Cited by 1,186Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

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Chronic Inflammation in Obesity and the Metabolic Syndrome

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Monteiro, Rosário, Azevedo, Isabel·2010·Mediators of Inflammation

DOI 10.1155/2010/289645PMC PMC2913796

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Abstract

The increasing incidence of obesity and the metabolic syndrome is disturbing. The activation of inflammatory pathways, used normally as host defence, reminds the seriousness of this condition. There is probably more than one cause for activation of inflammation. Apparently, metabolic overload evokes stress reactions, such as oxidative, inflammatory, organelle and cell hypertrophy, generating vicious cycles. Adipocyte hypertrophy, through physical reasons, facilitates cell rupture, what will evoke an inflammatory reaction. Inability of adipose tissue development to engulf incoming fat leads to deposition in other organs, mainly in the liver, with consequences on insulin resistance. The oxidative stress which accompanies feeding, particularly when there is excessive ingestion of fat and/or other macronutrients without concomitant ingestion of antioxidant-rich foods/beverages, may contribute to inflammation attributed to obesity. Moreover, data on the interaction of microbiota with food and obesity brought new hypothesis for the obesity/fat diet relationship with inflammation. Beyond these, other phenomena, for instance psychological and/or circadian rhythm disturbances, may likewise contribute to oxidative/inflammatory status. The difficulty in the management of obesity/metabolic syndrome is linked to their multifactorial nature where environmental, genetic and psychosocial factors interact through complex networks.

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Figure 1 Overview of the complex interplay between obesity-inflammation-metabolic syndrome: metabolic overload impacts on adipose tissue, leading to organelle stress with production of ROS and adipokines, as well as activation of kinases that potentiate the transcription of inflammatory genes and interfere with insulin signaling. Hyperthrophy facilitates rupture of adipocytes which attract and activate macrophages that markedly reinforce the inflammatory process through further production of ROS and inflammatory cytokines. Production of adiponectin, an anti-inflammatory cytokine, is reduced. Increase of FFA concentration, namely, SFA, coming both from feeding and adipose tissue overflow, accumulates in the liver, among other organs. Fat accumulation in the liver leads to overproduction of LDLs and, together with IL-6, of CRP. NAFLD is a frequent consequence of these metabolic dysregulations, and all this impacts on insulin sensitivity. SFA activates TOLL-like receptors in adipocytes, contributing to the activation of the inflammatory response. Fat has also effects on intestinal permeability and on the microbiota, with systemic inflammatory consequences. Most excess metabolites and cytokines produced throughout these processes converge on insulin resistance, a central characteristic of the metabolic syndrome. AP-1: activator protein-1; CRP: C-reactive protein; FFA: free (nonesterified) fatty acids; IL-n: interleukins; IKK: inhibitor of NF-κB kinase; IL-6: interleukin-6; Int: intestine; IR: insulin resistance; JNK: c-Jun N-terminal kinase; LDL: low density lipoprotein; M: microbiota; NAFLD: nonalcoholic fatty liver disease; NF-κB: nuclear factor κB; OxS: oxidative stress; ROS: reactive oxygen species; PKC: protein kinase C; SFA: saturated fatty acids; TAG: triacylglycerols; TLR: TOLL-like receptors; TNFalpha: tumour necrosis factor alpha.CC BY · PubMed Central

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Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,094
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · cited 2×
“Other researchers have attempted to name this inflammatory state as “metaflammation”, meaning metabolically triggered inflammation [32], or “parainflammation” as a term to define an intermediate state between basal and inflammatory states [33].”
Background
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618 · cited 1×
“Other researchers have attempted to name this inflammatory state as “metaflammation”, meaning metabolically triggered inflammation [32], or “parainflammation” as a term to define an intermediate state between basal and inflammatory states [33].”
Background
The metabolic syndrome
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,317
The metabolic syndrome
Eckel, R. H., Grundy, S. M., & Zimmet, P. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66378-7 · Cited by 5,755
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · cited 2×
“[108] F.”
Result
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · cited 1×
“Macrophage crowns surrounding dead adipocytes in adipose tissue, as shown by Cinti and collaborators [71], are compatible with this hypothesis.”
Background
Phylogenetic Perspectives in Innate Immunity
Hoffmann, J. A., Kafatos, F. C., Janeway, C. A., & Ezekowitz, R. A. B. (1999) · Science · doi:10.1126/science.284.5418.1313 · Cited by 2,524 · cited 1×
“[72] J.”

