Cited by 296Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

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Adipo-myokines: two sides of the same coin–mediators of inflammation and mediators of exercise

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Raschke, Silja, Eckel, Jürgen·2013·Mediators of Inflammation

DOI 10.1155/2013/320724PMC PMC3686148

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Abstract

This review summarizes the current literature regarding the most discussed contraction-regulated moykines like IL-6, IL-15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP-1. It is suggested that the term myokine is restricted to proteins secreted from skeletal muscle cells, excluding proteins that are secreted by other cell types in skeletal muscle tissue and excluding proteins which are only described on the mRNA level. Interestingly, many of the contraction-regulated myokines described in the literature are additionally known to be secreted by adipocytes. We termed these proteins adipo-myokines. Within this review, we try to elaborate on the question why pro-inflammatory adipokines on the one hand are upregulated in the obese state, and have beneficial effects after exercise on the other hand. Both, adipokines and myokines do have autocrine effects within their corresponding tissues. In addition, they are involved in an endocrine crosstalk with other tissues. Depending on the extent and the kinetics of adipo-myokines in serum, these molecules seem to have a beneficial or an adverse effect on the target tissue.

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Authors: Raschke, S., & Eckel, J.
Affiliations: Deutsches Diabetes-Zentrum e.V. (DE)
Corresponding author: Eckel, Jürgen
ORCID: Raschke, Silja
Eckel, Jürgen
Venue: Mediators of Inflammation
Publisher: Wiley
Published: 2013
Volume: 2013
Pages: 1-16
ISSN: 0962-9351 (ISSN-L)
1466-1861
DOI: 10.1155/2013/320724
PMC: PMC3686148
OpenAlex: W2116932335
Cited by: 296
References: 179
Citations by year: 2026: 12 · 2025: 11 · 2024: 16 · 2023: 17 · 2022: 26 · 2021: 21 · 2020: 24 · 2019: 18 · 2018: 30 · 2017: 30 · 2016: 37 · 2015: 28 · 2014: 22 · 2013: 3
FWCI: 4.98
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Mediators of Inflammation (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Bundesministerium für Bildung und Forschung
Bundesministerium für Gesundheit
Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: myokines, adipokines, skeletal muscle contraction, interleukin-6, irisin, brain-derived neurotrophic factor, ANGPTL4, FGF21, myonectin, MCP-1, IL-15, obesity, inflammation, physical activity, autocrine signaling, adipocytes
MeSH terms: Angiopoietin-Like Protein 4, Adipose Tissue, Animals, Endocrine System, Fibroblast Growth Factors, Gene Expression Regulation, Humans, Inflammation, RNA, Messenger, Exercise, Interleukin-6, Muscle, Skeletal, Chemokine CCL2, Brain-Derived Neurotrophic Factor, Interleukin-15, Leptin, Follistatin-Related Proteins, Angiopoietins, Adipokines

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Adipo-myokines: two sides of the same coin–mediators of inflammation and mediators of exercise

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