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Cited by 80Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurological Disease Mechanisms and Treatments

Microglia and Synapse: Interactions in Health and Neurodegeneration

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Šišková, Zuzana, Tremblay, Marie-Ève·2013·Neural Plasticity
DOI 10.1155/2013/425845PMC PMC3874338
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Abstract

A series of discoveries spanning for the last few years has challenged our view of microglial function, the main form of immune defense in the brain. The surveillance of neuronal circuits executed by each microglial cell overseeing its territory occurs in the form of regular, dynamic interactions. Microglial contacts with individual neuronal compartments, such as dendritic spines and axonal terminals, ensure that redundant or dysfunctional elements are recognized and eliminated from the brain. Microglia take on a new shape that is large and amoeboid when a threat to brain integrity is detected. In this defensive form, they migrate to the endangered sites, where they help to minimize the extent of the brain insult. However, in neurodegenerative diseases that are associated with misfolding and aggregation of synaptic proteins, these vital defensive functions appear to be compromised. Many microglial functions, such as phagocytosis, might be overwhelmed during exposure to the abnormal levels of misfolded proteins in their proximity. This might prevent them from attending to their normal duties, such as the stripping of degenerating synaptic terminals, before neuronal function is irreparably impaired. In these conditions microglia become chronically activated and appear to take on new, destructive roles by direct or indirect inflammatory attack.

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Authors
Šišková, Z., & Tremblay, M.-È.
Affiliations
  • German Center for Neurodegenerative Diseases (DE)
  • Université Laval (CA)
Corresponding author
  • Šišková, Zuzana
  • Tremblay, Marie-Ève
ORCID
Tremblay, Marie-Ève
Venue
Neural Plasticity
Publisher
Wiley
Published
2013-01
Volume
2013
Issue
1
Pages
425845-425845
ISSN
  • 1687-5443 (ISSN-L)
  • 2090-5904
DOI
10.1155/2013/425845
PMC
PMC3874338
OpenAlex
W2027021810
Cited by
80
References
25
Citations by year
2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 9 · 2018: 8 · 2017: 4 · 2016: 14 · 2015: 7 · 2014: 6
FWCI
0.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Neural Plasticity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • DZNE Pub (submittedVersion, cc-by)
Funders
  • Banting Research Foundation
  • Université Laval and Centre de recherche du CHU de Québec
  • American Friends of the Alexander von Humboldt Foundation
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
microglia, synapses, neurodegeneration, microglial surveillance, dendritic spines, axonal terminals, phagocytosis, protein misfolding, microglial activation, neuroinflammation, synaptic pruning
MeSH terms
Alzheimer Disease, Animals, Health, Humans, Synapses, Prion Diseases, Microglia, Neurodegenerative Diseases

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