Cited by 296Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.

Adipo-myokines: two sides of the same coin–mediators of inflammation and mediators of exercise

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Raschke, Silja, Eckel, Jürgen·2013·Mediators of Inflammation

Abstract

This review summarizes the current literature regarding the most discussed contraction-regulated moykines like IL-6, IL-15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP-1. It is suggested that the term myokine is restricted to proteins secreted from skeletal muscle cells, excluding proteins that are secreted by other cell types in skeletal muscle tissue and excluding proteins which are only described on the mRNA level. Interestingly, many of the contraction-regulated myokines described in the literature are additionally known to be secreted by adipocytes. We termed these proteins adipo-myokines. Within this review, we try to elaborate on the question why pro-inflammatory adipokines on the one hand are upregulated in the obese state, and have beneficial effects after exercise on the other hand. Both, adipokines and myokines do have autocrine effects within their corresponding tissues. In addition, they are involved in an endocrine crosstalk with other tissues. Depending on the extent and the kinetics of adipo-myokines in serum, these molecules seem to have a beneficial or an adverse effect on the target tissue.

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Metadata

Authors
Raschke, S., & Eckel, J.
Affiliations
Deutsches Diabetes-Zentrum e.V. (DE)
Corresponding author
Eckel, Jürgen
Venue
Mediators of Inflammation
Publisher
Wiley
Published
2013
Volume
2013
Pages
1-16
ISSN
  • 0962-9351 (ISSN-L)
  • 1466-1861
OpenAlex
W2116932335
Cited by
296
References
179
Citations by year
2026: 12 · 2025: 11 · 2024: 16 · 2023: 17 · 2022: 26 · 2021: 21 · 2020: 24 · 2019: 18 · 2018: 30 · 2017: 30 · 2016: 37 · 2015: 28 · 2014: 22 · 2013: 3
FWCI
4.98
Type
journal article
Language
en
Open access
Locations
  • Mediators of Inflammation (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Bundesministerium für Bildung und Forschung
  • Bundesministerium für Gesundheit
  • Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen
Topics
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
myokines, adipokines, skeletal muscle contraction, interleukin-6, irisin, brain-derived neurotrophic factor, ANGPTL4, FGF21, myonectin, MCP-1, IL-15, obesity, inflammation, physical activity, autocrine signaling, adipocytes
MeSH terms
Angiopoietin-Like Protein 4, Adipose Tissue, Animals, Endocrine System, Fibroblast Growth Factors, Gene Expression Regulation, Humans, Inflammation, RNA, Messenger, Exercise, Interleukin-6, Muscle, Skeletal, Chemokine CCL2, Brain-Derived Neurotrophic Factor, Interleukin-15, Leptin, Follistatin-Related Proteins, Angiopoietins, Adipokines

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