Show all 124 references

Research works printed but not linked: 5

2003, Endocrine Practice, 9, 237
2000, Journal of Clinical Endocrinology and Metabolism, 85, 3338
2000, Diabetes and Metabolism, 26, 178
2008, International Journal of Obesity, 32, S11
2006, Journal of the American College of Nutrition, 25, 262S

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Method
Assessment of Physical Activity and Healthy Eating Behaviors Among US Adults Receiving Bariatric Surgery
Hong, Y., Yadav, S., Suk, R., Lee, A. M., Newsome, F. A., Johnson-Mann, C. N., Cardel, M. I., & Ross, K. M. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.17380 · Cited by 14
“We categorized the individuals into 3 mutually exclusive groups: (1) individuals with normal weight (BMI range, 18.”
Method
Gold nanoparticles application to the treatment of brain dysfunctions related to metabolic diseases: evidence from experimental studies
Silveira, P. C. L., Rodrigues, M. S., Gelain, D. P., & de Oliveira, J. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00929-2 · Cited by 16
“In this same study, AuNPs increased plasma insulin significantly, showing a potential antidiabetic effect of AuNPs (Venkatachalam et al. 2013). as adipocyte hypertrophy (Monteiro and Azevedo 2010; Longo et al. 2019).”
Background
Red Beetroot (Beta Vulgaris L.)
Székely, D., & Máté, M. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106692 · Cited by 16
Cathepsin S inhibitor reduces high-fat-induced adipogenesis, inflammatory infiltration, and hepatic lipid accumulation in obese mice
Zheng, J., Zhuang, H.-J., Zhang, T., et al. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5145 · Cited by 14
“Environmental factors, such as an unhealthy diet, insufficient physical exercise, fast food, ultra-processed foods, chemical contaminants, and the inflammatory response, are the main causes of obesity (5,6) .”
Obesity Contributes to Inflammation in Patients with IBS via Complement Component 3 and C-Reactive Protein
Thomas-Dupont, P., Velázquez-Soto, H., Izaguirre-Hernández, I. Y., Amieva‐Balmori, M., Triana‐Romero, A., Islas-Vázquez, L., Martínez, M. D. C. J., & Remes-Troche, J. M. (2022) · Nutrients · doi:10.3390/nu14245227 · Cited by 16
“besity is associated with low-grade chronic inflammation that promotes chronic iseases, such as type 2 diabetes (T2D) [19], cardiovascular (CVD) [20], metabolic alterations [21], hypertension (HT) [22], nonalcoholic steatohepatitis (NASH) [23], and some types of cancer [24].”
Background
Utility of Hypoglycemic Agents to Treat Asthma with Comorbid Obesity
Ge, D., Foer, D., & Cahill, K. N. (2022) · Pulmonary Therapy · doi:10.1007/s41030-022-00211-x · Cited by 14
Metabolic syndrome components can predict C reactive protein concentration in adolescents.
da Cruz, L. L., Cardoso, L. D., Pala, D., et al. (2014) · PubMed · doi:10.3305/nh.2013.28.5.6625 · Cited by 14
“The inflammation state that accompanies obesity is considered to be a chronic low-grade inflammation, generally associated with high concentrations of leukocytes, fibrinogen and other inflammatory biomarkers, such as C reactive protein Reactive Protein (CRP).(10,11) CRP is an acute phase reactant protein produced by h…”
Chlorella Protein Hydrolysate Attenuates Glucose Metabolic Disorder and Fatty Liver in High-fat Diet-induced Obese Mice
Noguchi, N., Yanagita, T., Rahman, S. M., & Ando, Y. (2016) · Journal of Oleo Science · doi:10.5650/jos.ess16034 · Cited by 14
Optimise the microbial flora with milk and yoghurt to prevent disease
Morris, J. A. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.02.031 · Cited by 14
Reduced intestinal FADS1 gene expression and plasma omega-3 fatty acids following Roux-en-Y gastric bypass
Garla, P., Sala, P., Torrinhas, R. S., Machado, N. M., Fonseca, D. C., da Silva, M. M., Ravacci, G. R., Belarmino, G., Ishida, R. K., Guarda, I. F. M. S., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.05.011 · Cited by 14
“342 Severe obesity is accompanied by a chronic low-grade inflammation and 343 disturbances in lipid metabolism linked with most of its comorbidities, such as 344 type 2 diabetes mellitus, hypertension and dyslipidemia.([33]) It is widely recognized 345 that n-3 and n-6 PUFAs can distinctly impact on inflammation and l…”
Background
Association between Body Mass Index and Gastric Cancer Risk According to Effect Modification by Helicobacter pylori Infection
Jang, J., Cho, E., Hwang, Y., Weiderpass, E., Ahn, C., Choi, J., Chang, S.-H., Shin, H., Lim, M. K., Yoo, K., et al. (2018) · Cancer Research and Treatment · doi:10.4143/crt.2018.182 · Cited by 14
Carvedilol protects against hepatic ischemia/reperfusion injury in high-fructose/high-fat diet-fed mice: Role of G protein-coupled receptor kinase 2 and 5
Mohammed, S. G., Ibrahim, I. A. A. E.-H., Mahmoud, M. F., et al. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114750 · Cited by 14
Anti-inflammatory effects of Sarcopoterium spinosum extract
Rozenberg, K., Wollman, A., Ben‐Shachar, M., Argaev-Frenkel, L., & Rosenzweig, T. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112391 · Cited by 14
Efficiency comparison of PGBR extract and γ‐oryzanol in antioxidative stress and anti‐inflammatory properties against metabolic syndrome
