Mitochondrial calcium exchange in physiology and disease

Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells

Parihar, M. S., Parihar, A., Fujita, M., Hashimoto, M., & Ghafourifar, P. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.05.008 · Cited by 206

The m -AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

König, T., Tröder, S. E., Bakka, K., Korwitz, A., Richter-Dennerlein, R., Lampe, P. A., Patron, M., Mühlmeister, M., Guerrero-Castillo, S., Brandt, U., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.020 · Cited by 201

Mdm38 protein depletion causes loss of mitochondrial K+/H+ exchange activity, osmotic swelling and mitophagy

Nowikovsky, K., Reipert, S., Devenish, R. J., & Schweyen, R. J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402167 · Cited by 200

Regulation of Intracellular and Mitochondrial Sodium in Health and Disease

Murphy, E., & Eisner, D. A. (2009) · Circulation Research · doi:10.1161/circresaha.108.189050 · Cited by 200

The Ca2+-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca2+ Uptake

Petrungaro, C., Zimmermann, K. M., Küttner, V., Fischer, M., Dengjel, J., Bogeski, I., & Riemer, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.019 · Cited by 200

Mitochondrial calcium and the regulation of metabolism in the heart

Williams, G. S. B., Boyman, L., & Lederer, W. J. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.10.019 · Cited by 197

The LETM1/YOL027 Gene Family Encodes a Factor of the Mitochondrial K+ Homeostasis with a Potential Role in the Wolf-Hirschhorn Syndrome

Nowikovsky, K., Froschauer, E. M., Zsurka, G., Samaj, J., Reipert, S., Kolisek, M., Wiesenberger, G., & Schweyen, R. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403607200 · Cited by 194

Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU

Paillard, M., Csordás, G., Szanda, G., Golenár, T., Debattisti, V., Bartok, A., Wang, N., Moffat, C., Seifert, E. L., Spät, A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.032 · Cited by 194

Calcium Homeostasis and Mitochondrial Dysfunction in Striatal Neurons of Huntington Disease

Lim, D., Fedrizzi, L., Tartari, M., Zuccato, C., Cattaneo, E., Brini, M., & Carafoli, E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m704704200 · Cited by 193

Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.

Sánchez-García, I., & Grütz, G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5287 · Cited by 192

The Mitochondrial Calcium Uniporter Controls Skeletal Muscle Trophism In Vivo

Mammucari, C., Gherardi, G., Zamparo, I., Raffaello, A., Boncompagni, S., Chemello, F., Cagnin, S., Braga, A., Zanin, S., Pallafacchina, G., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.056 · Cited by 190

Distinct mPTP activation mechanisms in ischaemia–reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate

Seidlmayer, L. K., Juettner, V. V., Kettlewell, S., Pavlov, E. V., Blatter, L. A., & Dedkova, E. N. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv097 · Cited by 189

Selectivity of Inhibition of Na+-Ca2+ Exchange of Heart Mitochondria by Benzothiazepine CGP-37157

Cox, D. A., Conforti, L., Sperelakis, N., & Matlib, M. A. (1993) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199304000-00013 · Cited by 186

Identification and characterization of the pore-forming protein in the outer membrane of rat liver mitochondria

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LETM1, deleted in Wolf Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability

Dimmer, K. S., Navoni, F., Casarin, A., Trevisson, E., Endele, S., Winterpacht, A., Salviati, L., & Scorrano, L. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm297 · Cited by 185

The Initial Velocities of Calcium Uptake by Rat Liver Mitochondria

Vinogradov, A., & Scarpa, A. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43634-x · Cited by 183

The Role of Mitochondrial Porins and the Permeability Transition Pore in Learning and Synaptic Plasticity

Weeber, E. J., Levy, M., Sampson, M. J., Anflous, K., Armstrong, D. L., Brown, S. E., Sweatt, J. D., & Craigen, W. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201649200 · Cited by 181

Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits

Lacampagne, A., Liu, X., Reiken, S., Bussiere, R., Meli, A. C., Lauritzen, I., Teich, A. F., Zalk, R., Saint, N., Arancio, O., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1733-7 · Cited by 181

AtWRKY15 perturbation abolishes the mitochondrial stress response that steers osmotic stress tolerance in Arabidopsis

Vanderauwera, S., Vandenbroucke, K., Inzé, A., van de Cotte, B., Mühlenbock, P., De Rycke, R., Naouar, N., Van Gaever, T., Van Montagu, M. C. E., & Van Breusegem, F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217516109 · Cited by 180

MCU encodes the pore conducting mitochondrial calcium currents

Chaudhuri, D., Sancak, Y., Mootha, V. K., & Clapham, D. E. (2013) · eLife · doi:10.7554/elife.00704 · Cited by 180

Spermine. A regulator of mitochondrial calcium cycling.

Nicchitta, C. V., & Williamson, J. R. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90643-5 · Cited by 177

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

Kostic, M., Ludtmann, M. H. R., Bading, H., Hershfinkel, M., Steer, E., Chu, C. T., Abramov, A. Y., & Sekler, I. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.079 · Cited by 177

The Mitochondrial Ca2+ Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells

Tarasov, A. I., Semplici, F., Ravier, M. A., Bellomo, E. A., Pullen, T. J., Gilon, P., Sekler, I., Rizzuto, R., & Rutter, G. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039722 · Cited by 174

Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.

Fanger, C. M., Hoth, M., Crabtree, G. R., & Lewis, R. S. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.3.655 · Cited by 173

MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype

Hong, Z., Chen, K.-H., DasGupta, A., Potus, F., Dunham-Snary, K., Bonnet, S., Tian, L., Fu, J., Breuils-Bonnet, S., Provencher, S., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201604-0814oc · Cited by 170

MICU1 drives glycolysis and chemoresistance in ovarian cancer

Chakraborty, P. K., Mustafi, S. B., Xiong, X., Dwivedi, S. K. D., Nesin, V., Saha, S., Zhang, M., Dhanasekaran, D., Jayaraman, M., Mannel, R., et al. (2017) · Nature Communications · doi:10.1038/ncomms14634 · Cited by 169

Evidence that mitochondria buffer physiological Ca2+ loads in lizard motor nerve terminals

David, G., Barrett, J. N., & Barrett, E. F. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.059bo.x · Cited by 168

Physiological and structural differences in spatially distinct subpopulations of cardiac mitochondria: influence of cardiac pathologies

Hollander, J. M., Thapa, D., & Shepherd, D. L. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00747.2013 · Cited by 167

Mitochondrial Retrograde Signaling: Triggers, Pathways, and Outcomes

da Cunha, F. M., Torelli, N. Q., & Kowaltowski, A. J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/482582 · Cited by 167

Evolutionary Diversity of the Mitochondrial Calcium Uniporter

Bick, A. G., Calvo, S. E., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1214977 · Cited by 165

Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas

Area-Gomez, E., Guardia-Laguarta, C., Schon, E. A., & Przedborski, S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci120848 · Cited by 164

An Interaction between Bcl-xL and the Voltage-dependent Anion Channel (VDAC) Promotes Mitochondrial Ca2+ Uptake

Huang, H., Hu, X., Eno, C. O., Zhao, G., Li, C., & White, C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.448290 · Cited by 163

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

Rasmussen, T. P., Wu, Y., Joiner, M.-L. A., Koval, O. M., Wilson, N. R., Luczak, E. D., Wang, Q., Chen, B., Gao, Z., Zhu, Z., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504705112 · Cited by 162

Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis

Rebane, A., Zimmermann, M., Aab, A., Baurecht, H., Koreck, A., Karelson, M., Abram, K., Metsalu, T., Pihlap, M., Meyer, N., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.02.020 · Cited by 162

MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma

Jin, M., Wang, J., Ji, X., Cao, H., Zhu, J., Chen, Y., Yang, J., Zhao, Z., Ren, T., & Xing, J. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1135-x · Cited by 162

The regulation of brain mitochondrial calcium-ion transport. The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms

Nicholls, D. G., & Scott, I. D. (1980) · Biochemical Journal · doi:10.1042/bj1860833 · Cited by 161

Type 1 ryanodine receptor in cardiac mitochondria: Transducer of excitation–metabolism coupling

Beutner, G., Sharma, V. K., Lin, L., Ryu, S.-Y., Dirksen, R. T., & Sheu, S.-S. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.09.016 · Cited by 161

Calcium transport in mitochondria

Selwyn, M. J., Dawson, A. P., & Dunnett, S. J. (1970) · FEBS Letters · doi:10.1016/0014-5793(70)80402-1 · Cited by 161

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

Woods, J. J., Nemani, N., Shanmughapriya, S., Kumar, A., Zhang, M., Nathan, S. R., Thomas, M., Carvalho, E., Ramachandran, K., Srikantan, S., et al. (2019) · ACS Central Science · doi:10.1021/acscentsci.8b00773 · Cited by 161

A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria.

Cox, D. A., & Matlib, M. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54024-2 · Cited by 160

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

Lombardi, A. A., Gibb, A. A., Arif, E., Kolmetzky, D. W., Tomar, D., Luongo, T. S., Jadiya, P., Murray, E. K., Lorkiewicz, P. K., Hajnóczky, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12103-x · Cited by 160

Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis

Pogwizd, S. M., Sipido, K. R., Verdonck, F., & Bers, D. M. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00735-6 · Cited by 159

Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson’s disease by disturbing calcium flux

Marongiu, R., Spencer, B. J., Crews, L. A., Adame, A., Patrick, C., Trejo, M., Dallapiccola, B., Valente, E. M., & Masliah, E. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05932.x · Cited by 158

LETM1, A Novel Gene Encoding a Putative EF-Hand Ca2+-Binding Protein, Flanks the Wolf–Hirschhorn Syndrome (WHS) Critical Region and Is Deleted in Most WHS Patients

Endele, S. U., Fuhry, M., Pak, S.-J., Zabel, B., & Winterpacht, A. (1999) · Genomics · doi:10.1006/geno.1999.5881 · Cited by 158

Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex

Tsai, M.-F., Phillips, C. B., Ranaghan, M., Tsai, C.-W., Wu, Y., Williams, C., & Miller, C. (2016) · eLife · doi:10.7554/elife.15545 · Cited by 158

Ca2+-induced Reactive Oxygen Species Production Promotes Cytochrome c Release from Rat Liver Mitochondria via Mitochondrial Permeability Transition (MPT)-dependent and MPT-independent Mechanisms

Petrosillo, G., Ruggiero, F. M., Pistolese, M., & Paradies, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407500200 · Cited by 157

E-health use, vaccination knowledge and perception of own risk: Drivers of vaccination uptake in medical students

Betsch, C., & Wicker, S. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.12.021 · Cited by 156

Monitoring phosphorylation of the pyruvate dehydrogenase complex

Rardin, M. J., Wiley, S. E., Naviaux, R. K., Murphy, A. N., & Dixon, J. E. (2009) · Analytical Biochemistry · doi:10.1016/j.ab.2009.03.040 · Cited by 155

EMRE Is a Matrix Ca2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca2+ Uniporter

Vais, H., Mallilankaraman, K. B., Mak, D. D., Hoff, H. B., Payne, R. J., Tanis, J. E., & Foskett, J. K. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.054 · Cited by 154

G protein-coupled receptor kinases as therapeutic targets in the heart

Pfleger, J. M., Gresham, K. S., & Koch, W. J. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0220-3 · Cited by 154

MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress

Lambert, J. P., Luongo, T. S., Tomar, D., Jadiya, P., Gao, E., Zhang, X., Lucchese, A. M., Kolmetzky, D. W., Shah, N. S., & Elrod, J. W. (2019) · Circulation · doi:10.1161/circulationaha.118.037968 · Cited by 154

Reconstitution of the mitochondrial calcium uniporter in yeast

Kovács-Bogdán, E., Sancak, Y., Kamer, K. J., Plovanich, M., Jambhekar, A., Huber, R. J., Myre, M. A., Blower, M. D., & Mootha, V. K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400514111 · Cited by 153

The mitochondrial uniporter controls fight or flight heart rate increases

Wu, Y., Rasmussen, T. P., Koval, O. M., Joiner, M.-L. A., Hall, D. D., Chen, B., Luczak, E. D., Wang, Q., Rokita, A. G., Wehrens, X. H. T., et al. (2015) · Nature Communications · doi:10.1038/ncomms7081 · Cited by 153

Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

Wiederkehr, A., Szanda, G., Akhmedov, D., Mataki, C., Heizmann, C. W., Schoonjans, K., Pozzan, T., Spät, A., & Wollheim, C. B. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.015 · Cited by 152

Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids

Montero, M., Lobatón, C. D., Hernández‐SanMiguel, E., Domingo, J. S., Vay, L., Moreno, A., & Álvarez, J. (2004) · Biochemical Journal · doi:10.1042/bj20040990 · Cited by 151

SLC25A23 augments mitochondrial Ca2+uptake, interacts with MCU, and induces oxidative stress–mediated cell death

Hoffman, N. E., Chandramoorthy, H. C. K., Shanmughapriya, S., Zhang, X. Q., Vallem, S., Doonan, P. J., Mallilankaraman, K. B., Guo, S., Rajan, S., Elrod, J. W., et al. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-08-0502 · Cited by 150

The rapid mode of calcium uptake into heart mitochondria (RaM): comparison to RaM in liver mitochondria

Buntinas, L., Gunter, K. K., Sparagna, G. C., & Gunter, T. E. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00254-1 · Cited by 149

High‐affinity cooperative Ca2+ binding by MICU1–MICU2 serves as an on–off switch for the uniporter

Kamer, K. J., Grabarek, Z., & Mootha, V. K. (2017) · EMBO Reports · doi:10.15252/embr.201643748 · Cited by 149

Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters

Baradaran, R., Wang, C., Siliciano, A. F., & Long, S. B. (2018) · Nature · doi:10.1038/s41586-018-0331-8 · Cited by 149

Mitochondrial Ca2+ Transport: Mechanisms, Molecular Structures, and Role in Cells

Belosludtsev, K. N., Dubinin, M. V., Belosludtseva, N. V., & Mironova, G. D. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919060026 · Cited by 149

Voltage-energized calcium-sensitive ATP production by mitochondria

Wescott, A. P., Kao, J. P. Y., Lederer, W. J., & Boyman, L. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0126-8 · Cited by 148

Lithium-Calcium Exchange Is Mediated by a Distinct Potassium-independent Sodium-Calcium Exchanger

Palty, R., Ohana, E., Hershfinkel, M., Volokita, M., Elgazar-Carmon, V., Beharier, O., Silverman, W. F., Argaman, M., & Sekler, I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401229200 · Cited by 147

The cationically selective state of the mitochondrial outer membrane pore: a study with intact mitochondria and reconstituted mitochondrial porin

Benz, R., Kottke, M., & Brdiczka, D. G. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90279-w · Cited by 147

The Sodium-Calcium Antiport of Heart Mitochondria Is Not Electroneutral

Jung, D. W., Baysal, K., & Brierley, G. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.2.672 · Cited by 146

AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression

Zhao, H., Li, T., Wang, K., Zhao, F. L., Chen, J., Xu, G., Zhao, J., Li, T., Chen, L., Li, L., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0296-3 · Cited by 146

