CoChat
Sign Up
Cited by 32Coffee research and impactsThermoregulation and physiological responsesBody Composition Measurement Techniques

Total body water and its compartments are not affected by ingesting a moderate dose of caffeine in healthy young adult males

Silva, Analiza M., Júdice, Pedro B., Matias, Catarina N., Santos, Diana A., Magalhães, João P., St-Onge, Marie-Pierre, Gonçalves, Ezequiel M., Armada-da-Silva, Paulo +1 more·2013·Applied Physiology, Nutrition, and Metabolism
DOI 10.1139/apnm-2012-0253
Open this paper in CoChat — free account

Abstract

Acute and chronic caffeine intakes have no impact on hydration status (R.J. Maughan and J. Griffin, J. Hum. Nutr. Diet. 16(6): 411-420, 2003), although no research has been conducted to analyze the effects using dilution techniques on total-body water (TBW) and its compartments. Therefore, the aim of this study was to investigate the effects of a moderate dose of caffeine on TBW, extracellular water (ECW), and intracellular water (ICW) during a 4-day period in active males. Thirty men, nonsmokers and low caffeine users (<100 mg·day(-1)), aged 20-39 years, participated in this double-blind, randomized, crossover trial (ClinicalTrials.gov: No. NCT01477294). The study included 2 conditions (5 mg·kg(-1)·day(-1) of caffeine and placebo (malt-dextrin)) of 4 days each, with a 3-day washout period. TBW and ECW were assessed by deuterium oxide and sodium bromide dilution, respectively, whereas ICW was calculated as TBW minus ECW. Body composition was assessed by dual-energy X-ray absorptiometry. Physical activity (PA) was assessed by accelerometry and water intake was assessed by dietary records. Repeated-measures analysis of variance (ANOVA) was used to test main effects. No changes in TBW, ECW, or ICW and no interaction between the randomly assigned order of treatment and time were observed (p > 0.05). TBW, ECW, and ICW were unrelated to fat-free mass, water ingestion, and PA (p > 0.05). These findings indicate that a moderate caffeine dose, equivalent to approximately 5 espresso cups of coffee or 7 servings of tea, does not alter TBW and fluid distribution in healthy men, regardless of body composition, PA, or daily water ingestion.

Integrity signals

Registry

Crossref · 10.1139/apnm-2012-0253

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Moderate consumption of caffeine does not disrupt total body water.

    “Our data confirms the author's conclusions that a moderate consumption of caffeine does not disrupt TBW.”

    From No Evidence of Dehydration with Moderate Daily Coffee Intake: A Counterbalanced Cross-Over Study in a Free-Living Population (2014) · cites this paper as [19]

  • A very recent study found no differences in total body water between a caffeine and placebo control group in 30 male low-caffeine users.

    “A very recent study investigated the effects of caffeine provided in capsules (5 mg/kg/day) on the TBW of 30 male participants classified as ‘low-caffeine users’ (<100 mg/day) [19]. No differences in TBW were observed between the caffeine and placebo control group.”

    From No Evidence of Dehydration with Moderate Daily Coffee Intake: A Counterbalanced Cross-Over Study in a Free-Living Population (2014) · cites this paper as [19]

  • In healthy males who were low habitual caffeine consumers (<100 mg/day), 5 mg/kg body weight of caffeine consumed daily for four consecutive days did not lead to significant changes in hydration measures compared with placebo.

    “Similar results were obtained in two studies with a similar design conduced in healthy males, in which 5 mg/kg bw of caffeine were consumed daily for four consecutive days by low habitual caffeine consumers (< 100 mg/day) (Silva et al., 2013)”

    From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Silva et al., 2013

Cites

Flagged first, then by citations

2 of the 40 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Silva, A. M., Júdice, P. B., Matias, C. N., Santos, D. A., Magalhães, J. P., St-Onge, M.-P., Gonçalves, E. M., Armada-da-Silva, P., & Sardinha, L. B.
Affiliations
  • Centro Interdisciplinar de Estudo da Performance Humana (PT)
  • Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The New York Obesity Nutrition Research Center, St Luke's–Roosevelt Hospital, New York, NY 10025, USA.
  • Universidade Estadual de Campinas (UNICAMP) (BR)
ORCID
Venue
Applied Physiology, Nutrition, and Metabolism
Publisher
Canadian Science Publishing
Published
2013-06
Volume
38
Issue
6
Pages
626-632
ISSN
  • 1715-5312 (ISSN-L)
  • 1715-5320
DOI
10.1139/apnm-2012-0253
OpenAlex
W2090878323
Cited by
32
References
40
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 2
FWCI
1.71
Type
journal article
Language
en
Open access
closed
Licence
www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations
  • Applied Physiology Nutrition and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
World Health Organization
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
Keywords
caffeine, total body water, extracellular water, intracellular water, hydration status, fluid distribution, deuterium dilution, body composition, physical activity, water intake, healthy young men
MeSH terms
Adult, Body Composition, Body Water, Caffeine, Double-Blind Method, Humans, Male, Absorptiometry, Photon, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review