Lin, H., Lin, S., Shen, K., et al. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.13129 · Cited by 14
Pancreastatin inhibitor PSTi8 protects the obesity associated skeletal muscle insulin resistance in diet induced streptozotocin-treated diabetic mice
Gupta, A. P., Garg, R., Singh, P., Goand, U. K., Syed, A. A., Valicherla, G. R., Riyazuddin, M., Mugale, M. N., & Gayen, J. R. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173204 · Cited by 14
Sendai virus intra-host population dynamics and host immunocompetence influence viral virulence duringin vivopassage
Peña, J., Chen‐Harris, H., Allen, J., Hwang, M. S., Elsheikh, M. M., Mabery, S. L., Bielefeldt‐Ohmann, H., Zemla, A. T., Bowen, R. A., & Borucki, M. K. (2016) · Virus Evolution · doi:10.1093/ve/vew008 · Cited by 17
“Similarly, obesity leads to increased oxidative stress and immune dysregulation although through a different mechanism driven by chronic inflammation (Monteiro and Azevedo 2010; Kanneganti and Dixit 2012; Aroor and DeMarco 2014) .”
Abnormal body mass index is associated with risk of multiple sclerosis: A systematic review and meta-analysis
Mohammadi, M., Mohammadi, A., Habibzadeh, A., Korkorian, R., Mohamadi, M., Shaygannejad, V., Zabeti, A., & Mirmosayyeb, O. (2024) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2024.11.005 · Cited by 15
Role of Nrf2 in Oxidative and Inflammatory Processes in Obesity and Metabolic Diseases
Bayliak, M. M., & Abrat, O. (2020) · Progress in inflammation research · doi:10.1007/978-3-030-44599-7_7 · Cited by 14
Role of Gut Microbiota in Overweight Susceptibility in an Adult Population in Italy
Politi, C., Mobrici, M., Parlongo, R. M., Spoto, B., Tripepi, G. L., Pizzini, P., Cutrupi, S., Franco, D., Tino, R., Farruggio, G., et al. (2023) · Nutrients · doi:10.3390/nu15132834 · Cited by 13
“Inflammation is known to be a hallmark of obesity [39], and is likely the driving force of the microbiota–obesity association [40].”
Background
Hypercoagulable state in patients with schizophrenia: different effects of acute and chronic antipsychotic medications
Zheng, C., Liu, H., Tu, W., Lin, L., & Xu, H. (2023) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253231200257 · Cited by 13
Structural characterization of DNA amplicons by ATR-FTIR spectroscopy as a guide for screening metainflammatory disorders in blood plasma
de Souza, N. M. P., da Rosa, D. K. A., de Moraes, C., et al. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.123897 · Cited by 13
Cardiometabolic profiles and proteomics associated with obesity phenotypes in a longitudinal cohort of young adults
Liao, J., Goodrich, J. A., Chen, W., Qiu, C., Chen, J. C., Costello, E. J., Alderete, T. L., Chatzi, L., Gilliland, F. D., & Chen, Z. (2024) · Scientific Reports · doi:10.1038/s41598-024-57751-2 · Cited by 12
EGCG Suppresses Adipogenesis and Promotes Browning of 3T3-L1 Cells by Inhibiting Notch1 Expression
Wang, Y., Li, C., Peng, W., Sheng, J., Zi, C., & Wu, X. (2024) · Molecules · doi:10.3390/molecules29112555 · Cited by 14
Association of systemic immune inflammatory index with obesity and abdominal obesity: A cross-sectional study from NHANES
Qiu, L., Ren, Y., Li, J., Li, M., Li, W., Qin, L., Ning, C., Zhang, J., & Gao, F. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2024.06.003 · Cited by 14
Melatonin and Metabolic Disorders: Unraveling the Interplay With Glucose and Lipid Metabolism, Adipose Tissue, and Inflammation
Hong, S. H., & Kim, J. (2024) · Sleep Medicine Research · doi:10.17241/smr.2024.02159 · Cited by 13
“Therefore, potential therapeutic interventions have gained increased attention [3,13,54].”
BackgroundInfluential
Plant-Based Foods for Chronic Skin Diseases: A Focus on the Mediterranean Diet
Annunziata, G., Verde, L., Zink, A., Muscogiuri, G., Albanesi, C., Paganelli, A., Barrea, L., & Scala, E. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00632-5 · Cited by 17
“Chronic inflammation is a key feature, often exacerbated by concurrent endocrine and metabolic disturbances such as obesity [142, 143].”
Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive Breast Cancer Associates with Postmenopausal Body Size and Recreational Physical Activity
McCullough, L. E. (2015) · International Journal of Cancer and Clinical Research · doi:10.23937/2378-3419/2/1/1013 · Cited by 13
“In addition to increased levels of estrogen, central adiposity has been associated with chronic low-grade inflammation [44].”
APO A2 -265T/C Polymorphism Is Associated with Increased Inflammatory Responses in Patients with Type 2 Diabetes Mellitus
Koohdani, F., Sadrzadeh-Yeganeh, H., Djalali, M., Eshraghian, M., Zamani, E., Sotoudeh, G., Mansournia, M. A., & Keramat, L. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.3.222 · Cited by 13
“Notably, it was shown that accumulated fat in the abdominal cavity could result in atherosclerosis via the production of inflammatory cytokines [16].”
Background
Pyrroloquinoline quinone attenuates obesity associated low grade inflammation
Devasani, K., & Majumdar, A. S. (2019) · Obesity Medicine · doi:10.1016/j.obmed.2019.100134 · Cited by 13
Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal study
