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Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression
Open accessAbstract
This study aims to identify key miRNAs in circulation, which predict ongoing beta-cell destruction and regeneration in children with newly diagnosed Type 1 Diabetes (T1D). We compared expression level of sera miRNAs from new onset T1D children and age-matched healthy controls and related the miRNAs expression levels to beta-cell function and glycaemic control. Global miRNA sequencing analyses were performed on sera pools from two T1D cohorts (n= 275 and 129, resp.) and one control group (n= 151). We identified twelve upregulated human miRNAs in T1D patients (miR-152, miR-30a-5p, miR-181a, miR-24, miR-148a, miR-210, miR-27a, miR-29a, miR-26a, miR-27b, miR-25, miR-200a); several of these miRNAs were linked to apoptosis and beta-cell networks. Furthermore, we identified miR-25 as negatively associated with residual beta-cell function (est.: −0.12,P= 0.0037), and positively associated with glycaemic control (HbA1c) (est.: 0.11,P= 0.0035) 3 months after onset. In conclusion this study demonstrates that miR-25 might be a “tissue-specific” miRNA for glycaemic control 3 months after diagnosis in new onset T1D children and therefore supports the role of circulating miRNAs as predictive biomarkers for tissue physiopathology and potential intervention targets.
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Circulating microRNAs as stable blood-based markers for cancer detection
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Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
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Cited by
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Wang, J., Chen, J., & Sen, S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25056 · Cited by 793
Circulating microRNAs as novel biomarkers for diabetes mellitus
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Interplay between miRNAs and human diseases
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MicroRNAs: biomarkers, diagnostics, and therapeutics
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Application of microRNAs in diabetes mellitus
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Metadata
- Authors
- Nielsen, L. B., Wang, C., Sørensen, K., Bang-Berthelsen, C. H., Hansen, L., Andersen, M.-L. M., Hougaard, P., Juul, A., Zhang, C.-Y., Pociot, F., & Mortensen, H. B.
- Venue
- Experimental Diabetes Research
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-7
- ISSN
- 1687-5214 (ISSN-L)
- 1687-5303
- OpenAlex
- W2069046566
- Cited by
- 287
- References
- 28
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nielsen, L. B., Wang, C., Sørensen, K., Bang-Berthelsen, C. H., Hansen, L., Andersen, M.-L. M., Hougaard, P., Juul, A., Zhang, C.-Y., Pociot, F., & Mortensen, H. B. (2012). Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression. Experimental Diabetes Research. https://doi.org/10.1155/2012/896362
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