Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

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Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer

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Safety and activity of anti-PD-L1 antibody in patients with advanced cancer

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mTOR Signaling in Growth, Metabolism, and Disease

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Oncology meets immunology: the cancer-immunity cycle.

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Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

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The emerging hallmarks of cancer metabolism

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The Immune Landscape of Cancer

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Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

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Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

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Cancer immunoediting: from immunosurveillance to tumor escape

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

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IL-17 and th17 cells

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Regulation of cancer cell metabolism

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

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Molecular and cellular insights into T cell exhaustion

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The biology and function of fibroblasts in cancer

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

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Tumor-Associated Macrophages: From Mechanisms to Therapy

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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Coordinated regulation of myeloid cells by tumours

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Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

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High Frequency of Mutations of the PIK3CA Gene in Human Cancers

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Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

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A guide to immunometabolism for immunologists

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Immunogenic cell death in cancer and infectious disease

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Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid

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Innate or adaptive immunity? The example of natural killer cells

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CSF-1R inhibition alters macrophage polarization and blocks glioma progression

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Understanding the Intersections between Metabolism and Cancer Biology

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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

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Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

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PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced: MDSC-mediated T cell activation

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Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

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Cellular Fatty Acid Metabolism and Cancer

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From Krebs to clinic: glutamine metabolism to cancer therapy

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mTOR Signaling in Growth, Metabolism, and Disease

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Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation

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Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

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Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

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HIF-1α is essential for myeloid cell-mediated inflammation

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The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

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Inhibitory effect of tumor cell-derived lactic acid on human T cells

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Turning foes to friends: targeting cancer-associated fibroblasts

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TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

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STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

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Pan-cancer patterns of somatic copy number alteration

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