Mitochondrial Ca2+ Uptake 1 (MICU1) and Mitochondrial Ca2+ Uniporter (MCU) Contribute to Metabolism-Secretion Coupling in Clonal Pancreatic β-Cells

Alam, M. R., Groschner, L. N., Parichatikanond, W., Liang, K., Bondarenko, A. I., Rost, R., Waldeck‐Weiermair, M., Malli, R., & Graier, W. F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.392084 · Cited by 145

Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs)

Marchi, S., Bittremieux, M., Missiroli, S., Morganti, C., Patergnani, S., Sbano, L., Rimessi, A., Kerkhofs, M., Parys, J. B., Bultynck, G., et al. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4567-7_4 · Cited by 144

Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1

Tsai, M.-F., Jiang, D., Zhao, L., Clapham, D. E., & Miller, C. (2013) · The Journal of General Physiology · doi:10.1085/jgp.201311096 · Cited by 142

Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD

Dafinca, R., Barbagallo, P., Farrimond, L. E., Candalija, A., Scaber, J., Ababneh, N. A., Sathyaprakash, C., Vowles, J., Cowley, S. A., & Talbot, K. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.03.023 · Cited by 142

Mitochondrial redox signaling enables repair of injured skeletal muscle cells

Horn, A. J., der Meulen, J. H. V., Defour, A., Hogarth, M. W., Sreetama, S. C., Reed, A., Scheffer, L., Chandel, N. S., & Jaiswal, J. K. (2017) · Science Signaling · doi:10.1126/scisignal.aaj1978 · Cited by 141

Cryo-EM structure of a mitochondrial calcium uniporter

Yoo, J., Wu, M., Yin, Y., Herzik, M. A., Lander, G. C., & Lee, S. (2018) · Science · doi:10.1126/science.aar4056 · Cited by 140

MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex

Gottschalk, B., Klec, C., Leitinger, G., Bernhart, E. M., Rost, R., Bischof, H., Madreiter‐Sokolowski, C. T., Radulović, S., Eroğlu, E., Sattler, W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11692-x · Cited by 140

Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L

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Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with regulation by adenine nucleotides and NADH/NAD+ ratios

Rutter, G. A., & Denton, R. M. (1988) · Biochemical Journal · doi:10.1042/bj2520181 · Cited by 138

Cyclosporin inhibits mitochondrial calcium efflux in isolated adult rat ventricular cardiomyocytes

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MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

Hoffman, N. E., Chandramoorthy, H. C. K., Shanmughapriya, S., Zhang, X., Rajan, S., Mallilankaraman, K. B., Gandhirajan, R. K., Vagnozzi, R. J., Ferrer, L. M., Sreekrishnanilayam, K., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.026 · Cited by 136

Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter

Wang, Y., Nguyen, N. X., She, J., Zeng, W., Yang, Y., Bai, X., & Jiang, Y. (2019) · Cell · doi:10.1016/j.cell.2019.03.050 · Cited by 136

Altered Mitochondrial Sensitivity for ADP and Maintenance of Creatine-stimulated Respiration in Oxidative Striated Muscles from VDAC1-deficient Mice

Anflous, K., Armstrong, D. D., & Craigen, W. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006587200 · Cited by 135

Cryo-EM structure of a fungal mitochondrial calcium uniporter

Nguyen, N. X., Armache, J., Lee, C., Yang, Y., Zeng, W., Mootha, V. K., Cheng, Y., Bai, X., & Jiang, Y. (2018) · Nature · doi:10.1038/s41586-018-0333-6 · Cited by 135

X-ray and cryo-EM structures of the mitochondrial calcium uniporter

Fan, C., Fan, M., Orlando, B. J., Fastman, N. M., Zhang, J., Xu, Y., Chambers, M. G., Xu, X., Perry, K., Liao, M., et al. (2018) · Nature · doi:10.1038/s41586-018-0330-9 · Cited by 135

Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery

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Mitochondrial Ca2+ and neurodegeneration

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Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening

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