Cited by 312Cancer, Hypoxia, and MetabolismCancer Immunotherapy and BiomarkersImmune cells in cancer

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Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

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Riera-Domingo, Carla, Audigé, Annette, Granja, Sara, Cheng, Wan-Chen, Ho, Ping-Chih, Baltazar, Fátima, Stockmann, Christian, Mazzone, Massimiliano·2020·Physiological Reviews

DOI 10.1152/physrev.00018.2019

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Abstract

It is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and ultimately impairs immune cell fitness and effector functions. The major aims of this review are to provide an overview on the immune system in cancer; to position oxygen shortage and metabolic competition as the ground of a restrictive TME and as important players in the anti-tumor immune response; to define how immunotherapies affect hypoxia/oxygen delivery and the metabolic landscape of the tumor; and vice versa, how oxygen and metabolites within the TME impinge on the success of immunotherapies. By analyzing preclinical and clinical endeavors, we will discuss how a metabolic characterization of the TME can identify novel targets and signatures that could be exploited in combination with standard immunotherapies and can help to predict the benefit of new and traditional immunotherapeutic drugs.

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Authors: Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M.
Affiliations: Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven, Belgium; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium; Institute of Anatomy, University of Zurich, Zurich, Switzerland; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal; Department of Fundamental...
Ludwig Cancer Research (BE)
ORCID: Audigé, Annette
Granja, Sara
Ho, Ping-Chih
Baltazar, Fátima
Stockmann, Christian
Mazzone, Massimiliano
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2020-01-01
Volume: 100
Issue: 1
Pages: 1-102
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00018.2019
OpenAlex: W2968149989
Cited by: 310
References: 808
Citations by year: 2026: 18 · 2025: 31 · 2024: 69 · 2023: 52 · 2022: 69 · 2021: 56 · 2020: 15
FWCI: 3.40
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Physiological Reviews (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
Lirias (submittedVersion, other-oa)
IRIS (submittedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
SERVAL (Université de Lausanne) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Funders: EC | European Research Council (773208)
Fonds Wetenschappelijk Onderzoek (1108919N, G0D1717N, G066515N)
Stichting Tegen Kanker (2014197)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: tumor microenvironment, tumor hypoxia, cancer metabolism, antitumor immunity, immunotherapy, metabolic crosstalk, oxygen delivery, metabolic competition, predictive biomarkers, combination immunotherapy
MeSH terms: Animals, Hypoxia, Humans, Immunity, Immunotherapy, Neoplasms, Tumor Microenvironment

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Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

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