Okamura, T., Hashimoto, Y., Hamaguchi, M., Obora, A., Kojima, T., & Fukui, M. (2020) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2020-000400 · Cited by 13
Evaluation of clinical, endocrine and metabolic findings in obese children with and without hepatosteatosis
Başarır, G., Özcabı, B., Sayman, Ö. A., Akay, H., & Yıldız, F. (2021) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2021-0034 · Cited by 13
Pathogenesis, Diagnosis, and Management of Metabolic Syndrome: A Comprehensive Review
Ananthy, V., Priyadharsini, R. P., & Subramanian, U. (2021) · SBV Journal of Basic Clinical and Applied Health Science · doi:10.5005/jp-journals-10082-03111 · Cited by 13
“Metab Syndr Relat Disord 2009;7(4):271–277.”
Immune Sexual Dimorphism: Connecting the Dots
Gal-Oz, S. T., & Shay, T. (2021) · Physiology · doi:10.1152/physiol.00006.2021 · Cited by 13
Predictive Modeling of MAFLD Based on Hsp90α and the Therapeutic Application of Teprenone in a Diet-Induced Mouse Model
Xie, Y., Chen, L., Xu, Z., Li, C., Ni, Y., Hou, M., Chen, L., Chang, H., Yang, Y., Wang, H., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.743202 · Cited by 13
“It is well known that obesity, T2DM, and Mets are chronic inflammatory diseases (9).”
Background
Spectral-domain OCT measurements in obesity: A systematic review and meta-analysis
Salehi, M. A., Karimi, A., Mohammadi, S., & Arévalo, J. F. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267495 · Cited by 13
“The adipokines then provoke the production of reactive oxygen species (ROS) and promote the level of oxidative stress [61].”
Background
Inflammation biomarkers and inflammatory genes expression in metabolically healthy obese patients
Spoto, B., Betta, E. D., Pizzini, P., Lonardi, S., Mallamaci, F., Tripepi, G. L., Kanbay, M., Cancarini, G. C., & Zoccali, C. (2022) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.12.008 · Cited by 13
Maternal Thyroid Antibodies Associates With Cardiometabolic Risk Factors in Children at the Age of 16
Heikkinen, A.-L., Päkkilä, F., Hartikainen, A., Vääräsmäki, M., Männistö, T. I., & Suvanto, E. T. J. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01137 · Cited by 13
“Inflammation is often found along with metabolic syndrome (30).”
Background
The impact of obesity on cardiovascular disease risk factor
Kumar, A. (2018) · Asian Journal of Medical Sciences · doi:10.3126/ajms.v10i1.21294 · Cited by 19
Dipeptidyl dipeptidase-4 inhibitor recovered ischemia through an increase in vasculogenic endothelial progenitor cells and regeneration-associated cells in diet-induced obese mice
Salybekov, A. A., Masuda, H., Miyazaki, K., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0205477 · Cited by 13
Investigation of Mineral and Vitamin C Contents in Different Parts of Beetroots (Beta vulgaris L.)
Székely, D., Furulyás, D., & Stéger‐Máté, M. (2019) · Notulae Botanicae Horti Agrobotanici Cluj-Napoca · doi:10.15835/nbha47311394 · Cited by 17
“Consumption of beetroot reduces inflammation an innate response including inflection, erythema, edema, trauma, fever and pain that are caused due to cell damage by antigens (Monteiro and Azevedo, 2010).”
Background
A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes
Qin, J.-H., Ma, J., Yang, X., Hu, Y., Zhou, J., Fu, L., Tian, R.-H., Liu, S., Xu, G., & Shen, X. (2015) · Natural Products and Bioprospecting · doi:10.1007/s13659-015-0063-5 · Cited by 13
The Influence of Obesity on Postoperative Inflammatory Cytokine Levels
Chung, M.-Y., Hong, S.-J., & Lee, J.-Y. (2011) · Journal of International Medical Research · doi:10.1177/147323001103900637 · Cited by 13
Using Natural Language Processing to Identify Child Maltreatment in Health Systems
Negriff, S., Lynch, F. L., Cronkite, D. J., Pardee, R. E., & Penfold, R. (2023) · International Journal of Child Abuse & Neglect · doi:10.1016/j.chiabu.2023.106090 · Cited by 14
Higher body mass index increases the risk of shoulder adhesive capsulitis in young adults: a nationwide cohort study
Kim, J.-H., Baek, J.-Y., Han, K., Kim, B.-S., & Kwon, H.-S. (2024) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2024.03.063 · Cited by 12
Hesperetin protects against rotenone-induced motor disability and neurotoxicity via the regulation of SIRT1/NLRP3 signaling
Ateyya, H., Atif, H. M., El‐Fadeal, N. M. A., Abul-Ela, E. S. A.-A., Nadeem, R. I., Rizk, N. I., Gomaa, F. A. M., Abdelkhalig, S. M., Aldahish, A. A., Fawzy, M. S., et al. (2024) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2024.2390646 · Cited by 12
“NFκB correlates with tNF-α and il-1β production (hoesel and schmid 2013) and amplifies the inflammatory burden (Monteiro and azevedo 2010). strong evidence specifies that NlRP3 inflammasome is an essential component of neuroinflammation seen in PD (lee et al. 2019; ).”
Global burden, risk factor analysis, and prediction study of leukaemia from 1990 to 2030
Wang, W., Zhang, D., Liang, Q., et al. (2024) · Journal of Global Health · doi:10.7189/jogh.14.04150 · Cited by 12
WGCNA analysis of the subcutaneous fat transcriptome in a novel tree shrew model
Han, Y., Wang, W., Jia, J., Sun, X., Kuang, D., Tong, P., Li, N., Lü, C., Zhang, H., & Dai, J. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220915180 · Cited by 12

