø, J., González, F., Diéguez, C., Leis, R., Nogueiras, R., & López, M. (2015) · Endocrine · doi:10.1007/s12020-015-0658-y · Cited by 189

Adipose Depots Possess Unique Developmental Gene Signatures

Yamamoto, Y., Gesta, S., Lee, K. Y., Tran, T. T., Saadatirad, P., & Kahn, C. R. (2010) · Obesity · doi:10.1038/oby.2009.512 · Cited by 185

The Role of Adrenergic Stimulation in Regulation of Heat Production and Recruitment of Brown Adipose Tissue

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Brown adipose tissue as a heat-producing thermoeffector

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Acute and Long-Term Regulation of Brown Adipose Tissue Thermogenesis: Physiological and Pathological Implications

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adipose tissue: function and physiological significance. Physiol Rev 84

Cannon, B., & Nedergaard, J. (2004)

Brown Adipose Tissue: A Seasonal Tissue in Mammals, Including Humans?

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