The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases
Open accessAbstract
Chronic inflammation is involved in the pathogenesis of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. Regular exercise offers protection against type 2 diabetes, cardiovascular diseases, colon cancer, breast cancer, and dementia. Evidence suggests that the protective effect of exercise may to some extent be ascribed to the antiinflammatory effect of regular exercise. Here we suggest that exercise may exert its anti-inflammatory effect via a reduction in visceral fat mass and/or by induction of an anti-inflammatory environment with each bout of exercise. According to our theory, such effects may in part be mediated via muscle-derived peptides, so-called “myokines”. Contracting skeletal muscles release myokines with endocrine effects, mediating direct anti-inflammatory effects, and/or specific effects on visceral fat. Other myokines work locally within the muscle and exert their effects on signalling pathways involved in fat oxidation and glucose uptake. By mediating anti-inflammatory effects in the muscle itself, myokines may also counteract TNF-driven insulin resistance. In conclusion, exercise-induced myokines appear to be involved in mediating both systemic as well as local anti-inflammatory effects.
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Citations
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · cited 1×
“The reduction was, thus, the same as in the Finnish trial [2], whereas treatment with metformin only reduced the risk of diabetes by 31%.”
ResultThe anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100 · cited 1×
“Several studies show that markers of inflammation are reduced following longer-term behavioural changes involving both reduced energy intake and increased physical activity, reviewed in [48].”
BackgroundSelf-citationMuscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
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“Importantly, also tumour progression is stimulated by systemic elevation of proinflammatory cytokines [15, 27].”
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Interleukin-6-deficient mice develop mature-onset obesity
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Cited by
Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575
Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226
“The role of myokines has previously been reviewed (7, 11-37), identifying more than 650 myokines (38).”
BackgroundSelf-citationAgudelo, L. Z., Femenía, T., Orhan, F., Porsmyr-Palmertz, M., Goiny, M., Martinez-Redondo, V., Correia, J. C., Izadi, M., Bhat, M., Schuppe-Koistinen, I., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.051 · Cited by 739
Pedersen, B. K. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120033 · Cited by 516
Self-citationSkeletal muscle: an endocrine organ
Pratesi, A. (2013) · Clinical cases in mineral and bone metabolism · doi:10.11138/ccmbm/2013.10.1.011 · Cited by 185
Metadata
- Authors
- Brandt, C., & Pedersen, B. K.
- Venue
- Journal of Biomedicine and Biotechnology
- Publisher
- Wiley
- Published
- 2010
- Volume
- 2010
- Pages
- 1-6
- ISSN
- 1110-7243 (ISSN-L)
- 1110-7251
- OpenAlex
- W1986700047
- Cited by
- 430
- References
- 23
- FWCI
- 28.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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