Authors: Monteiro, R., & Azevedo, I.
Affiliations: Universidade do Porto (PT)
Corresponding author: Monteiro, Rosário
ORCID: Monteiro, Rosário
Azevedo, Isabel
Venue: Mediators of Inflammation
Publisher: Wiley
Published: 2010
Volume: 2010
Pages: 1-10
ISSN: 0962-9351 (ISSN-L)
1466-1861
DOI: 10.1155/2010/289645
PMC: PMC2913796
OpenAlex: W1997248937
Cited by: 1,186
References: 124
Citations by year: 2026: 40 · 2025: 93 · 2024: 104 · 2023: 99 · 2022: 126 · 2021: 102 · 2020: 120 · 2019: 113 · 2018: 95 · 2017: 68 · 2016: 47 · 2015: 33 · 2014: 29 · 2013: 45 · 2012: 34
FWCI: 4.15
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Mediators of Inflammation (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: obesity, metabolic syndrome, chronic inflammation, adipocyte hypertrophy, oxidative stress, insulin resistance, hepatic lipid accumulation, gut microbiota, dietary fat, circadian rhythm, psychological factors, adipose tissue
MeSH terms: Animals, Energy Metabolism, Humans, Inflammation, Obesity, Adipocytes, Metabolic Syndrome

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Chronic Inflammation in Obesity and the Metabolic Syndrome

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